JP2016196472A5 - - Google Patents
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- JP2016196472A5 JP2016196472A5 JP2016103689A JP2016103689A JP2016196472A5 JP 2016196472 A5 JP2016196472 A5 JP 2016196472A5 JP 2016103689 A JP2016103689 A JP 2016103689A JP 2016103689 A JP2016103689 A JP 2016103689A JP 2016196472 A5 JP2016196472 A5 JP 2016196472A5
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- Prior art keywords
- formula
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- polypeptide
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- flu
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- 229920001184 polypeptide Polymers 0.000 claims 87
- 102000004196 processed proteins & peptides Human genes 0.000 claims 87
- 108090000765 processed proteins & peptides Proteins 0.000 claims 87
- 206010022000 influenza Diseases 0.000 claims 33
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 230000002163 immunogen Effects 0.000 claims 15
- 241000712461 unidentified influenza virus Species 0.000 claims 10
- 210000001744 T-lymphocyte Anatomy 0.000 claims 8
- 125000000539 amino acid group Chemical group 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 230000003053 immunization Effects 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 108010040721 Flagellin Proteins 0.000 claims 4
- 241000607142 Salmonella Species 0.000 claims 4
- 102000002689 Toll-like receptor Human genes 0.000 claims 4
- 108020000411 Toll-like receptor Proteins 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 102000011931 Nucleoproteins Human genes 0.000 claims 2
- 108010061100 Nucleoproteins Proteins 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 101710154606 Hemagglutinin Proteins 0.000 claims 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 1
- 101710176177 Protein A56 Proteins 0.000 claims 1
- 239000000185 hemagglutinin Substances 0.000 claims 1
- 208000037797 influenza A Diseases 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30589810P | 2010-02-18 | 2010-02-18 | |
| US61/305,898 | 2010-02-18 | ||
| US12/788,103 US8673314B2 (en) | 2009-05-26 | 2010-05-26 | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| US12/788,103 | 2010-05-26 | ||
| US35416010P | 2010-06-11 | 2010-06-11 | |
| US61/354,160 | 2010-06-11 | ||
| US38508310P | 2010-09-21 | 2010-09-21 | |
| US61/385,083 | 2010-09-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012554060A Division JP2013520172A (ja) | 2010-02-18 | 2011-02-18 | インフルエンザウイルス疾患の予防及び治療で用いるためのワクチン |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018126633A Division JP2018166515A (ja) | 2010-02-18 | 2018-07-03 | インフルエンザウイルス疾患の予防及び治療で用いるためのワクチン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016196472A JP2016196472A (ja) | 2016-11-24 |
| JP2016196472A5 true JP2016196472A5 (enExample) | 2017-01-05 |
Family
ID=44483593
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012554060A Withdrawn JP2013520172A (ja) | 2010-02-18 | 2011-02-18 | インフルエンザウイルス疾患の予防及び治療で用いるためのワクチン |
| JP2016103689A Withdrawn JP2016196472A (ja) | 2010-02-18 | 2016-05-24 | インフルエンザウイルス疾患の予防及び治療で用いるためのワクチン |
| JP2018126633A Pending JP2018166515A (ja) | 2010-02-18 | 2018-07-03 | インフルエンザウイルス疾患の予防及び治療で用いるためのワクチン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012554060A Withdrawn JP2013520172A (ja) | 2010-02-18 | 2011-02-18 | インフルエンザウイルス疾患の予防及び治療で用いるためのワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018126633A Pending JP2018166515A (ja) | 2010-02-18 | 2018-07-03 | インフルエンザウイルス疾患の予防及び治療で用いるためのワクチン |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9701723B2 (enExample) |
| EP (1) | EP2536425B1 (enExample) |
| JP (3) | JP2013520172A (enExample) |
| KR (1) | KR20120132506A (enExample) |
| CN (1) | CN102939096B (enExample) |
| AU (1) | AU2011217903B2 (enExample) |
| BR (1) | BR112012020839A2 (enExample) |
| CA (1) | CA2790380A1 (enExample) |
| MX (1) | MX342716B (enExample) |
| WO (1) | WO2011103453A2 (enExample) |
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| US9051359B2 (en) | 2009-03-30 | 2015-06-09 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
| US8673314B2 (en) | 2009-05-26 | 2014-03-18 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| WO2011103453A2 (en) | 2010-02-18 | 2011-08-25 | Mount Sinai School Of Medicine | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| US9708373B2 (en) | 2010-03-30 | 2017-07-18 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccine and uses thereof |
| WO2013043729A1 (en) | 2011-09-20 | 2013-03-28 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
| EP2934581B1 (en) | 2012-12-18 | 2022-09-14 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| AU2016209032A1 (en) | 2015-01-23 | 2017-08-10 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| KR101768600B1 (ko) * | 2015-05-18 | 2017-08-17 | 한국생명공학연구원 | 범용성 개 인플루엔자 바이러스 백신 조성물 |
| JP6868763B2 (ja) * | 2016-04-01 | 2021-05-12 | パナソニックＩｐマネジメント株式会社 | インフルエンザウィルスに結合する抗体 |
| EP3471767A4 (en) | 2016-06-15 | 2020-01-15 | Icahn School of Medicine at Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| US10478488B2 (en) | 2017-10-03 | 2019-11-19 | Southwest Research Institute | Liposomal flu vaccine formulation |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP3606555A4 (en) | 2017-04-07 | 2021-08-04 | Icahn School of Medicine at Mount Sinai | INFLUENZA VIRUS TYPE B ANTI-NEURAMINIDASE ANTIBODIES AND THEIR USES |
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| RU2757013C2 (ru) * | 2017-12-19 | 2021-10-08 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт гриппа имени А.А. Смородинцева" Министерства здравоохранения Российской Федерации | Рекомбинантная противогриппозная вакцина с широким спектром защиты и способ ее получения |
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| CN108840911B (zh) * | 2018-06-09 | 2021-03-30 | 西北农林科技大学 | 新城疫病毒基质蛋白的抗原表位、抗体、鉴定方法和应用 |
| EP3810634A4 (en) | 2018-06-21 | 2022-07-27 | Icahn School of Medicine at Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| TW202011986A (zh) | 2018-07-23 | 2020-04-01 | 公益財團法人日本健康科學振興財團 | 包含流感疫苗之組合物 |
| CN109097341B (zh) * | 2018-08-28 | 2021-09-24 | 青岛农业大学 | 一种同时表达ha和hef的复制缺陷型重组流感病毒 |
| CN111363017B (zh) * | 2018-12-25 | 2022-03-15 | 中国科学院微生物研究所 | A型流感病毒核蛋白s69位突变序列及其突变体与应用 |
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| TWI857017B (zh) * | 2019-03-04 | 2024-10-01 | 國立感染症研究所長代表之日本國 | 流感ha裂解疫苗之製造方法 |
| CN111134250A (zh) * | 2019-12-03 | 2020-05-12 | 海南大学 | 一种草地贪夜蛾幼虫食用人工饲料的配方和制作方法 |
| CN111298098B (zh) * | 2020-02-25 | 2021-10-29 | 中国科学院微生物研究所 | 卡泊芬净在制备抑制冠状病毒的产品中的应用 |
| EP4120863A4 (en) * | 2020-03-19 | 2024-04-24 | Renibus Therapeutics, Inc. | METHOD FOR TREATING CORONAVIRUS INFECTION |
| CN117229370B (zh) * | 2022-06-08 | 2024-11-01 | 中科南京生命健康高等研究院 | H5n6禽流感广谱性疫苗的开发及其应用 |
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| AU2010247530B2 (en) | 2009-05-11 | 2016-10-13 | Janssen Vaccines & Prevention B.V. | Human binding molecules capable of neutralizing influenza virus H3N2 and uses thereof |
| US8673314B2 (en) | 2009-05-26 | 2014-03-18 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| HRP20180706T1 (hr) | 2009-06-24 | 2018-06-01 | Medicago Inc. | Kimerna gripa nalik čestici koja sadrži hemaglutinin |
| CA2805505C (en) | 2009-07-30 | 2021-08-03 | Mount Sinai School Of Medecine | Chimeric influenza viruses having reduced ability to reassort with other influenza viruses and uses thereof |
| JP5463107B2 (ja) | 2009-09-14 | 2014-04-09 | 独立行政法人国立国際医療研究センター | 新型インフルエンザを特異的に鑑別するモノクローナル抗体とそれを利用した免疫検出試薬 |
| JP2013060367A (ja) | 2010-01-15 | 2013-04-04 | Osaka Univ | 抗インフルエンザ抗体及びインフルエンザ検出用デバイス |
| US8298820B2 (en) * | 2010-01-26 | 2012-10-30 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
| WO2011103453A2 (en) | 2010-02-18 | 2011-08-25 | Mount Sinai School Of Medicine | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| EP2545074A4 (en) | 2010-03-08 | 2014-01-08 | Celltrion Inc | HUMAN MONOCLONAL ANTIBODIES MADE FROM HUMAN B-CELLS WITH NEUTRALIZING EFFECT AGAINST INFLUENZA A-VIRUS |
| US9708373B2 (en) | 2010-03-30 | 2017-07-18 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccine and uses thereof |
| AU2011282423B2 (en) | 2010-07-22 | 2015-05-14 | Schrader, Sabariah | Cross-protective pathogen protection, methods and compositions thereof |
| WO2013043729A1 (en) | 2011-09-20 | 2013-03-28 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
| CN104066446B (zh) | 2011-11-28 | 2017-10-03 | 扬森疫苗与预防公司 | 流感病毒疫苗及其用途 |
| US10023629B2 (en) | 2012-12-11 | 2018-07-17 | Vib Vzw | Anti-influenza antibody |
| EP2934581B1 (en) | 2012-12-18 | 2022-09-14 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
-
2011
- 2011-02-18 WO PCT/US2011/025467 patent/WO2011103453A2/en not_active Ceased
- 2011-02-18 CN CN201180019658.1A patent/CN102939096B/zh not_active Expired - Fee Related
- 2011-02-18 KR KR1020127024205A patent/KR20120132506A/ko not_active Ceased
- 2011-02-18 EP EP11745345.6A patent/EP2536425B1/en active Active
- 2011-02-18 MX MX2012009581A patent/MX342716B/es active IP Right Grant
- 2011-02-18 JP JP2012554060A patent/JP2013520172A/ja not_active Withdrawn
- 2011-02-18 BR BR112012020839A patent/BR112012020839A2/pt not_active Application Discontinuation
- 2011-02-18 US US13/579,845 patent/US9701723B2/en active Active
- 2011-02-18 AU AU2011217903A patent/AU2011217903B2/en not_active Ceased
- 2011-02-18 CA CA2790380A patent/CA2790380A1/en not_active Abandoned
-
2016
- 2016-05-24 JP JP2016103689A patent/JP2016196472A/ja not_active Withdrawn
-
2018
- 2018-07-03 JP JP2018126633A patent/JP2018166515A/ja active Pending
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