BRPI0816994B8 - derivado uracila ou timina para tratar hepatite c - Google Patents

derivado uracila ou timina para tratar hepatite c

Info

Publication number
BRPI0816994B8
BRPI0816994B8 BRPI0816994A BRPI0816994A BRPI0816994B8 BR PI0816994 B8 BRPI0816994 B8 BR PI0816994B8 BR PI0816994 A BRPI0816994 A BR PI0816994A BR PI0816994 A BRPI0816994 A BR PI0816994A BR PI0816994 B8 BRPI0816994 B8 BR PI0816994B8
Authority
BR
Brazil
Prior art keywords
uracil
compounds
dioxo
butyl
derivative
Prior art date
Application number
BRPI0816994A
Other languages
English (en)
Inventor
C Krueger Allan
R Haight Anthony
J Kotecki Brian
A Flentge Charles
E Motter Christopher
J Maring Clarence
Liu Dachun
A Betebenner David
A Degoey David
M Barnes David
K Hutchinson Douglas
G Z Zhang Geoff
E Hengeveld John
K Pratt John
T Randolph John
Sarris Kathy
D Stewart Kent
L Longenecker Kenton
D Tufano Michael
L Donner Pamela
P Huang Peggy
F Henry Rodger
Chen Shuang
S Franczyk Ii Thaddeus
W Rockway Todd
Rolf Wagner
M Kati Warren
Lou Xiaochun
Liu Yaya
Gao Yi
Original Assignee
Abbott Lab
Abbvie Bahamas Ltd
Abbvie Inc
Abbvie Ireland Unlimited Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39948002&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0816994(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab, Abbvie Bahamas Ltd, Abbvie Inc, Abbvie Ireland Unlimited Co filed Critical Abbott Lab
Publication of BRPI0816994A2 publication Critical patent/BRPI0816994A2/pt
Publication of BRPI0816994B1 publication Critical patent/BRPI0816994B1/pt
Publication of BRPI0816994B8 publication Critical patent/BRPI0816994B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

derivado uracila ou tamina para tratar hepatite c a presente aplicação relaciona se compostos de fórmula i úteis pata tratar infecções de hepatite c (hcv) na estrutura dos compostos revelados está o derivado uracila ou timona ligado através de um fenileno eo ou de sistema cíclico de 2 anéis fusionados (r6) ou alternativamente através de dois átomos ligantes adicionais (l) a um monociclo de 5-6 membros (r6) aplicação ainda revela polímorfos e pseudopolímorfos de dois compostos especifícos : n(6(3-t-butil-592,4-dioxo-3,4diidropirimidin-1-(2h)-il)-2-metoxifenil)neflalen-2-ilmetanosulfonamida e (e)-n-(4(3-t-butil-5-(2,4-dioxo-3,4didropririmidin-1-(2h)-il)-2-metoxiestiril-fenil)metanosulfonamida.
BRPI0816994A 2007-09-17 2008-09-17 derivado uracila ou timina para tratar hepatite c BRPI0816994B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97287707P 2007-09-17 2007-09-17
US9679108P 2008-09-13 2008-09-13
PCT/US2008/076576 WO2009039127A1 (en) 2007-09-17 2008-09-17 Uracil or thymine derivative for treating hepatitis c

Publications (3)

Publication Number Publication Date
BRPI0816994A2 BRPI0816994A2 (pt) 2015-03-24
BRPI0816994B1 BRPI0816994B1 (pt) 2019-12-24
BRPI0816994B8 true BRPI0816994B8 (pt) 2021-05-25

Family

ID=39948002

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0816994A BRPI0816994B8 (pt) 2007-09-17 2008-09-17 derivado uracila ou timina para tratar hepatite c

Country Status (31)

