JP2010537639A - 非対称性干渉ｒｎａの組成物およびその使用 - Google Patents

非対称性干渉ｒｎａの組成物およびその使用 Download PDF

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JP2010537639A
JP2010537639A JP2010523120A JP2010523120A JP2010537639A JP 2010537639 A JP2010537639 A JP 2010537639A JP 2010523120 A JP2010523120 A JP 2010523120A JP 2010523120 A JP2010523120 A JP 2010523120A JP 2010537639 A JP2010537639 A JP 2010537639A
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strand
rna molecule
double
stranded rna
nucleotides
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JP2010537639A5 (enExample
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チャン チア リー，
シャンガオ サン，
ハリー ロゴフ，
ユーチー リー，
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ボストン バイオメディカル， インコーポレイテッド
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/50—Physical structure
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    • C12N2330/50—Biochemical production, i.e. in a transformed host cell
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JP2010523120A 2007-08-27 2008-08-27 非対称性干渉ｒｎａの組成物およびその使用 Pending JP2010537639A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US96825707P 2007-08-27 2007-08-27
US2975308P 2008-02-19 2008-02-19
US3895408P 2008-03-24 2008-03-24
PCT/US2008/074528 WO2009029688A2 (en) 2007-08-27 2008-08-27 Compositions of asymmetric interfering rna and uses thereof

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JP2014032700A Division JP5986596B2 (ja) 2007-08-27 2014-02-24 非対称性干渉ｒｎａの組成物およびその使用

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JP2010537639A true JP2010537639A (ja) 2010-12-09
JP2010537639A5 JP2010537639A5 (enExample) 2013-01-24

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JP2010523120A Pending JP2010537639A (ja) 2007-08-27 2008-08-27 非対称性干渉ｒｎａの組成物およびその使用
JP2010523121A Pending JP2010537640A (ja) 2007-08-27 2008-08-27 マイクロｒｎａ模倣剤または阻害剤としての非対称性ｒｎａ二重鎖の組成物
JP2014032700A Active JP5986596B2 (ja) 2007-08-27 2014-02-24 非対称性干渉ｒｎａの組成物およびその使用
JP2015085681A Pending JP2015130885A (ja) 2007-08-27 2015-04-20 非対称性干渉ｒｎａの組成物およびその使用
JP2016113256A Active JP6236498B2 (ja) 2007-08-27 2016-06-07 非対称性干渉ｒｎａの組成物およびその使用
JP2016122512A Active JP6453275B2 (ja) 2007-08-27 2016-06-21 非対称性干渉ｒｎａの組成物およびその使用
JP2017091309A Pending JP2017127333A (ja) 2007-08-27 2017-05-01 非対称性干渉ｒｎａの組成物およびその使用

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JP2010523121A Pending JP2010537640A (ja) 2007-08-27 2008-08-27 マイクロｒｎａ模倣剤または阻害剤としての非対称性ｒｎａ二重鎖の組成物
JP2014032700A Active JP5986596B2 (ja) 2007-08-27 2014-02-24 非対称性干渉ｒｎａの組成物およびその使用
JP2015085681A Pending JP2015130885A (ja) 2007-08-27 2015-04-20 非対称性干渉ｒｎａの組成物およびその使用
JP2016113256A Active JP6236498B2 (ja) 2007-08-27 2016-06-07 非対称性干渉ｒｎａの組成物およびその使用
JP2016122512A Active JP6453275B2 (ja) 2007-08-27 2016-06-21 非対称性干渉ｒｎａの組成物およびその使用
JP2017091309A Pending JP2017127333A (ja) 2007-08-27 2017-05-01 非対称性干渉ｒｎａの組成物およびその使用

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US (6) US20100286378A1 (enExample)
EP (4) EP2193140B1 (enExample)
JP (7) JP2010537639A (enExample)
CN (3) CN101842381A (enExample)
CA (2) CA2735167A1 (enExample)
DK (1) DK2193140T3 (enExample)
ES (2) ES2873350T3 (enExample)
WO (2) WO2009029688A2 (enExample)

