RU2543620C2 - Производные урацила или тимина для лечения гепатита с - Google Patents
Производные урацила или тимина для лечения гепатита с Download PDFInfo
- Publication number
- RU2543620C2 RU2543620C2 RU2010114828/04A RU2010114828A RU2543620C2 RU 2543620 C2 RU2543620 C2 RU 2543620C2 RU 2010114828/04 A RU2010114828/04 A RU 2010114828/04A RU 2010114828 A RU2010114828 A RU 2010114828A RU 2543620 C2 RU2543620 C2 RU 2543620C2
- Authority
- RU
- Russia
- Prior art keywords
- tert
- butyl
- dioxotetrahydropyrimidin
- group
- phenyl
- Prior art date
Links
- 0 *c1cc(N(C(*)=C(*)C(N2*)=O)C2=O)cc(*)c1* Chemical compound *c1cc(N(C(*)=C(*)C(N2*)=O)C2=O)cc(*)c1* 0.000 description 17
- XNYKCPSGPBBQBQ-JLQKSHHBSA-N CC(C)(C)c(cc(cc1NC(c(cc2)ccc2NS(C)(=O)=O)=O)/C(/CCCC(CC2=N)=O)=C\C2=O)c1OC Chemical compound CC(C)(C)c(cc(cc1NC(c(cc2)ccc2NS(C)(=O)=O)=O)/C(/CCCC(CC2=N)=O)=C\C2=O)c1OC XNYKCPSGPBBQBQ-JLQKSHHBSA-N 0.000 description 1
- IGHHIJGOIDFCFW-OMSIOKFJSA-N CC(C)(C)c1cc(/C(/CCCC(CC2=N)=O)=C\C2=O)cc(C#Cc2c(CNS=O)cccn2)c1OC Chemical compound CC(C)(C)c1cc(/C(/CCCC(CC2=N)=O)=C\C2=O)cc(C#Cc2c(CNS=O)cccn2)c1OC IGHHIJGOIDFCFW-OMSIOKFJSA-N 0.000 description 1
- WPFLYXZIWPSJBA-UHFFFAOYSA-N CC(C)(C)c1cc(N(C=CC(N2)=O)C2=O)cc(-c2cc3ncc(NSC)nc3cc2)c1OC Chemical compound CC(C)(C)c1cc(N(C=CC(N2)=O)C2=O)cc(-c2cc3ncc(NSC)nc3cc2)c1OC WPFLYXZIWPSJBA-UHFFFAOYSA-N 0.000 description 1
- QFNWRWSMBBUABM-UHFFFAOYSA-N CC(C)(C)c1cc(N(C=CC(N2)=O)C2=O)cc(-c2ccc(C(CC3)NS(C)(=O)=O)c3c2)c1OC Chemical compound CC(C)(C)c1cc(N(C=CC(N2)=O)C2=O)cc(-c2ccc(C(CC3)NS(C)(=O)=O)c3c2)c1OC QFNWRWSMBBUABM-UHFFFAOYSA-N 0.000 description 1
- DGTXGWLRWHJWAO-UHFFFAOYSA-N CC(C)(C)c1cc(N(C=CC(N2)=O)C2=O)cc(-c2ccc3nc(-[n]4c(C)ccc4C)[s]c3c2)c1OC Chemical compound CC(C)(C)c1cc(N(C=CC(N2)=O)C2=O)cc(-c2ccc3nc(-[n]4c(C)ccc4C)[s]c3c2)c1OC DGTXGWLRWHJWAO-UHFFFAOYSA-N 0.000 description 1
- ZYQGLTZMFGKEDJ-UHFFFAOYSA-N CC(C)(C)c1cc(N(C=CC(N2)=O)C2=O)cc(-c2ccc3nc(NS=O)[s]c3c2)c1OC Chemical compound CC(C)(C)c1cc(N(C=CC(N2)=O)C2=O)cc(-c2ccc3nc(NS=O)[s]c3c2)c1OC ZYQGLTZMFGKEDJ-UHFFFAOYSA-N 0.000 description 1
- WQFKBVALGPRPPV-UHFFFAOYSA-N CC(C)(C)c1cc(N(C=CC(N2)=O)C2=O)cc(N(CCc2c3)Cc2ccc3NSC)c1OC Chemical compound CC(C)(C)c1cc(N(C=CC(N2)=O)C2=O)cc(N(CCc2c3)Cc2ccc3NSC)c1OC WQFKBVALGPRPPV-UHFFFAOYSA-N 0.000 description 1
- ZKBISQZXGWNNJF-RMKNXTFCSA-N CC(C)(C)c1cc(N(CCC(N2)=O)C2=O)cc(/C=C/c(cc2)ccc2OC)c1OC Chemical compound CC(C)(C)c1cc(N(CCC(N2)=O)C2=O)cc(/C=C/c(cc2)ccc2OC)c1OC ZKBISQZXGWNNJF-RMKNXTFCSA-N 0.000 description 1
- CUTIIZCDHVRSIE-UHFFFAOYSA-N CC(C)(C)c1cc(N(CCC(N2)=O)C2=O)cc(COc(cc2)ccc2N)c1OC Chemical compound CC(C)(C)c1cc(N(CCC(N2)=O)C2=O)cc(COc(cc2)ccc2N)c1OC CUTIIZCDHVRSIE-UHFFFAOYSA-N 0.000 description 1
- LLXDDUTVWPFUJE-UHFFFAOYSA-N CCCC(OCN(c(cc1)ccc1NC(c(cc(cc1C(C)(C)C)N(CCC(N2COC(CCC)=O)=O)C2=O)c1OC)=O)/S(/C)=C\C)=O Chemical compound CCCC(OCN(c(cc1)ccc1NC(c(cc(cc1C(C)(C)C)N(CCC(N2COC(CCC)=O)=O)C2=O)c1OC)=O)/S(/C)=C\C)=O LLXDDUTVWPFUJE-UHFFFAOYSA-N 0.000 description 1
