JP2010539186A5 - - Google Patents
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- Publication number
- JP2010539186A5 JP2010539186A5 JP2010525102A JP2010525102A JP2010539186A5 JP 2010539186 A5 JP2010539186 A5 JP 2010539186A5 JP 2010525102 A JP2010525102 A JP 2010525102A JP 2010525102 A JP2010525102 A JP 2010525102A JP 2010539186 A5 JP2010539186 A5 JP 2010539186A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- independently
- alkyl
- alkenyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001424 substituent group Chemical group 0.000 claims 66
- 125000000217 alkyl group Chemical group 0.000 claims 44
- 125000003342 alkenyl group Chemical group 0.000 claims 43
- 125000000304 alkynyl group Chemical group 0.000 claims 41
- -1 hydroxy, methyl Chemical group 0.000 claims 39
- 125000000623 heterocyclic group Chemical group 0.000 claims 35
- 125000001475 halogen functional group Chemical group 0.000 claims 33
- 125000003545 alkoxy group Chemical group 0.000 claims 31
- 125000004452 carbocyclyl group Chemical group 0.000 claims 29
- 150000001875 compounds Chemical class 0.000 claims 29
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 26
- 150000003839 salts Chemical class 0.000 claims 23
- 125000004043 oxo group Chemical group O=* 0.000 claims 22
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 21
- 125000005133 alkynyloxy group Chemical group 0.000 claims 21
- 125000003302 alkenyloxy group Chemical group 0.000 claims 20
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 20
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 19
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 16
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 15
- 125000004093 cyano group Chemical group *C#N 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims 12
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 claims 10
- 125000005198 alkynylcarbonyloxy group Chemical group 0.000 claims 10
- 125000005225 alkynyloxycarbonyl group Chemical group 0.000 claims 10
- 125000005139 alkynylsulfonyl group Chemical group 0.000 claims 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- DYMRYCZRMAHYKE-UHFFFAOYSA-N n-diazonitramide Chemical compound [O-][N+](=O)N=[N+]=[N-] DYMRYCZRMAHYKE-UHFFFAOYSA-N 0.000 claims 9
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 9
- 125000005090 alkenylcarbonyl group Chemical group 0.000 claims 8
- 125000005193 alkenylcarbonyloxy group Chemical group 0.000 claims 8
- 125000005137 alkenylsulfonyl group Chemical group 0.000 claims 8
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 8
- 125000005087 alkynylcarbonyl group Chemical group 0.000 claims 6
- 125000005884 carbocyclylalkyl group Chemical group 0.000 claims 6
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 6
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- KWEDUNSJJZVRKR-UHFFFAOYSA-N carbononitridic azide Chemical compound [N-]=[N+]=NC#N KWEDUNSJJZVRKR-UHFFFAOYSA-N 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 241000711549 Hepacivirus C Species 0.000 claims 3
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims 3
- 125000005097 aminocarbonylalkyl group Chemical group 0.000 claims 3
- CREXVNNSNOKDHW-UHFFFAOYSA-N azaniumylideneazanide Chemical group N[N] CREXVNNSNOKDHW-UHFFFAOYSA-N 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 125000005091 alkenylcarbonylamino group Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims 2
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 2
