JP2015527366A5 - - Google Patents
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- Publication number
- JP2015527366A5 JP2015527366A5 JP2015528591A JP2015528591A JP2015527366A5 JP 2015527366 A5 JP2015527366 A5 JP 2015527366A5 JP 2015528591 A JP2015528591 A JP 2015528591A JP 2015528591 A JP2015528591 A JP 2015528591A JP 2015527366 A5 JP2015527366 A5 JP 2015527366A5
- Authority
- JP
- Japan
- Prior art keywords
- stradobody
- domain
- domains
- igg2 hinge
- carboxy terminus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261691057P | 2012-08-20 | 2012-08-20 | |
| US61/691,057 | 2012-08-20 | ||
| US201361785144P | 2013-03-14 | 2013-03-14 | |
| US61/785,144 | 2013-03-14 | ||
| PCT/US2013/055800 WO2014031646A2 (en) | 2012-08-20 | 2013-08-20 | Molecules with antigen binding and polyvalent fc gamma receptor binding activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015527366A JP2015527366A (ja) | 2015-09-17 |
| JP2015527366A5 true JP2015527366A5 (enExample) | 2016-09-23 |
Family
ID=50150476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015528591A Pending JP2015527366A (ja) | 2012-08-20 | 2013-08-20 | 抗原結合および多価ｆｃガンマ受容体結合活性を有する分子 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9683044B2 (enExample) |
| EP (1) | EP2885320A4 (enExample) |
| JP (1) | JP2015527366A (enExample) |
| KR (1) | KR20150058236A (enExample) |
| CN (1) | CN104718223A (enExample) |
| AU (1) | AU2013305885B2 (enExample) |
| BR (1) | BR112015003459A2 (enExample) |
| CA (1) | CA2882296A1 (enExample) |
| HK (1) | HK1210792A1 (enExample) |
| IL (1) | IL237307A0 (enExample) |
| MX (1) | MX2015002269A (enExample) |
| RU (1) | RU2015109591A (enExample) |
| WO (1) | WO2014031646A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103897063B (zh) | 2007-06-01 | 2017-04-12 | 马里兰大学巴尔的摩分校 | 免疫球蛋白恒定区Fc受体结合剂 |
| EP3543257A1 (en) | 2010-07-28 | 2019-09-25 | Gliknik Inc. | Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions |
| KR20150058236A (ko) * | 2012-08-20 | 2015-05-28 | 글리크닉 인코포레이티드 | 항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자 |
| RU2016139006A (ru) | 2014-03-05 | 2018-04-05 | Юсб Биофарма Спрл | Мультимерные fc-белки |
| SG10201913507SA (en) | 2014-05-02 | 2020-02-27 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| WO2016073917A1 (en) * | 2014-11-06 | 2016-05-12 | Gliknik Inc. | Molecules with bimodal activity depleting target at low dose and increasing immunosuppression at higher dose |
| ES2736106T3 (es) * | 2015-03-10 | 2019-12-26 | Bristol Myers Squibb Co | Anticuerpos que se pueden conjugar mediante la transglutaminasa y conjugados producidos a partir de ellos |
| SI3325011T1 (sl) * | 2015-07-24 | 2021-02-26 | Gliknik Inc. | Fuzijski proteini humanih proteinskih fragmentov za tvorbo pravilnih multimeriziranih imunoglobulin FC sestavkov s povečanim vezanjem komplementa |
| HK1255329A1 (zh) * | 2015-07-29 | 2019-08-16 | 纳米提克斯有限责任公司 | 用於清除可溶性生物分子的模块化组合物及其相关方法 |
| CN106554968A (zh) * | 2015-09-29 | 2017-04-05 | 中国农业科学院上海兽医研究所 | 日本血吸虫重组蛋白及其制备方法和应用 |
| WO2017151971A2 (en) * | 2016-03-02 | 2017-09-08 | Momenta Pharmaceuticals, Inc. | METHODS RELATED TO ENGINEERED Fc CONSTRUCTS |
| CN105647946B (zh) * | 2016-03-18 | 2019-09-20 | 江苏普瑞康生物医药科技有限公司 | 一种基于FcγRⅢa的嵌合基因及其用途 |
| EP3436484B1 (en) * | 2016-03-30 | 2025-10-01 | AB Biosciences, Inc. | Recombinant intravenous immunoglobulin (rivig) compositions and methods for their production and use |
| CA3025310A1 (en) | 2016-05-23 | 2017-11-30 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc constructs |