Country Link
US (3) US8415351B2 (pt)
EP (2) EP2725015A1 (pt)
JP (2) JP5734654B2 (pt)
KR (2) KR101552474B1 (pt)
CN (2) CN102746239B (pt)
AR (2) AR070027A1 (pt)
AU (1) AU2008302448B2 (pt)
BR (1) BRPI0816994B8 (pt)
CA (2) CA2699981C (pt)
CL (2) CL2008002794A1 (pt)
CO (1) CO6260076A2 (pt)
CR (2) CR11316A (pt)
DO (2) DOP2010000084A (pt)
ES (1) ES2453591T3 (pt)
GT (1) GT201000061A (pt)
HK (1) HK1147256A1 (pt)
IL (1) IL204547A (pt)
IN (1) IN2012DN05113A (pt)
MX (2) MX2010002905A (pt)
MY (1) MY162760A (pt)
NZ (3) NZ600371A (pt)
PA (1) PA8796201A1 (pt)
PE (2) PE20130209A1 (pt)
PH (1) PH12013500365A1 (pt)
RU (2) RU2543620C2 (pt)
SG (1) SG183733A1 (pt)
TW (2) TWI437994B (pt)
UA (1) UA117800C2 (pt)
UY (1) UY31344A1 (pt)
WO (1) WO2009039127A1 (pt)
ZA (2) ZA201204224B (pt)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009039127A1 (en) 2007-09-17 2009-03-26 Abbott Laboratories Uracil or thymine derivative for treating hepatitis c
EP2548873A1 (en) 2007-09-17 2013-01-23 Abbott Laboratories N-phenyl-dioxo-hydropyrimidines useful as hepatitis c virus (hcv) inhibitors
PT2639226T (pt) 2007-09-17 2016-12-09 Abbvie Bahamas Ltd Pirimidinas anti-infeciosas e suas utilizações
CA2705586A1 (en) * 2007-11-16 2009-05-22 Schering Corporation 3-heterocyclic substituted indole derivatives and methods of use thereof
JP2011528686A (ja) 2008-07-23 2011-11-24 エフ．ホフマン−ラ ロシュ アーゲー ヘテロ環式抗ウイルス性化合物
BRPI0920513A2 (pt) 2008-09-26 2019-09-24 F Hoffamann La Roche Ag derivados de pirina ou pirazina para tratar hcv
EP2411372B1 (en) * 2009-03-24 2014-07-23 AbbVie Bahamas Ltd. Process for preparing an antiviral compound
WO2010111437A1 (en) * 2009-03-25 2010-09-30 Abbott Laboratories Antiviral compounds and uses thereof
WO2010111653A2 (en) * 2009-03-27 2010-09-30 The Uab Research Foundation Modulating ires-mediated translation
EP2421831A1 (en) 2009-04-25 2012-02-29 F. Hoffmann-La Roche AG Heterocyclic antiviral compounds
AR077004A1 (es) 2009-06-09 2011-07-27 Hoffmann La Roche Compuestos heterociclicos antivirales
EP2445875A2 (en) 2009-06-24 2012-05-02 F. Hoffmann-La Roche AG Heterocyclic antiviral compound
JP2011057661A (ja) * 2009-08-14 2011-03-24 Bayer Cropscience Ag 殺虫性カルボキサミド類
CN102498100A (zh) 2009-09-21 2012-06-13 弗·哈夫曼-拉罗切有限公司 抗病毒杂环化合物
JP2013511489A (ja) * 2009-11-21 2013-04-04 エフ．ホフマン−ラ ロシュ アーゲー 複素環式抗ウイルス化合物
AR079440A1 (es) * 2009-12-14 2012-01-25 Hoffmann La Roche Compuestos heterociclicos antivirales
US9216952B2 (en) 2010-03-23 2015-12-22 Abbvie Inc. Process for preparing antiviral compound
JP5651239B2 (ja) 2010-07-07 2015-01-07 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 複素環式抗ウイルス化合物
AU2015201698B2 (en) * 2010-07-16 2017-02-02 Abbvie Ireland Unlimited Company Process for preparing antiviral compounds
MX338725B (es) 2010-07-16 2016-04-28 Abbvie Bahamas Ltd Ligando de fosfina para reacciones cataliticas.
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
MY167881A (en) * 2010-07-16 2018-09-26 Abbvie Bahamas Ltd Process for preparing antiviral compounds
RU2436786C1 (ru) * 2010-07-23 2011-12-20 Александр Васильевич Иващенко Замещенные индолы, противовирусный активный компонент, способ получения и применения
WO2012020725A1 (ja) * 2010-08-10 2012-02-16 塩野義製薬株式会社 Ｎｐｙ ｙ５受容体拮抗作用を有するヘテロ環誘導体
