JP2010529961A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010529961A5 JP2010529961A5 JP2010510954A JP2010510954A JP2010529961A5 JP 2010529961 A5 JP2010529961 A5 JP 2010529961A5 JP 2010510954 A JP2010510954 A JP 2010510954A JP 2010510954 A JP2010510954 A JP 2010510954A JP 2010529961 A5 JP2010529961 A5 JP 2010529961A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- represented
- group
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 21
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000002877 alkyl aryl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000003106 haloaryl group Chemical group 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- -1 hydrate Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 2
- 150000001204 N-oxides Chemical class 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 1
- 229910052785 arsenic Inorganic materials 0.000 claims 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 1
- 229910052732 germanium Inorganic materials 0.000 claims 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims 1
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- 239000010703 silicon Substances 0.000 claims 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 1
- FWODXGRCBRQTLP-UHFFFAOYSA-N CC(c(cc1CN2CCOCC2)cc(CN2CCOCC2)c1O)(c(cc1CN2CCOCC2)cc(CN2CCOCC2)c1O)c(cc1CN2CCOCC2)cc(CN2CCOCC2)c1O Chemical compound CC(c(cc1CN2CCOCC2)cc(CN2CCOCC2)c1O)(c(cc1CN2CCOCC2)cc(CN2CCOCC2)c1O)c(cc1CN2CCOCC2)cc(CN2CCOCC2)c1O FWODXGRCBRQTLP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92487507P | 2007-06-04 | 2007-06-04 | |
| US60/924,875 | 2007-06-04 | ||
| US92952507P | 2007-07-02 | 2007-07-02 | |
| US92952407P | 2007-07-02 | 2007-07-02 | |
| US60/929,524 | 2007-07-02 | ||
| US60/929,525 | 2007-07-02 | ||
| US692408P | 2008-02-06 | 2008-02-06 | |
| US61/006,924 | 2008-02-06 | ||
| PCT/IL2008/000747 WO2008149345A2 (en) | 2007-06-04 | 2008-06-03 | Tri-aryl compounds and compositions comprising the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010529961A JP2010529961A (ja) | 2010-09-02 |
| JP2010529961A5 true JP2010529961A5 (enExample) | 2011-07-21 |
| JP5508258B2 JP5508258B2 (ja) | 2014-05-28 |
Family
ID=40094272
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510954A Active JP5508258B2 (ja) | 2007-06-04 | 2008-06-03 | トリアリール化合物および前記化合物を含む組成物 |
| JP2010510957A Active JP5922328B2 (ja) | 2007-06-04 | 2008-06-04 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2014158101A Expired - Fee Related JP5964898B2 (ja) | 2007-06-04 | 2014-08-01 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2016013177A Expired - Fee Related JP6134824B2 (ja) | 2007-06-04 | 2016-01-27 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2016130028A Pending JP2017019774A (ja) | 2007-06-04 | 2016-06-30 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2017085145A Pending JP2017149762A (ja) | 2007-06-04 | 2017-04-24 | テロメラーゼ活性化化合物及びその使用方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510957A Active JP5922328B2 (ja) | 2007-06-04 | 2008-06-04 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2014158101A Expired - Fee Related JP5964898B2 (ja) | 2007-06-04 | 2014-08-01 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2016013177A Expired - Fee Related JP6134824B2 (ja) | 2007-06-04 | 2016-01-27 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2016130028A Pending JP2017019774A (ja) | 2007-06-04 | 2016-06-30 | テロメラーゼ活性化化合物及びその使用方法 |
