CA2735166C - Compositions of asymmetric interfering rna and uses thereof - Google Patents

Compositions of asymmetric interfering rna and uses thereof Download PDF

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Publication number
CA2735166C
CA2735166C CA2735166A CA2735166A CA2735166C CA 2735166 C CA2735166 C CA 2735166C CA 2735166 A CA2735166 A CA 2735166A CA 2735166 A CA2735166 A CA 2735166A CA 2735166 C CA2735166 C CA 2735166C
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strand
gene encoding
gene
rna molecule
duplex
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French (fr)
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CA2735166A1 (en
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Chiang Jia Li
Xiangao Sun
Harry Rogoff
Youzhi Li
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1Globe Health Institute LLC
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1Globe Health Institute LLC
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/53—Methods for regulating/modulating their activity reducing unwanted side-effects
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    • C12N2330/00—Production
    • C12N2330/50—Biochemical production, i.e. in a transformed host cell
    • C12N2330/51—Specially adapted vectors

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CA2735166A 2007-08-27 2008-08-27 Compositions of asymmetric interfering rna and uses thereof Active CA2735166C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US96825707P 2007-08-27 2007-08-27
US60/968,257 2007-08-27
US2975308P 2008-02-19 2008-02-19
US61/029,753 2008-02-19
US3895408P 2008-03-24 2008-03-24
US61/038,954 2008-03-24
PCT/US2008/074528 WO2009029688A2 (en) 2007-08-27 2008-08-27 Compositions of asymmetric interfering rna and uses thereof

Publications (2)

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CA2735166A1 CA2735166A1 (en) 2009-03-05
CA2735166C true CA2735166C (en) 2020-12-01

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CA2735167A Abandoned CA2735167A1 (en) 2007-08-27 2008-08-27 Composition of asymmetric rna duplex as microrna mimetic or inhibitor
CA2735166A Active CA2735166C (en) 2007-08-27 2008-08-27 Compositions of asymmetric interfering rna and uses thereof

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CA2735167A Abandoned CA2735167A1 (en) 2007-08-27 2008-08-27 Composition of asymmetric rna duplex as microrna mimetic or inhibitor

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US (6) US9328345B2 (enExample)
EP (4) EP3121281B1 (enExample)
JP (7) JP2010537640A (enExample)
CN (3) CN101842381A (enExample)
CA (2) CA2735167A1 (enExample)
DK (1) DK2193140T3 (enExample)
ES (2) ES2873350T3 (enExample)
WO (2) WO2009029688A2 (enExample)

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