JP2014530009A5 - - Google Patents
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- Publication number
- JP2014530009A5 JP2014530009A5 JP2014533232A JP2014533232A JP2014530009A5 JP 2014530009 A5 JP2014530009 A5 JP 2014530009A5 JP 2014533232 A JP2014533232 A JP 2014533232A JP 2014533232 A JP2014533232 A JP 2014533232A JP 2014530009 A5 JP2014530009 A5 JP 2014530009A5
- Authority
- JP
- Japan
- Prior art keywords
- proteinaceous
- proteinaceous molecule
- specific binding
- molecule
- molecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000027455 binding Effects 0.000 claims description 13
- 230000002159 abnormal effect Effects 0.000 claims description 11
- 230000009870 specific binding Effects 0.000 claims description 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- 238000012737 microarray-based gene expression Methods 0.000 claims description 2
- 238000012243 multiplex automated genomic engineering Methods 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000000440 Melanoma-associated antigen Human genes 0.000 claims 1
- 108050008953 Melanoma-associated antigen Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 12
- 206010028980 Neoplasm Diseases 0.000 description 5
- 239000000427 antigen Substances 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 108091008874 T cell receptors Proteins 0.000 description 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000004186 co-expression Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161540920P | 2011-09-29 | 2011-09-29 | |
| US61/540,920 | 2011-09-29 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017173519A Division JP2018046811A (ja) | 2011-09-29 | 2017-09-08 | 異常細胞を標的とする多重特異性結合分子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014530009A JP2014530009A (ja) | 2014-11-17 |
| JP2014530009A5 true JP2014530009A5 (enExample) | 2017-01-19 |
Family
ID=47018432
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014533232A Pending JP2014530009A (ja) | 2011-09-29 | 2012-09-26 | 異常細胞を標的とする多重特異性結合分子 |
| JP2017173519A Pending JP2018046811A (ja) | 2011-09-29 | 2017-09-08 | 異常細胞を標的とする多重特異性結合分子 |
| JP2019211793A Pending JP2020058354A (ja) | 2011-09-29 | 2019-11-22 | 異常細胞を標的とする多重特異性結合分子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017173519A Pending JP2018046811A (ja) | 2011-09-29 | 2017-09-08 | 異常細胞を標的とする多重特異性結合分子 |
| JP2019211793A Pending JP2020058354A (ja) | 2011-09-29 | 2019-11-22 | 異常細胞を標的とする多重特異性結合分子 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11098115B2 (enExample) |
| EP (2) | EP3388451A1 (enExample) |
| JP (3) | JP2014530009A (enExample) |
| AU (3) | AU2012316859A1 (enExample) |
| CA (1) | CA2850291A1 (enExample) |
| WO (1) | WO2013048243A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012091564A2 (en) * | 2010-12-27 | 2012-07-05 | Apo-T B.V. | A cross-linking polypeptide that induces apoptosis |
| WO2013048243A1 (en) | 2011-09-29 | 2013-04-04 | Apo-T B.V. | Multi-specific binding molecules targeting aberrant cells |
| EP2802356A1 (en) | 2012-01-13 | 2014-11-19 | Apo-T B.V. | Aberrant cell-restricted immunoglobulins provided with a toxic moiety |
| WO2014003552A1 (en) * | 2012-06-26 | 2014-01-03 | Apo-T B.V. | Binding molecules targeting pathogens |
| WO2016077720A1 (en) * | 2014-11-14 | 2016-05-19 | Protein One, Llc | Binding agents and uses thereof |
| TWI603980B (zh) * | 2015-09-01 | 2017-11-01 | 免疫功坊股份有限公司 | 用以治療病理性血栓的聯合接合物構型藥物 |
| US20190031785A1 (en) * | 2016-01-13 | 2019-01-31 | Compass Therapeutics Llc | Multispecific immunomodulatory antigen-binding constructs |