| JP2017085145A Pending JP2017149762A (ja) | 2007-06-04 | 2017-04-24 | テロメラーゼ活性化化合物及びその使用方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (7) | US8604245B2 (enExample) |
| EP (3) | EP2152663B1 (enExample) |
| JP (6) | JP5508258B2 (enExample) |
| KR (4) | KR101560844B1 (enExample) |
| CN (4) | CN101742906A (enExample) |
| AU (2) | AU2008259342B2 (enExample) |
| CA (4) | CA2963857A1 (enExample) |
| CY (1) | CY1115919T1 (enExample) |
| DK (2) | DK2152663T3 (enExample) |
| EA (4) | EA021544B1 (enExample) |
| ES (2) | ES2465216T3 (enExample) |
| HR (2) | HRP20140394T1 (enExample) |
| IL (4) | IL202424A (enExample) |
| MX (2) | MX2009013354A (enExample) |
| PL (2) | PL2152663T3 (enExample) |
| PT (2) | PT2152663E (enExample) |
| SI (2) | SI2152663T1 (enExample) |
| TW (1) | TWI430796B (enExample) |
| WO (3) | WO2008149345A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA021544B1 (ru) | 2007-06-04 | 2015-07-30 | Бен-Гурион Юниверсити Оф Дзе Негев Рисерч Энд Дивелопмент Оторити | Триарильные соединения и фармацевтические композиции, их содержащие |
| RU2537186C2 (ru) * | 2008-12-22 | 2014-12-27 | Пола Кемикал Индастриз Инк. | Ингибитор продуцирования меланина |
| CA2795981C (en) | 2009-05-18 | 2017-06-27 | Geron Corporation | Compositions and methods for increasing telomerase activity |
| AU2014347668A1 (en) | 2013-11-05 | 2016-05-19 | Ben-Gurion University Of The Negev Research And Development Authority | Compounds for the treatment of diabetes and disease complications arising from same |
| WO2017176087A1 (ko) | 2016-04-07 | 2017-10-12 | 주식회사 젬백스앤카엘 | 텔로머라제 활성 증가 및 텔로미어 연장 효능을 가지는 펩티드 및 이를 포함하는 조성물 |
| IL257470B2 (en) * | 2018-02-11 | 2023-12-01 | Ben Gurion Univ Of The Negev Research And Development Authority | Telomerase activator compounds for use in fertility and related applications |
| US11857516B2 (en) | 2017-02-12 | 2024-01-02 | Neuromagen Pharma, Ltd. | Telomerase activating compounds for use in fertility and related applications |
| KR102099335B1 (ko) | 2017-11-03 | 2020-04-09 | 한국과학기술연구원 | Prox1의 발현 또는 활성 조절제를 포함하는 텔로머라제 역전사효소의 발현 조절용 조성물 또는 텔로머라제 역전사효소 조절제의 스크리닝 방법 |
| US10098922B1 (en) * | 2017-11-30 | 2018-10-16 | Optigenex, Inc. | Increasing telomere length in a cell |
| JP7474702B2 (ja) | 2018-03-28 | 2024-04-25 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | エキソソームから単離されたｄｎａにおけるエピジェネティック変化の同定法 |
| US20210206901A1 (en) * | 2018-08-24 | 2021-07-08 | Mitsubishi Gas Chemical Company, Inc. | Compound, composition containing the same, method for forming resist pattern and method for forming insulating film |
| JP7646118B2 (ja) * | 2018-08-24 | 2025-03-17 | 三菱瓦斯化学株式会社 | 化合物、及びそれを含む組成物、並びに、レジストパターンの形成方法及び絶縁膜の形成方法 |
| CN113543882A (zh) * | 2018-12-31 | 2021-10-22 | 本-古里安大学B.G.内盖夫技术和应用公司 | 捕获流测定装置和方法 |