MX2013001273A (es) 2010-08-13 2013-04-10 Hoffmann La Roche Compuestos heterociclicos antivirales.
CN102675092B (zh) * 2011-03-14 2014-11-05 江苏中丹药物研究有限公司 一种制备2-芳基-2,2-二甲基乙酸甲酯的方法
CA2829768A1 (en) 2011-03-18 2012-09-27 Abbvie Inc. Formulations of phenyl uracil compounds
CN103764169B (zh) * 2011-03-31 2017-06-13 康斯坦策·沙费尔 用于非病毒转移核酸的全氟化化合物
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
JP5734124B2 (ja) * 2011-07-21 2015-06-10 株式会社 東邦アーステック １，３−ジヨードヒダントイン類の製造方法
KR20140062476A (ko) 2011-08-01 2014-05-23 다이닛본 스미토모 세이야꾸 가부시끼가이샤 우라실 유도체 및 그 의약 용도
GB2515941A (en) 2011-10-21 2015-01-07 Abbvie Inc Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
EA201490836A1 (ru) 2011-10-21 2014-11-28 Эббви Инк. Комбинационное лечение (например, с abt-072 или abt-333) с помощью daa для применения при лечении hcv
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
AU2015200715A1 (en) * 2011-10-21 2015-03-05 Abbvie Ireland Unlimited Company Methods for treating HCV
AP3613A (en) 2012-05-15 2016-02-29 Novartis Ag Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1 abl1abl2 bcr-abl1
KR20150008406A (ko) 2012-05-15 2015-01-22 노파르티스 아게 Abl1, abl2 및 bcr-abl1의 활성을 억제하기 위한 벤즈아미드 유도체
PT2900637T (pt) 2012-05-15 2017-11-15 Novartis Ag Derivados de amida de pirimidina, piridina e pirazina substituídos com tiazole ou imidazole e compostos relacionados como inibidores de abl1, abl2 e bcr-abl1 para tratamento do cancro, infecções virais específicas e disturbios do snc específicos
MX2014013373A (es) 2012-05-15 2015-08-14 Novartis Ag Derivados de benzamida para inhibir la actividad de abl1, abl2 y bcr-abl1.
WO2014004674A2 (en) 2012-06-27 2014-01-03 Abbvie Inc. Methods for treating hcv
JP6469571B2 (ja) * 2012-08-21 2019-02-13 アッヴィ・アイルランド・アンリミテッド・カンパニー 抗ウイルス性化合物を調製するための方法
SG11201503051QA (en) 2012-10-18 2015-05-28 Abbvie Inc Formulations of pyrimidinedione derivative compounds
JP2014101316A (ja) * 2012-11-20 2014-06-05 Toyobo Co Ltd ベンゾ［１，２−ｄ；４，５−ｄ’］ビスチアゾール化合物の製造方法
CA2916912A1 (en) 2013-07-02 2015-01-08 Abbvie Inc. Methods for treating hcv
ES2728531T3 (es) 2013-07-08 2019-10-25 Bayer Cropscience Ag Derivados de arilsulfuro y arilsulfóxido de seis miembros enlazados con C-N como agentes para combatir parásitos
ES2927955T3 (es) 2013-09-11 2022-11-14 Univ Emory Composiciones de nucleótidos y nucleósidos y sus usos
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
US20150209403A1 (en) 2014-01-28 2015-07-30 Abbvie Inc. Dose Adjustment
SG11201606080SA (en) 2014-02-03 2016-08-30 Vitae Pharmaceuticals Inc Dihydropyrrolopyridine inhibitors of ror-gamma
CN106065009B (zh) * 2014-06-28 2019-03-01 广东东阳光药业有限公司 作为丙型肝炎抑制剂的化合物及其在药物中的应用
WO2016004513A1 (en) * 2014-07-11 2016-01-14 Simon Fraser University Anti-bacterial pyruvate kinase modulator compounds, compositions, uses and methods
DK3174868T3 (da) 2014-08-01 2021-11-08 Nuevolution As Forbindelser, der er aktive mod bromodomæner
US20160074462A1 (en) 2014-09-11 2016-03-17 Abbvie Inc. Method of Treating HCV
HUE042335T2 (hu) 2014-10-14 2019-06-28 Vitae Pharmaceuticals Inc ROR-gamma dihidropirrolopiridin inhibitorai
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
WO2016105547A1 (en) 2014-12-24 2016-06-30 Concert Pharmaceuticals, Inc. Deuterated dasabuvir