- CFNHVUGPXZUTRR-UHFFFAOYSA-N CCCNCCN Chemical compound CCCNCCN CFNHVUGPXZUTRR-UHFFFAOYSA-N 0.000 description 1
- DIPWXBIVAXCYIP-SCSAIBSYSA-N CCN[C@H](C1)[I]1O Chemical compound CCN[C@H](C1)[I]1O DIPWXBIVAXCYIP-SCSAIBSYSA-N 0.000 description 1
- UZAAZICNWHJGFD-SZXQPVLSSA-N COc(c(-c1ccc[o]1)cc(N(C=CC(N1)=O)C1=O)c1)c1-c1ccc(CC/C2=N\NS(C)(=O)=O)c2c1 Chemical compound COc(c(-c1ccc[o]1)cc(N(C=CC(N1)=O)C1=O)c1)c1-c1ccc(CC/C2=N\NS(C)(=O)=O)c2c1 UZAAZICNWHJGFD-SZXQPVLSSA-N 0.000 description 1
- WTLGVHMLSDGNGC-SZXQPVLSSA-N COc(c(-c1ccc[s]1)cc(N(C=CC(N1)=O)C1=O)c1)c1-c1ccc(CC/C2=N\NS(C)(=O)=O)c2c1 Chemical compound COc(c(-c1ccc[s]1)cc(N(C=CC(N1)=O)C1=O)c1)c1-c1ccc(CC/C2=N\NS(C)(=O)=O)c2c1 WTLGVHMLSDGNGC-SZXQPVLSSA-N 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97287707P | 2007-09-17 | 2007-09-17 | |
| US60/972,877 | 2007-09-17 | ||
| US9679108P | 2008-09-13 | 2008-09-13 | |
| US61/096,791 | 2008-09-13 | ||
| PCT/US2008/076576 WO2009039127A1 (en) | 2007-09-17 | 2008-09-17 | Uracil or thymine derivative for treating hepatitis c |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013104270/04A Division RU2599635C2 (ru) | 2007-09-17 | 2013-02-01 | Производные урацила или тимина для лечения гепатита с |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010114828A RU2010114828A (ru) | 2011-10-27 |
| RU2543620C2 true RU2543620C2 (ru) | 2015-03-10 |
Family
ID=39948002
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010114828/04A RU2543620C2 (ru) | 2007-09-17 | 2008-09-17 | Производные урацила или тимина для лечения гепатита с |
| RU2013104270/04A RU2599635C2 (ru) | 2007-09-17 | 2013-02-01 | Производные урацила или тимина для лечения гепатита с |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013104270/04A RU2599635C2 (ru) | 2007-09-17 | 2013-02-01 | Производные урацила или тимина для лечения гепатита с |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US8415351B2 (enExample) |
| EP (2) | EP2222646B1 (enExample) |
| JP (2) | JP5734654B2 (enExample) |
| KR (2) | KR101660360B1 (enExample) |
| CN (2) | CN102746239B (enExample) |
| AR (2) | AR070027A1 (enExample) |
| AU (1) | AU2008302448B2 (enExample) |
| BR (1) | BRPI0816994B8 (enExample) |
| CA (2) | CA2699981C (enExample) |
| CL (2) | CL2008002794A1 (enExample) |
| CO (1) | CO6260076A2 (enExample) |
| CR (2) | CR11316A (enExample) |
| DO (2) | DOP2010000084A (enExample) |
| ES (1) | ES2453591T3 (enExample) |
| GT (1) | GT201000061A (enExample) |
| IL (1) | IL204547A (enExample) |
| IN (1) | IN2012DN05113A (enExample) |
| MX (2) | MX2010002905A (enExample) |
| MY (1) | MY162760A (enExample) |
| NZ (3) | NZ600371A (enExample) |
| PA (1) | PA8796201A1 (enExample) |
| PE (2) | PE20130209A1 (enExample) |
| PH (1) | PH12013500365A1 (enExample) |
| RU (2) | RU2543620C2 (enExample) |
| SG (1) | SG183733A1 (enExample) |
| TW (2) | TWI534137B (enExample) |
| UA (1) | UA117800C2 (enExample) |
| UY (1) | UY31344A1 (enExample) |