| AU2020217747B2 (en) * | 2019-02-08 | 2025-01-02 | Board Of Regents, The University Of Texas System | Telomerase-containing exosomes for treatment of diseases associated with aging and age-related organ dysfunction |
| KR102214612B1 (ko) | 2020-03-23 | 2021-02-15 | 한국과학기술연구원 | Prox1의 발현 또는 활성 조절제를 포함하는 텔로머라제 역전사효소의 발현 조절용 조성물 또는 텔로머라제 역전사효소 조절제의 스크리닝 방법 |
| US12305233B1 (en) | 2020-07-09 | 2025-05-20 | Arizona Board Of Regents On Behalf Of Arizona | Ultra-high-throughput assay for telomerase repeat addition processivity |
| KR102666470B1 (ko) | 2023-05-04 | 2024-05-17 | 주식회사 아리바이오 | 텔로머라제 활성화제와 나노 입자를 포함하는 약물 전달용 조성물 및 이를 포함하는 탈모 예방, 개선 또는 치료용 조성물 |
| KR102666469B1 (ko) | 2023-05-04 | 2024-05-17 | 주식회사 아리바이오 | 텔로머라제 활성화제와 나노 입자를 포함하는 약물 전달용 조성물 및 이를 포함하는 탈모 예방, 개선 또는 치료용 조성물 |
| CN116850119B (zh) * | 2023-07-19 | 2024-10-22 | 上海联衡生物科技有限公司 | 端粒酶组合物的制备方法及在防脱发护发素中的应用 |
| KR102647264B1 (ko) | 2023-11-01 | 2024-03-14 | 주식회사 아리바이오 | 텔로머라제 활성화제와 나노 입자를 포함하는 약물 전달용 조성물 및 이를 포함하는 탈모 예방, 개선 또는 치료용 조성물 |
Family Cites Families (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093557A (en) * | 1976-09-16 | 1978-06-06 | Hercules Incorporated | Process for inhibiting corrosion of metals in aqueous systems |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| AR240698A1 (es) | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US4740330A (en) * | 1986-09-03 | 1988-04-26 | The Dow Chemical Company | Method for allylating aromatic hydroxyl-containing compounds |
| US4835202A (en) | 1987-11-20 | 1989-05-30 | Ciba-Geigy Corporation | (Hydroxyphenyl) phosphine stabilized compositions |
| US4783495A (en) | 1987-11-20 | 1988-11-08 | Ciba-Geigy Corporation | (Hydroxyphenyl) silane stabilizers |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| JPH02121941A (ja) * | 1988-10-28 | 1990-05-09 | Teijin Chem Ltd | ハロゲン化トリスフェニル誘導体および難燃性熱可塑性樹脂組成物 |
| IE61928B1 (en) | 1988-11-29 | 1994-11-30 | Boots Co Plc | Treatment of obesity |
| US5219727A (en) * | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| JPH04268328A (ja) * | 1991-02-22 | 1992-09-24 | Idemitsu Petrochem Co Ltd | 分岐ポリカーボネート |
| JPH04328555A (ja) | 1991-04-26 | 1992-11-17 | Fuji Photo Film Co Ltd | ポジ型フオトレジスト組成物 |
| US5198531A (en) * | 1991-06-14 | 1993-03-30 | Research Diagnostic Antibodies | Polymeric resin for peptide synthesis |
| JP3560243B2 (ja) | 1992-02-03 | 2004-09-02 | ヘキスト・セラニーズ・コーポレーション | 紫外線安定剤，酸化防止剤および着色剤である４´−ヒドロキシアセトフェノン，４−ヒドロキシスチレン，１，１，１−トリス（４´−ヒドロキシフェニル）エタン，および１，３，５−トリス（４´−ヒドロキシフェニル）ベンゼンの誘導体 |
| US5629154A (en) | 1993-11-12 | 1997-05-13 | Geron Corporation | Telomerase activity assays |
| US6007989A (en) | 1992-05-13 | 1999-12-28 | Board Of Regents, The University Of Texas System | Methods of screening for compounds that derepress or increase telomerase activity |
| FR2692575B1 (fr) | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| GB9218830D0 (en) | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
| JP2845743B2 (ja) | 1992-12-28 | 1999-01-13 | 三菱化学株式会社 | 新規なナフタレン誘導体 |
| JP3534787B2 (ja) * | 1993-05-06 | 2004-06-07 | 本州化学工業株式会社 | トリスフェノールへのヒドロキシベンジル基付加体 |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| JP3026707B2 (ja) | 1993-10-05 | 2000-03-27 | 出光石油化学株式会社 | 分岐状ポリカーボネートの製造方法 |
