EA201692493A8 - Противомикробные фармацевтические композиции со способностями ингибирования множественной лекарственной устойчивости - Google Patents

Противомикробные фармацевтические композиции со способностями ингибирования множественной лекарственной устойчивости

Info

Publication number
EA201692493A8
EA201692493A8 EA201692493A EA201692493A EA201692493A8 EA 201692493 A8 EA201692493 A8 EA 201692493A8 EA 201692493 A EA201692493 A EA 201692493A EA 201692493 A EA201692493 A EA 201692493A EA 201692493 A8 EA201692493 A8 EA 201692493A8
Authority
EA
Eurasian Patent Office
Prior art keywords
antimicrobial
sustainability
ability
pharmaceutical compositions
multiple dose
Prior art date
Application number
EA201692493A
Other languages
English (en)
Other versions
EA201692493A1 (ru
Inventor
Лоуренс Т. Фридхофф
Максим Владимирович СКУЛАЧЕВ
Федор Федорович СЕВЕРИН
Дмитрий Алексеевич КНОРРЕ
Юлия Евгеньевна Караваева
Павел Александрович Назаров
Юрий Николаевич Антоненко
Original Assignee
Митотех С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Митотех С.А. filed Critical Митотех С.А.
Publication of EA201692493A1 publication Critical patent/EA201692493A1/ru
Publication of EA201692493A8 publication Critical patent/EA201692493A8/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/10—Amino derivatives of triarylmethanes
    • C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/001—Dyes containing an onium group attached to the dye skeleton via a bridge

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к способу лечения микробной инфекции у инфицированного индивидуума, включающему введение индивидууму противомикробной композиции, содержащей терапевтически эффективное количество одного или нескольких липофильных катионов и, необязательно, другое одно или несколько противомикробных соединений или противомикробных средств. Изобретение дополнительно относится к фармацевтической композиции с противомикробными свойствами, содержащей терапевтически эффективное количество одного или нескольких липофильных катионов и другое одно или несколько противомикробных соединений или противомикробных средств.
EA201692493A 2014-05-30 2015-05-29 Противомикробные фармацевтические композиции со способностями ингибирования множественной лекарственной устойчивости EA201692493A8 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462005128P 2014-05-30 2014-05-30
PCT/US2015/033242 WO2015184296A1 (en) 2014-05-30 2015-05-29 Antimicrobial pharmaceutical compositions with multiple drug resistance inhibiting properties

Publications (2)

Publication Number Publication Date
EA201692493A1 EA201692493A1 (ru) 2017-11-30
EA201692493A8 true EA201692493A8 (ru) 2018-10-31

Family

ID=54699880

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201692493A EA201692493A8 (ru) 2014-05-30 2015-05-29 Противомикробные фармацевтические композиции со способностями ингибирования множественной лекарственной устойчивости

Country Status (5)

Country Link
US (1) US20170128467A1 (ru)
EP (1) EP3148520A4 (ru)
CN (1) CN106794158A (ru)
EA (1) EA201692493A8 (ru)
WO (1) WO2015184296A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109232219A (zh) * 2018-11-11 2019-01-18 苏州怡彼得生物技术有限公司 一种线粒体靶向抗氧化剂skq1中间体2,3-二甲基-对苯醌的合成方法
JP2023520698A (ja) * 2020-04-03 2023-05-18 ミトテック ソシエテ アノニム 重度の炎症状態を処置するためのミトコンドリア標的抗酸化物質の使用
WO2023023113A1 (en) * 2021-08-17 2023-02-23 Emory University Quaternary phosphonium compounds and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6366000A (en) * 1999-07-23 2001-02-13 Colorado State University Research Foundation Multidrug resistance pump inhibitors and uses thereof
KR101715631B1 (ko) * 2008-04-01 2017-03-13 안티포딘 파마슈티칼스, 인코포레이티드 피부 관리를 위한 조성물 및 방법
UA104320C2 (ru) * 2009-06-10 2014-01-27 Общество С Ограниченной Ответственностью "Мимотех" Фармацевтическая композиция на основе митохондриально-адресованного антиоксиданта для применения в медицинской и ветеринарной офтальмологии
WO2014116591A2 (en) * 2013-01-22 2014-07-31 Mitotech Sa Pharmaceutical formulations containing mitochondrially-targeted antioxidants

Also Published As

Publication number Publication date
EP3148520A4 (en) 2018-01-10
WO2015184296A1 (en) 2015-12-03
US20170128467A1 (en) 2017-05-11
EA201692493A1 (ru) 2017-11-30
CN106794158A (zh) 2017-05-31
EP3148520A1 (en) 2017-04-05

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