JP2015527366A5 - - Google Patents
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- JP2015527366A5 JP2015527366A5 JP2015528591A JP2015528591A JP2015527366A5 JP 2015527366 A5 JP2015527366 A5 JP 2015527366A5 JP 2015528591 A JP2015528591 A JP 2015528591A JP 2015528591 A JP2015528591 A JP 2015528591A JP 2015527366 A5 JP2015527366 A5 JP 2015527366A5
- Authority
- JP
- Japan
- Prior art keywords
- stradobody
- domain
- domains
- igg2 hinge
- carboxy terminus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 9
- 210000004899 c-terminal region Anatomy 0.000 claims 9
- 229960000310 isoleucine Drugs 0.000 claims 9
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 150000001413 amino acids Chemical group 0.000 claims 3
- GVVPGTZRZFNKDS-JXMROGBWSA-N geranyl diphosphate Chemical group CC(C)=CCC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O GVVPGTZRZFNKDS-JXMROGBWSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261691057P | 2012-08-20 | 2012-08-20 | |
| US61/691,057 | 2012-08-20 | ||
| US201361785144P | 2013-03-14 | 2013-03-14 | |
| US61/785,144 | 2013-03-14 | ||
| PCT/US2013/055800 WO2014031646A2 (en) | 2012-08-20 | 2013-08-20 | Molecules with antigen binding and polyvalent fc gamma receptor binding activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015527366A JP2015527366A (ja) | 2015-09-17 |
| JP2015527366A5 true JP2015527366A5 (enExample) | 2016-09-23 |
Family
ID=50150476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015528591A Pending JP2015527366A (ja) | 2012-08-20 | 2013-08-20 | 抗原結合および多価ｆｃガンマ受容体結合活性を有する分子 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9683044B2 (enExample) |
| EP (1) | EP2885320A4 (enExample) |
| JP (1) | JP2015527366A (enExample) |
| KR (1) | KR20150058236A (enExample) |
| CN (1) | CN104718223A (enExample) |
| AU (1) | AU2013305885B2 (enExample) |
| BR (1) | BR112015003459A2 (enExample) |
| CA (1) | CA2882296A1 (enExample) |
| HK (1) | HK1210792A1 (enExample) |
| IL (1) | IL237307A0 (enExample) |
| MX (1) | MX2015002269A (enExample) |
| RU (1) | RU2015109591A (enExample) |
| WO (1) | WO2014031646A2 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101580937B1 (ko) | 2007-06-01 | 2015-12-31 | 유니버시티 오브 매릴랜드, 발티모어 | 면역글로불린 불변영역 Ｆｃ 수용체 결합제 |
| AU2011282579B2 (en) | 2010-07-28 | 2014-10-23 | Gliknik Inc. | Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin Fc compositions |
| MX2015002269A (es) * | 2012-08-20 | 2015-07-06 | Gliknik Inc | Moleculas con actividad de union al antigeno y al receptor fc gamma polivalente. |
| TW201619188A (zh) | 2014-03-05 | 2016-06-01 | 優稀美生物醫藥公司 | 多聚體Ｆｃ蛋白質 |
| AU2015252866B2 (en) * | 2014-05-02 | 2021-01-28 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered Fc constructs |
| US20180282424A1 (en) * | 2014-11-06 | 2018-10-04 | Gliknik Inc. | Molecules with bimodal activity depleting target at low dose and increasing immunosuppression at higher dose |
| CN107406496A (zh) * | 2015-03-10 | 2017-11-28 | 百时美施贵宝公司 | 可通过转谷氨酰胺酶缀合的抗体和由其制备的缀合物 |