RU2590952C1 (ru) * 2015-05-26 2016-07-10 Вячеслав Энгельсович Семёнов Средство гепатопротекторного действия
WO2016196280A1 (en) 2015-06-02 2016-12-08 E I Du Pont De Nemours And Company Heterocycle-substituted bicyclic pesticides
CN108137514A (zh) * 2015-07-30 2018-06-08 百时美施贵宝公司 芳基取代的二环杂芳基化合物
EP3331876B1 (en) 2015-08-05 2020-10-07 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
EP3377482B1 (en) 2015-11-20 2021-05-12 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
TWI757266B (zh) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
CN109689063A (zh) 2016-04-28 2019-04-26 埃默里大学 含有炔烃的核苷酸和核苷治疗组合物及其相关用途
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
MX2020000887A (es) 2017-07-24 2020-07-22 Vitae Pharmaceuticals Llc Inhibidores de ror?.
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
CN107266373A (zh) * 2017-08-01 2017-10-20 安徽拜善晟制药有限公司 一种原料药达沙布韦的制备方法
CN110483496B (zh) * 2019-07-17 2021-05-04 杭州市西溪医院 一类具有尿嘧啶-苯并噻唑结构衍生物、其制备方法及抗hcv药物的应用
EP3819006A1 (en) 2019-11-05 2021-05-12 Technische Universität Dresden Compounds with thymine skeleton for use in medicine
CN111518036A (zh) * 2020-04-29 2020-08-11 杭州勇诚睿生物科技有限公司 一种达沙布韦关键中间体的制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239888A (en) * 1974-11-04 1980-12-16 Pfizer Inc. 1-Phenyluracils
JPS60243017A (ja) * 1984-05-16 1985-12-03 Kyowa Hakko Kogyo Co Ltd 抗けいれん組成物
AU627906B2 (en) * 1989-07-14 1992-09-03 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
US5084084A (en) * 1989-07-14 1992-01-28 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
EP0442473B1 (en) 1990-02-15 1998-08-19 Takeda Chemical Industries, Ltd. Pyrimidinedione derivatives, their production and use
NL9001075A (pt) * 1990-05-04 1991-12-02 Duphar Int Res
EP0489480A1 (en) * 1990-12-05 1992-06-10 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
JPH05213755A (ja) 1992-02-07 1993-08-24 Nikko Kyodo Co Ltd 肝臓障害治療薬
DE19528305A1 (de) 1995-08-02 1997-02-06 Bayer Ag Substituierte Phenyluracile
JP3824935B2 (ja) * 1999-12-06 2006-09-20 エフ．ホフマン−ラ ロシュ アーゲー ４−ピリミジニル−ｎ−アシル−ｌ−フェニルアラニン
US6380387B1 (en) * 1999-12-06 2002-04-30 Hoffmann-La Roche Inc. 4-Pyrimidinyl-n-acyl-l phenylalanines
RU2264395C2 (ru) * 2000-02-04 2005-11-20 Сумитомо Кемикал Компани, Лимитед Производные урацила, гербицидная композиция, способ борьбы с сорняками и промежуточные продукты (варианты)
IL167954A (en) * 2000-02-04 2007-10-31 Sumitomo Chemical Co History of pyrimidine
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
TW200505872A (en) * 2003-06-13 2005-02-16 Lg Life Science Ltd Hepatitis C virus inhibitors
US7163937B2 (en) 2003-08-21 2007-01-16 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
TWI394747B (zh) * 2006-06-23 2013-05-01 Smithkline Beecham Corp 脯胺醯基羥化酶抑制劑
EP2548873A1 (en) * 2007-09-17 2013-01-23 Abbott Laboratories N-phenyl-dioxo-hydropyrimidines useful as hepatitis c virus (hcv) inhibitors
WO2009039127A1 (en) * 2007-09-17 2009-03-26 Abbott Laboratories Uracil or thymine derivative for treating hepatitis c
PT2639226T (pt) * 2007-09-17 2016-12-09 Abbvie Bahamas Ltd Pirimidinas anti-infeciosas e suas utilizações
JP2011528686A (ja) 2008-07-23 2011-11-24 エフ．ホフマン−ラ ロシュ アーゲー ヘテロ環式抗ウイルス性化合物

