CN105018492B - 不对称干扰rna的组合物及其用途 - Google Patents
不对称干扰rna的组合物及其用途 Download PDFInfo
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- CN105018492B CN105018492B CN201510250692.XA CN201510250692A CN105018492B CN 105018492 B CN105018492 B CN 105018492B CN 201510250692 A CN201510250692 A CN 201510250692A CN 105018492 B CN105018492 B CN 105018492B
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C12N2320/00—Applications; Uses
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- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/53—Methods for regulating/modulating their activity reducing unwanted side-effects
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- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
- C12N2330/51—Specially adapted vectors
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
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- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96825707P | 2007-08-27 | 2007-08-27 | |
| US60/968,257 | 2007-08-27 | ||
| US2975308P | 2008-02-19 | 2008-02-19 | |
| US61/029,753 | 2008-02-19 | ||
| US3895408P | 2008-03-24 | 2008-03-24 | |
| US61/038,954 | 2008-03-24 | ||
| CN200880113236.9A CN101835789B (zh) | 2007-08-27 | 2008-08-27 | 不对称干扰rna的组合物及其用途 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880113236.9A Division CN101835789B (zh) | 2007-08-27 | 2008-08-27 | 不对称干扰rna的组合物及其用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105018492A CN105018492A (zh) | 2015-11-04 |
| CN105018492B true CN105018492B (zh) | 2018-08-24 |
Family
ID=40387778
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510250692.XA Active CN105018492B (zh) | 2007-08-27 | 2008-08-27 | 不对称干扰rna的组合物及其用途 |
| CN200880113236.9A Active CN101835789B (zh) | 2007-08-27 | 2008-08-27 | 不对称干扰rna的组合物及其用途 |
| CN200880113323A Pending CN101842381A (zh) | 2007-08-27 | 2008-08-27 | 作为微小rna模拟物或抑制剂的不对称rna双链体的组合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880113236.9A Active CN101835789B (zh) | 2007-08-27 | 2008-08-27 | 不对称干扰rna的组合物及其用途 |
| CN200880113323A Pending CN101842381A (zh) | 2007-08-27 | 2008-08-27 | 作为微小rna模拟物或抑制剂的不对称rna双链体的组合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US9328345B2 (enExample) |
| EP (4) | EP3889261A1 (enExample) |
| JP (7) | JP2010537640A (enExample) |
| CN (3) | CN105018492B (enExample) |
| CA (2) | CA2735166C (enExample) |
| DK (1) | DK2193140T3 (enExample) |
| ES (2) | ES2617877T3 (enExample) |
| WO (2) | WO2009029688A2 (enExample) |
Families Citing this family (145)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0720219A2 (pt) | 2006-12-08 | 2013-12-24 | Univ Iowa State Res Found Inc | Genes de planta envolvidos em absorção e metabolismo de nitrato |
| ES2617877T3 (es) * | 2007-08-27 | 2017-06-20 | 1Globe Health Institute Llc | Composiciones de ARN interferente asimétrico y uso de las mismas |
| US8097712B2 (en) | 2007-11-07 | 2012-01-17 | Beelogics Inc. | Compositions for conferring tolerance to viral disease in social insects, and the use thereof |
| KR100949791B1 (ko) * | 2007-12-18 | 2010-03-30 | 이동기 | 오프-타겟 효과를 최소화하고 RNAi 기구를 포화시키지않는 신규한 siRNA 구조 및 그 용도 |
| CA2753338A1 (en) | 2008-09-22 | 2010-03-25 | Rxi Pharmaceuticals Corporation | Neutral nanotransporters |
| CA2738019A1 (en) | 2008-09-23 | 2010-04-08 | President And Fellows Of Harvard College | Sirt4 and uses thereof |
| WO2010045384A2 (en) * | 2008-10-15 | 2010-04-22 | Somagenics Inc. | Short hairpin rnas for inhibition of gene expression |
| WO2010078536A1 (en) | 2009-01-05 | 2010-07-08 | Rxi Pharmaceuticals Corporation | Inhibition of pcsk9 through rnai |
| US9745574B2 (en) | 2009-02-04 | 2017-08-29 | Rxi Pharmaceuticals Corporation | RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
| ES2921573T3 (es) * | 2009-04-03 | 2022-08-29 | Dicerna Pharmaceuticals Inc | Métodos y composiciones para la inhibición específica de KRAS por RNA bicatenario asimétrico |
| EP2756845B1 (en) * | 2009-04-03 | 2017-03-15 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA |
| WO2010141933A1 (en) * | 2009-06-05 | 2010-12-09 | Dicerna Pharmaceuticals, Inc. | Specific inhibition of gene expression by nucleic acid containing a dicer substrate |
| US8871730B2 (en) | 2009-07-13 | 2014-10-28 | Somagenics Inc. | Chemical modification of short small hairpin RNAs for inhibition of gene expression |
| WO2011034811A1 (en) | 2009-09-17 | 2011-03-24 | Sigma-Aldrich Co. | Short rna mimetics |
| US20120301463A1 (en) | 2009-09-30 | 2012-11-29 | President And Fellows Of Harvard College | Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products |
| US20150025122A1 (en) | 2009-10-12 | 2015-01-22 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
| US8962584B2 (en) | 2009-10-14 | 2015-02-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Compositions for controlling Varroa mites in bees |
| KR101237036B1 (ko) * | 2009-11-04 | 2013-02-25 | 성균관대학교산학협력단 | 안티센스 가닥에 의한 오프-타겟 효과를 최소화한 신규한 siRNA 구조 및 그 용도 |
| WO2011072390A1 (en) * | 2009-12-16 | 2011-06-23 | The University Of Western Ontario | Compositions and methods related to mirna in diabetic conditions |
| SG183407A1 (en) | 2010-03-08 | 2012-09-27 | Monsanto Technology Llc | Polynucleotide molecules for gene regulation in plants |
| EP3578183B1 (en) | 2010-03-24 | 2021-09-08 | Phio Pharmaceuticals Corp. | Rna interference in ocular indications |
| RU2615143C2 (ru) | 2010-03-24 | 2017-04-04 | Адвирна | Самодоставляющие PHKi соединения уменьшенного размера |
| AU2011232365A1 (en) | 2010-03-24 | 2012-10-25 | Rxi Pharmaceuticals Corporation | RNA interference in dermal and fibrotic indications |
| HUE040278T2 (hu) | 2010-04-23 | 2019-02-28 | Cold Spring Harbor Laboratory | Új szerkezetileg tervezett shRNS-ek |
| GB201006841D0 (en) * | 2010-04-26 | 2010-06-09 | Thomsen Lars | Method, device and system for targetted cell lysis |
| EP2631291B1 (en) | 2010-10-22 | 2019-05-15 | OliX Pharmaceuticals, Inc. | Nucleic acid molecules inducing rna interference, and uses thereof |
| CN101979558B (zh) * | 2010-10-28 | 2015-09-02 | 百奥迈科生物技术有限公司 | 一种靶向乙型肝炎病毒基因的siRNA分子及其应用 |
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| US20130273655A1 (en) * | 2012-03-12 | 2013-10-17 | Shannon Eaker | ENGRAFTMENT POTENTIAL OF EMBRYONIC STEM CELLS AND PLURIPOTENT STEM CELLS USING MICRO RNAs |
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| US9096853B2 (en) * | 2012-09-24 | 2015-08-04 | U.S. Department Of Veterans Affairs | Modified siRNA molecules incorporating 5-fluoro-2′-deoxyuridine residues to enhance cytotoxicity |
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| CN105263329B (zh) | 2013-03-13 | 2020-09-18 | 孟山都技术公司 | 用于杂草控制的方法和组合物 |
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