JP2011511773A5 - - Google Patents
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- JP2011511773A5 JP2011511773A5 JP2010544697A JP2010544697A JP2011511773A5 JP 2011511773 A5 JP2011511773 A5 JP 2011511773A5 JP 2010544697 A JP2010544697 A JP 2010544697A JP 2010544697 A JP2010544697 A JP 2010544697A JP 2011511773 A5 JP2011511773 A5 JP 2011511773A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- composition
- cancer
- cell
- epitopes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 31
- 210000003719 b-lymphocyte Anatomy 0.000 claims 12
- 239000002105 nanoparticle Substances 0.000 claims 12
- 210000001744 T-lymphocyte Anatomy 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 230000028993 immune response Effects 0.000 claims 10
- 238000006384 oligomerization reaction Methods 0.000 claims 9
- 230000001939 inductive effect Effects 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 201000004792 malaria Diseases 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 101800001690 Transmembrane protein gp41 Proteins 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 101710154606 Hemagglutinin Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 101710176177 Protein A56 Proteins 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 239000013566 allergen Substances 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 239000000185 hemagglutinin Substances 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 244000144972 livestock Species 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08101221 | 2008-02-01 | ||
| EP08101221.3 | 2008-02-01 | ||
| PCT/EP2009/050996 WO2009109428A2 (en) | 2008-02-01 | 2009-01-29 | Self-assembling peptide nanoparticles useful as vaccines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011511773A JP2011511773A (ja) | 2011-04-14 |
| JP2011511773A5 true JP2011511773A5 (enExample) | 2012-03-08 |
| JP6088123B2 JP6088123B2 (ja) | 2017-03-01 |
Family
ID=39276265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544697A Expired - Fee Related JP6088123B2 (ja) | 2008-02-01 | 2009-01-29 | ワクチンとして有用な自己会合ペプチドナノ粒子 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8546337B2 (enExample) |
| EP (1) | EP2235043A2 (enExample) |
| JP (1) | JP6088123B2 (enExample) |
| CN (1) | CN101932594A (enExample) |
| AU (1) | AU2009221419B2 (enExample) |
| CA (1) | CA2713879C (enExample) |
| RU (1) | RU2540871C2 (enExample) |
| WO (1) | WO2009109428A2 (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| US9267937B2 (en) | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
| CA2648099C (en) | 2006-03-31 | 2012-05-29 | The Brigham And Women's Hospital, Inc | System for targeted delivery of therapeutic agents |
| US8367113B2 (en) | 2006-05-15 | 2013-02-05 | Massachusetts Institute Of Technology | Polymers for functional particles |
| US9381477B2 (en) | 2006-06-23 | 2016-07-05 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| US9217129B2 (en) | 2007-02-09 | 2015-12-22 | Massachusetts Institute Of Technology | Oscillating cell culture bioreactor |
| JP2010523595A (ja) | 2007-04-04 | 2010-07-15 | マサチューセッツ インスティテュート オブ テクノロジー | ポリ（アミノ酸）ターゲッティング部分 |
| CA2917512C (en) | 2007-10-12 | 2025-08-05 | President And Fellows Of Harvard College | VACCINE NANOTECHNOLOGY |
| EP2313108A4 (en) * | 2008-06-30 | 2013-06-12 | Us Army As Represented By The Secretary Of The Army | MALARIA VACCINE FROM SELF-ORGANIZING POLYPEPTIDE NANOTEHICLES |