| MX394116B (es) | 2015-07-24 | 2025-03-19 | Gliknik Inc | Proteinas de fusion de fragmentos de proteina humana para crear composiciones de fc de inmunoglobulina multimerizada de forma ordenada con union al complemento aumentada. |
| KR20180034619A (ko) * | 2015-07-29 | 2018-04-04 | 나노틱스 엘엘씨 | 가용성 생체분자를 소거하기 위한 모듈 조성물 및 이와 관련된 방법 |
| CN106554968A (zh) * | 2015-09-29 | 2017-04-05 | 中国农业科学院上海兽医研究所 | 日本血吸虫重组蛋白及其制备方法和应用 |
| EP3423572B1 (en) * | 2016-03-02 | 2023-11-29 | Momenta Pharmaceuticals, Inc. | Methods related to engineered fc constructs |
| CN105647946B (zh) * | 2016-03-18 | 2019-09-20 | 江苏普瑞康生物医药科技有限公司 | 一种基于FcγRⅢa的嵌合基因及其用途 |
| MX2018011865A (es) | 2016-03-30 | 2019-03-28 | Ab biosciences inc | Composiciones de inmunoglobulina intravenosa recombinante (rivig) y metodos para su produccion y uso. |
| US11623964B2 (en) * | 2016-05-23 | 2023-04-11 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered Fc constructs |
| CA3026420A1 (en) * | 2016-06-07 | 2017-12-14 | Gliknik Inc. | Cysteine-optimized stradomers |
| CN110461868A (zh) | 2016-11-01 | 2019-11-15 | 根马布私人有限公司 | 多肽变体及其用途 |
| EP3551647A4 (en) | 2016-12-09 | 2021-01-13 | Gliknik Inc. | MANUFACTURING OPTIMIZATION OF GL-2045, MULTIMERIZING STRADOMER |
| US11331372B2 (en) | 2016-12-09 | 2022-05-17 | Gliknik Inc. | Methods of treating inflammatory disorders with multivalent Fc compounds |
| US11220531B2 (en) | 2017-01-06 | 2022-01-11 | Janssen Biotech, Inc. | Engineered Fc constructs |
| UA128814C2 (uk) | 2017-02-10 | 2024-10-30 | Генмаб Б.В. | Поліпептид та його застосування |
| EP3706786A4 (en) * | 2017-11-09 | 2021-09-01 | Medimmune, LLC | BIS SPECIFIC FUSION POLYPEPTIDES AND METHOD OF USING THEREOF |
| WO2019145455A1 (en) | 2018-01-24 | 2019-08-01 | Genmab B.V. | Polypeptide variants and uses thereof |
| SG11202010601VA (en) | 2018-05-03 | 2020-11-27 | Genmab Bv | Antibody variant combinations and uses thereof |
| CN110540590B (zh) | 2018-05-29 | 2023-08-18 | 康诺亚生物医药科技（成都）有限公司 | 一种自免疫抑制物的开发和应用 |
| JP7513530B2 (ja) | 2018-06-22 | 2024-07-09 | ジェンマブ ホールディング ビー．ブイ． | 抗ｃｄ３７抗体および抗ｃｄ２０抗体、組成物、ならびにそれらの使用方法 |
| MX2021000280A (es) * | 2018-07-11 | 2021-11-12 | Momenta Pharmaceuticals Inc | Composiciones y métodos relacionados con constructos de dominio de unión a antígeno-fc modificados genéticamente. |
| KR20210042326A (ko) * | 2018-07-11 | 2021-04-19 | 모멘타 파머슈티컬스 인코포레이티드 | 조작된 Fc-항원 결합 도메인 작제물에 관련된 조성물 및 방법 |
| CN120865412A (zh) | 2018-07-13 | 2025-10-31 | 根马布股份公司 | Cd38抗体变体及其用途 |
| EP3820890A1 (en) | 2018-07-13 | 2021-05-19 | Genmab A/S | Trogocytosis-mediated therapy using cd38 antibodies |
| JP2022531894A (ja) | 2019-05-09 | 2022-07-12 | ゲンマブ ビー．ブイ． | がんの処置において使用するための抗ｄｒ５抗体の組み合わせの投与レジメン |
| WO2021089850A1 (en) | 2019-11-06 | 2021-05-14 | Genmab B.V. | Antibody variant combinations and uses thereof |
| BR112022013553A2 (pt) | 2020-01-16 | 2022-09-06 | Genmab As | Composição farmacêutica, anticorpo, e, método para tratar uma doença |