- 125000005197 alkyl carbonyloxy alkyl group Chemical group 0.000 claims 2
- 125000005088 alkynylcarbonylamino group Chemical group 0.000 claims 2
- 125000006598 aminocarbonylamino group Chemical group 0.000 claims 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 2
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 claims 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 2
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920002477 rna polymer Polymers 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
- 241001504592 Trachurus trachurus Species 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- YZDBZOOCRDOXFK-UHFFFAOYSA-N cyano-(diazidoamino)carbamic acid Chemical compound C(=O)(O)N(N(N=[N+]=[N-])N=[N+]=[N-])C#N YZDBZOOCRDOXFK-UHFFFAOYSA-N 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 241001493065 dsRNA viruses Species 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 125000005280 halo alkyl sulfonyloxy group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- AMWGUROGSNBGMR-UHFFFAOYSA-N n-[4-[2-[3-cyclopropyl-5-(2,4-dioxo-1,3-diazinan-1-yl)-2-methoxyphenyl]ethynyl]phenyl]methanesulfonamide Chemical compound COC1=C(C#CC=2C=CC(NS(C)(=O)=O)=CC=2)C=C(N2C(NC(=O)CC2)=O)C=C1C1CC1 AMWGUROGSNBGMR-UHFFFAOYSA-N 0.000 claims 1
- RLLFSFIWQNEYIL-UHFFFAOYSA-N n-[4-[2-[3-tert-butyl-5-(2,4-dioxo-1,3-diazinan-1-yl)-2-methoxyphenyl]ethynyl]-3-(trifluoromethyl)phenyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C#CC=2C(=CC(NS(C)(=O)=O)=CC=2)C(F)(F)F)C=C1N1CCC(=O)NC1=O RLLFSFIWQNEYIL-UHFFFAOYSA-N 0.000 claims 1
- JJOQBONMMNFIBP-UHFFFAOYSA-N n-[4-[2-[3-tert-butyl-5-(2,4-dioxo-1,3-diazinan-1-yl)-2-methoxyphenyl]ethynyl]-3-methylphenyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C#CC=2C(=CC(NS(C)(=O)=O)=CC=2)C)C=C1N1CCC(=O)NC1=O JJOQBONMMNFIBP-UHFFFAOYSA-N 0.000 claims 1
- MQYIPJLZVCEUNC-UHFFFAOYSA-N n-[4-[2-[3-tert-butyl-5-(2,4-dioxo-1,3-diazinan-1-yl)phenyl]ethynyl]-3-chlorophenyl]methanesulfonamide Chemical compound C=1C(C(C)(C)C)=CC(C#CC=2C(=CC(NS(C)(=O)=O)=CC=2)Cl)=CC=1N1CCC(=O)NC1=O MQYIPJLZVCEUNC-UHFFFAOYSA-N 0.000 claims 1
- JXAZRWXUXDUQGZ-UHFFFAOYSA-N n-[4-[2-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]ethynyl]-3-(trifluoromethyl)phenyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C#CC=2C(=CC(NS(C)(=O)=O)=CC=2)C(F)(F)F)C=C1N1C=CC(=O)NC1=O JXAZRWXUXDUQGZ-UHFFFAOYSA-N 0.000 claims 1
- CHWMJTMBVMPENO-UHFFFAOYSA-N n-[4-[2-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]ethynyl]-3-methylphenyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C#CC=2C(=CC(NS(C)(=O)=O)=CC=2)C)C=C1N1C=CC(=O)NC1=O CHWMJTMBVMPENO-UHFFFAOYSA-N 0.000 claims 1
- ZTRPQRNGMGNOMB-UHFFFAOYSA-N n-[4-[2-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]ethynyl]phenyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C#CC=2C=CC(NS(C)(=O)=O)=CC=2)C=C1N1C=CC(=O)NC1=O ZTRPQRNGMGNOMB-UHFFFAOYSA-N 0.000 claims 1
- ZEEDHMLCVRZTLZ-UHFFFAOYSA-N n-[4-[2-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)phenyl]ethynyl]-3-chlorophenyl]methanesulfonamide Chemical compound C=1C(C(C)(C)C)=CC(C#CC=2C(=CC(NS(C)(=O)=O)=CC=2)Cl)=CC=1N1C=CC(=O)NC1=O ZEEDHMLCVRZTLZ-UHFFFAOYSA-N 0.000 claims 1
- FFJDYHJZZBMVIM-UHFFFAOYSA-N n-[6-[2-[3-tert-butyl-5-(2,4-dioxo-1,3-diazinan-1-yl)-2-methoxyphenyl]ethynyl]pyridin-3-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C#CC=2N=CC(NS(C)(=O)=O)=CC=2)C=C1N1CCC(=O)NC1=O FFJDYHJZZBMVIM-UHFFFAOYSA-N 0.000 claims 1