| US5863726A (en) | 1993-11-12 | 1999-01-26 | Geron Corporation | Telomerase activity assays |
| US5583016A (en) | 1994-07-07 | 1996-12-10 | Geron Corporation | Mammalian telomerase |
| US6028103A (en) * | 1994-09-16 | 2000-02-22 | Children's Medical Center Corporation | Triaryl methane compounds and analogues thereof useful for the treatment or prevention of sickle cell disease or diseases characterized by abnormal cell proliferation |
| CA2200084C (en) * | 1994-09-16 | 2007-03-27 | Jose Halperin | Use of aromatic halides for treating mammalian cell proliferation |
| WO1997034589A1 (en) * | 1996-03-20 | 1997-09-25 | President And Fellows Of Harvard College | Triaryl methane compounds for sickle cell disease |
| DE4439947A1 (de) | 1994-11-09 | 1996-05-15 | Boehringer Mannheim Gmbh | 2,2-Dichloralkancarbonsäuren, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| US5571825A (en) * | 1995-03-31 | 1996-11-05 | Warner-Lambert Company | Method of selectively inhibiting prostaglandin G/H synthase-2 |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| CZ293016B6 (cs) | 1995-06-01 | 2004-01-14 | Sankyo Company Limited | Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem |
| US5880146A (en) * | 1995-06-07 | 1999-03-09 | Fuji Immunopharmaceuticals Corporation | Inhibition of IL-12-induced IFN-γ synthesis by specific bis-phenol compounds as a method of immune modulation |
| GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| US5889038A (en) * | 1996-03-20 | 1999-03-30 | Children's Hospital | Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds |
| US6191165B1 (en) * | 1996-05-31 | 2001-02-20 | Allelix Neuroscience Inc. | Pharmaceutical for treatment of neurological and neuropsychiatric disorders |
| ES2283025T3 (es) | 1996-08-30 | 2007-10-16 | Novo Nordisk A/S | Derivados de glp-1.1. |
| JP4128247B2 (ja) * | 1996-11-01 | 2008-07-30 | 株式会社リコー | フェノール系化合物及び電子写真感光体 |
| JPH10153884A (ja) * | 1996-11-25 | 1998-06-09 | Minolta Co Ltd | 静電潜像現像用トナー |
| EP0981611A1 (en) | 1997-02-05 | 2000-03-01 | 1149336 Ontario Inc. | Polynucleotides encoding proexendin, and methods and uses thereof |
| DE19711617A1 (de) | 1997-03-20 | 1998-09-24 | Boehringer Mannheim Gmbh | Neue Thiazolidindione, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| DE19823831A1 (de) | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
| US6428852B1 (en) | 1998-07-02 | 2002-08-06 | Mykrolis Corporation | Process for coating a solid surface with a liquid composition |
| FR2783246B1 (fr) | 1998-09-11 | 2000-11-17 | Aventis Pharma Sa | Derives d'azetidine, leur preparation et les medicaments les contenant |
| DE19844547C2 (de) | 1998-09-29 | 2002-11-07 | Aventis Pharma Gmbh | Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| KR100353014B1 (ko) | 1998-11-11 | 2002-09-18 | 동아제약 주식회사 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물 |
| CO5150173A1 (es) | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
| US6380378B1 (en) * | 1998-12-24 | 2002-04-30 | Toagosei Company, Ltd. | Nucleotide compound, nucleotide block oligonucleotide, and method for producing them |
| GB9900416D0 (en) | 1999-01-08 | 1999-02-24 | Alizyme Therapeutics Ltd | Inhibitors |
