JOP20090061B1 - طريقة معالجة سرطان البروستاتا بمضادات الهرمونات التناسلية GnRH - Google Patents

طريقة معالجة سرطان البروستاتا بمضادات الهرمونات التناسلية GnRH

Info

Publication number
JOP20090061B1
JOP20090061B1 JOP/2009/0061A JOP20090061A JOP20090061B1 JO P20090061 B1 JOP20090061 B1 JO P20090061B1 JO P20090061 A JOP20090061 A JO P20090061A JO P20090061 B1 JOP20090061 B1 JO P20090061B1
Authority
JO
Jordan
Prior art keywords
prostate cancer
methods
treating prostate
gnrh antagonist
gnrh
Prior art date
Application number
JOP/2009/0061A
Other languages
English (en)
Inventor
Kold Olesen Tine
Cantor Per
Persson Bo-Eric
Slott Jensen Jens-Kristian
A Van Der Meulen Egbert
Original Assignee
Ferring Int Center Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39718285&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JOP20090061(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring Int Center Sa filed Critical Ferring Int Center Sa
Application granted granted Critical
Publication of JOP20090061B1 publication Critical patent/JOP20090061B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Abstract

يتعلق الاختراع الحالي بتوفير استخدامات وأنظمة جرعة خاصة هرمون اطلاق المنشط التناسلي (GnRH) وذلك من اجل اجراءات الامان والمعالجة الفعالة لسرطان البروستاتا المعتمد على الاندروجين وبدون التسبب في ارتفاع حاد في التستوسترون و/او اثار جانبية اخرى خاصة بالمعالجة بمساعد (GnRH) مثل عدوى القناة البولية او الالم المفصلي المرتبط بالتاثير الجانبي القلبي الوعائي. شكل (1).
JOP/2009/0061A 2008-02-11 2009-02-09 طريقة معالجة سرطان البروستاتا بمضادات الهرمونات التناسلية GnRH JOP20090061B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2774108P 2008-02-11 2008-02-11
EP08250703 2008-02-29

Publications (1)

Publication Number Publication Date
JOP20090061B1 true JOP20090061B1 (ar) 2021-08-17

Family

ID=39718285

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2009/0061A JOP20090061B1 (ar) 2008-02-11 2009-02-09 طريقة معالجة سرطان البروستاتا بمضادات الهرمونات التناسلية GnRH

Country Status (25)