- LHIQDTJNTVZGGE-UHFFFAOYSA-N n-[6-[2-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]ethynyl]pyridin-3-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C#CC=2N=CC(NS(C)(=O)=O)=CC=2)C=C1N1C=CC(=O)NC1=O LHIQDTJNTVZGGE-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229960000329 ribavirin Drugs 0.000 claims 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 claims 1
- 230000029812 viral genome replication Effects 0.000 claims 1
- 0 *C(C(*)N(c1cc(I*)c(*)c(*)c1)C(N1*)=O)C1=O Chemical compound *C(C(*)N(c1cc(I*)c(*)c(*)c1)C(N1*)=O)C1=O 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97287707P | 2007-09-17 | 2007-09-17 | |
| US60/972,877 | 2007-09-17 | ||
| US9679108P | 2008-09-13 | 2008-09-13 | |
| US61/096,791 | 2008-09-13 | ||
| PCT/US2008/076576 WO2009039127A1 (en) | 2007-09-17 | 2008-09-17 | Uracil or thymine derivative for treating hepatitis c |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012225875A Division JP2013049681A (ja) | 2007-09-17 | 2012-10-11 | Ｃ型肝炎を治療するためのウラシルまたはチミン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539186A JP2010539186A (ja) | 2010-12-16 |
| JP2010539186A5 true JP2010539186A5 (enExample) | 2012-11-15 |
| JP5734654B2 JP5734654B2 (ja) | 2015-06-17 |
Family
ID=39948002
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010525102A Expired - Fee Related JP5734654B2 (ja) | 2007-09-17 | 2008-09-17 | Ｃ型肝炎を治療するためのウラシルまたはチミン誘導体 |
| JP2012225875A Pending JP2013049681A (ja) | 2007-09-17 | 2012-10-11 | Ｃ型肝炎を治療するためのウラシルまたはチミン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012225875A Pending JP2013049681A (ja) | 2007-09-17 | 2012-10-11 | Ｃ型肝炎を治療するためのウラシルまたはチミン誘導体 |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US8415351B2 (enExample) |
| EP (2) | EP2222646B1 (enExample) |
| JP (2) | JP5734654B2 (enExample) |
| KR (2) | KR101660360B1 (enExample) |
| CN (2) | CN102746239B (enExample) |
| AR (2) | AR070027A1 (enExample) |
| AU (1) | AU2008302448B2 (enExample) |
| BR (1) | BRPI0816994B8 (enExample) |
| CA (2) | CA2699981C (enExample) |
| CL (2) | CL2008002794A1 (enExample) |
| CO (1) | CO6260076A2 (enExample) |
| CR (2) | CR11316A (enExample) |
| DO (2) | DOP2010000084A (enExample) |
| ES (1) | ES2453591T3 (enExample) |
| GT (1) | GT201000061A (enExample) |
| IL (1) | IL204547A (enExample) |
| IN (1) | IN2012DN05113A (enExample) |
| MX (2) | MX2010002905A (enExample) |
| MY (1) | MY162760A (enExample) |
| NZ (3) | NZ600371A (enExample) |
| PA (1) | PA8796201A1 (enExample) |
| PE (2) | PE20130209A1 (enExample) |
| PH (1) | PH12013500365A1 (enExample) |
| RU (2) | RU2543620C2 (enExample) |
| SG (1) | SG183733A1 (enExample) |
| TW (2) | TWI534137B (enExample) |
| UA (1) | UA117800C2 (enExample) |
| UY (1) | UY31344A1 (enExample) |
| WO (1) | WO2009039127A1 (enExample) |
| ZA (2) | ZA201204224B (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010002904A (es) | 2007-09-17 | 2010-06-02 | Abbott Lab | N-fenil-dioxo-hidropirimidinas utiles como inhibidores de virus de hepatitis c (hcv). |
| AU2008302448B2 (en) | 2007-09-17 | 2014-11-06 | Abbvie Ireland Unlimited Company | Uracil or thymine derivative for treating hepatitis C |
| PL2639226T3 (pl) | 2007-09-17 | 2017-02-28 | Abbvie Bahamas Ltd. | Pirymidyny o działaniu przeciw zakaźnym oraz ich zastosowania |
| CA2705586A1 (en) * | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-heterocyclic substituted indole derivatives and methods of use thereof |
| KR20110033291A (ko) | 2008-07-23 | 2011-03-30 | 에프. 호프만-라 로슈 아게 | 헤테로사이클릭 항바이러스 화합물 |
| CA2736472A1 (en) | 2008-09-26 | 2010-04-01 | F. Hoffmann-La Roche Ag | Pyrine or pyrazine derivatives for treating hcv |