| FR2789079B3 (fr) | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
| US6417208B1 (en) | 1999-02-05 | 2002-07-09 | Albert Einstein College Of Medicine Of Yeshiva University | Method of identification of inhibitors of PDE1C |
| JP4195145B2 (ja) * | 1999-04-01 | 2008-12-10 | 出光興産株式会社 | ポリカーボネートの製造方法 |
| US6262118B1 (en) | 1999-06-04 | 2001-07-17 | Metabolex, Inc. | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia |
| EP1076066A1 (en) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
| EP1207873B1 (en) * | 1999-07-28 | 2009-11-18 | The Trustees Of The University Of Pennsylvania | Methods of inhibiting osteoclast activity |
| CA2383466C (en) | 1999-09-16 | 2009-08-25 | Tanabe Seiyaku Co., Ltd. | Aromatic nitrogen-containing 6-membered cyclic compounds |
| TW200514783A (en) | 1999-09-22 | 2005-05-01 | Bristol Myers Squibb Co | Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method |
| WO2001030771A1 (en) * | 1999-10-28 | 2001-05-03 | Kyowa Hakko Kogyo Co., Ltd. | Thiazolidinedione derivatives |
| SE9904413D0 (sv) | 1999-12-03 | 1999-12-03 | Astra Ab | Comminuted form |
| CZ301401B6 (cs) | 1999-12-22 | 2010-02-17 | Metabasis Therapeutics, Inc. | Bisamidátfosfonátová predléciva a farmaceutické prostredky s jejich obsahem |
| US6803375B1 (en) * | 2000-01-06 | 2004-10-12 | The Regents Of The University Of California | Non-peptide inhibition of T-lymphocyte activation and therapies related thereto |
| JP4187934B2 (ja) * | 2000-02-18 | 2008-11-26 | 富士フイルム株式会社 | ポジ型レジスト組成物 |
| US6395767B2 (en) | 2000-03-10 | 2002-05-28 | Bristol-Myers Squibb Company | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method |
| CA2419033A1 (en) | 2000-08-11 | 2002-02-21 | Earl Michael Gibbs | Treatment of the insulin resistance syndrome with selective cgmp pde5 inhibitors |
| ATE512964T1 (de) * | 2000-10-12 | 2011-07-15 | Cancer Rec Tech Ltd | N8,n13-disubstituierte chinoä4,3,2,klüacridinium salze als arzneimittel |
| GB0031103D0 (en) | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| WO2002056880A1 (en) * | 2001-01-19 | 2002-07-25 | Cytokinetics, Inc. | Triphenylmethane kinesin inhibitors |
| US6683080B2 (en) | 2001-02-02 | 2004-01-27 | Pfizer Inc. | Treatment of diabetes mellitus |
| PL368051A1 (en) | 2001-06-07 | 2005-03-21 | Eli Lilly And Company | Modulators of peroxisome proliferator activated receptors |
| DE60222667T2 (de) | 2001-06-27 | 2008-07-17 | Smithkline Beecham Corp. | Fluorpyrrolidine als dipeptidylpeptidaseinhibitoren |
| UA74912C2 (en) | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| US7045523B2 (en) * | 2001-10-18 | 2006-05-16 | Novartis Ag | Combination comprising N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and telomerase inhibitor |
| JP2005508978A (ja) | 2001-11-02 | 2005-04-07 | ファイザー・プロダクツ・インク | Ｐｄｅ９阻害薬によるインスリン抵抗性症候群及び２型糖尿病の治療 |
| CA2484556A1 (en) | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| AU2003212936A1 (en) * | 2002-02-04 | 2003-09-02 | Ceremedix, Inc. | Peptide-dependent upregulation of telomerase expression |
| MXPA04008195A (es) | 2002-03-14 | 2004-11-26 | Bayer Pharmaceuticals Corp | Metodos para el tratamiento de la diabetes empleando inhibidores de pde11a. |