Country Link
US (15) US20090203623A1 (ar)
EP (7) EP2650012B1 (ar)
JP (10) JP5876652B2 (ar)
KR (7) KR20230088848A (ar)
CN (4) CN101998861A (ar)
AU (2) AU2009213751B2 (ar)
BR (2) BRPI0908127A2 (ar)
CA (3) CA3235099A1 (ar)
CY (3) CY1115561T1 (ar)
DK (3) DK2249859T3 (ar)
EA (4) EA026521B1 (ar)
ES (3) ES2479441T3 (ar)
HK (4) HK1198243A1 (ar)
HR (3) HRP20140665T1 (ar)
IL (3) IL207295A (ar)
JO (1) JOP20090061B1 (ar)
MX (2) MX2010008817A (ar)
NZ (4) NZ603932A (ar)
PL (3) PL2650012T3 (ar)
PT (3) PT2650012E (ar)
RU (2) RU2504393C2 (ar)
SI (3) SI2505204T1 (ar)
TW (2) TWI442932B (ar)
WO (2) WO2009101530A1 (ar)
ZA (1) ZA201005697B (ar)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0117057D0 (en) * 2001-07-12 2001-09-05 Ferring Bv Pharmaceutical composition
JO3525B1 (ar) * 2008-02-11 2020-07-05 Ferring Int Center Sa علاج سرطان البروستاتا في المرحلة النقيلية بدواء ديجاريليكس
TWI442932B (zh) * 2008-02-11 2014-07-01 Ferring Int Ct Sa 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法
NZ595767A (en) * 2009-05-01 2012-12-21 Ferring Bv Composition for the treatment of prostate cancer
TW201043221A (en) * 2009-05-06 2010-12-16 Ferring Int Ct Sa Kit and method for preparation of a Degarelix solution
US20110039787A1 (en) * 2009-07-06 2011-02-17 Ferring International Center S.A. Compositions, kits and methods for treating benign prostate hyperplasia
FR2964323B1 (fr) * 2010-09-08 2012-11-09 Jean Pierre Raynaud Utilisation de la testosterone chez un patient en deficit androgenique et atteint d'un cancer de la prostate
ES2617336T3 (es) 2010-10-27 2017-06-16 Ferring B.V. Procedimiento para la fabricación de degarelix y sus productos intermedios
EP2447276A1 (en) 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
JO3755B1 (ar) 2011-01-26 2021-01-31 Ferring Bv تركيبات تستوستيرون
CN104169425A (zh) 2011-03-09 2014-11-26 理查德·G·佩斯泰尔 前列腺癌细胞系、遗传标志及其用途
CN102204889B (zh) * 2011-05-23 2013-09-18 蚌埠丰原涂山制药有限公司 一种醋酸地加瑞克冻干粉针剂及其制备方法
WO2013104745A1 (en) * 2012-01-13 2013-07-18 Ferring Bv Pharmaceutical composition
US9453836B2 (en) 2012-05-14 2016-09-27 Richard G. Pestell Use of modulators of CCR5 in the treatment of cancer and cancer metastasis
AR092840A1 (es) 2012-06-01 2015-05-06 Ferring Bv Elaboracion de degarelix
UA117663C2 (uk) 2012-09-26 2018-09-10 Арагон Фармасьютікалз, Інк. Антиандроген для лікування неметастатичного кастраційно-резистентного раку передміхурової залози
US10881659B2 (en) 2013-03-15 2021-01-05 Abbvie Inc. Methods of treating heavy menstrual bleeding
WO2014186608A1 (en) * 2013-05-15 2014-11-20 Adverse Events, Inc. System and method for surveillance and evaluation of safety risks associated with medical interventions
EP3185881B1 (en) * 2014-08-26 2022-03-09 Betanien Hospital Methods, agents and compositions for treatment of inflammatory conditions
CA2984188A1 (en) 2015-05-12 2016-11-17 Drexel University Compounds and compositions useful for treating or preventing cancer metastasis, and methods using same
CA3051182A1 (en) * 2017-01-30 2018-08-02 Finn Larsen A composition comprising at least one gnrh antagonist
WO2019203870A1 (en) 2018-04-19 2019-10-24 Abbvie Inc. Methods of treating heavy menstrual bleeding
EP3697398A1 (en) 2017-10-16 2020-08-26 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer
WO2020028630A1 (en) * 2018-08-01 2020-02-06 Abbvie Inc. Dosing regimens for elagolix
RU2731002C1 (ru) * 2019-10-22 2020-08-26 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ лечения рака предстательной железы
CN116407494A (zh) * 2023-03-02 2023-07-11 山东大学齐鲁医院 一种醋酸地加瑞克注射液及其制备方法、用途

