AU2009213751B2 - Treatment of metastatic stage prostate cancer with degarelix - Google Patents

Treatment of metastatic stage prostate cancer with degarelix Download PDF

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Publication number
AU2009213751B2
AU2009213751B2 AU2009213751A AU2009213751A AU2009213751B2 AU 2009213751 B2 AU2009213751 B2 AU 2009213751B2 AU 2009213751 A AU2009213751 A AU 2009213751A AU 2009213751 A AU2009213751 A AU 2009213751A AU 2009213751 B2 AU2009213751 B2 AU 2009213751B2
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Prior art keywords
degarelix
subject
treatment
prostate cancer
level
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AU2009213751A1 (en
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Bo-Eric Persson
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Ferring International Center SA
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Ferring International Center SA
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/09Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2009213751A 2008-02-11 2009-02-10 Treatment of metastatic stage prostate cancer with degarelix Active AU2009213751B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US2774108P 2008-02-11 2008-02-11
US61/027,741 2008-02-11
EP08250703.9 2008-02-29
EP08250703 2008-02-29
US14795609P 2009-01-28 2009-01-28
US61/147,956 2009-01-28
PCT/IB2009/000370 WO2009101533A1 (en) 2008-02-11 2009-02-10 Treatment of metastatic stage prostate cancer with degarelix

Publications (2)

Publication Number Publication Date
AU2009213751A1 AU2009213751A1 (en) 2009-08-20
AU2009213751B2 true AU2009213751B2 (en) 2014-09-25

Family

ID=39718285

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2009213751A Active AU2009213751B2 (en) 2008-02-11 2009-02-10 Treatment of metastatic stage prostate cancer with degarelix
AU2009213748A Active AU2009213748B9 (en) 2008-02-11 2009-02-10 Method of treating prostate cancer with the GnRH antagonist degarelix

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2009213748A Active AU2009213748B9 (en) 2008-02-11 2009-02-10 Method of treating prostate cancer with the GnRH antagonist degarelix

Country Status (25)