| CA3026420A1 (en) * | 2016-06-07 | 2017-12-14 | Gliknik Inc. | Cysteine-optimized stradomers |
| JP7277363B2 (ja) | 2016-11-01 | 2023-05-18 | ジェンマブ ビー．ブイ． | ポリペプチド変異体およびその使用 |
| EP3551647A4 (en) | 2016-12-09 | 2021-01-13 | Gliknik Inc. | MANUFACTURING OPTIMIZATION OF GL-2045, A MULTIMERIZING STRADOMER |
| IL266988B2 (en) | 2016-12-09 | 2024-11-01 | Gliknik Inc | Methods of treating inflammatory disorders with multivalent fc compounds |
| KR102624254B1 (ko) | 2017-01-06 | 2024-01-12 | 모멘타 파머슈티컬스 인코포레이티드 | 유전자 조작 Fc 작제물에 관한 조성물 및 방법 |
| AU2018218345B2 (en) | 2017-02-10 | 2025-04-03 | Genmab B.V. | Polypeptide variants and uses thereof |
| US20190241659A1 (en) * | 2017-11-09 | 2019-08-08 | Medimmune, Llc | Bispecific fusion polypeptides and methods of use thereof |
| MA51666A (fr) | 2018-01-24 | 2020-12-02 | Genmab Bv | Variants polypeptidiques et leurs utilisations |
| AU2019264217B2 (en) | 2018-05-03 | 2026-03-05 | Genmab B.V. | Antibody variant combinations and uses thereof |
| CN113101364B (zh) * | 2018-05-29 | 2023-12-01 | 康诺亚生物医药科技（成都）有限公司 | 一种自免疫抑制剂的开发和应用 |
| US12275797B2 (en) | 2018-06-22 | 2025-04-15 | Genmab Holding B.V. | Anti-CD37 antibodies and anti-CD20 antibodies, compositions and methods of use thereof |
| US20220267460A1 (en) * | 2018-07-11 | 2022-08-25 | Momenta Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS RELATED TO ENGINEERED Fc-ANTIGEN BINDING DOMAIN CONSTRUCTS |
| AU2019301684A1 (en) * | 2018-07-11 | 2021-02-18 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered Fc-antigen binding domain constructs |
| MA53123A (fr) | 2018-07-13 | 2021-05-19 | Genmab As | Thérapie à médiation par trogocytose utilisant des anticorps cd38 |
| BR112020026432A2 (pt) | 2018-07-13 | 2021-03-23 | Genmab A/S | variante de anticorpo, ácido nucleico isolado, vetor de expressão, ácido nucleico, combinação de ácidos nucleicos, veículo de dispensação, célula hospedeira recombinante, métodos para produção de uma variante de um anticorpo, para aumentar pelo menos uma função efetora de um anticorpo parental e para tratar uma doença, anticorpo, composição, composição farmacêutica, e, variante de anticorpo para uso |
| US20220315661A1 (en) | 2019-05-09 | 2022-10-06 | Genmab B.V. | Dosage regimens for a combination of anti-dr5 antibodies for use in treating cancer |
| EP4055046A1 (en) | 2019-11-06 | 2022-09-14 | Genmab B.V. | Antibody variant combinations and uses thereof |
| MX2022008050A (es) | 2020-01-16 | 2022-07-27 | Genmab As | Formulaciones de anticuerpos anti cumulo de diferenciacion 38 (cd38) y usos de las mismas. |
| JP2023535677A (ja) | 2020-07-10 | 2023-08-21 | バイオモレキュラー・ホールディングス・エルエルシー | 四面体抗体 |
| EP4185388A1 (en) | 2020-07-23 | 2023-05-31 | Genmab B.V. | A combination of anti-dr5 antibodies and an immunomodulatory imide drug for use in treating multiple myeloma |
| KR20230080437A (ko) | 2020-10-02 | 2023-06-07 | 젠맵 에이/에스 | Ror2에 결합할 수 있는 항체 및 ror2 및 cd3에 결합하는 이중특이적 항체 |
| US20230109496A1 (en) | 2021-09-06 | 2023-04-06 | Genmab B.V. | Antibodies capable of binding to cd27, variants thereof and uses thereof |
| CA3237844A1 (en) | 2021-11-15 | 2023-05-19 | Systimmune, Inc. | Bispecific antibody-camptothecin drug conjugate and pharmaceutical use thereof |
| US20250084169A1 (en) | 2022-01-12 | 2025-03-13 | Biomolecular Holdings Llc | Nk/monocyte engagers |
| CN119365215A (zh) | 2022-05-12 | 2025-01-24 | 健玛保 | 在组合疗法中能够结合cd27的结合剂 |