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4072668A (en) 1973-11-06 1978-02-07 The Salk Institute For Biological Studies LH-RH Analogs
EP0002749B2 (en) 1977-12-26 1987-08-12 IHARA CHEMICAL INDUSTRY Co., Ltd. Process for producing aromatic monocarboxylic acid
US5296468A (en) 1989-10-30 1994-03-22 The Salk Institute For Biological Studies GnRH analogs
DE593491T1 (de) 1991-04-25 1994-11-17 Romano Deghenghi LHRH-Antagonisten.
ATE200428T1 (de) 1992-02-12 2001-04-15 Daikyo Gomu Seiko Kk Medizinisches gerät
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
SI9300468A (en) * 1992-10-14 1994-06-30 Hoffmann La Roche Injectable composition for the sustained release of biologically active compounds
US5506207A (en) 1994-03-18 1996-04-09 The Salk Institute For Biological Studies GNRH antagonists XIII
US5595760A (en) 1994-09-02 1997-01-21 Delab Sustained release of peptides from pharmaceutical compositions
US5825730A (en) 1995-03-10 1998-10-20 Kabushiki Kaisha Toshiba Mastering machine having non-repetitive runout compensation
US6379669B1 (en) 1995-08-04 2002-04-30 Akhouri A. Sinha Targeting of organs by immunoconjugates
US5710246A (en) 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists
US5860957A (en) 1997-02-07 1999-01-19 Sarcos, Inc. Multipathway electronically-controlled drug delivery system
US5925730A (en) 1997-04-11 1999-07-20 Ferring Bv GnRH antagonists
US5821230A (en) * 1997-04-11 1998-10-13 Ferring Bv GnRH antagonist decapeptides
AU1590699A (en) 1997-11-20 1999-06-15 Ortho-Mcneil Pharmaceutical, Inc. Liquid phase process for the preparation of gnrh peptides
FR2776520B1 (fr) 1998-03-25 2000-05-05 Sod Conseils Rech Applic Nouvelles compositions pharmaceutiques destinees a la liberation prolongee de peptides et leur procede de preparation
JP2002521331A (ja) 1998-07-20 2002-07-16 ペプテック リミテッド バイオインプラント製剤
US20040198706A1 (en) 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
US20020103131A1 (en) 2001-01-26 2002-08-01 Jacobson Jill D. Prevention of diabetes by administration of GnRH antagonists
MXPA03010804A (es) * 2001-06-01 2004-11-22 Cornell Res Foundation Inc Anticuerpos modificados para antigeno de membrana especifico de la prostata y usos de los mismos.
GB0117057D0 (en) * 2001-07-12 2001-09-05 Ferring Bv Pharmaceutical composition
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
US20070015713A1 (en) 2005-07-14 2007-01-18 Voyager Pharmaceutical Corporation Methods for treating prostate cancer
US20060234918A1 (en) * 2001-12-19 2006-10-19 Voyager Pharmaceutical Corporation Methods for treating and preventing cancers that express the hypothalamic-pituitary-gonadal axis of hormones and receptors
SE0104463D0 (sv) 2001-12-29 2001-12-29 Carlbiotech Ltd As Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister
CN1411803A (zh) 2002-08-29 2003-04-23 四川大学 制备前体脂质体的方法及其装置
ME00509B (me) 2002-09-27 2011-10-10 Zentaris Gmbh Oblik za terapijsku primjenu aktivnih peptida sa dugotrajnim oslobođenjem aktivnog sastojka i postupak za njihovo dobijanje