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JP2013544505A (ja) * 2010-10-22 2013-12-19 ソンギュングヮン ユニバーシティ ファウンデーション フォー コーポレート コラボレーション Ｒｎａ干渉を誘導する核酸分子及びその用途
JP2016099252A (ja) * 2014-11-21 2016-05-30 株式会社バイオシンクタンク 抗腫瘍剤の選択方法およびその抗腫瘍剤が含有するｓｉＲＮＡ
JP2018537104A (ja) * 2015-12-13 2018-12-20 日東電工株式会社 高活性及びオフターゲット削減のためのｓｉＲＮＡ構造
JP2019172696A (ja) * 2014-02-05 2019-10-10 イェダ リサーチ アンド ディベロップメント カンパニー リミテッドＹｅｄａ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏ．Ｌｔｄ． セロトニン放出ホルモン、アドレナリン放出ホルモン、ノルアドレナリン放出ホルモン、グルタミン酸放出ホルモンおよび副腎皮質刺激ホルモン放出ホルモン関連の医学的状態の処置および診断のためのマイクロｒｎａおよび該マイクロｒｎａを含む組成物
US12016876B2 (en) 2011-08-04 2024-06-25 Research And Development Co. Ltd. Micro-RNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions

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BRPI0720219A2 (pt) 2006-12-08 2013-12-24 Univ Iowa State Res Found Inc Genes de planta envolvidos em absorção e metabolismo de nitrato
ES2873350T3 (es) * 2007-08-27 2021-11-03 1Globe Health Inst Llc Composiciones de ARN interferente asimétrico y usos de las mismas
US8097712B2 (en) 2007-11-07 2012-01-17 Beelogics Inc. Compositions for conferring tolerance to viral disease in social insects, and the use thereof
KR100949791B1 (ko) * 2007-12-18 2010-03-30 이동기 오프-타겟 효과를 최소화하고 ＲＮＡｉ 기구를 포화시키지않는 신규한 ｓｉＲＮＡ 구조 및 그 용도
CN108165548B (zh) 2008-09-22 2022-10-14 菲奥医药公司 减小大小的自递送RNAi化合物
WO2010039536A2 (en) 2008-09-23 2010-04-08 President And Fellows Of Harvard College Sirt4 and uses thereof
CN102245772A (zh) 2008-10-15 2011-11-16 索马根尼科斯公司 抑制基因表达的短发卡rna
WO2010078536A1 (en) 2009-01-05 2010-07-08 Rxi Pharmaceuticals Corporation Inhibition of pcsk9 through rnai
US9745574B2 (en) 2009-02-04 2017-08-29 Rxi Pharmaceuticals Corporation RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
KR101791702B1 (ko) * 2009-04-03 2017-10-30 다이서나 파마수이티컬, 인크. 비대칭 이중가닥 ｒｎａ에 의한 ｋｒａｓ의 특이적 저해를 위한 방법 및 조성물
EP2756845B1 (en) * 2009-04-03 2017-03-15 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA
WO2010141933A1 (en) * 2009-06-05 2010-12-09 Dicerna Pharmaceuticals, Inc. Specific inhibition of gene expression by nucleic acid containing a dicer substrate
WO2011008730A2 (en) 2009-07-13 2011-01-20 Somagenics Inc. Chemical modification of small hairpin rnas for inhibition of gene expression
WO2011034811A1 (en) 2009-09-17 2011-03-24 Sigma-Aldrich Co. Short rna mimetics
US20120301463A1 (en) 2009-09-30 2012-11-29 President And Fellows Of Harvard College Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products
US20150025122A1 (en) 2009-10-12 2015-01-22 Larry J. Smith Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
US8962584B2 (en) 2009-10-14 2015-02-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Compositions for controlling Varroa mites in bees
KR101237036B1 (ko) * 2009-11-04 2013-02-25 성균관대학교산학협력단 안티센스 가닥에 의한 오프-타겟 효과를 최소화한 신규한 ｓｉＲＮＡ 구조 및 그 용도
CA2784297A1 (en) * 2009-12-16 2011-06-23 Subrata Chakrabarti Compositions and methods related to mirna in diabetic conditions
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