AU2012316859A1 - Multi-specific binding molecules targeting aberrant cells - Google Patents

Multi-specific binding molecules targeting aberrant cells Download PDF

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Publication number
AU2012316859A1
AU2012316859A1 AU2012316859A AU2012316859A AU2012316859A1 AU 2012316859 A1 AU2012316859 A1 AU 2012316859A1 AU 2012316859 A AU2012316859 A AU 2012316859A AU 2012316859 A AU2012316859 A AU 2012316859A AU 2012316859 A1 AU2012316859 A1 AU 2012316859A1
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AU
Australia
Prior art keywords
binding
molecules
proteinaceous
cells
domains
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Abandoned
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AU2012316859A
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English (en)
Inventor
Johan Renes
Ralph Alexander Willemsen
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APO-T BV
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APO T BV
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Filing date
Publication date
Application filed by APO T BV filed Critical APO T BV
Publication of AU2012316859A1 publication Critical patent/AU2012316859A1/en
Priority to AU2017248425A priority Critical patent/AU2017248425B2/en
Priority to AU2020200888A priority patent/AU2020200888A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/33Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
AU2012316859A 2011-09-29 2012-09-26 Multi-specific binding molecules targeting aberrant cells Abandoned AU2012316859A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2017248425A AU2017248425B2 (en) 2011-09-29 2017-10-17 Multi-specific binding molecules targeting aberrant cells
AU2020200888A AU2020200888A1 (en) 2011-09-29 2020-02-07 Multi-specific binding molecules targeting aberrant cells

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161540920P 2011-09-29 2011-09-29
US61/540,920 2011-09-29
PCT/NL2012/050675 WO2013048243A1 (en) 2011-09-29 2012-09-26 Multi-specific binding molecules targeting aberrant cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017248425A Division AU2017248425B2 (en) 2011-09-29 2017-10-17 Multi-specific binding molecules targeting aberrant cells

Publications (1)

Publication Number Publication Date
AU2012316859A1 true AU2012316859A1 (en) 2014-04-17

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
AU2012316859A Abandoned AU2012316859A1 (en) 2011-09-29 2012-09-26 Multi-specific binding molecules targeting aberrant cells
AU2017248425A Active AU2017248425B2 (en) 2011-09-29 2017-10-17 Multi-specific binding molecules targeting aberrant cells
AU2020200888A Abandoned AU2020200888A1 (en) 2011-09-29 2020-02-07 Multi-specific binding molecules targeting aberrant cells

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AU2017248425A Active AU2017248425B2 (en) 2011-09-29 2017-10-17 Multi-specific binding molecules targeting aberrant cells
AU2020200888A Abandoned AU2020200888A1 (en) 2011-09-29 2020-02-07 Multi-specific binding molecules targeting aberrant cells

Country Status (6)

Country Link
US (3) US11098115B2 (enExample)
EP (2) EP2760892A1 (enExample)
JP (3) JP2014530009A (enExample)
AU (3) AU2012316859A1 (enExample)
CA (1) CA2850291A1 (enExample)
WO (1) WO2013048243A1 (enExample)

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KR20230031981A (ko) 2019-05-14 2023-03-07 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
KR20230092863A (ko) 2020-06-11 2023-06-26 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
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Also Published As

Publication number Publication date
AU2017248425B2 (en) 2019-11-14
US20140227273A1 (en) 2014-08-14
JP2014530009A (ja) 2014-11-17
JP2020058354A (ja) 2020-04-16
WO2013048243A1 (en) 2013-04-04
CA2850291A1 (en) 2013-04-04
US20210355209A1 (en) 2021-11-18
US11098115B2 (en) 2021-08-24
EP3388451A1 (en) 2018-10-17
AU2017248425A1 (en) 2017-11-02
AU2020200888A1 (en) 2020-02-27
EP2760892A1 (en) 2014-08-06
US20250115662A1 (en) 2025-04-10
JP2018046811A (ja) 2018-03-29

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