| EP4185388A1 (en) | 2020-07-23 | 2023-05-31 | Genmab B.V. | A combination of anti-dr5 antibodies and an immunomodulatory imide drug for use in treating multiple myeloma |
| EP4221742A1 (en) | 2020-10-02 | 2023-08-09 | Genmab A/S | Antibodies capable of binding to ror2 and bispecific antibodies binding to ror2 and cd3 |
| AU2022338208A1 (en) | 2021-09-06 | 2024-03-21 | Genmab A/S | Antibodies capable of binding to cd27, variants thereof and uses thereof |
| US20250084169A1 (en) | 2022-01-12 | 2025-03-13 | Biomolecular Holdings Llc | Nk/monocyte engagers |
| TW202413412A (zh) | 2022-05-12 | 2024-04-01 | 丹麥商珍美寶股份有限公司 | 在組合療法中能夠結合到ｃｄ２７之結合劑 |
| EP4522275A1 (en) | 2022-05-12 | 2025-03-19 | Genmab A/S | Binding agents capable of binding to cd27 in combination therapy |
| US20250382378A1 (en) | 2022-10-31 | 2025-12-18 | Genmab A/S | Cd38 antibodies and uses thereof |
| WO2024219894A1 (ko) * | 2023-04-21 | 2024-10-24 | 상트네어바이오사이언스 주식회사 | 두 개의 fc 도메인을 포함하는 항원 결합 단백질 및 이의 용도 |
| TW202509071A (zh) | 2023-05-12 | 2025-03-01 | 丹麥商珍美寶股份有限公司 | 能夠與ｏｘ４０結合之抗體、其變異體及其用途 |
| TW202540189A (zh) | 2023-11-30 | 2025-10-16 | 德商生物新技術公司 | 在組合療法中能夠結合ｏｘ４０之抗體 |
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| US6004781A (en) | 1988-01-22 | 1999-12-21 | The General Hospital Corporation | Nucleic acid encoding Ig-CD4 fusion proteins |
| GB8824869D0 (en) | 1988-10-24 | 1988-11-30 | Stevenson G T | Synthetic antibody |
| US5681566A (en) | 1988-10-24 | 1997-10-28 | 3I Research Exploitation Limited | Antibody conjugates with two or more covalently linked FC regions |
| EP0680337A4 (en) | 1993-01-12 | 1997-07-30 | Anthony George Gristina | METHODS AND COMPOSITIONS FOR DIRECT APPLICATION WITH HIGH CONCENTRATION OF ANTIBODIES, PRODUCING PASSIVE IMMUNITY. |
| US5877396A (en) | 1993-04-23 | 1999-03-02 | Sloan Kettering Institute For Cancer Research | Mice mutant for functional Fc receptors and method of treating autoimmune diseases |
| US6750334B1 (en) | 1996-02-02 | 2004-06-15 | Repligen Corporation | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor |
| WO1999056777A1 (en) | 1998-05-06 | 1999-11-11 | Temple University - Of The Commonwealth System Of Higher Education | REVERSAL OF PROINFLAMMATORY RESPONSE BY LIGATING THE MACROPHAGE FcηRI RECEPTOR |
| CA2341029A1 (en) | 1998-08-17 | 2000-02-24 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
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| ATE359812T1 (de) | 2001-01-12 | 2007-05-15 | Becton Dickinson Co | Intrinsische fluoreszierende, selbstmultimerisierende mhc-fusionsproteine und deren komplexe |
| US7511121B2 (en) | 2001-03-09 | 2009-03-31 | Arnason Barry G W | Polymeric immunoglobulin fusion proteins that target low-affinity Fcγreceptors |
| AU2002315052A1 (en) | 2001-05-15 | 2002-11-25 | Emory University | Polynucleotides and polypeptides relating to the modulation of sirp alpha-cd47 |
| AU2003217912A1 (en) | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| WO2006061650A2 (en) | 2004-12-10 | 2006-06-15 | Trigen Gmbh | Methods, products and uses involving platelets and/or the vasculature |
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| PL1606318T3 (pl) | 2003-03-26 | 2010-01-29 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | Ulepszone białka fuzyjne FC |
| AU2004257142A1 (en) | 2003-05-30 | 2005-01-27 | Alexion Pharmaceuticals, Inc. | Antibodies and fusion proteins that include engineered constant regions |
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| EP2006305B1 (en) | 2006-03-03 | 2016-08-10 | The Chemo-Sero-Therapeutic Research Institute | Modified antibody with enhanced bioactivity |
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| DK2368999T3 (da) | 2007-05-11 | 2014-05-26 | Alexion Pharma Holding | Knoglemålrettet alkalisk fosfatase, kits og fremgangsmåder til anvendelse deraf |
| KR20100021601A (ko) * | 2007-05-14 | 2010-02-25 | 바이오겐 아이덱 엠에이 인코포레이티드 | 단일-쇄 Ｆｃ(ＳｃＦｃ) 부분, 이를 포함하는 결합 폴리펩타이드, 및 이에 관련된 방법 |
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| KR101580937B1 (ko) * | 2007-06-01 | 2015-12-31 | 유니버시티 오브 매릴랜드, 발티모어 | 면역글로불린 불변영역 Ｆｃ 수용체 결합제 |
| CN103880965B (zh) * | 2007-09-21 | 2018-02-16 | 加利福尼亚大学董事会 | 被导靶的干扰素显示强的细胞凋亡和抗肿瘤活性 |
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| PT2499165T (pt) | 2009-11-13 | 2016-10-28 | Grifols Therapeutics Inc | Preparações que contêm o fator de von willebrand (vwf), e métodos, kits e utilizações relacionadas com as mesmas |
| US20130209463A1 (en) | 2010-06-30 | 2013-08-15 | Compugen Ltd. | Polypeptides and uses thereof as a drug for treatment of multiple sclerosis, rheumatoid arthritis and other autoimmune disorders |
| AU2011282579B2 (en) * | 2010-07-28 | 2014-10-23 | Gliknik Inc. | Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin Fc compositions |
| JP2015506372A (ja) | 2012-01-27 | 2015-03-02 | グリックニック インコーポレイテッド | ＩｇＧ２ヒンジドメインを含む融合タンパク質 |
| MX2015002269A (es) * | 2012-08-20 | 2015-07-06 | Gliknik Inc | Moleculas con actividad de union al antigeno y al receptor fc gamma polivalente. |
-
2013
- 2013-08-20 MX MX2015002269A patent/MX2015002269A/es unknown
- 2013-08-20 AU AU2013305885A patent/AU2013305885B2/en active Active
- 2013-08-20 US US13/971,584 patent/US9683044B2/en active Active
- 2013-08-20 RU RU2015109591A patent/RU2015109591A/ru not_active Application Discontinuation
- 2013-08-20 HK HK15111563.7A patent/HK1210792A1/xx unknown
- 2013-08-20 WO PCT/US2013/055800 patent/WO2014031646A2/en not_active Ceased
- 2013-08-20 EP EP13830394.6A patent/EP2885320A4/en not_active Withdrawn
- 2013-08-20 CN CN201380053362.0A patent/CN104718223A/zh active Pending
- 2013-08-20 CA CA2882296A patent/CA2882296A1/en not_active Abandoned
- 2013-08-20 KR KR1020157006960A patent/KR20150058236A/ko not_active Withdrawn
- 2013-08-20 BR BR112015003459A patent/BR112015003459A2/pt not_active IP Right Cessation
- 2013-08-20 JP JP2015528591A patent/JP2015527366A/ja active Pending
-
2015
- 2015-02-19 IL IL237307A patent/IL237307A0/en unknown
-
2017
- 2017-05-16 US US15/596,178 patent/US20180094061A1/en not_active Abandoned
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