JP2011516483A5 - - Google Patents
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- Publication number
- JP2011516483A5 JP2011516483A5 JP2011503035A JP2011503035A JP2011516483A5 JP 2011516483 A5 JP2011516483 A5 JP 2011516483A5 JP 2011503035 A JP2011503035 A JP 2011503035A JP 2011503035 A JP2011503035 A JP 2011503035A JP 2011516483 A5 JP2011516483 A5 JP 2011516483A5
- Authority
- JP
- Japan
- Prior art keywords
- skin
- antioxidant
- group
- moiety
- reactive oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003963 antioxidant agent Substances 0.000 claims 40
- 230000003078 antioxidant effect Effects 0.000 claims 40
- 235000006708 antioxidants Nutrition 0.000 claims 40
- 150000001875 compounds Chemical class 0.000 claims 26
- 239000003642 reactive oxygen metabolite Substances 0.000 claims 18
- 210000003491 skin Anatomy 0.000 claims 16
- 150000001450 anions Chemical class 0.000 claims 14
- 230000000295 complement effect Effects 0.000 claims 12
- -1 triphenylphosphonium cation Chemical class 0.000 claims 12
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 11
- 229940080296 2-naphthalenesulfonate Drugs 0.000 claims 10
- 150000008052 alkyl sulfonates Chemical class 0.000 claims 10
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 claims 10
- 229940077388 benzenesulfonate Drugs 0.000 claims 10
- 150000001768 cations Chemical group 0.000 claims 10
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- KVBGVZZKJNLNJU-UHFFFAOYSA-M naphthalene-2-sulfonate Chemical compound C1=CC=CC2=CC(S(=O)(=O)[O-])=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-M 0.000 claims 10
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 10
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 8
- 229920000858 Cyclodextrin Polymers 0.000 claims 8
- 102000007665 Extracellular Signal-Regulated MAP Kinases Human genes 0.000 claims 8
- 108010007457 Extracellular Signal-Regulated MAP Kinases Proteins 0.000 claims 8
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims 8
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 claims 8
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 claims 8
- 210000002510 keratinocyte Anatomy 0.000 claims 8
- LCFWOFKPFDWYLR-CEFNRUSXSA-N alpha-tocopheryloxyacetic acid Chemical compound OC(=O)COC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C LCFWOFKPFDWYLR-CEFNRUSXSA-N 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 6
- 125000000687 hydroquinonyl group Chemical group C1(O)=C(C=C(O)C=C1)* 0.000 claims 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims 6
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 6
- 210000001626 skin fibroblast Anatomy 0.000 claims 6
- 230000000699 topical effect Effects 0.000 claims 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 4
- 201000004624 Dermatitis Diseases 0.000 claims 4
- 206010015150 Erythema Diseases 0.000 claims 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 4
- 208000006877 Insect Bites and Stings Diseases 0.000 claims 4
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims 4
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims 4
- 208000003251 Pruritus Diseases 0.000 claims 4
- 206010042496 Sunburn Diseases 0.000 claims 4
- 235000010323 ascorbic acid Nutrition 0.000 claims 4
- 239000011668 ascorbic acid Substances 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000004054 inflammatory process Effects 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 4
- 230000026731 phosphorylation Effects 0.000 claims 4
- 238000006366 phosphorylation reaction Methods 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 4
- 230000037380 skin damage Effects 0.000 claims 4
- 229910052708 sodium Inorganic materials 0.000 claims 4