| MXPA05009242A (es) | 2003-03-17 | 2006-04-18 | Pfizer Prod Inc | Tratamiento de la diabetes tipo 1 con los inhibidores de la pde5. |
| US20040220186A1 (en) | 2003-04-30 | 2004-11-04 | Pfizer Inc. | PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease |
| JP4517723B2 (ja) * | 2003-05-22 | 2010-08-04 | 住友ベークライト株式会社 | ナフトキノンジアジドスルホン酸エステル、それを用いたポジ型感光性樹脂組成物、半導体装置及び表示素子 |
| ZA200509846B (en) * | 2003-06-23 | 2007-04-25 | Geron Corp | Compositions and methods for increasing telomerase activity |
| AU2004253690B2 (en) | 2003-06-30 | 2010-03-25 | Nycomed Gmbh | Pyrrolodihydroisoquinolines as PDE10 inhibitors |
| JP2007508241A (ja) | 2003-07-31 | 2007-04-05 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | Ｐｄｅ１０ａ阻害剤を用いる糖尿病および関連障害の処置方法 |
| US20050049208A1 (en) | 2003-09-03 | 2005-03-03 | Kaufmann Doug A. | Method of treating and method of preventing diabetes |
| CN102127057A (zh) | 2004-03-15 | 2011-07-20 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
| WO2005113810A2 (en) * | 2004-04-07 | 2005-12-01 | Eppendorf Ag | One component and two component dna pol iii replicases and uses thereof |
| CA2568929A1 (en) | 2004-06-07 | 2005-12-22 | Pfizer Products Inc. | Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions |
| WO2006007864A1 (en) * | 2004-07-17 | 2006-01-26 | Max Planck Geselllschaft Zur Förderung Der Wissenschaft | Treating neurodegenerative conditions |
| JP4929569B2 (ja) * | 2004-08-20 | 2012-05-09 | 東レ株式会社 | 高分子電解質材、ならびにそれを用いた高分子電解質膜、膜電極複合体および高分子電解質型燃料電池 |
| US7541392B2 (en) * | 2004-09-14 | 2009-06-02 | E.I. Du Pont De Nemours And Company | Materials leading to improved dental composites and dental composites made therefrom |
| EP1845970B1 (en) * | 2005-01-31 | 2013-08-28 | Cephalon, Inc. | Tumor necrosis factor inhibitors |
| US7709533B2 (en) * | 2005-02-01 | 2010-05-04 | Icagen, Inc. | Imines as ion channel modulators |
| JP5211438B2 (ja) | 2005-06-09 | 2013-06-12 | 東レ株式会社 | 樹脂組成物およびそれを用いた表示装置 |
| DK2066680T3 (da) * | 2006-09-28 | 2012-10-22 | Medical Res Council | Triphenylphosphoniumthionitrit-nitrogenoxiddonorer |
| EA021544B1 (ru) * | 2007-06-04 | 2015-07-30 | Бен-Гурион Юниверсити Оф Дзе Негев Рисерч Энд Дивелопмент Оторити | Триарильные соединения и фармацевтические композиции, их содержащие |
-
2008
- 2008-06-03 EA EA200971140A patent/EA021544B1/ru not_active IP Right Cessation
- 2008-06-03 HR HRP20140394AT patent/HRP20140394T1/hr unknown
- 2008-06-03 CA CA2963857A patent/CA2963857A1/en not_active Abandoned
- 2008-06-03 JP JP2010510954A patent/JP5508258B2/ja active Active
- 2008-06-03 EA EA201401193A patent/EA201401193A1/ru unknown
- 2008-06-03 MX MX2009013354A patent/MX2009013354A/es active IP Right Grant
- 2008-06-03 ES ES08763505.8T patent/ES2465216T3/es active Active
- 2008-06-03 CN CN200880024660A patent/CN101742906A/zh active Pending
- 2008-06-03 DK DK08763505.8T patent/DK2152663T3/da active
- 2008-06-03 EP EP08763505.8A patent/EP2152663B1/en active Active
- 2008-06-03 WO PCT/IL2008/000747 patent/WO2008149345A2/en not_active Ceased
- 2008-06-03 WO PCT/IL2008/000748 patent/WO2008149346A2/en not_active Ceased