| CA2753825C (en) * | 2009-03-24 | 2017-10-17 | Abbott Laboratories | Process for preparing substituted pyrimidine antiviral compound |
| CN102448952B (zh) * | 2009-03-25 | 2014-10-29 | Abbvie公司 | 抗病毒化合物和其用途 |
| US20120065247A1 (en) * | 2009-03-27 | 2012-03-15 | Discoverybiomed, Inc. | Modulating ires-mediated translation |
| SG175774A1 (en) | 2009-04-25 | 2011-12-29 | Hoffmann La Roche | Heterocyclic antiviral compounds |
| TWI428332B (zh) | 2009-06-09 | 2014-03-01 | Hoffmann La Roche | 雜環抗病毒化合物 |
| EP2445875A2 (en) * | 2009-06-24 | 2012-05-02 | F. Hoffmann-La Roche AG | Heterocyclic antiviral compound |
| JP2011057661A (ja) * | 2009-08-14 | 2011-03-24 | Bayer Cropscience Ag | 殺虫性カルボキサミド類 |
| WO2011033045A1 (en) | 2009-09-21 | 2011-03-24 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| KR20120085918A (ko) * | 2009-11-21 | 2012-08-01 | 에프. 호프만-라 로슈 아게 | 헤테로환형 항바이러스성 화합물 |
| WO2011073114A1 (en) | 2009-12-14 | 2011-06-23 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| US9216952B2 (en) | 2010-03-23 | 2015-12-22 | Abbvie Inc. | Process for preparing antiviral compound |
| CN102971305B (zh) | 2010-07-07 | 2016-02-03 | 弗·哈夫曼-拉罗切有限公司 | 抗病毒的杂环化合物 |
| CN105622525B (zh) | 2010-07-16 | 2019-02-15 | 艾伯维巴哈马有限公司 | 用于制备抗病毒化合物的方法 |
| EA030228B1 (ru) | 2010-07-16 | 2018-07-31 | ЭббВи Айэленд Анлимитед Компани | Фосфиновые лиганды для каталитических реакций |
| US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
| US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
| AU2015201698B2 (en) * | 2010-07-16 | 2017-02-02 | Abbvie Ireland Unlimited Company | Process for preparing antiviral compounds |
| RU2436786C1 (ru) * | 2010-07-23 | 2011-12-20 | Александр Васильевич Иващенко | Замещенные индолы, противовирусный активный компонент, способ получения и применения |
| WO2012020725A1 (ja) * | 2010-08-10 | 2012-02-16 | 塩野義製薬株式会社 | Ｎｐｙ ｙ５受容体拮抗作用を有するヘテロ環誘導体 |
| CA2806547A1 (en) | 2010-08-13 | 2012-02-16 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| CN102675092B (zh) * | 2011-03-14 | 2014-11-05 | 江苏中丹药物研究有限公司 | 一种制备2-芳基-2,2-二甲基乙酸甲酯的方法 |
| TWI558400B (zh) | 2011-03-18 | 2016-11-21 | 艾伯維有限公司 | 苯基尿嘧啶化合物之調配物 |
| JP2014510743A (ja) * | 2011-03-31 | 2014-05-01 | シェファー、コンスタンツェ | 核酸の非ウイルスの導入のためのパーフルオロ化化合物 |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| JP5734124B2 (ja) * | 2011-07-21 | 2015-06-10 | 株式会社 東邦アーステック | １，３−ジヨードヒダントイン類の製造方法 |
| EP2740728A4 (en) | 2011-08-01 | 2015-04-01 | Sumitomo Dainippon Pharma Co Ltd | URACIL DERIVATIVE AND ITS USE FOR MEDICAL PURPOSES |
| DE112012003457T5 (de) | 2011-10-21 | 2015-03-12 | Abbvie Inc. | Kombinationsbehandlung (z.B. mit ABT-072 oder ABT-333 von DAAs zur Verwendung in der Behandlung von HCV) |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| TWI532487B (zh) | 2011-10-21 | 2016-05-11 | 艾伯維有限公司 | 治療ｃ型肝炎病毒（ｈｃｖ）之方法 |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| AU2015200715A1 (en) * | 2011-10-21 | 2015-03-05 | Abbvie Ireland Unlimited Company | Methods for treating HCV |
| EP2861579B9 (en) | 2012-05-15 | 2018-08-29 | Novartis AG | Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1 |
| US9315489B2 (en) | 2012-05-15 | 2016-04-19 | Novartis Ag | Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 |
| CN104379574B (zh) | 2012-05-15 | 2017-03-01 | 诺华股份有限公司 | 用于抑制abl1、abl2和bcr‑abl1的活性的苯甲酰胺衍生物 |
| US9340537B2 (en) | 2012-05-15 | 2016-05-17 | Novatis Ag | Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 |
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