- 239000011734 sodium Substances 0.000 claims 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 claims 2
- MANKOBPDSPNOFP-UHFFFAOYSA-N 1-tert-butyl-2-nitrosobenzene Chemical compound CC(C)(C)C1=CC=CC=C1N=O MANKOBPDSPNOFP-UHFFFAOYSA-N 0.000 claims 2
- GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 claims 2
- VCUVETGKTILCLC-UHFFFAOYSA-N 5,5-dimethyl-1-pyrroline N-oxide Chemical compound CC1(C)CCC=[N+]1[O-] VCUVETGKTILCLC-UHFFFAOYSA-N 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 2
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 claims 2
- IELOKBJPULMYRW-NJQVLOCASA-N D-alpha-Tocopheryl Acid Succinate Chemical compound OC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C IELOKBJPULMYRW-NJQVLOCASA-N 0.000 claims 2
- SBJKKFFYIZUCET-JLAZNSOCSA-N Dehydro-L-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-JLAZNSOCSA-N 0.000 claims 2
- SBJKKFFYIZUCET-UHFFFAOYSA-N Dehydroascorbic acid Natural products OCC(O)C1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-UHFFFAOYSA-N 0.000 claims 2
- 208000010201 Exanthema Diseases 0.000 claims 2
- 239000001116 FEMA 4028 Substances 0.000 claims 2
- 206010017533 Fungal infection Diseases 0.000 claims 2
- 206010020649 Hyperkeratosis Diseases 0.000 claims 2
- 208000001126 Keratosis Diseases 0.000 claims 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 2
- 150000000996 L-ascorbic acids Chemical class 0.000 claims 2
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims 2
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims 2
- 208000031888 Mycoses Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 2
- 208000030852 Parasitic disease Diseases 0.000 claims 2
- 206010051246 Photodermatosis Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 241001303601 Rosacea Species 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 206010040844 Skin exfoliation Diseases 0.000 claims 2
- 206010043189 Telangiectasia Diseases 0.000 claims 2
- 208000025865 Ulcer Diseases 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 229930003427 Vitamin E Natural products 0.000 claims 2
- 206010047642 Vitiligo Diseases 0.000 claims 2
- 229960004308 acetylcysteine Drugs 0.000 claims 2
- 206010000496 acne Diseases 0.000 claims 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 2
- 229940087168 alpha tocopherol Drugs 0.000 claims 2
- AGBQKNBQESQNJD-UHFFFAOYSA-N alpha-Lipoic acid Natural products OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims 2
- 206010002022 amyloidosis Diseases 0.000 claims 2
- 229940072107 ascorbate Drugs 0.000 claims 2
- 229960005070 ascorbic acid Drugs 0.000 claims 2
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 208000010668 atopic eczema Diseases 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 206010004398 benign neoplasm of skin Diseases 0.000 claims 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 2
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 2
- 229960004853 betadex Drugs 0.000 claims 2
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims 2
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims 2
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims 2
- 125000002091 cationic group Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229940099418 d- alpha-tocopherol succinate Drugs 0.000 claims 2
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims 2
- 235000020960 dehydroascorbic acid Nutrition 0.000 claims 2
- 239000011615 dehydroascorbic acid Substances 0.000 claims 2
- 230000008021 deposition Effects 0.000 claims 2
- 230000035618 desquamation Effects 0.000 claims 2
- 125000001311 dihydrolipoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(S[H])([H])C([H])([H])C([H])([H])S[H] 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 230000002500 effect on skin Effects 0.000 claims 2