- 2008-06-03 US US12/602,632 patent/US8604245B2/en active Active
- 2008-06-03 AU AU2008259342A patent/AU2008259342B2/en not_active Ceased
- 2008-06-03 PL PL08763505T patent/PL2152663T3/pl unknown
- 2008-06-03 KR KR1020097027207A patent/KR101560844B1/ko not_active Expired - Fee Related
- 2008-06-03 CA CA2690004A patent/CA2690004C/en not_active Expired - Fee Related
- 2008-06-03 PT PT87635058T patent/PT2152663E/pt unknown
- 2008-06-03 SI SI200831209T patent/SI2152663T1/sl unknown
- 2008-06-04 CN CN201310337885.XA patent/CN103553939B/zh active Active
- 2008-06-04 CN CN200880024705.XA patent/CN101742994B/zh active Active
- 2008-06-04 CN CN201410208371.9A patent/CN104000806B/zh active Active
- 2008-06-04 SI SI200831358T patent/SI2152256T1/sl unknown
- 2008-06-04 TW TW097120858A patent/TWI430796B/zh not_active IP Right Cessation
- 2008-06-04 MX MX2009013353A patent/MX2009013353A/es active IP Right Grant
- 2008-06-04 AU AU2008259350A patent/AU2008259350B2/en not_active Ceased
- 2008-06-04 HR HRP20141264TT patent/HRP20141264T1/hr unknown
- 2008-06-04 KR KR1020177005742A patent/KR20170029015A/ko not_active Abandoned
- 2008-06-04 KR KR1020097027515A patent/KR101600374B1/ko not_active Expired - Fee Related
- 2008-06-04 EP EP08763514.0A patent/EP2152256B1/en active Active
- 2008-06-04 ES ES08763514.0T patent/ES2527759T3/es active Active
- 2008-06-04 EA EA201500403A patent/EA201500403A1/ru unknown
- 2008-06-04 PT PT87635140T patent/PT2152256E/pt unknown
- 2008-06-04 KR KR1020157031358A patent/KR20160051682A/ko not_active Ceased
- 2008-06-04 WO PCT/IL2008/000756 patent/WO2008149353A2/en not_active Ceased
- 2008-06-04 PL PL08763514T patent/PL2152256T3/pl unknown
- 2008-06-04 EA EA200971141A patent/EA022472B1/ru not_active IP Right Cessation
- 2008-06-04 CA CA2690013A patent/CA2690013C/en not_active Expired - Fee Related
- 2008-06-04 JP JP2010510957A patent/JP5922328B2/ja active Active
- 2008-06-04 EP EP20140183298 patent/EP2826472A3/en not_active Withdrawn
- 2008-06-04 CA CA2913459A patent/CA2913459A1/en not_active Abandoned
- 2008-06-04 DK DK08763514.0T patent/DK2152256T3/en active
- 2008-06-04 US US12/602,956 patent/US8609736B2/en active Active
-
2009
- 2009-12-01 IL IL202424A patent/IL202424A/en active IP Right Grant
- 2009-12-01 IL IL202425A patent/IL202425A/en active IP Right Grant
-
2013
- 2013-11-01 US US14/070,073 patent/US9663448B2/en active Active
- 2013-11-12 US US14/077,989 patent/US9670138B2/en active Active
- 2013-12-17 US US14/109,309 patent/US9670139B2/en active Active
-
2014
- 2014-08-01 JP JP2014158101A patent/JP5964898B2/ja not_active Expired - Fee Related
-
2015
- 2015-01-13 CY CY20151100028T patent/CY1115919T1/el unknown
- 2015-08-27 IL IL240895A patent/IL240895A0/en unknown
-
2016
- 2016-01-27 JP JP2016013177A patent/JP6134824B2/ja not_active Expired - Fee Related
- 2016-06-30 JP JP2016130028A patent/JP2017019774A/ja active Pending
- 2016-12-28 IL IL249838A patent/IL249838A0/en unknown
-
2017
- 2017-04-24 JP JP2017085145A patent/JP2017149762A/ja active Pending
- 2017-05-08 US US15/589,501 patent/US10214481B2/en active Active
- 2017-05-08 US US15/589,303 patent/US20170305836A1/en not_active Abandoned