| WO (1) | WO2009039127A1 (enExample) |
| ZA (2) | ZA201204224B (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010002904A (es) | 2007-09-17 | 2010-06-02 | Abbott Lab | N-fenil-dioxo-hidropirimidinas utiles como inhibidores de virus de hepatitis c (hcv). |
| AU2008302448B2 (en) | 2007-09-17 | 2014-11-06 | Abbvie Ireland Unlimited Company | Uracil or thymine derivative for treating hepatitis C |
| PL2639226T3 (pl) | 2007-09-17 | 2017-02-28 | Abbvie Bahamas Ltd. | Pirymidyny o działaniu przeciw zakaźnym oraz ich zastosowania |
| CA2705586A1 (en) * | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-heterocyclic substituted indole derivatives and methods of use thereof |
| KR20110033291A (ko) | 2008-07-23 | 2011-03-30 | 에프. 호프만-라 로슈 아게 | 헤테로사이클릭 항바이러스 화합물 |
| CA2736472A1 (en) | 2008-09-26 | 2010-04-01 | F. Hoffmann-La Roche Ag | Pyrine or pyrazine derivatives for treating hcv |
| CA2753825C (en) * | 2009-03-24 | 2017-10-17 | Abbott Laboratories | Process for preparing substituted pyrimidine antiviral compound |
| CN102448952B (zh) * | 2009-03-25 | 2014-10-29 | Abbvie公司 | 抗病毒化合物和其用途 |
| US20120065247A1 (en) * | 2009-03-27 | 2012-03-15 | Discoverybiomed, Inc. | Modulating ires-mediated translation |
| SG175774A1 (en) | 2009-04-25 | 2011-12-29 | Hoffmann La Roche | Heterocyclic antiviral compounds |
| TWI428332B (zh) | 2009-06-09 | 2014-03-01 | Hoffmann La Roche | 雜環抗病毒化合物 |
| EP2445875A2 (en) * | 2009-06-24 | 2012-05-02 | F. Hoffmann-La Roche AG | Heterocyclic antiviral compound |
| JP2011057661A (ja) * | 2009-08-14 | 2011-03-24 | Bayer Cropscience Ag | 殺虫性カルボキサミド類 |
| WO2011033045A1 (en) | 2009-09-21 | 2011-03-24 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| KR20120085918A (ko) * | 2009-11-21 | 2012-08-01 | 에프. 호프만-라 로슈 아게 | 헤테로환형 항바이러스성 화합물 |
| WO2011073114A1 (en) | 2009-12-14 | 2011-06-23 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| US9216952B2 (en) | 2010-03-23 | 2015-12-22 | Abbvie Inc. | Process for preparing antiviral compound |
| CN102971305B (zh) | 2010-07-07 | 2016-02-03 | 弗·哈夫曼-拉罗切有限公司 | 抗病毒的杂环化合物 |
| CN105622525B (zh) | 2010-07-16 | 2019-02-15 | 艾伯维巴哈马有限公司 | 用于制备抗病毒化合物的方法 |
| EA030228B1 (ru) | 2010-07-16 | 2018-07-31 | ЭббВи Айэленд Анлимитед Компани | Фосфиновые лиганды для каталитических реакций |
| US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
| US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
| AU2015201698B2 (en) * | 2010-07-16 | 2017-02-02 | Abbvie Ireland Unlimited Company | Process for preparing antiviral compounds |
| RU2436786C1 (ru) * | 2010-07-23 | 2011-12-20 | Александр Васильевич Иващенко | Замещенные индолы, противовирусный активный компонент, способ получения и применения |
| WO2012020725A1 (ja) * | 2010-08-10 | 2012-02-16 | 塩野義製薬株式会社 | Ｎｐｙ ｙ５受容体拮抗作用を有するヘテロ環誘導体 |
| CA2806547A1 (en) | 2010-08-13 | 2012-02-16 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
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