- 231100000321 erythema Toxicity 0.000 claims 2
- 201000005884 exanthem Diseases 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 229910003472 fullerene Inorganic materials 0.000 claims 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 2
- 230000012010 growth Effects 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 201000011066 hemangioma Diseases 0.000 claims 2
- 206010021198 ichthyosis Diseases 0.000 claims 2
- 150000002500 ions Chemical class 0.000 claims 2
- 238000002430 laser surgery Methods 0.000 claims 2
- 235000019136 lipoic acid Nutrition 0.000 claims 2
- 210000003470 mitochondria Anatomy 0.000 claims 2
- JYIYPKOJFKMEKS-UHFFFAOYSA-N n-(2,2-dimethyl-1-phenylpropylidene)hydroxylamine Chemical compound CC(C)(C)C(=NO)C1=CC=CC=C1 JYIYPKOJFKMEKS-UHFFFAOYSA-N 0.000 claims 2
- 230000009826 neoplastic cell growth Effects 0.000 claims 2
- 230000000269 nucleophilic effect Effects 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 230000008845 photoaging Effects 0.000 claims 2
- 239000011148 porous material Substances 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 206010037844 rash Diseases 0.000 claims 2
- 230000009257 reactivity Effects 0.000 claims 2
- 229930002330 retinoic acid Natural products 0.000 claims 2
- 201000004700 rosacea Diseases 0.000 claims 2
- 231100000241 scar Toxicity 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 230000037394 skin elasticity Effects 0.000 claims 2
- 206010040872 skin infection Diseases 0.000 claims 2
- 230000036548 skin texture Effects 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 238000013319 spin trapping Methods 0.000 claims 2
- 208000028684 sweat gland disease Diseases 0.000 claims 2
- 208000009056 telangiectasis Diseases 0.000 claims 2
- 229960002663 thioctic acid Drugs 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 229960000984 tocofersolan Drugs 0.000 claims 2
- 229940042585 tocopherol acetate Drugs 0.000 claims 2
- 229930003802 tocotrienol Natural products 0.000 claims 2
- 239000011731 tocotrienol Substances 0.000 claims 2
- 235000019148 tocotrienols Nutrition 0.000 claims 2
- 229960001727 tretinoin Drugs 0.000 claims 2
- 231100000397 ulcer Toxicity 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 229940046009 vitamin E Drugs 0.000 claims 2
- 235000019165 vitamin E Nutrition 0.000 claims 2
- 239000011709 vitamin E Substances 0.000 claims 2
- 150000003712 vitamin E derivatives Chemical class 0.000 claims 2
- 230000029663 wound healing Effects 0.000 claims 2
- 230000037303 wrinkles Effects 0.000 claims 2
- 235000004835 α-tocopherol Nutrition 0.000 claims 2
- 239000002076 α-tocopherol Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical group CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 0 CCCCCCCCCCCC(C(C([O+])=C1O)=O)=C(*)C1=O Chemical compound CCCCCCCCCCCC(C(C([O+])=C1O)=O)=C(*)C1=O 0.000 description 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Cc1ccccc1 Chemical compound Cc1ccccc1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4155108P | 2008-04-01 | 2008-04-01 | |
| US61/041,551 | 2008-04-01 | ||
| PCT/US2009/038123 WO2009145982A1 (en) | 2008-04-01 | 2009-03-24 | Compositions and methods for skin care |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015167314A Division JP2016028050A (ja) | 2008-04-01 | 2015-08-27 | スキンケア用組成物及び方法 |
| JP2017151392A Division JP2017226685A (ja) | 2008-04-01 | 2017-08-04 | スキンケア用組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011516483A JP2011516483A (ja) | 2011-05-26 |
| JP2011516483A5 true JP2011516483A5 (https=) | 2012-05-17 |
| JP6227856B2 JP6227856B2 (ja) | 2017-11-08 |
Family
ID=41164501
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011503035A Active JP6227856B2 (ja) | 2008-04-01 | 2009-03-24 | スキンケア用組成物及び方法 |
