JP2011511785A5 - - Google Patents
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- JP2011511785A5 JP2011511785A5 JP2010545575A JP2010545575A JP2011511785A5 JP 2011511785 A5 JP2011511785 A5 JP 2011511785A5 JP 2010545575 A JP2010545575 A JP 2010545575A JP 2010545575 A JP2010545575 A JP 2010545575A JP 2011511785 A5 JP2011511785 A5 JP 2011511785A5
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- 239000000203 mixture Substances 0.000 claims 22
- 208000024172 Cardiovascular disease Diseases 0.000 claims 11
- 206010060862 Prostate cancer Diseases 0.000 claims 10
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 10
- 210000002966 serum Anatomy 0.000 claims 10
- 108010052004 acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide Proteins 0.000 claims 9
- 229960002272 degarelix Drugs 0.000 claims 9
- MEUCPCLKGZSHTA-XYAYPHGZSA-N degarelix Chemical compound C([C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CC=1C=CC(NC(=O)[C@H]2NC(=O)NC(=O)C2)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(NC(N)=O)C=C1 MEUCPCLKGZSHTA-XYAYPHGZSA-N 0.000 claims 9
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 6
- 102100038358 Prostate-specific antigen Human genes 0.000 claims 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 4
- 108010074051 C-Reactive Protein Proteins 0.000 claims 3
- 102100032752 C-reactive protein Human genes 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- 206010003671 Atrioventricular Block Diseases 0.000 claims 2
- 206010008479 Chest Pain Diseases 0.000 claims 2
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 2
- 108010049003 Fibrinogen Proteins 0.000 claims 2
- 102000008946 Fibrinogen Human genes 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 108010023302 HDL Cholesterol Proteins 0.000 claims 2
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims 2
- 108010028554 LDL Cholesterol Proteins 0.000 claims 2
- 206010047249 Venous thrombosis Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940012952 fibrinogen Drugs 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 230000007794 irritation Effects 0.000 claims 2
- 238000012423 maintenance Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000031225 myocardial ischemia Diseases 0.000 claims 2
- 229960003604 testosterone Drugs 0.000 claims 2
- 208000006820 Arthralgia Diseases 0.000 claims 1
- NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 claims 1
- 208000035211 Heart Murmurs Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 108010000817 Leuprolide Proteins 0.000 claims 1
- 108010033266 Lipoprotein(a) Proteins 0.000 claims 1
- 102000057248 Lipoprotein(a) Human genes 0.000 claims 1
- 208000023178 Musculoskeletal disease Diseases 0.000 claims 1
- 206010052904 Musculoskeletal stiffness Diseases 0.000 claims 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 claims 1
- 206010046555 Urinary retention Diseases 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 claims 1
- 208000018631 connective tissue disease Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 201000003146 cystitis Diseases 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 230000002650 habitual effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 claims 1
- 229960004338 leuprorelin Drugs 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000000391 smoking effect Effects 0.000 claims 1
- 230000002485 urinary effect Effects 0.000 claims 1
- 208000019206 urinary tract infection Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2774108P | 2008-02-11 | 2008-02-11 | |