| CA3102254A1 (en) * | 2018-06-04 | 2019-12-12 | Apo-T B.V. | Methods and means for attracting immune effector cells to tumor cells |
| JP7137696B2 (ja) | 2019-05-14 | 2022-09-14 | プロヴェンション・バイオ・インコーポレイテッド | １型糖尿病を予防するための方法および組成物 |
| DE102019121007A1 (de) * | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Antigenbindende Proteine, die spezifisch an MAGE-A binden |
| KR20230092863A (ko) | 2020-06-11 | 2023-06-26 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| WO2021263221A1 (en) * | 2020-06-26 | 2021-12-30 | Novather, Inc. | Binding modulator |
| JP2024504903A (ja) * | 2021-01-29 | 2024-02-02 | 中外製薬株式会社 | 細胞死が観察される組織において特異的に作用する分子 |
| US12435444B2 (en) | 2021-03-09 | 2025-10-07 | Cdr-Life Ag | Rabbit-derived antigen binding protein nucleic acid libraries and methods of making the same |
| EP4304726A1 (en) | 2021-03-09 | 2024-01-17 | CDR-Life AG | Mage-a4 peptide-mhc antigen binding proteins |
| KR20240004937A (ko) | 2021-05-05 | 2024-01-11 | 이매틱스 바이오테크놀로지스 게엠베하 | Bma031 항원 결합 폴리펩타이드 |
| MX2023013851A (es) | 2021-05-24 | 2023-12-08 | Provention Bio Inc | Metodos para el tratamiento de diabetes tipo 1. |
| EP4587046A1 (en) | 2022-09-14 | 2025-07-23 | CDR-Life AG | Mage-a4 peptide dual t cell engagers |
| JP2025534663A (ja) * | 2022-10-14 | 2025-10-17 | フラッグシップ パイオニアリング イノベーションズ セブン，エルエルシー | 治療薬の標的化送達のための組成物及び方法 |
| CN119529098B (zh) * | 2025-01-22 | 2025-05-30 | 北京可瑞生物科技有限公司 | 对mage-a1具有特异性的结合分子和抗cd3的融合蛋白 |
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| US3687370A (en) | 1971-01-18 | 1972-08-29 | Instapak Corp | Liquid mixing and dispensing apparatus |
| NL9001639A (nl) | 1990-07-19 | 1992-02-17 | Amc Amsterdam | Pt-houdende verbinding, werkwijze voor de bereiding ervan, alsmede toepassing van dergelijke verbindingen. |
| US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
| NZ307633A (en) | 1995-05-09 | 2000-01-28 | Kreatech Biotechnology Bv | Methods for the production of platinum-based linkers between labels and bio-organic molecules, for labelling bio-organic molecules, for detecting |
| EP0973785B1 (en) | 1997-04-10 | 2003-12-03 | Kreatech Biotechnology B.V. | Trans-platinum compound, and diagnostic kit |
| PL196605B1 (pl) | 1997-08-12 | 2008-01-31 | Leadd Bv | Sposób oznaczania zdolności transformującej, sposób oznaczania predyspozycji do przekształcania się w komórkę nowotworową, sposób oznaczania predyspozycji do dziedziczenia rodzajów raka, sposób oznaczania mutacji genu i diagnostyczny zestaw testowy |
| ID26964A (id) | 1998-02-19 | 2001-02-22 | Xcyte Therapies Inc | Komposisi dan metode untuk pengaturan pengaktifan limfosit |
| EP1124568B1 (en) * | 1998-10-21 | 2007-08-22 | Altor BioScience Corporation | Polyspecific binding molecules and uses thereof |
| IL127142A0 (en) | 1998-11-19 | 1999-09-22 | Yeda Res & Dev | Immune cells having predefined biological specificity |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US7527787B2 (en) | 2005-10-19 | 2009-05-05 | Ibc Pharmaceuticals, Inc. | Multivalent immunoglobulin-based bioactive assemblies |
| EP1377667B1 (en) | 2001-03-30 | 2008-11-19 | Leadd B.V. | Fusion proteins for specific treatment of cancer and auto-immune diseases |
| CN1294148C (zh) | 2001-04-11 | 2007-01-10 | 中国科学院遗传与发育生物学研究所 | 环状单链三特异抗体 |
| JP4049297B2 (ja) | 2001-06-11 | 2008-02-20 | 株式会社ルネサステクノロジ | 半導体記憶装置 |
| GB0115841D0 (en) | 2001-06-28 | 2001-08-22 | Medical Res Council | Ligand |
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| US20100081792A1 (en) * | 2001-06-28 | 2010-04-01 | Smithkline Beecham Corporation | Ligand |