GB0223367D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Therapeutic treatment
AR042815A1 (es) 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
EP1674082A1 (de) 2004-12-22 2006-06-28 Zentaris GmbH Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel
WO2006069779A1 (en) 2004-12-30 2006-07-06 F. Hoffmann-La Roche Ag Preparing of peptides with excellent solubility
US8158152B2 (en) 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
WO2007130809A2 (en) 2006-05-06 2007-11-15 Volodymyr Brodskyy An automatic injectable drug mixing device
EP1891964A1 (en) * 2006-08-08 2008-02-27 AEterna Zentaris GmbH Application of initial doses of LHRH analogues and maintenance doses of LHRH antagonists for the treatment of hormone-dependent cancers and corresponding pharmaceutical kits
EP1967202A1 (en) 2007-03-05 2008-09-10 AEterna Zentaris GmbH Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity
IL182922A0 (en) 2007-05-02 2007-09-20 Medimop Medical Projects Ltd Automatic liquid drug reconstitution apparatus
WO2009048932A2 (en) 2007-10-09 2009-04-16 Children's Medical Center Corporation Methods to regulate mirna processing by targeting lin-28
WO2009090189A1 (en) 2008-01-15 2009-07-23 Abbott Gmbh & Co.Kg Powdered protein compositions and methods of making same
TWI442932B (zh) 2008-02-11 2014-07-01 Ferring Int Ct Sa 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法
EP2257324B1 (en) * 2008-02-11 2016-07-27 Safety Syringes, Inc. Syringe with safety needle guard and clip to prevent release of guard during reconstitution process
WO2010121835A1 (en) 2009-04-24 2010-10-28 Polypeptide Laboratories A/S Method for the manufacture of degarelix
NZ595767A (en) 2009-05-01 2012-12-21 Ferring Bv Composition for the treatment of prostate cancer
TW201043221A (en) 2009-05-06 2010-12-16 Ferring Int Ct Sa Kit and method for preparation of a Degarelix solution
US20110039787A1 (en) 2009-07-06 2011-02-17 Ferring International Center S.A. Compositions, kits and methods for treating benign prostate hyperplasia
WO2011066386A1 (en) 2009-11-25 2011-06-03 Novetide, Ltd. Process for production of degarelix
ES2385240B1 (es) 2010-07-26 2013-09-23 Gp-Pharm, S.A. Cápsulas de principios activos farmacéuticos y ácidos grasos poliinsaturados para el tratamiento de enfermedades de la próstata.
EP2447276A1 (en) 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
ES2617336T3 (es) 2010-10-27 2017-06-16 Ferring B.V. Procedimiento para la fabricación de degarelix y sus productos intermedios
JO3755B1 (ar) 2011-01-26 2021-01-31 Ferring Bv تركيبات تستوستيرون
CN102204889B (zh) 2011-05-23 2013-09-18 蚌埠丰原涂山制药有限公司 一种醋酸地加瑞克冻干粉针剂及其制备方法
DK2731607T3 (en) 2011-07-15 2018-01-02 Ferring Bv Method for adjusting the timing of a colonoscopy in which a picosulfate composition is administered.
AR092840A1 (es) 2012-06-01 2015-05-06 Ferring Bv Elaboracion de degarelix