Country Link
US (17) US20090203623A1 (enExample)
EP (7) EP4257197A3 (enExample)
JP (11) JP5924866B2 (enExample)
KR (8) KR20180118830A (enExample)
CN (4) CN101939020B (enExample)
AU (2) AU2009213751B2 (enExample)
BR (2) BRPI0908129A2 (enExample)
CA (3) CA2714444A1 (enExample)
CY (3) CY1115561T1 (enExample)
DK (3) DK2650012T3 (enExample)
EA (4) EA020543B1 (enExample)
ES (3) ES2479441T3 (enExample)
HK (1) HK1198243A1 (enExample)
HR (3) HRP20140665T1 (enExample)
IL (3) IL207295A (enExample)
JO (1) JOP20090061B1 (enExample)
MX (2) MX2010008816A (enExample)
NZ (4) NZ603932A (enExample)
PL (3) PL2505204T3 (enExample)
PT (3) PT2249859E (enExample)
RU (2) RU2504394C2 (enExample)
SI (3) SI2505204T1 (enExample)
TW (2) TWI539959B (enExample)
WO (2) WO2009101533A1 (enExample)
ZA (1) ZA201005697B (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0117057D0 (en) * 2001-07-12 2001-09-05 Ferring Bv Pharmaceutical composition
TWI539959B (zh) 2008-02-11 2016-07-01 菲瑞茵國際中心股份有限公司 治療轉移階段攝護腺癌的方法
JO3525B1 (ar) * 2008-02-11 2020-07-05 Ferring Int Center Sa علاج سرطان البروستاتا في المرحلة النقيلية بدواء ديجاريليكس
US8722088B2 (en) * 2009-05-01 2014-05-13 Ferring International Center S.A. Pharmaceutical compositions and methods for the treatment of prostate cancer
TW201043221A (en) * 2009-05-06 2010-12-16 Ferring Int Ct Sa Kit and method for preparation of a Degarelix solution
US20110039787A1 (en) * 2009-07-06 2011-02-17 Ferring International Center S.A. Compositions, kits and methods for treating benign prostate hyperplasia
FR2964323B1 (fr) * 2010-09-08 2012-11-09 Jean Pierre Raynaud Utilisation de la testosterone chez un patient en deficit androgenique et atteint d'un cancer de la prostate
WO2012055903A1 (en) 2010-10-27 2012-05-03 Ferring B.V. Process for the manufacture of degarelix and its intermediates
EP2447276A1 (en) 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
JO3755B1 (ar) 2011-01-26 2021-01-31 Ferring Bv تركيبات تستوستيرون
MX2013010330A (es) 2011-03-09 2014-11-26 Richard G Pestell Líneas de célula cancerosa de próstata, signaturas de gen, y usos de las mismas.
CN102204889B (zh) * 2011-05-23 2013-09-18 蚌埠丰原涂山制药有限公司 一种醋酸地加瑞克冻干粉针剂及其制备方法
WO2013104745A1 (en) * 2012-01-13 2013-07-18 Ferring Bv Pharmaceutical composition
HK1209673A1 (en) 2012-05-14 2016-04-08 Prostagene Llc Using modulators of ccr5 for treating cancer
EP2854831B1 (en) 2012-06-01 2024-07-10 Ferring B.V. Manufacture of degarelix
PT3305285T (pt) 2012-09-26 2020-11-24 Aragon Pharmaceuticals Inc Antiandrogénios para o tratamento de cancro da próstata resistente à castração não metastático
HUE044048T2 (hu) 2012-09-28 2019-09-30 Takeda Pharmaceuticals Co Eljárás tienopirimidin származék elõállítására
CA2906894A1 (en) 2013-03-15 2014-09-18 Abbvie Inc. Compositions comprising elagolix for use in treating pain associated with endometriosis
US20140358576A1 (en) * 2013-05-15 2014-12-04 Adverse Events, Inc. System and method for surveillance and evaluation of safety risks associated with medical interventions
EP3185881B1 (en) * 2014-08-26 2022-03-09 Betanien Hospital Methods, agents and compositions for treatment of inflammatory conditions
AU2016261770B2 (en) * 2015-05-12 2022-06-02 Drexel University Compounds and compositions useful for treating or preventing cancer metastasis, and methods using same
HUE070578T2 (hu) 2016-09-30 2025-06-28 Sumitomo Pharma Switzerland Gmbh Prosztatarák kezelése
CN110248679A (zh) * 2017-01-30 2019-09-17 安迪威有限公司 包含至少一种GnRH拮抗剂的组合物
EP4438126A3 (en) 2017-10-16 2025-01-01 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer
CN112261942A (zh) 2018-04-19 2021-01-22 艾伯维公司 治疗重度月经出血的方法
WO2020028630A1 (en) * 2018-08-01 2020-02-06 Abbvie Inc. Dosing regimens for elagolix
RU2731002C1 (ru) * 2019-10-22 2020-08-26 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ лечения рака предстательной железы
CN116407494B (zh) * 2023-03-02 2024-07-09 山东大学齐鲁医院 一种醋酸地加瑞克注射液及其制备方法、用途

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
ZA735680B (en) * 1972-09-21 1974-07-31 Hoffmann La Roche Polypeptides
US4072668A (en) 1973-11-06 1978-02-07 The Salk Institute For Biological Studies LH-RH Analogs
DE2862341D1 (en) 1977-12-26 1983-11-24 Ihara Chemical Ind Co Process for producing aromatic monocarboxylic acid
US5296468A (en) 1989-10-30 1994-03-22 The Salk Institute For Biological Studies GnRH analogs
ATE144538T1 (de) 1991-04-25 1996-11-15 Romano Deghenghi Lhrh-antagonisten
DE69330107T3 (de) 1992-02-12 2004-12-30 Daikyo Gomu Seiko, Ltd. Medizinisches Gerät
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
SI9300468A (en) * 1992-10-14 1994-06-30 Hoffmann La Roche Injectable composition for the sustained release of biologically active compounds
DE4305225A1 (de) * 1993-02-19 1994-08-25 Asta Medica Ag Neues Herstellverfahren für Cetrorelix Lyophilisat
US5506207A (en) 1994-03-18 1996-04-09 The Salk Institute For Biological Studies GNRH antagonists XIII
US5595760A (en) * 1994-09-02 1997-01-21 Delab Sustained release of peptides from pharmaceutical compositions
JP3688381B2 (ja) 1995-03-10 2005-08-24 株式会社東芝 光ディスク原盤露光装置
US6379669B1 (en) 1995-08-04 2002-04-30 Akhouri A. Sinha Targeting of organs by immunoconjugates
US5710246A (en) 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists
US5860957A (en) * 1997-02-07 1999-01-19 Sarcos, Inc. Multipathway electronically-controlled drug delivery system
US5821230A (en) * 1997-04-11 1998-10-13 Ferring Bv GnRH antagonist decapeptides
US5925730A (en) 1997-04-11 1999-07-20 Ferring Bv GnRH antagonists
US5977302A (en) 1997-11-20 1999-11-02 Ortho-Mcneil Pharmaceutical, Inc. Liquid phase process for the preparation of GnRH peptides
FR2776520B1 (fr) * 1998-03-25 2000-05-05 Sod Conseils Rech Applic Nouvelles compositions pharmaceutiques destinees a la liberation prolongee de peptides et leur procede de preparation
WO2000004897A1 (en) 1998-07-20 2000-02-03 Peptech Limited Bioimplant formulation
MXPA02008870A (es) * 2000-03-14 2003-06-24 Zentaris Ag Novedosos antagonistas de lhrh, produccion de los mismos y sus uso como medicamentos.
US20040198706A1 (en) 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
US20020103131A1 (en) 2001-01-26 2002-08-01 Jacobson Jill D. Prevention of diabetes by administration of GnRH antagonists
JP4619651B2 (ja) * 2001-06-01 2011-01-26 コーネル・リサーチ・ファンデーション・インコーポレイテッド 前立腺特異的膜抗原に対する修飾抗体およびその使用
GB0117057D0 (en) * 2001-07-12 2001-09-05 Ferring Bv Pharmaceutical composition
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
US20060234918A1 (en) * 2001-12-19 2006-10-19 Voyager Pharmaceutical Corporation Methods for treating and preventing cancers that express the hypothalamic-pituitary-gonadal axis of hormones and receptors
US20070015713A1 (en) 2005-07-14 2007-01-18 Voyager Pharmaceutical Corporation Methods for treating prostate cancer
SE0104463D0 (sv) 2001-12-29 2001-12-29 Carlbiotech Ltd As Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister
CN1411803A (zh) 2002-08-29 2003-04-23 四川大学 制备前体脂质体的方法及其装置
RS52966B (sr) 2002-09-27 2014-02-28 Zentaris Gmbh Oblik za terapijsku primenu aktivnih peptida sa produženim oslobađanjem aktivnog sastojka i postupak za njihovo dobijanje
GB0223367D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Therapeutic treatment
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
EP1674082A1 (de) * 2004-12-22 2006-06-28 Zentaris GmbH Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel
WO2006069779A1 (en) 2004-12-30 2006-07-06 F. Hoffmann-La Roche Ag Preparing of peptides with excellent solubility
US8158152B2 (en) 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
WO2007130809A2 (en) 2006-05-06 2007-11-15 Volodymyr Brodskyy An automatic injectable drug mixing device
EP1891964A1 (en) 2006-08-08 2008-02-27 AEterna Zentaris GmbH Application of initial doses of LHRH analogues and maintenance doses of LHRH antagonists for the treatment of hormone-dependent cancers and corresponding pharmaceutical kits
EP1967202A1 (en) 2007-03-05 2008-09-10 AEterna Zentaris GmbH Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity
IL182922A0 (en) 2007-05-02 2007-09-20 Medimop Medical Projects Ltd Automatic liquid drug reconstitution apparatus
US8283331B2 (en) 2007-10-09 2012-10-09 Children's Medical Center Corporation Methods to regulate miRNA processing by targeting Lin-28
NZ621174A (en) 2008-01-15 2015-09-25 Abbvie Deutschland Powdered protein compositions and methods of making same
WO2009102720A1 (en) * 2008-02-11 2009-08-20 Safety Syringes, Inc. Reconstitution means for safety device
TWI539959B (zh) * 2008-02-11 2016-07-01 菲瑞茵國際中心股份有限公司 治療轉移階段攝護腺癌的方法
ES2538828T3 (es) 2009-04-24 2015-06-24 Polypeptide Laboratories A/S Método para la fabricación de degarelix
US8722088B2 (en) * 2009-05-01 2014-05-13 Ferring International Center S.A. Pharmaceutical compositions and methods for the treatment of prostate cancer
TW201043221A (en) * 2009-05-06 2010-12-16 Ferring Int Ct Sa Kit and method for preparation of a Degarelix solution
US20110039787A1 (en) 2009-07-06 2011-02-17 Ferring International Center S.A. Compositions, kits and methods for treating benign prostate hyperplasia
WO2011066386A1 (en) 2009-11-25 2011-06-03 Novetide, Ltd. Process for production of degarelix
ES2385240B1 (es) 2010-07-26 2013-09-23 Gp-Pharm, S.A. Cápsulas de principios activos farmacéuticos y ácidos grasos poliinsaturados para el tratamiento de enfermedades de la próstata.
EP2447276A1 (en) 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
WO2012055903A1 (en) * 2010-10-27 2012-05-03 Ferring B.V. Process for the manufacture of degarelix and its intermediates
JO3755B1 (ar) * 2011-01-26 2021-01-31 Ferring Bv تركيبات تستوستيرون
CN102204889B (zh) 2011-05-23 2013-09-18 蚌埠丰原涂山制药有限公司 一种醋酸地加瑞克冻干粉针剂及其制备方法
CN103841970A (zh) * 2011-07-15 2014-06-04 辉凌公司 其中施用匹可硫酸盐组合物的结肠镜检查定时方法
EP2854831B1 (en) 2012-06-01 2024-07-10 Ferring B.V. Manufacture of degarelix

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
BOCCON-GIBOD, L. European Urology Supplements, Vol. 4, No. 8, page 21-29. November 2005. *
BOYLE, H. et al European Journal of Cancer, Supplement, Vol 3, No. 3, page 331-338. October 2005. *
DEBRUYNE, F. M. J. Reviews in Urology, Vol. 6, Supplement 7, page S25-S32. 2004 *
DOEHN, C. et al IDRUGS: The Investigational Drugs Journal, Vol. 9, No. 8, page 565-572. August 2006. *
GITTELMAN, M. et al Urology, Vol 70, supplement 3A, page 83-84, item MP-08.21. September 2007. *
GONZALEZ-BARCENA, D. et al Urology, Vol. 45, No. 2, page 275-281. February 1995. *
HUIRNE, J. A. F. et al The Lancet, Vol. 358, page 1793-1803. November 2001. *
IVERSEN et al Urology, Vol. 68, Supplement 5A, page 102, item MP-08.18. November 2006 *
KLOTZ, L. et al BJU International, Vol. 102, No. 11, page 1531-1538. 11 December 2008 *
MONGIAT-ARTUS, P. et al Eropean Urology Supplements, Vol. 4, No. 5, page 4-13. July 2005. *
TAMMELA, T. et al European Urology Supplements, Vol. 4, No. 3, page 228, item 904. March 2005. *
VAN POPPEL, H et al European Urology Supplements, Vol. 5, No. 2, page 251, item 915. April 2006. *
VAN POPPEL, H. et al European Urology Supplements, Vol.6, No. 2, page 28, item 23. March 2007. *

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DK2505204T3 (da) 2015-03-16
ES2479441T3 (es) 2014-07-24
MX2010008817A (es) 2010-09-09
IL207295A (en) 2015-03-31
AU2009213751A1 (en) 2009-08-20
EA017582B1 (ru) 2013-01-30
US20130029910A1 (en) 2013-01-31
EP3360565A1 (en) 2018-08-15
JP2024028869A (ja) 2024-03-05
EP4257197A2 (en) 2023-10-11
HK1190912A1 (en) 2014-07-18
CN101998861A (zh) 2011-03-30
JP2022133426A (ja) 2022-09-13
BRPI0908129A2 (pt) 2015-08-04
PT2505204E (pt) 2015-03-26
JOP20090061B1 (ar) 2021-08-17
US20170290879A1 (en) 2017-10-12
IL207400A (en) 2014-12-31
US20220218783A1 (en) 2022-07-14
CA3235099A1 (en) 2009-08-20
EP4257197A3 (en) 2023-11-29
CN107412726A (zh) 2017-12-01
IL207295A0 (en) 2010-12-30
EP2505204A2 (en) 2012-10-03
PT2650012E (pt) 2015-06-30
JP2014141505A (ja) 2014-08-07
US20140349935A1 (en) 2014-11-27
US20220031801A1 (en) 2022-02-03
US20090203622A1 (en) 2009-08-13
US10695398B2 (en) 2020-06-30
SI2249859T1 (sl) 2014-08-29
IL223124A0 (en) 2012-12-31
JP2011511786A (ja) 2011-04-14
AU2009213748A1 (en) 2009-08-20
US8841081B2 (en) 2014-09-23
CN101939020A (zh) 2011-01-05
ZA201005697B (en) 2014-01-24
PL2249859T3 (pl) 2014-10-31
US20170035833A1 (en) 2017-02-09
HRP20140665T1 (hr) 2014-10-10
CY1116341T1 (el) 2017-02-08
IL207400A0 (en) 2010-12-30
TW200938218A (en) 2009-09-16
US9415085B2 (en) 2016-08-16
CA2714445A1 (en) 2009-08-20
NZ603932A (en) 2014-04-30
TWI539959B (zh) 2016-07-01
AU2009213748B9 (en) 2014-05-22
NZ587088A (en) 2012-12-21
KR20150091543A (ko) 2015-08-11
EP2799085A1 (en) 2014-11-05
RU2504393C2 (ru) 2014-01-20
US10973870B2 (en) 2021-04-13
JP2011511785A (ja) 2011-04-14
EA036695B1 (ru) 2020-12-09
KR101542480B1 (ko) 2015-08-07
US20220226422A1 (en) 2022-07-21
US20240316142A1 (en) 2024-09-26
JP2018039814A (ja) 2018-03-15
US9877999B2 (en) 2018-01-30
WO2009101530A1 (en) 2009-08-20
JP6254042B2 (ja) 2017-12-27
BRPI0908127A2 (pt) 2015-08-04
PL2650012T3 (pl) 2015-08-31
US11826397B2 (en) 2023-11-28
SI2505204T1 (sl) 2015-04-30
US20140113870A1 (en) 2014-04-24
EP2249858A1 (en) 2010-11-17
CN101939020B (zh) 2012-12-26
SI2650012T1 (sl) 2015-06-30
RU2504394C2 (ru) 2014-01-20
ES2532709T3 (es) 2015-03-31
EA201300742A1 (ru) 2014-02-28
EP2249859B1 (en) 2014-04-23
KR20230088848A (ko) 2023-06-20
JP5876652B2 (ja) 2016-03-02
HRP20150633T1 (hr) 2015-07-31
KR20140130757A (ko) 2014-11-11
WO2009101533A1 (en) 2009-08-20
KR20180118830A (ko) 2018-10-31
EA200901074A1 (ru) 2010-04-30
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