| US61/027,741 | 2008-02-11 | ||
| EP08250703.9 | 2008-02-29 | ||
| EP08250703 | 2008-02-29 | ||
| PCT/IB2009/000350 WO2009101530A1 (en) | 2008-02-11 | 2009-02-10 | Method of treating prostate cancer with the gnrh antagonist degarelix |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014051197A Division JP6189234B2 (ja) | 2008-02-11 | 2014-03-14 | Ｇｎｒｈアンタゴニストであるデガレリクスを用いる前立腺癌の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011511785A JP2011511785A (ja) | 2011-04-14 |
| JP2011511785A5 true JP2011511785A5 (enExample) | 2012-03-22 |
| JP5924866B2 JP5924866B2 (ja) | 2016-05-25 |
Family
ID=39718285
Family Applications (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545575A Active JP5924866B2 (ja) | 2008-02-11 | 2009-02-10 | Ｇｎｒｈアンタゴニストであるデガレリクスを用いる前立腺癌の治療方法 |
| JP2010545576A Active JP5876652B2 (ja) | 2008-02-11 | 2009-02-10 | 転移期前立腺癌を治療する方法 |
| JP2014051197A Active JP6189234B2 (ja) | 2008-02-11 | 2014-03-14 | Ｇｎｒｈアンタゴニストであるデガレリクスを用いる前立腺癌の治療方法 |
| JP2014087895A Active JP6254042B2 (ja) | 2008-02-11 | 2014-04-22 | 転移期前立腺癌を治療する方法 |
| JP2016095555A Pending JP2016193910A (ja) | 2008-02-11 | 2016-05-11 | 転移期前立腺癌を治療する方法 |
| JP2016099437A Pending JP2016216455A (ja) | 2008-02-11 | 2016-05-18 | Ｇｎｒｈアンタゴニストであるデガレリクスを用いる前立腺癌の治療方法 |
| JP2017185676A Active JP6618967B2 (ja) | 2008-02-11 | 2017-09-27 | 転移期前立腺癌を治療する方法 |
| JP2022109616A Active JP7400029B2 (ja) | 2008-02-11 | 2022-07-07 | Ｇｎｒｈアンタゴニストであるデガレリクスを用いる前立腺癌の治療方法 |
| JP2022142833A Pending JP2022184898A (ja) | 2008-02-11 | 2022-09-08 | 転移期前立腺癌を治療する方法 |
| JP2023206150A Pending JP2024028869A (ja) | 2008-02-11 | 2023-12-06 | Ｇｎｒｈアンタゴニストであるデガレリクスを用いる前立腺癌の治療方法 |
| JP2025106071A Pending JP2025160167A (ja) | 2008-02-11 | 2025-06-24 | 転移期前立腺癌を治療する方法 |
Family Applications After (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545576A Active JP5876652B2 (ja) | 2008-02-11 | 2009-02-10 | 転移期前立腺癌を治療する方法 |
| JP2014051197A Active JP6189234B2 (ja) | 2008-02-11 | 2014-03-14 | Ｇｎｒｈアンタゴニストであるデガレリクスを用いる前立腺癌の治療方法 |
| JP2014087895A Active JP6254042B2 (ja) | 2008-02-11 | 2014-04-22 | 転移期前立腺癌を治療する方法 |
| JP2016095555A Pending JP2016193910A (ja) | 2008-02-11 | 2016-05-11 | 転移期前立腺癌を治療する方法 |
| JP2016099437A Pending JP2016216455A (ja) | 2008-02-11 | 2016-05-18 | Ｇｎｒｈアンタゴニストであるデガレリクスを用いる前立腺癌の治療方法 |
| JP2017185676A Active JP6618967B2 (ja) | 2008-02-11 | 2017-09-27 | 転移期前立腺癌を治療する方法 |
| JP2022109616A Active JP7400029B2 (ja) | 2008-02-11 | 2022-07-07 | Ｇｎｒｈアンタゴニストであるデガレリクスを用いる前立腺癌の治療方法 |
| JP2022142833A Pending JP2022184898A (ja) | 2008-02-11 | 2022-09-08 | 転移期前立腺癌を治療する方法 |
| JP2023206150A Pending JP2024028869A (ja) | 2008-02-11 | 2023-12-06 | Ｇｎｒｈアンタゴニストであるデガレリクスを用いる前立腺癌の治療方法 |
| JP2025106071A Pending JP2025160167A (ja) | 2008-02-11 | 2025-06-24 | 転移期前立腺癌を治療する方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (17) | US20090203623A1 (enExample) |
| EP (7) | EP4257197A3 (enExample) |
| JP (11) | JP5924866B2 (enExample) |
| KR (8) | KR20180118830A (enExample) |
| CN (4) | CN101939020B (enExample) |
| AU (2) | AU2009213751B2 (enExample) |
| BR (2) | BRPI0908129A2 (enExample) |
| CA (3) | CA2714444A1 (enExample) |
| CY (3) | CY1115561T1 (enExample) |
| DK (3) | DK2650012T3 (enExample) |
| EA (4) | EA020543B1 (enExample) |
| ES (3) | ES2479441T3 (enExample) |
| HK (1) | HK1198243A1 (enExample) |
| HR (3) | HRP20140665T1 (enExample) |
| IL (3) | IL207295A (enExample) |
| JO (1) | JOP20090061B1 (enExample) |
| MX (2) | MX2010008816A (enExample) |
| NZ (4) | NZ603932A (enExample) |
| PL (3) | PL2505204T3 (enExample) |
| PT (3) | PT2249859E (enExample) |
| RU (2) | RU2504394C2 (enExample) |
| SI (3) | SI2505204T1 (enExample) |
| TW (2) | TWI539959B (enExample) |
| WO (2) | WO2009101533A1 (enExample) |
| ZA (1) | ZA201005697B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0117057D0 (en) * | 2001-07-12 | 2001-09-05 | Ferring Bv | Pharmaceutical composition |
| TWI539959B (zh) | 2008-02-11 | 2016-07-01 | 菲瑞茵國際中心股份有限公司 | 治療轉移階段攝護腺癌的方法 |
| JO3525B1 (ar) * | 2008-02-11 | 2020-07-05 | Ferring Int Center Sa | علاج سرطان البروستاتا في المرحلة النقيلية بدواء ديجاريليكس |
| US8722088B2 (en) * | 2009-05-01 | 2014-05-13 | Ferring International Center S.A. | Pharmaceutical compositions and methods for the treatment of prostate cancer |
| TW201043221A (en) * | 2009-05-06 | 2010-12-16 | Ferring Int Ct Sa | Kit and method for preparation of a Degarelix solution |
| US20110039787A1 (en) * | 2009-07-06 | 2011-02-17 | Ferring International Center S.A. | Compositions, kits and methods for treating benign prostate hyperplasia |
| FR2964323B1 (fr) * | 2010-09-08 | 2012-11-09 | Jean Pierre Raynaud | Utilisation de la testosterone chez un patient en deficit androgenique et atteint d'un cancer de la prostate |
| WO2012055903A1 (en) | 2010-10-27 | 2012-05-03 | Ferring B.V. | Process for the manufacture of degarelix and its intermediates |
| EP2447276A1 (en) | 2010-10-27 | 2012-05-02 | Ferring B.V. | Process for the manufacture of Degarelix and its intermediates |
| JO3755B1 (ar) | 2011-01-26 | 2021-01-31 | Ferring Bv | تركيبات تستوستيرون |
| MX2013010330A (es) | 2011-03-09 | 2014-11-26 | Richard G Pestell | Líneas de célula cancerosa de próstata, signaturas de gen, y usos de las mismas. |
| CN102204889B (zh) * | 2011-05-23 | 2013-09-18 | 蚌埠丰原涂山制药有限公司 | 一种醋酸地加瑞克冻干粉针剂及其制备方法 |
| WO2013104745A1 (en) * | 2012-01-13 | 2013-07-18 | Ferring Bv | Pharmaceutical composition |
| HK1209673A1 (en) | 2012-05-14 | 2016-04-08 | Prostagene Llc | Using modulators of ccr5 for treating cancer |
| EP2854831B1 (en) | 2012-06-01 | 2024-07-10 | Ferring B.V. | Manufacture of degarelix |
| PT3305285T (pt) | 2012-09-26 | 2020-11-24 | Aragon Pharmaceuticals Inc | Antiandrogénios para o tratamento de cancro da próstata resistente à castração não metastático |
| HUE044048T2 (hu) | 2012-09-28 | 2019-09-30 | Takeda Pharmaceuticals Co | Eljárás tienopirimidin származék elõállítására |
| CA2906894A1 (en) | 2013-03-15 | 2014-09-18 | Abbvie Inc. | Compositions comprising elagolix for use in treating pain associated with endometriosis |
| US20140358576A1 (en) * | 2013-05-15 | 2014-12-04 | Adverse Events, Inc. | System and method for surveillance and evaluation of safety risks associated with medical interventions |
| EP3185881B1 (en) * | 2014-08-26 | 2022-03-09 | Betanien Hospital | Methods, agents and compositions for treatment of inflammatory conditions |
| AU2016261770B2 (en) * | 2015-05-12 | 2022-06-02 | Drexel University | Compounds and compositions useful for treating or preventing cancer metastasis, and methods using same |
| HUE070578T2 (hu) | 2016-09-30 | 2025-06-28 | Sumitomo Pharma Switzerland Gmbh | Prosztatarák kezelése |
| CN110248679A (zh) * | 2017-01-30 | 2019-09-17 | 安迪威有限公司 | 包含至少一种GnRH拮抗剂的组合物 |
| EP4438126A3 (en) | 2017-10-16 | 2025-01-01 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer |
| CN112261942A (zh) | 2018-04-19 | 2021-01-22 | 艾伯维公司 | 治疗重度月经出血的方法 |
| WO2020028630A1 (en) * | 2018-08-01 | 2020-02-06 | Abbvie Inc. | Dosing regimens for elagolix |
| RU2731002C1 (ru) * | 2019-10-22 | 2020-08-26 | Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) | Способ лечения рака предстательной железы |
| CN116407494B (zh) * | 2023-03-02 | 2024-07-09 | 山东大学齐鲁医院 | 一种醋酸地加瑞克注射液及其制备方法、用途 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| ZA735680B (en) * | 1972-09-21 | 1974-07-31 | Hoffmann La Roche | Polypeptides |
| US4072668A (en) | 1973-11-06 | 1978-02-07 | The Salk Institute For Biological Studies | LH-RH Analogs |
| DE2862341D1 (en) | 1977-12-26 | 1983-11-24 | Ihara Chemical Ind Co | Process for producing aromatic monocarboxylic acid |
| US5296468A (en) | 1989-10-30 | 1994-03-22 | The Salk Institute For Biological Studies | GnRH analogs |
| ATE144538T1 (de) | 1991-04-25 | 1996-11-15 | Romano Deghenghi | Lhrh-antagonisten |
| DE69330107T3 (de) | 1992-02-12 | 2004-12-30 | Daikyo Gomu Seiko, Ltd. | Medizinisches Gerät |
| GB9211268D0 (en) * | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
| SI9300468A (en) * | 1992-10-14 | 1994-06-30 | Hoffmann La Roche | Injectable composition for the sustained release of biologically active compounds |
| DE4305225A1 (de) * | 1993-02-19 | 1994-08-25 | Asta Medica Ag | Neues Herstellverfahren für Cetrorelix Lyophilisat |
| US5506207A (en) | 1994-03-18 | 1996-04-09 | The Salk Institute For Biological Studies | GNRH antagonists XIII |
| US5595760A (en) * | 1994-09-02 | 1997-01-21 | Delab | Sustained release of peptides from pharmaceutical compositions |
| JP3688381B2 (ja) | 1995-03-10 | 2005-08-24 | 株式会社東芝 | 光ディスク原盤露光装置 |
| US6379669B1 (en) | 1995-08-04 | 2002-04-30 | Akhouri A. Sinha | Targeting of organs by immunoconjugates |
| US5710246A (en) | 1996-03-19 | 1998-01-20 | Abbott Laboratories | Process for intermediates for the synthesis of LHRH antagonists |
| US5860957A (en) * | 1997-02-07 | 1999-01-19 | Sarcos, Inc. | Multipathway electronically-controlled drug delivery system |
| US5821230A (en) * | 1997-04-11 | 1998-10-13 | Ferring Bv | GnRH antagonist decapeptides |
| US5925730A (en) | 1997-04-11 | 1999-07-20 | Ferring Bv | GnRH antagonists |
| US5977302A (en) | 1997-11-20 | 1999-11-02 | Ortho-Mcneil Pharmaceutical, Inc. | Liquid phase process for the preparation of GnRH peptides |
| FR2776520B1 (fr) * | 1998-03-25 | 2000-05-05 | Sod Conseils Rech Applic | Nouvelles compositions pharmaceutiques destinees a la liberation prolongee de peptides et leur procede de preparation |
| WO2000004897A1 (en) | 1998-07-20 | 2000-02-03 | Peptech Limited | Bioimplant formulation |
| MXPA02008870A (es) * | 2000-03-14 | 2003-06-24 | Zentaris Ag | Novedosos antagonistas de lhrh, produccion de los mismos y sus uso como medicamentos. |
| US20040198706A1 (en) | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
| US20020103131A1 (en) | 2001-01-26 | 2002-08-01 | Jacobson Jill D. | Prevention of diabetes by administration of GnRH antagonists |
| JP4619651B2 (ja) * | 2001-06-01 | 2011-01-26 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 前立腺特異的膜抗原に対する修飾抗体およびその使用 |
| GB0117057D0 (en) * | 2001-07-12 | 2001-09-05 | Ferring Bv | Pharmaceutical composition |
| US7229774B2 (en) | 2001-08-02 | 2007-06-12 | Regents Of The University Of Michigan | Expression profile of prostate cancer |
| US20060234918A1 (en) * | 2001-12-19 | 2006-10-19 | Voyager Pharmaceutical Corporation | Methods for treating and preventing cancers that express the hypothalamic-pituitary-gonadal axis of hormones and receptors |
| US20070015713A1 (en) | 2005-07-14 | 2007-01-18 | Voyager Pharmaceutical Corporation | Methods for treating prostate cancer |