Also Published As

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TWI442932B (zh) 2014-07-01
AU2009213748B9 (en) 2014-05-22
JP2011511786A (ja) 2011-04-14
PL2650012T3 (pl) 2015-08-31
EP2650012A1 (en) 2013-10-16
HK1176552A1 (en) 2013-08-02
KR20140130757A (ko) 2014-11-11
HRP20150290T1 (hr) 2015-04-10
US20220218782A1 (en) 2022-07-14
KR20230088848A (ko) 2023-06-20
US20170035833A1 (en) 2017-02-09
US9877999B2 (en) 2018-01-30
CY1115561T1 (el) 2017-01-04
US20140349935A1 (en) 2014-11-27
KR20220009504A (ko) 2022-01-24
IL207400A (en) 2014-12-31
AU2009213748A1 (en) 2009-08-20
PL2505204T3 (pl) 2015-05-29
CA2714445C (en) 2018-01-16
BRPI0908127A2 (pt) 2015-08-04
KR101542480B1 (ko) 2015-08-07
JP2016216455A (ja) 2016-12-22
HK1145011A1 (en) 2011-03-25
KR20180118830A (ko) 2018-10-31
EA036695B1 (ru) 2020-12-09
ES2479441T3 (es) 2014-07-24
JP5924866B2 (ja) 2016-05-25
EP2505204B1 (en) 2014-12-24
US20200237854A1 (en) 2020-07-30
RU2010133480A (ru) 2012-03-20
JP6189234B2 (ja) 2017-08-30
EA020543B1 (ru) 2014-12-30
CA3235099A1 (en) 2009-08-20
WO2009101530A1 (en) 2009-08-20
DK2249859T3 (da) 2014-06-02
TW200938217A (en) 2009-09-16
JP2022184898A (ja) 2022-12-13
TW200938218A (en) 2009-09-16
US20220323538A1 (en) 2022-10-13
SI2505204T1 (sl) 2015-04-30
KR20100126362A (ko) 2010-12-01
CN107412726A (zh) 2017-12-01
RU2504393C2 (ru) 2014-01-20
DK2650012T3 (da) 2015-06-15
CA2714444A1 (en) 2009-08-20
EA201300741A1 (ru) 2014-02-28
KR20100123714A (ko) 2010-11-24
BRPI0908129A2 (pt) 2015-08-04
US9579359B2 (en) 2017-02-28
US20140113870A1 (en) 2014-04-24
PT2505204E (pt) 2015-03-26
JP7400029B2 (ja) 2023-12-18
NZ587057A (en) 2012-12-21
EP3360565A1 (en) 2018-08-15
US9415085B2 (en) 2016-08-16
EA201300742A1 (ru) 2014-02-28
CN101939020A (zh) 2011-01-05
HK1198243A1 (en) 2015-03-20
US20170290879A1 (en) 2017-10-12
EP2249859B1 (en) 2014-04-23
CY1116289T1 (el) 2017-02-08
MX2010008816A (es) 2010-09-07
EP4257197A3 (en) 2023-11-29
PL2249859T3 (pl) 2014-10-31
PT2650012E (pt) 2015-06-30
AU2009213748B2 (en) 2014-03-13
CN101939020B (zh) 2012-12-26
JP2018039814A (ja) 2018-03-15
US10729739B2 (en) 2020-08-04
RU2010133481A (ru) 2012-03-20
US20090203623A1 (en) 2009-08-13
US10973870B2 (en) 2021-04-13
DK2505204T3 (da) 2015-03-16
KR20150091543A (ko) 2015-08-11
WO2009101533A1 (en) 2009-08-20
IL207295A (en) 2015-03-31
EP2650012B1 (en) 2015-03-25
RU2504394C2 (ru) 2014-01-20
NZ587088A (en) 2012-12-21
JP2014141505A (ja) 2014-08-07
HRP20150633T1 (hr) 2015-07-31
EP4257197A2 (en) 2023-10-11
HK1190912A1 (en) 2014-07-18
US20090203622A1 (en) 2009-08-13
ES2540235T3 (es) 2015-07-09
SI2650012T1 (sl) 2015-06-30
PT2249859E (pt) 2014-07-31
JP6618967B2 (ja) 2019-12-11
JP2022133426A (ja) 2022-09-13
IL223124A0 (en) 2012-12-31
SI2249859T1 (sl) 2014-08-29
US20130029910A1 (en) 2013-01-31
EP2249859A1 (en) 2010-11-17
CN103990107A (zh) 2014-08-20
US8841081B2 (en) 2014-09-23
EA026521B1 (ru) 2017-04-28
HRP20140665T1 (hr) 2014-10-10
EP2505204A2 (en) 2012-10-03
US20220218783A1 (en) 2022-07-14
JP6254042B2 (ja) 2017-12-27
NZ603958A (en) 2013-03-28
CY1116341T1 (el) 2017-02-08
US20210128673A1 (en) 2021-05-06
IL207400A0 (en) 2010-12-30
JP2016193910A (ja) 2016-11-17
JP5876652B2 (ja) 2016-03-02
US11766468B2 (en) 2023-09-26
US20190167755A1 (en) 2019-06-06
JP2011511785A (ja) 2011-04-14
AU2009213751A1 (en) 2009-08-20
EP2505204A3 (en) 2013-01-09
EP2249858A1 (en) 2010-11-17
NZ603932A (en) 2014-04-30
JP2024028869A (ja) 2024-03-05
TWI539959B (zh) 2016-07-01
IL207295A0 (en) 2010-12-30
US10695398B2 (en) 2020-06-30
ZA201005697B (en) 2014-01-24
ES2532709T3 (es) 2015-03-31
US11826397B2 (en) 2023-11-28
JP2014167009A (ja) 2014-09-11
AU2009213751B2 (en) 2014-09-25
MX2010008817A (es) 2010-09-09
CA2714445A1 (en) 2009-08-20
US20220226422A1 (en) 2022-07-21
EA200901074A1 (ru) 2010-04-30
CN101998861A (zh) 2011-03-30
US20220031801A1 (en) 2022-02-03
EA017582B1 (ru) 2013-01-30
EA200901075A1 (ru) 2010-04-30
EP2799085A1 (en) 2014-11-05

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