Also Published As

Publication number Publication date
PE20130209A1 (es) 2013-03-24
IN2012DN05113A (pt) 2015-10-23
TW200918066A (en) 2009-05-01
TWI437994B (zh) 2014-05-21
CN101801935A (zh) 2010-08-11
CL2008002794A1 (es) 2009-09-04
AU2008302448A1 (en) 2009-03-26
WO2009039127A1 (en) 2009-03-26
MY162760A (en) 2017-07-14
ZA201204224B (en) 2015-12-23
US20110070193A1 (en) 2011-03-24
PH12013500365A1 (en) 2014-09-08
NZ584720A (en) 2012-07-27
MX338555B (es) 2016-04-20
UY31344A1 (es) 2009-04-30
JP2010539186A (ja) 2010-12-16
CN102746239B (zh) 2016-02-10
JP2013049681A (ja) 2013-03-14
CR20150238A (es) 2015-07-01
PA8796201A1 (es) 2009-04-23
KR20100068289A (ko) 2010-06-22
TWI534137B (zh) 2016-05-21
CL2013000372A1 (es) 2013-10-04
AU2008302448B2 (en) 2014-11-06
KR101552474B1 (ko) 2015-09-11
TW201443027A (zh) 2014-11-16
BRPI0816994A2 (pt) 2015-03-24
US8415351B2 (en) 2013-04-09
NZ600371A (en) 2014-07-25
EP2222646A1 (en) 2010-09-01
BRPI0816994B1 (pt) 2019-12-24
IL204547A0 (en) 2010-11-30
CA2699981A1 (en) 2009-03-26
JP5734654B2 (ja) 2015-06-17
NZ618277A (en) 2015-07-31
AR070027A1 (es) 2010-03-10
KR101660360B1 (ko) 2016-09-27
CN101801935B (zh) 2014-12-03
MX2010002905A (es) 2010-07-05
RU2599635C2 (ru) 2016-10-10
SG183733A1 (en) 2012-09-27
ES2453591T3 (es) 2014-04-08
UA117800C2 (uk) 2018-10-10
CA2699981C (en) 2017-08-22
ZA201204223B (en) 2015-12-23
CO6260076A2 (es) 2011-03-22
RU2010114828A (ru) 2011-10-27
DOP2010000396A (es) 2013-12-31
US9095590B2 (en) 2015-08-04
AR087472A2 (es) 2014-03-26
RU2013104270A (ru) 2014-08-10
RU2543620C2 (ru) 2015-03-10
IL204547A (en) 2016-04-21
CA2976793A1 (en) 2009-03-26
US8685991B2 (en) 2014-04-01
EP2222646B1 (en) 2014-01-22
CR11316A (es) 2010-10-05
EP2725015A1 (en) 2014-04-30
CN102746239A (zh) 2012-10-24
US20140235638A1 (en) 2014-08-21
HK1147256A1 (en) 2011-08-05
KR20150117632A (ko) 2015-10-20
GT201000061A (es) 2012-03-26
PE20090705A1 (es) 2009-07-17
US20120213733A1 (en) 2012-08-23
DOP2010000084A (es) 2010-06-15