| US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| EP2376107B1 (en) * | 2008-12-09 | 2014-05-21 | Coley Pharmaceutical Group, Inc. | Immunostimulatory oligonucleotides |
| US8580274B2 (en) | 2009-02-10 | 2013-11-12 | University Of The Ryukyus | Drug transporter, and adjuvant and vaccine each utilizing same |
| WO2010138193A2 (en) | 2009-05-27 | 2010-12-02 | Selecta Biosciences, Inc. | Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents |
| EP3311833A3 (en) * | 2009-08-26 | 2018-07-25 | Selecta Biosciences, Inc. | Compositions that induce t cell help |
| EP2528622A2 (en) * | 2010-01-26 | 2012-12-05 | The Regents of the University of Colorado | Influenza virus epitopes templated into double-stranded coiled coils and use thereof in immunization |
| WO2011150264A2 (en) * | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Synthetic nanocarrier combination vaccines |
| WO2012061717A1 (en) | 2010-11-05 | 2012-05-10 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
| CA2833425C (en) * | 2011-04-07 | 2018-08-21 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health | Protease cleavage site peptides as an hiv vaccine |
| CA2843274A1 (en) | 2011-07-29 | 2013-02-07 | Selecta Biosciences, Inc. | Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses |
| WO2013028843A1 (en) * | 2011-08-23 | 2013-02-28 | President And Fellows Of Harvard College | Peptide nanoparticles and uses thereof |
| SI23902A (sl) * | 2011-10-07 | 2013-04-30 | Kemijski inštitut | Samosestavljivi polipeptidni poliedri |
| EP2766386A1 (en) * | 2011-10-12 | 2014-08-20 | Alpha-o Peptides AG | Self-assembling peptide nanoparticles as vaccines against infection with norovirus |
| WO2013177283A2 (en) * | 2012-05-22 | 2013-11-28 | The Board Of Trustees Of The Leland Stanford Junior University | Disulfide stabilized foldon polypeptides |
| EP2852396A4 (en) * | 2012-05-23 | 2016-04-20 | Univ Leland Stanford Junior | INFLUENZA VACCINE CONSTRUCTS |
| EP2703483A1 (en) * | 2012-08-29 | 2014-03-05 | Affiris AG | PCSK9 peptide vaccine |
| EA201590683A1 (ru) | 2012-11-20 | 2015-11-30 | Глаксосмитклайн Байолоджикалс С.А. | Тримеры rsv f, предшествующие слиянию |
| US10248758B2 (en) * | 2013-02-07 | 2019-04-02 | University Of Washington Through Its Center For Commercialization | Self-assembling protein nanostructures |
| JP2016532712A (ja) * | 2013-09-05 | 2016-10-20 | イミューン デザイン コーポレイション | 薬物中毒に対するワクチン組成物 |
| CN104513293A (zh) * | 2013-09-26 | 2015-04-15 | 深圳信立泰药业股份有限公司 | 一种多肽疫苗的盐及其制备方法和含有该盐的药物制品 |
| WO2015054639A1 (en) | 2013-10-11 | 2015-04-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Epstein-barr virus vaccines |
| AU2015205567B2 (en) * | 2014-01-09 | 2019-04-04 | Alpha-O Peptides Ag | Flagellin-containing protein nanoparticles as a vaccine platform |
| EP3134104B1 (en) * | 2014-04-25 | 2018-12-26 | Tria Bioscience Corp. | Synthetic hapten carrier compositions and methods |
| EP2974739A1 (en) | 2014-07-15 | 2016-01-20 | Novartis AG | RSVF trimerization domains |
| WO2016109792A2 (en) | 2014-12-31 | 2016-07-07 | The Usa, As Represented By The Secretary, Detp. Of Health And Human Services | Novel multivalent nanoparticle-based vaccines |
| WO2016122414A1 (en) * | 2015-01-29 | 2016-08-04 | Agency For Science, Technology And Research | Nanocapsules carrying chikungunya-associated peptides |