| JP2015167314A Pending JP2016028050A (ja) | 2008-04-01 | 2015-08-27 | スキンケア用組成物及び方法 |
| JP2017151392A Pending JP2017226685A (ja) | 2008-04-01 | 2017-08-04 | スキンケア用組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015167314A Pending JP2016028050A (ja) | 2008-04-01 | 2015-08-27 | スキンケア用組成物及び方法 |
| JP2017151392A Pending JP2017226685A (ja) | 2008-04-01 | 2017-08-04 | スキンケア用組成物及び方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US20090258841A1 (https=) |
| EP (1) | EP2271349B1 (https=) |
| JP (3) | JP6227856B2 (https=) |
| KR (2) | KR101715631B1 (https=) |
| CN (1) | CN102046178B (https=) |
| AU (1) | AU2009251711B2 (https=) |
| BR (1) | BRPI0910874B8 (https=) |
| CA (1) | CA2719658C (https=) |
| ES (1) | ES2628407T3 (https=) |
| IL (1) | IL208458A (https=) |
| MX (1) | MX2010010713A (https=) |
| NZ (1) | NZ588806A (https=) |
| RU (1) | RU2517594C2 (https=) |
| SG (2) | SG10201608068SA (https=) |
| WO (1) | WO2009145982A1 (https=) |
| ZA (1) | ZA201006941B (https=) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4648319B2 (ja) * | 2003-08-22 | 2011-03-09 | アンティポディーン ファーマシューティカルズ インコーポレイティド | ミトコンドリアを標的とする抗酸化剤として使用されるミトキノン誘導体 |
| US7888334B2 (en) | 2003-08-22 | 2011-02-15 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| US9999635B2 (en) | 2007-01-16 | 2018-06-19 | Realm Therapeutics, Inc. | Methods and compositions for treating inflammatory disorders |
| KR101715631B1 (ko) * | 2008-04-01 | 2017-03-13 | 안티포딘 파마슈티칼스, 인코포레이티드 | 피부 관리를 위한 조성물 및 방법 |
| CN102223876A (zh) * | 2008-09-26 | 2011-10-19 | 纳米生物公司 | 纳米乳剂治疗性组合物及其使用方法 |
| DE102008061340A1 (de) * | 2008-12-11 | 2010-09-23 | Henkel Ag & Co. Kgaa | Antioxidative Zusammensetzungen |
| US8192429B2 (en) | 2010-06-29 | 2012-06-05 | Theravant, Inc. | Abnormality eradication through resonance |
| WO2012040342A2 (en) * | 2010-09-21 | 2012-03-29 | Conrex Pharmaceutical Corporation | Restoration of hair |
| US9345720B2 (en) * | 2010-10-26 | 2016-05-24 | Exeltis Usa Dermatology, Inc. | Composition and method for treating wounds |
| US9034926B2 (en) * | 2010-12-30 | 2015-05-19 | Nicholas V. Perricone | Topical nitrone spin trap compositions for psoriasis |
| US20120207838A1 (en) * | 2011-02-10 | 2012-08-16 | Perricone Nicholas V | Treatment of Psoriasis Using Oral Dosage Forms of Nitrone Spin Traps |
| US9381214B2 (en) | 2011-03-18 | 2016-07-05 | Puricore, Inc. | Methods for treating skin irritation |
| DE202012012769U1 (de) * | 2011-04-06 | 2014-01-29 | Mary Kay Inc. | Topische Hautpflegeformulierungen, die Pflanzenextrake umfassen |
| WO2012148930A2 (en) | 2011-04-26 | 2012-11-01 | Retrotope, Inc. | Oxidative retinal diseases |
| JP6106157B2 (ja) | 2011-04-26 | 2017-03-29 | レトロトップ、 インコーポレイテッドＲｅｔｒｏｔｏｐｅ， Ｉｎｃ． | 神経変性障害および筋疾患に関与するｐｕｆａ |
| KR102112087B1 (ko) | 2011-04-26 | 2020-05-18 | 레트로토프 인코포레이티드 | 에너지 프로세싱 손상 장애 및 미토콘드리아 결함 |
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2009
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- 2009-03-24 RU RU2010143806/15A patent/RU2517594C2/ru active
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- 2009-03-24 NZ NZ588806A patent/NZ588806A/xx unknown
- 2009-03-24 KR KR1020167028145A patent/KR20160121610A/ko not_active Withdrawn
- 2009-03-24 AU AU2009251711A patent/AU2009251711B2/en active Active
- 2009-03-24 SG SG2013023155A patent/SG189714A1/en unknown
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- 2009-03-24 EP EP09755345.7A patent/EP2271349B1/en active Active
- 2009-03-24 US US12/410,318 patent/US20090258841A1/en not_active Abandoned
- 2009-03-24 WO PCT/US2009/038123 patent/WO2009145982A1/en not_active Ceased
- 2009-03-24 CN CN200980120366XA patent/CN102046178B/zh active Active
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