| CA3253038A1 (en) | 2022-05-12 | 2023-11-16 | Genmab A/S | LIAISON AGENTS CAPABLE OF BINDING TO CD27 IN POLYTHERAPY |
| US20250382378A1 (en) | 2022-10-31 | 2025-12-18 | Genmab A/S | Cd38 antibodies and uses thereof |
| WO2024219894A1 (ko) * | 2023-04-21 | 2024-10-24 | 상트네어바이오사이언스 주식회사 | 두 개의 fc 도메인을 포함하는 항원 결합 단백질 및 이의 용도 |
| US12410258B2 (en) | 2023-05-12 | 2025-09-09 | Ganmab A/S | Antibodies capable of binding to OX40, variants thereof and uses thereof |
| WO2025114541A1 (en) | 2023-11-30 | 2025-06-05 | Genmab A/S | Antibodies capable of binding to ox40 in combination therapy |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6004781A (en) | 1988-01-22 | 1999-12-21 | The General Hospital Corporation | Nucleic acid encoding Ig-CD4 fusion proteins |
| US5681566A (en) | 1988-10-24 | 1997-10-28 | 3I Research Exploitation Limited | Antibody conjugates with two or more covalently linked FC regions |
| GB8824869D0 (en) | 1988-10-24 | 1988-11-30 | Stevenson G T | Synthetic antibody |
| CA2153661A1 (en) | 1993-01-12 | 1994-07-21 | Anthony George Gristina | Methods and compositions for the direct concentrated delivery of passive immunity |
| US5877396A (en) | 1993-04-23 | 1999-03-02 | Sloan Kettering Institute For Cancer Research | Mice mutant for functional Fc receptors and method of treating autoimmune diseases |
| US6750334B1 (en) | 1996-02-02 | 2004-06-15 | Repligen Corporation | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor |
| AU3871099A (en) | 1998-05-06 | 1999-11-23 | Temple University - Of The Commonwealth System Of Higher Education | Reversal of proinflammatory response by ligating the macrophage fcgammari receptor |
| EP1105427A2 (en) | 1998-08-17 | 2001-06-13 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| ATE360031T1 (de) | 2000-01-03 | 2007-05-15 | Tr Associates L L C | Chimäre proteine und anwendungen |
| WO2002055992A2 (en) | 2001-01-12 | 2002-07-18 | Becton Dickinson Co | Intrinsically fluorescent, self-multimerizing mhc fusion proteins and complexes thereof |
| AU2002250293B2 (en) | 2001-03-09 | 2007-10-11 | Arnason, Barry G. Mr | Polymeric immunoglobulin fusion proteins that target low-affinity FCGammaReceptors |
| AU2002315052A1 (en) | 2001-05-15 | 2002-11-25 | Emory University | Polynucleotides and polypeptides relating to the modulation of sirp alpha-cd47 |
| AU2003217912A1 (en) | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| EP1542721A4 (en) | 2002-06-14 | 2007-05-02 | Centocor Inc | MODIFIED "S" ANTIBODIES |
| DK1606318T3 (da) | 2003-03-26 | 2009-11-02 | Apogenix Gmbh | Forbedrede Fc-fusionsproteiner |
| JP2007501021A (ja) | 2003-05-30 | 2007-01-25 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 遺伝子操作された定常領域を含む、抗体および融合タンパク質 |
| US20050033029A1 (en) | 2003-06-30 | 2005-02-10 | Jin Lu | Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses |
| WO2005047337A1 (en) | 2003-11-13 | 2005-05-26 | Hanmi Pharmaceutical Co., Ltd. | A pharmaceutical composition comprising an immunoglobulin fc region as a carrier |
| WO2005077981A2 (en) | 2003-12-22 | 2005-08-25 | Xencor, Inc. | Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES |
| WO2005089503A2 (en) | 2004-03-19 | 2005-09-29 | Progenics Pharmaceuticals, Inc. | Cd4-igg2 formulations |
| WO2006008739A2 (en) | 2004-07-19 | 2006-01-26 | Elutex Ltd. | Modified conductive surfaces having active substances attached thereto |
| EP1824979A2 (en) | 2004-12-10 | 2007-08-29 | Trigen GmbH | Methods, products and uses involving platelets and/or the vasculature |