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| EP1442301A1 (en) | 2001-11-09 | 2004-08-04 | Kreatech Biotechnology B.V. | Means and methods for the detection of immunoglobulin capable of binding to mycobacterium antigen |
| US6992176B2 (en) | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
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| WO2003089467A1 (en) | 2002-04-19 | 2003-10-30 | Leadd B.V. | Fragments of apoptin |
| CN1678634A (zh) | 2002-06-28 | 2005-10-05 | 多曼蒂斯有限公司 | 免疫球蛋白单个变体抗原结合区及其特异性构建体 |
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| ES2296423B1 (es) * | 2003-07-31 | 2009-03-16 | Consejo Sup. Investig. Cientificas | Construccion de adn para la produccion de proteinas de fusion dimericas y sus aplicaciones. |
| US7488793B2 (en) * | 2003-09-22 | 2009-02-10 | Ludwig Institute For Cancer Research | Isolated peptide which binds to HLA-Cw*07 and uses thereof |
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| PT2418220T (pt) | 2003-12-10 | 2017-10-04 | Squibb & Sons Llc | Anticorpos contra interferão alfa e suas utilizações |
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| CA2747644C (en) | 2008-12-19 | 2023-01-24 | Ablynx N.V. | Method for generation of immunoglobulin sequences |
| GB0908613D0 (en) * | 2009-05-20 | 2009-06-24 | Immunocore Ltd | T Cell Reseptors |
| SG176219A1 (en) | 2009-05-27 | 2011-12-29 | Hoffmann La Roche | Tri- or tetraspecific antibodies |
| GB0911566D0 (en) * | 2009-07-03 | 2009-08-12 | Immunocore Ltd | T cell receptors |
| EP2504360B1 (en) * | 2009-11-23 | 2018-08-15 | Amgen Inc. | Monomeric antibody fc |
| EP2504358B1 (en) | 2009-11-24 | 2016-10-19 | ChronTech Pharma AB | T cell receptors specific for immunodominant ctl epitopes of hcv |
| WO2011085473A1 (en) | 2010-01-13 | 2011-07-21 | Linda Penn | Treating cancer with statins and compounds having dipyridamole activity |
| US20120123218A1 (en) | 2010-11-16 | 2012-05-17 | JPWaVe BV | Methods and means for clinical investigations |
| WO2012091564A2 (en) * | 2010-12-27 | 2012-07-05 | Apo-T B.V. | A cross-linking polypeptide that induces apoptosis |
| DK2658872T3 (da) | 2010-12-27 | 2020-10-12 | Apo T B V | Polypeptid, der binder aberrerende celler og inducerer apoptose |
| WO2013048243A1 (en) | 2011-09-29 | 2013-04-04 | Apo-T B.V. | Multi-specific binding molecules targeting aberrant cells |
| EP2802356A1 (en) | 2012-01-13 | 2014-11-19 | Apo-T B.V. | Aberrant cell-restricted immunoglobulins provided with a toxic moiety |
| WO2014003552A1 (en) | 2012-06-26 | 2014-01-03 | Apo-T B.V. | Binding molecules targeting pathogens |
-
2012
- 2012-09-26 WO PCT/NL2012/050675 patent/WO2013048243A1/en not_active Ceased
- 2012-09-26 EP EP18153459.5A patent/EP3388451A1/en active Pending
- 2012-09-26 CA CA2850291A patent/CA2850291A1/en not_active Abandoned
- 2012-09-26 US US14/348,465 patent/US11098115B2/en active Active
- 2012-09-26 AU AU2012316859A patent/AU2012316859A1/en not_active Abandoned
- 2012-09-26 EP EP12772530.7A patent/EP2760892A1/en not_active Ceased
- 2012-09-26 JP JP2014533232A patent/JP2014530009A/ja active Pending
-
2017
- 2017-09-08 JP JP2017173519A patent/JP2018046811A/ja active Pending
- 2017-10-17 AU AU2017248425A patent/AU2017248425B2/en active Active
-
2019
- 2019-11-22 JP JP2019211793A patent/JP2020058354A/ja active Pending
-
2020
- 2020-02-07 AU AU2020200888A patent/AU2020200888A1/en not_active Abandoned
-
2021
- 2021-07-19 US US17/379,822 patent/US20210355209A1/en not_active Abandoned
-
2024
- 2024-11-21 US US18/955,569 patent/US20250115662A1/en active Pending
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