| WO2016138525A1 (en) | 2015-02-27 | 2016-09-01 | University Of Washington | Polypeptide assemblies and methods for the production thereof |
| US9834583B2 (en) | 2015-03-16 | 2017-12-05 | The Catholic University Of America | Authentic trimeric HIV-1 GP140 envelope glycoproteins comprising a long linker and tag |
| WO2016207782A1 (en) * | 2015-06-22 | 2016-12-29 | STRELNIKOV, Evgeny | Immunogenic synthetic oligopeptides for a vaccine against hiv |
| CN105409831A (zh) * | 2015-10-30 | 2016-03-23 | 河南科技学院 | 一种利用ghrelin减少新生雏鸡脂肪细胞分化和降低脂肪沉积的方法及应用 |
| CN105210995A (zh) * | 2015-10-30 | 2016-01-06 | 河南科技学院 | 一种利用ghrelin促进新生雏鸡免疫器官发育的方法及应用 |
| CN105393976A (zh) * | 2015-10-30 | 2016-03-16 | 河南科技学院 | 一种利用ghrelin促进新生雏鸡生长性能的方法及应用 |
| US10188136B2 (en) | 2016-02-16 | 2019-01-29 | Indian Institute Of Science Education And Research | Hydrophobin mimics: process for preparation thereof |
| FR3050448A1 (fr) * | 2016-04-21 | 2017-10-27 | Bioaster | Nanoparticules a base d'encapsuline. |
| WO2017192434A1 (en) | 2016-05-02 | 2017-11-09 | The Scripps Research Institute | Compositions and methods related to hiv-1 immunogens |
| KR20190056382A (ko) | 2016-09-02 | 2019-05-24 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 안정화된 그룹 2 인플루엔자 헤마글루티닌 줄기 영역 삼량체 및 그의 용도 |
| WO2018127689A1 (en) * | 2017-01-03 | 2018-07-12 | Emergex Vaccines Holdings Ltd | Universal influenza vaccine compositions |
| US20200061172A1 (en) | 2017-02-23 | 2020-02-27 | Alpha-O Peptides Ag | Self-assembling protein nanoparticles encapsulating immunostimulatory nucleid acids |
| WO2018172447A1 (en) | 2017-03-23 | 2018-09-27 | Alpha-O Peptides Ag | Self-assembling protein nanoparticles with built-in six-helix bundle proteins |
| EP3661968B1 (en) | 2017-08-04 | 2022-03-02 | The Hospital for Sick Children | Nanoparticle platform for antibody and vaccine delivery |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| WO2019089817A1 (en) * | 2017-11-01 | 2019-05-09 | The Scripps Research Institute | Novel scaffolded hiv-1 vaccine immunogens |
| CN112135908A (zh) * | 2018-01-22 | 2020-12-25 | 国立传染病研究所长代表日本国 | 选择性cd8阳性t细胞诱导疫苗抗原 |
| US11225502B1 (en) * | 2018-06-11 | 2022-01-18 | Battelle Memorial Institute | Controlled synthesis of hierarchically-structured hybrid materials through peptoid engineering |
| SG11202012313PA (en) | 2018-06-13 | 2021-01-28 | Scripps Research Inst | Nanoparticle vaccines with novel structural components |
| US11213582B2 (en) * | 2018-08-08 | 2022-01-04 | The Regents Of The University Of California | Protection against recurrent genital herpes by therapeutic immunization with herpes simplex virus type 2 ribonucleotide reductase protein subunits |
| RU2713723C1 (ru) * | 2018-11-15 | 2020-02-06 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Искусственные гены, кодирующие белки-иммуногены EV.CTL и EV.Th, рекомбинантные плазмидные ДНК pEV.CTL и pEV.Th, обеспечивающие экспрессию искусственных генов, и искусственные Т-клеточные полиэпитопные белки-иммуногены EV.CTL и EV.Th, содержащие эпитопы антигенов вируса Эбола, используемые для создания вакцины против вируса Эбола |
| WO2020146906A2 (en) | 2019-01-12 | 2020-07-16 | The Methodist Hospital | Self-assembled peptide nanoparticle and use thereof |
| CN113993523A (zh) | 2019-04-17 | 2022-01-28 | 指南针探路者有限公司 | 用赛洛西宾治疗抑郁症和其他各种病症 |