| WO2006113889A2 (en) | 2005-04-19 | 2006-10-26 | University Of Maryland | Compositions and methods for modulating interleukin-10 |
| PL2161336T5 (pl) | 2005-05-09 | 2017-10-31 | Ono Pharmaceutical Co | Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| US7666622B2 (en) | 2005-10-19 | 2010-02-23 | Regeneron Pharmaceuticals, Inc. | Monomeric self-associating fusion polypeptides and therapeutic uses thereof |
| EP1991578A2 (en) | 2006-02-17 | 2008-11-19 | Rappaport Family Institute For Research in the Medical Sciences | Molecules and methods of using same for treating ccr5/ccr5 ligands associated diseases |
| EP2006305B1 (en) | 2006-03-03 | 2016-08-10 | The Chemo-Sero-Therapeutic Research Institute | Modified antibody with enhanced bioactivity |
| AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
| GB0614780D0 (en) | 2006-07-25 | 2006-09-06 | Ucb Sa | Biological products |
| CA2682605A1 (en) | 2007-04-18 | 2008-10-30 | Zymogenetics, Inc. | Single chain fc, methods of making and methods of treatment |
| RS53302B (sr) | 2007-05-11 | 2014-08-29 | Alexion Pharma Holding | Alkalna fosfataza koja je usmerena na kosti, pribor i postupci upotrebe |
| EP2158318A2 (en) | 2007-05-14 | 2010-03-03 | Biogen Idec MA, Inc. | Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto |
| AU2008260498B2 (en) | 2007-05-30 | 2012-11-29 | Xencor, Inc. | Methods and compositions for inhibiting CD32b expressing cells |
| CN103897063B (zh) | 2007-06-01 | 2017-04-12 | 马里兰大学巴尔的摩分校 | 免疫球蛋白恒定区Fc受体结合剂 |
| CN101868246A (zh) * | 2007-09-21 | 2010-10-20 | 加利福尼亚大学董事会 | 被导靶的干扰素显示强的细胞凋亡和抗肿瘤活性 |
| WO2010065578A2 (en) | 2008-12-04 | 2010-06-10 | Leukosight Inc. | POLYPEPTIDES COMPRISING Fc FRAGMENTS OF IMMUNOGLOBULIN G (IgG) AND METHODS OF USING THE SAME |
| KR101808751B1 (ko) | 2009-11-13 | 2017-12-13 | 그리폴스 테라퓨틱스 인코포레이티드 | 폰 빌레브란트 인자(ｖＷＦ)-함유 제제, 및 그와 관련된 방법, 키트 및 용도 |
| CA2805024A1 (en) | 2010-06-30 | 2012-01-05 | Compugen Ltd. | Polypeptides and uses thereof as a drug for treatment of multiples sclerosis, rheumatoid arthritis and other autoimmune disorders |
| EP3543257A1 (en) | 2010-07-28 | 2019-09-25 | Gliknik Inc. | Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions |
| US20140370012A1 (en) | 2012-01-27 | 2014-12-18 | Gliknik Inc. | Fusion proteins comprising igg2 hinge domains |
| KR20150058236A (ko) * | 2012-08-20 | 2015-05-28 | 글리크닉 인코포레이티드 | 항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자 |
-
2013
- 2013-08-20 KR KR1020157006960A patent/KR20150058236A/ko not_active Withdrawn
- 2013-08-20 CN CN201380053362.0A patent/CN104718223A/zh active Pending
- 2013-08-20 CA CA2882296A patent/CA2882296A1/en not_active Abandoned
- 2013-08-20 BR BR112015003459A patent/BR112015003459A2/pt not_active IP Right Cessation
- 2013-08-20 HK HK15111563.7A patent/HK1210792A1/xx unknown
- 2013-08-20 EP EP13830394.6A patent/EP2885320A4/en not_active Withdrawn
- 2013-08-20 JP JP2015528591A patent/JP2015527366A/ja active Pending
- 2013-08-20 US US13/971,584 patent/US9683044B2/en active Active
- 2013-08-20 MX MX2015002269A patent/MX2015002269A/es unknown
- 2013-08-20 RU RU2015109591A patent/RU2015109591A/ru not_active Application Discontinuation
- 2013-08-20 AU AU2013305885A patent/AU2013305885B2/en not_active Ceased
- 2013-08-20 WO PCT/US2013/055800 patent/WO2014031646A2/en not_active Ceased
-
2015
- 2015-02-19 IL IL237307A patent/IL237307A0/en unknown
-
2017
- 2017-05-16 US US15/596,178 patent/US20180094061A1/en not_active Abandoned
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