| SE0104463D0 (sv) | 2001-12-29 | 2001-12-29 | Carlbiotech Ltd As | Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister |
| CN1411803A (zh) | 2002-08-29 | 2003-04-23 | 四川大学 | 制备前体脂质体的方法及其装置 |
| RS52966B (sr) | 2002-09-27 | 2014-02-28 | Zentaris Gmbh | Oblik za terapijsku primenu aktivnih peptida sa produženim oslobađanjem aktivnog sastojka i postupak za njihovo dobijanje |
| GB0223367D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Therapeutic treatment |
| AR042815A1 (es) * | 2002-12-26 | 2005-07-06 | Alza Corp | Dispositivo de suministro de agente activo que tiene miembros compuestos |
| EP1674082A1 (de) * | 2004-12-22 | 2006-06-28 | Zentaris GmbH | Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel |
| WO2006069779A1 (en) | 2004-12-30 | 2006-07-06 | F. Hoffmann-La Roche Ag | Preparing of peptides with excellent solubility |
| US8158152B2 (en) | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| WO2007130809A2 (en) | 2006-05-06 | 2007-11-15 | Volodymyr Brodskyy | An automatic injectable drug mixing device |
| EP1891964A1 (en) | 2006-08-08 | 2008-02-27 | AEterna Zentaris GmbH | Application of initial doses of LHRH analogues and maintenance doses of LHRH antagonists for the treatment of hormone-dependent cancers and corresponding pharmaceutical kits |
| EP1967202A1 (en) | 2007-03-05 | 2008-09-10 | AEterna Zentaris GmbH | Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity |
| IL182922A0 (en) | 2007-05-02 | 2007-09-20 | Medimop Medical Projects Ltd | Automatic liquid drug reconstitution apparatus |
| US8283331B2 (en) | 2007-10-09 | 2012-10-09 | Children's Medical Center Corporation | Methods to regulate miRNA processing by targeting Lin-28 |
| NZ621174A (en) | 2008-01-15 | 2015-09-25 | Abbvie Deutschland | Powdered protein compositions and methods of making same |
| WO2009102720A1 (en) * | 2008-02-11 | 2009-08-20 | Safety Syringes, Inc. | Reconstitution means for safety device |
| TWI539959B (zh) * | 2008-02-11 | 2016-07-01 | 菲瑞茵國際中心股份有限公司 | 治療轉移階段攝護腺癌的方法 |
| ES2538828T3 (es) | 2009-04-24 | 2015-06-24 | Polypeptide Laboratories A/S | Método para la fabricación de degarelix |
| US8722088B2 (en) * | 2009-05-01 | 2014-05-13 | Ferring International Center S.A. | Pharmaceutical compositions and methods for the treatment of prostate cancer |
| TW201043221A (en) * | 2009-05-06 | 2010-12-16 | Ferring Int Ct Sa | Kit and method for preparation of a Degarelix solution |
| US20110039787A1 (en) | 2009-07-06 | 2011-02-17 | Ferring International Center S.A. | Compositions, kits and methods for treating benign prostate hyperplasia |
| WO2011066386A1 (en) | 2009-11-25 | 2011-06-03 | Novetide, Ltd. | Process for production of degarelix |
| ES2385240B1 (es) | 2010-07-26 | 2013-09-23 | Gp-Pharm, S.A. | Cápsulas de principios activos farmacéuticos y ácidos grasos poliinsaturados para el tratamiento de enfermedades de la próstata. |
| EP2447276A1 (en) | 2010-10-27 | 2012-05-02 | Ferring B.V. | Process for the manufacture of Degarelix and its intermediates |
| WO2012055903A1 (en) * | 2010-10-27 | 2012-05-03 | Ferring B.V. | Process for the manufacture of degarelix and its intermediates |
| JO3755B1 (ar) * | 2011-01-26 | 2021-01-31 | Ferring Bv | تركيبات تستوستيرون |
| CN102204889B (zh) | 2011-05-23 | 2013-09-18 | 蚌埠丰原涂山制药有限公司 | 一种醋酸地加瑞克冻干粉针剂及其制备方法 |
| CN103841970A (zh) * | 2011-07-15 | 2014-06-04 | 辉凌公司 | 其中施用匹可硫酸盐组合物的结肠镜检查定时方法 |
| EP2854831B1 (en) | 2012-06-01 | 2024-07-10 | Ferring B.V. | Manufacture of degarelix |
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