Similar Documents

Publication Publication Date Title
BRPI0816994B8 (pt) derivado uracila ou timina para tratar hepatite c
ATE512973T1 (de) Nukleosid-arylphosphoramidate und ihre verwendung als antivirale mittel zur behandlung von hepatitis-c-virus
DE602005013922D1 (de) Kondensierte heterotetracyclische verbindungen und deren verwendung als hcv-polymerase-inhibitor
BR0316407A (pt) Derivados de nucleosìdeo antiviral
BR112015025766A2 (pt) derivado de nucleosídeo altamente ativo para o tratamento de hcv
DE602005023015D1 (de) Indolderivate als viruzide
MA33642B1 (fr) Composés chimiques
MX2010005435A (es) Derivados de pirimidina para el tratamiento de asma, epoc, rinitis alergica, conjuntivitis alergica, dermatitis atopica, cancer, hepatitis b, hepatitis c, vih, vph, infecciones bacterianas y dermatosis.
PE20141308A1 (es) Nuevos compuestos inhibidores de la fosfodiesterasa tipo 10a
CY1112848T1 (el) Αναστολεις του ιου της ηπατιτιδας c
EA200801996A1 (ru) 2-замещенные производные 4-бензилфталазинонов в качестве гистаминовых h1- и h3-антагонистов
EA201000100A1 (ru) Гетероциклические соединения, полезные в качестве ингибиторов mk2
BRPI0614493B8 (pt) uso de um composto derivado de quinolina, sua combinação, composição farmacêutica, uso da referida combinação, produto, processo para a preparação de um composto e o referido composto
BRPI0408353A (pt) composto, composição farmacêutica, métodos para o tratamento de neoplasias suscetìveis e para o tratamento de infecções virais, e, uso de um composto
EA200901241A1 (ru) Соединения для лечения гепатита с
BR112013020042A2 (pt) inibidores de vírus da hepatite c
BR112012015951A2 (pt) 4 azido-nucleosídeos como compostos anti-hcv
MA31229B1 (fr) Composés de 6-benzyl-2, 3,4, 7-tétrahydro-indolo [2, 3-c] quinoline utiles en tant qu'inhibiteurs de pde5
BR0215016A (pt) Piridoquinoxalinas antivirìcas
BRPI0809983A2 (pt) Quinolinas e seu uso terapêutico
EA200970615A1 (ru) Соединения имидазолидинониламинопиримидина для лечения рака
ATE491706T1 (de) Heterocyclische antivirale verbindungen
TH98071B (th) สารประกอบต้านไวรัส
TH124666A (th) สไปโรไซคลิก โพรลีน และการใช้สารเหล่านั้นในการรักษาการติดเชื้อ hcv
MY142331A (en) Bicyclic heteroaryl derivatives for treating viruses

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: ABBVIE INC. (US)

B25A Requested transfer of rights approved

Owner name: ABBVIE BAHAMAS LTD. (US)

B25A Requested transfer of rights approved

Owner name: ABBVIE IRELAND UNLIMITED COMPANY (BM)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/12/2019, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/09/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF