JP2010536767A5 - - Google Patents

Download PDF

Info

Publication number
JP2010536767A5
JP2010536767A5 JP2010521081A JP2010521081A JP2010536767A5 JP 2010536767 A5 JP2010536767 A5 JP 2010536767A5 JP 2010521081 A JP2010521081 A JP 2010521081A JP 2010521081 A JP2010521081 A JP 2010521081A JP 2010536767 A5 JP2010536767 A5 JP 2010536767A5
Authority
JP
Japan
Prior art keywords
alkyl
cycloalkyl
ring
independently
haloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010521081A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010536767A (ja
JP5965102B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/072074 external-priority patent/WO2009025983A2/en
Publication of JP2010536767A publication Critical patent/JP2010536767A/ja
Publication of JP2010536767A5 publication Critical patent/JP2010536767A5/ja
Application granted granted Critical
Publication of JP5965102B2 publication Critical patent/JP5965102B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010521081A 2007-08-17 2008-08-04 ５−ハロアルキル−４，５−ジヒドロイソキサゾール誘導体を調製する方法 Active JP5965102B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US96511507P 2007-08-17 2007-08-17
US60/965,115 2007-08-17
US4345908P 2008-04-09 2008-04-09
US61/043,459 2008-04-09
US8045408P 2008-07-14 2008-07-14
US61/080,454 2008-07-14
PCT/US2008/072074 WO2009025983A2 (en) 2007-08-17 2008-08-04 Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014125041A Division JP2014221775A (ja) 2007-08-17 2014-06-18 ５−ハロアルキル−４，５−ジヒドロイソキサゾール誘導体を調製する方法

Publications (3)

Publication Number Publication Date
JP2010536767A JP2010536767A (ja) 2010-12-02
JP2010536767A5 true JP2010536767A5 (enExample) 2011-09-15
JP5965102B2 JP5965102B2 (ja) 2016-08-03

Family

ID=40350174

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010521081A Active JP5965102B2 (ja) 2007-08-17 2008-08-04 ５−ハロアルキル−４，５−ジヒドロイソキサゾール誘導体を調製する方法
JP2014125041A Pending JP2014221775A (ja) 2007-08-17 2014-06-18 ５−ハロアルキル−４，５−ジヒドロイソキサゾール誘導体を調製する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014125041A Pending JP2014221775A (ja) 2007-08-17 2014-06-18 ５−ハロアルキル−４，５−ジヒドロイソキサゾール誘導体を調製する方法

Country Status (19)

Country Link
US (2) US8217180B2 (enExample)
EP (1) EP2176244B1 (enExample)
JP (2) JP5965102B2 (enExample)
KR (2) KR101597839B1 (enExample)
CN (2) CN101855215A (enExample)
AR (1) AR067948A1 (enExample)
AU (1) AU2008289321B2 (enExample)
BR (1) BRPI0814153B8 (enExample)
CA (1) CA2693067C (enExample)
CO (1) CO6260136A2 (enExample)
ES (1) ES2587386T3 (enExample)
IL (1) IL203174A (enExample)
MX (2) MX2010001773A (enExample)
MY (2) MY176115A (enExample)
PT (1) PT2176244T (enExample)
RU (1) RU2536039C2 (enExample)
TW (3) TWI649303B (enExample)
WO (1) WO2009025983A2 (enExample)
ZA (1) ZA201000214B (enExample)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0508140B1 (pt) 2004-03-05 2015-03-17 Nissan Chemical Ind Ltd Composto benzamida substituída por isoxazolina da fórmula (1); da fórmula (2) substituído por 3,5-bis (aril substituído); da fórmula (4) substituída por alquinibenzeno ou um sal do mesmo; "pesticida, agroquímico, inseticida, parasiticida contendo como ingrediente ativo um ou mais composto benzamida substituída por isoxazolina e sal do mesmo"
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 杜邦股份有限公司 控制無脊椎害蟲之異唑啉
WO2008154528A2 (en) * 2007-06-13 2008-12-18 E. I. Du Pont De Nemours And Company Isoxazoline insecticides
TWI430995B (zh) * 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
DK2182945T3 (en) 2007-06-27 2015-11-16 Du Pont PROCEDURE TO COMBAT PESTS WITH ANIMALS
EP2172462A4 (en) 2007-06-27 2010-12-15 Nissan Chemical Ind Ltd METHOD FOR PRODUCING A 3-HYDROXYPROPAN-1-ON COMPOUND, METHOD FOR PRODUCING A 2-PROPENE-1-ON COMPOUND, AND METHOD FOR PRODUCING AN ISOXAZOLINE COMPOUND
TWI649303B (zh) * 2007-08-17 2019-02-01 杜邦股份有限公司 製備４-乙醯基-ｎ-〔２-側氧基-２-〔（２，２，２-三氟乙基）胺基〕乙基〕-１-萘甲醯胺之化合物及方法
US8367584B2 (en) * 2007-10-03 2013-02-05 E.I. Du Pont De Nemours And Company Naphthalene isoxazoline compounds for control of invertebrate pests
TW201444787A (zh) * 2008-04-09 2014-12-01 Du Pont 製備３-三氟甲基查耳酮（ｃｈａｌｃｏｎｅ）之方法
CN102088857A (zh) 2008-07-09 2011-06-08 巴斯夫欧洲公司 包含异噁唑啉化合物的杀虫活性混合物ⅱ
BRPI0915665B1 (pt) 2008-07-09 2018-01-02 Basf Se Misturas pesticidas, métodos para proteger plantas do ataque ou infestação por insetos, acarídeos ou nematódeos, para controlar insetos, aracnídeos ou nematódeos, uso de uma mistura, e, composição pesticida ou parasiticida
MX2011001851A (es) 2008-08-22 2011-03-21 Syngenta Participations Ag Compuestos insecticidas.
US20110269804A1 (en) 2008-08-22 2011-11-03 Syngenta Crop Protection Llc Insecticidal compounds
JP2012501989A (ja) 2008-09-04 2012-01-26 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 殺虫化合物
CN102325759A (zh) 2008-12-23 2012-01-18 巴斯夫欧洲公司 用于防治动物害虫的取代脒化合物
EP2382196B1 (en) 2008-12-23 2015-08-12 Basf Se Imine compounds for combating invertebrate pests
EP2414353A1 (en) * 2009-04-01 2012-02-08 Basf Se Isoxazoline compounds for combating invertebrate pests
PT3078664T (pt) 2009-12-17 2019-05-31 Boehringer Ingelheim Animal Health Usa Inc Composições antiparasitárias de di-hidroazoles
KR20120125332A (ko) 2010-02-01 2012-11-14 바스프 에스이 동물 해충을 퇴치하기 위한 치환된 케톤계 이속사졸린 화합물 및 유도체
EP2576523B1 (en) 2010-05-27 2016-01-13 E. I. du Pont de Nemours and Company Crystalline form of 4-[5 - [3 -chloro-5 -(trifluoromethyl)phenyl] -4,5 -dihydro-5 -(trifluoromethyl)-3 - isoxazolyl]-n-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1- naphthalenecarboxamide
UY33403A (es) 2010-06-17 2011-12-30 Novartis Ag Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales
WO2012038851A1 (en) 2010-09-24 2012-03-29 Pfizer Inc. Isoxazoline oximes as antiparasitic agents
WO2012047543A1 (en) * 2010-09-27 2012-04-12 E.I. Du Pont De Nemours And Company Method for preparing 2-amino-n-(2,2,2-trifluoroethyl) acetamide
CA2826067A1 (en) 2011-02-10 2012-08-16 Novartis Ag Isoxazoline derivatives for controlling invertebrate pests
AR085657A1 (es) 2011-03-10 2013-10-16 Novartis Ag Compuestos de isoxazol
JP6075563B2 (ja) 2011-11-08 2017-02-08 日産化学工業株式会社 光学活性イソキサゾリン化合物の触媒的不斉合成方法及び光学活性イソキサゾリン化合物
US9732051B2 (en) 2011-12-23 2017-08-15 Basf Se Isothiazoline compounds for combating invertebrate pests
NZ716598A (en) 2012-11-20 2017-02-24 Merial Inc Anthelmintic compounds and compositions and method of using thereof
WO2015066277A1 (en) 2013-11-01 2015-05-07 Merial Limited Antiparisitic and pesticidal isoxazoline compounds
NZ726874A (en) 2014-05-19 2018-03-23 Merial Inc Anthelmintic compounds
AU2015339096B2 (en) 2014-10-31 2018-08-02 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal composition comprising fipronil
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
MY189534A (en) 2016-04-06 2022-02-16 Merial Inc Process for the preparation of isoxazoline compounds
JP2019535655A (ja) 2016-10-14 2019-12-12 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 殺虫性及び殺寄生虫性ビニルイソオキサゾリン化合物
CA3059114A1 (en) * 2017-04-05 2018-10-11 Boehringer Ingelheim Animal Health USA Inc. Crystalline forms of (s)-afoxolaner
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
MX2020001724A (es) 2017-08-14 2020-07-29 Boehringer Ingelheim Animal Health Usa Inc Compuestos de pirazol-isoxazolina plaguicidas y parasiticidas.
WO2019160882A1 (en) 2018-02-13 2019-08-22 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
KR102591947B1 (ko) 2018-04-19 2023-10-25 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
MX2020011267A (es) * 2018-04-27 2020-11-12 Kumiai Chemical Industry Co Metodo de produccion para 4,5-dihidroisoxazol 5,5-disustituido.
PE20210642A1 (es) 2018-07-13 2021-03-23 Gilead Sciences Inc Inhibidores de pd-1/pd-l1
US11236085B2 (en) 2018-10-24 2022-02-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
KR20220116146A (ko) 2019-10-08 2022-08-22 도날드슨 컴파니, 인코포레이티드 혼합된 직경 미세 섬유를 포함하는 필터 매체 층
US12497370B2 (en) 2019-12-18 2025-12-16 Elanco Tiergesundheit Ag Isoxazoline derivatives
CN116194187A (zh) 2020-04-02 2023-05-30 唐纳森公司 过滤介质、复合材料以及使用该过滤介质的面罩系统
EP4126295A1 (en) 2020-04-03 2023-02-08 Donaldson Company, Inc. Filtration media
BR112022024071A2 (pt) 2020-05-27 2022-12-20 Axial Therapeutics Inc Compostos moduladores de tlr2, composições farmacêuticas e usos dos mesmos
CN117098541A (zh) 2020-11-25 2023-11-21 阿卡格拉医药公司 用于递送核酸的脂质纳米粒及相关使用方法
US20250091998A1 (en) * 2021-08-01 2025-03-20 Zenfold Sustainable Technologies Private Limited A process for the preparation of carbamoyl benzamide phenyl isoxazoline class drug/s and its intermediates
CN115710185B (zh) * 2021-08-23 2024-05-03 中国石油化工股份有限公司 利用金属碳化物催化剂生产甲胺的方法
WO2023230587A2 (en) 2022-05-25 2023-11-30 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids and methods of use thereof
CN116253658B (zh) * 2022-11-25 2023-08-11 济南久隆医药科技有限公司 一种阿福拉纳中间体合成方法
CN115772091B (zh) * 2023-01-05 2023-06-23 济南久隆医药科技有限公司 一种2-氨基-n-(2,2,2-三氟乙基)乙酰胺的合成方法
CN119899156A (zh) * 2023-10-27 2025-04-29 华北制药集团动物保健品有限责任公司 一种阿福拉纳的制备方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3879532A (en) 1974-01-18 1975-04-22 Shell Oil Co Control by isoxazoles of endoparasitic nematodes
US4129568A (en) 1977-05-12 1978-12-12 Monsanto Company 2-[3-Aryl-2-isoxazolin-5-yl]benzoates
US5849736A (en) 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
GB9505651D0 (en) 1995-03-21 1995-05-10 Agrevo Uk Ltd AgrEvo UK Limited
EP0900795B1 (en) 1996-04-26 2004-04-21 Nippon Soda Co., Ltd. Benzene derivatives substituted by heterocycles and herbicides
AR007292A1 (es) 1996-06-06 1999-10-27 Rohm & Haas Compuestos aromaticos benciloxi sustituidos, una composicion fungicida, un metodo para controlar hongos fitopatogenicos y un metodo para controlarinsectos.
GB2351081A (en) 1999-06-18 2000-12-20 Lilly Forschung Gmbh Pharmaceutically active imidazoline compounds and analogues thereof
DE10114597A1 (de) 2001-03-23 2002-10-02 Bayer Cropscience Gmbh Arylisoxazolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel
EP1538138A4 (en) 2002-08-26 2007-07-25 Nissan Chemical Ind Ltd SUBSTITUTED BENZANILIDE COMPOUND AND PROTECTIVE AGENTS
DE10320782A1 (de) 2003-05-09 2004-11-25 Bayer Cropscience Ag Substituierte Oxyarene
JP2005272452A (ja) 2004-02-23 2005-10-06 Nissan Chem Ind Ltd 置換ベンズアニリド化合物及び有害生物防除剤
BRPI0508140B1 (pt) 2004-03-05 2015-03-17 Nissan Chemical Ind Ltd Composto benzamida substituída por isoxazolina da fórmula (1); da fórmula (2) substituído por 3,5-bis (aril substituído); da fórmula (4) substituída por alquinibenzeno ou um sal do mesmo; "pesticida, agroquímico, inseticida, parasiticida contendo como ingrediente ativo um ou mais composto benzamida substituída por isoxazolina e sal do mesmo"
BRPI0507818A (pt) 2004-03-26 2007-07-10 Cytokine Pharmasciences Inc composto e métodos de inibição
JP5051340B2 (ja) 2005-06-06 2012-10-17 日産化学工業株式会社 置換イソキサゾリン化合物及び有害生物防除剤
MY146795A (en) 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds
GB0514071D0 (en) 2005-07-07 2005-08-17 Zealand Pharma As N- or C- terminally modified small peptides
KR100546831B1 (ko) 2005-08-31 2006-01-25 (주) 마이크로프랜드 프로브 카드의 탐침팁 공정 방법
BRPI0617076B1 (pt) 2005-09-02 2021-07-06 Nissan Chemical Corporation Composto benzamida substituída por isoxazolina da fórmula (1) ou sal do mesmo; composto benzamida substituido por 4-hidroxiiminametila da fórmula (2) ou sal do mesmo; pesticida; agente agroquímico; parasiticida interno ou externo para mamíferos ou aves; inseticida ou acaricida
JP2007106756A (ja) 2005-09-14 2007-04-26 Nissan Chem Ind Ltd 置換イソキサゾリン化合物及び有害生物防除剤
TWI266597B (en) * 2005-09-27 2006-11-11 Delta Electronics Inc Electronic apparatus capable of dissipating heat uniformly
EP1965645A2 (en) 2005-12-14 2008-09-10 E.I. Du Pont De Nemours And Company Isoxazolines for controlling invertebrate pests
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
US7700808B2 (en) 2005-12-26 2010-04-20 Nissan Chemical Industries, Ltd. 1-3-bis(substituted phenyl)-3-hydroxypropan-1-one or 2-propen-1-one compound, and salt thereof
TWI412322B (zh) 2005-12-30 2013-10-21 杜邦股份有限公司 控制無脊椎害蟲之異唑啉
EP1997813B1 (en) 2006-03-10 2010-05-05 Nissan Chemical Industries, Ltd. Substituted isoxazoline compound and pest control agent
WO2007123855A2 (en) 2006-04-20 2007-11-01 E. I. Du Pont De Nemours And Company Pyrazolines for controlling invertebrate pests
JPWO2007125984A1 (ja) 2006-04-28 2009-09-10 日本農薬株式会社 イソキサゾリン誘導体及び有害生物防除剤並びにその使用方法
JP2008044880A (ja) 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
EP2151437A4 (en) 2007-03-07 2012-05-02 Nissan Chemical Ind Ltd ISOXAZOLINE SUBSTITUTED BENZAMIDE COMPOUND AND PEST CONTROL AGENT
NZ580241A (en) 2007-04-10 2011-02-25 Bayer Cropscience Ag Insecticidal aryl isoxazoline derivatives
WO2008154528A2 (en) 2007-06-13 2008-12-18 E. I. Du Pont De Nemours And Company Isoxazoline insecticides
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
DK2182945T3 (en) 2007-06-27 2015-11-16 Du Pont PROCEDURE TO COMBAT PESTS WITH ANIMALS
EP2172462A4 (en) * 2007-06-27 2010-12-15 Nissan Chemical Ind Ltd METHOD FOR PRODUCING A 3-HYDROXYPROPAN-1-ON COMPOUND, METHOD FOR PRODUCING A 2-PROPENE-1-ON COMPOUND, AND METHOD FOR PRODUCING AN ISOXAZOLINE COMPOUND
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
TWI649303B (zh) 2007-08-17 2019-02-01 杜邦股份有限公司 製備４-乙醯基-ｎ-〔２-側氧基-２-〔（２，２，２-三氟乙基）胺基〕乙基〕-１-萘甲醯胺之化合物及方法
JP5365806B2 (ja) 2007-09-10 2013-12-11 日産化学工業株式会社 置換イソキサゾリン化合物及び有害生物防除剤
US8367584B2 (en) 2007-10-03 2013-02-05 E.I. Du Pont De Nemours And Company Naphthalene isoxazoline compounds for control of invertebrate pests

Similar Documents

Publication Publication Date Title
RU2010109881A (ru) Способ получения производных 5-галогеналкил-4,5-дигидроизоксазола
TWI455919B (zh) 製備３－三氟甲基查耳酮（ｃｈａｌｃｏｎｅ）之方法
RU2010130559A (ru) Гербицидные пиридазиновые производные
JP2018502148A5 (enExample)
JP2013501720A5 (enExample)
JP2017039755A5 (enExample)
JP2016528201A5 (enExample)
JP2016530310A5 (enExample)
RU2011139893A (ru) Фунгицидные пиразолы
JP2005505576A5 (enExample)
JP2011507893A5 (enExample)
JP2018509418A5 (enExample)
JP2010540650A5 (enExample)
JP2017526667A5 (enExample)
JP2018502912A5 (enExample)
JP2012519693A5 (enExample)
RU2015102834A (ru) Фунгицидные гетероциклические карбоксамиды
JP2017538785A5 (enExample)
JP2010523570A5 (enExample)
JP2005502661A5 (enExample)
JP2013536856A5 (enExample)
JP2003528070A5 (enExample)
JP2005524706A5 (enExample)
JP2016504378A5 (enExample)
RU2017134973A (ru) Бутиролактоны в качестве гербицидов