| US20220265804A1 (en) * | 2019-04-29 | 2022-08-25 | Academy Of Military Medical Sciences | Fusion protein capable of self-assembling into protein nanoparticles and application thereof |
| CN111150841B (zh) * | 2019-12-31 | 2023-08-15 | 优锐生物医药科技(深圳)有限公司 | 一种主动免疫调控微粒及其制备方法和应用 |
| CN111150842B (zh) * | 2019-12-31 | 2023-09-05 | 优锐生物医药科技(深圳)有限公司 | 一种用于中和胃泌素的主动免疫调控微粒及其制备方法和应用 |
| CN112022066A (zh) * | 2020-09-25 | 2020-12-04 | 电子科技大学 | 一种基于深度学习的消化道钩虫发现方法及系统 |
| WO2022106860A1 (en) * | 2020-11-20 | 2022-05-27 | Pécsi Tudományegyetem | Recombinant peptides for use in therapy |
| WO2022149609A1 (ja) * | 2021-01-07 | 2022-07-14 | 国立大学法人東京工業大学 | Ｍｈｃ分子に適合する病原微生物由来のペプチドが担持された複合蛋白質単量体、当該単量体の会合体、及び当該会合体を有効成分とするコンポーネントワクチン、並びに、免疫後の生理活性物質の分泌に関する情報の取得方法 |
| WO2025172892A1 (en) | 2024-02-16 | 2025-08-21 | Glaxosmithkline Biologicals Sa | Modified proteins and methods |
| WO2025242657A1 (en) | 2024-05-21 | 2025-11-27 | Shape Biopharmaceuticals Ag | Lipopeptide building blocks and aggregates |
| CN119060144B (zh) * | 2024-10-31 | 2025-03-18 | 南京澄实生物医药科技有限公司 | 一种预防犬瘟热病毒感染的融合蛋白和疫苗及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK519188D0 (da) * | 1988-09-16 | 1988-09-16 | Statens Seruminstitut | Kemisk forbindelse |
| CA2037151A1 (en) * | 1990-03-23 | 1991-09-24 | F. Hoffmann-La Roche Ag | Plasmodium sporozoite antigen |
| IL109664A0 (en) | 1993-05-18 | 1994-08-26 | Rijksuniversiteit | Peptides of human influenza virus for use in human t cell response inducing compositions |
| WO2000011179A1 (en) * | 1998-08-21 | 2000-03-02 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | RECOMBINANT MULTIVALENT MALARIAL VACCINE AGAINST $i(PLASMODIUM FALCIPARUM) |
| DK1135162T3 (da) * | 1998-11-30 | 2009-01-19 | Cytos Biotechnology Ag | Ordnet molekylær præsentation af allergener, fremstillingsfremgangsmåde samt anvendelse |
| US6756039B1 (en) * | 1999-05-10 | 2004-06-29 | The Regents Of The University Of California | Self assembling proteins |
| DE60014372T2 (de) | 1999-06-25 | 2006-02-02 | The Governors Of The University Of Alberta, Edmonton | Polypeptid-enthaltende zusammensetzungen, hergestellt durch verwendung von matrizen in gestalt eines coiled-coil und deren gebrauch |
| EP1303533A2 (en) * | 2000-05-05 | 2003-04-23 | Aphton Corporation | Chimeric peptide immunogens, their preparation and use |
| WO2002100325A2 (en) | 2000-10-13 | 2002-12-19 | Ligocyte Pharmaceuticals, Inc. | Polyvalent nanoparticles |
| AU2002349204A1 (en) | 2001-11-26 | 2003-06-10 | University Health Network | Self-assembling p53 peptides as gene delivery vehicles |
| JP4509999B2 (ja) * | 2003-02-17 | 2010-07-21 | ブルクハルト，ペーター | 医薬送達及び抗原提示システムとしてのペプチドナノ粒子 |
| US7964196B2 (en) | 2004-05-25 | 2011-06-21 | Chimeros, Inc. | Self-assembling nanoparticle drug delivery system |
-
2009
- 2009-01-29 AU AU2009221419A patent/AU2009221419B2/en not_active Ceased
- 2009-01-29 CN CN2009801037674A patent/CN101932594A/zh active Pending
- 2009-01-29 US US12/864,576 patent/US8546337B2/en active Active
- 2009-01-29 JP JP2010544697A patent/JP6088123B2/ja not_active Expired - Fee Related
- 2009-01-29 CA CA2713879A patent/CA2713879C/en active Active
- 2009-01-29 WO PCT/EP2009/050996 patent/WO2009109428A2/en not_active Ceased
- 2009-01-29 EP EP09717471A patent/EP2235043A2/en not_active Ceased
- 2009-01-29 RU RU2010135965/10A patent/RU2540871C2/ru active
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