JP5508258B2 - トリアリール化合物および前記化合物を含む組成物 - Google Patents

トリアリール化合物および前記化合物を含む組成物 Download PDF

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JP5508258B2
JP5508258B2 JP2010510954A JP2010510954A JP5508258B2 JP 5508258 B2 JP5508258 B2 JP 5508258B2 JP 2010510954 A JP2010510954 A JP 2010510954A JP 2010510954 A JP2010510954 A JP 2010510954A JP 5508258 B2 JP5508258 B2 JP 5508258B2
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JP2010529961A (ja
JP2010529961A5 (enExample
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プリエル、エッシャー
ガジット、アヴィヴ
スラヴィン、シモン
イジャック、サラ
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JP2010510954A 2007-06-04 2008-06-03 トリアリール化合物および前記化合物を含む組成物 Active JP5508258B2 (ja)

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Application Number Priority Date Filing Date Title
US92487507P 2007-06-04 2007-06-04
US60/924,875 2007-06-04
US92952507P 2007-07-02 2007-07-02
US92952407P 2007-07-02 2007-07-02
US60/929,524 2007-07-02
US60/929,525 2007-07-02
US692408P 2008-02-06 2008-02-06
US61/006,924 2008-02-06
PCT/IL2008/000747 WO2008149345A2 (en) 2007-06-04 2008-06-03 Tri-aryl compounds and compositions comprising the same

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JP2010529961A JP2010529961A (ja) 2010-09-02
JP2010529961A5 JP2010529961A5 (enExample) 2011-07-21
JP5508258B2 true JP5508258B2 (ja) 2014-05-28

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JP2010510957A Active JP5922328B2 (ja) 2007-06-04 2008-06-04 テロメラーゼ活性化化合物及びその使用方法
JP2014158101A Expired - Fee Related JP5964898B2 (ja) 2007-06-04 2014-08-01 テロメラーゼ活性化化合物及びその使用方法
JP2016013177A Expired - Fee Related JP6134824B2 (ja) 2007-06-04 2016-01-27 テロメラーゼ活性化化合物及びその使用方法
JP2016130028A Pending JP2017019774A (ja) 2007-06-04 2016-06-30 テロメラーゼ活性化化合物及びその使用方法
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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008149346A2 (en) 2007-06-04 2008-12-11 Ben Gurion University Of The Negev Research And Development Authority Enhanced sensitivity polymerase chain reactions
CA2934300A1 (en) * 2008-12-22 2010-07-01 Pola Chemical Industries Inc. Melanin production inhibitor
JP5830013B2 (ja) 2009-05-18 2015-12-09 テロメレイズ アクティベイション サイエンシズ，インコーポレーテッド テロメラーゼ活性を増大させるための組成物および方法
JP6657101B2 (ja) 2013-11-05 2020-03-04 ベン グリオン ユニバーシティ オブ ザ ネガフ リサーチ アンド ディベロップメント オーソリティ 糖尿病及びそれから生じる疾患合併症の治療のための化合物
CN109328068A (zh) 2016-04-07 2019-02-12 珍白斯凯尔有限公司 具有增加端粒酶活性和延长端粒的效果的肽以及包含该肽的组合物
IL257470B2 (en) * 2018-02-11 2023-12-01 Ben Gurion Univ Of The Negev Research And Development Authority Telomerase activator compounds for use in fertility and related applications
EP3579824A1 (en) 2017-02-12 2019-12-18 Ben-Gurion University Of The Negev Research And Development Authority Telomerase activating compounds for use in fertility and related applications
KR102099335B1 (ko) 2017-11-03 2020-04-09 한국과학기술연구원 Prox1의 발현 또는 활성 조절제를 포함하는 텔로머라제 역전사효소의 발현 조절용 조성물 또는 텔로머라제 역전사효소 조절제의 스크리닝 방법
US10098922B1 (en) * 2017-11-30 2018-10-16 Optigenex, Inc. Increasing telomere length in a cell
CN112513297B (zh) 2018-03-28 2024-10-22 得克萨斯州大学系统董事会 鉴定从外排体分离的dna中的表观遗传改变
EP3842491A4 (en) * 2018-08-24 2021-11-17 Mitsubishi Gas Chemical Company, Inc. COMPOUND, COMPOSITION CONTAINING IT, PROCESS FOR FORMING A RESIST PATTERN, AND PROCESS FOR FORMING INSULATION FILM
TW202024006A (zh) * 2018-08-24 2020-07-01 日商三菱瓦斯化學股份有限公司 化合物，及包含其之組成物，以及阻劑圖型之形成方法及絕緣膜之形成方法
WO2020141525A1 (en) * 2018-12-31 2020-07-09 B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University Capture flow assay device and methods
CA3129248A1 (en) * 2019-02-08 2020-08-13 Board Of Regents, The University Of Texas System Telomerase-containing exosomes for treatment of diseases associated with aging and age-related organ dysfunction
KR102214612B1 (ko) 2020-03-23 2021-02-15 한국과학기술연구원 Prox1의 발현 또는 활성 조절제를 포함하는 텔로머라제 역전사효소의 발현 조절용 조성물 또는 텔로머라제 역전사효소 조절제의 스크리닝 방법
US12305233B1 (en) 2020-07-09 2025-05-20 Arizona Board Of Regents On Behalf Of Arizona Ultra-high-throughput assay for telomerase repeat addition processivity
KR102666469B1 (ko) * 2023-05-04 2024-05-17 주식회사 아리바이오 텔로머라제 활성화제와 나노 입자를 포함하는 약물 전달용 조성물 및 이를 포함하는 탈모 예방, 개선 또는 치료용 조성물
KR102666470B1 (ko) 2023-05-04 2024-05-17 주식회사 아리바이오 텔로머라제 활성화제와 나노 입자를 포함하는 약물 전달용 조성물 및 이를 포함하는 탈모 예방, 개선 또는 치료용 조성물
CN116850119B (zh) * 2023-07-19 2024-10-22 上海联衡生物科技有限公司 端粒酶组合物的制备方法及在防脱发护发素中的应用
KR102647264B1 (ko) 2023-11-01 2024-03-14 주식회사 아리바이오 텔로머라제 활성화제와 나노 입자를 포함하는 약물 전달용 조성물 및 이를 포함하는 탈모 예방, 개선 또는 치료용 조성물

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093557A (en) * 1976-09-16 1978-06-06 Hercules Incorporated Process for inhibiting corrosion of metals in aqueous systems
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
AR240698A1 (es) 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US4740330A (en) * 1986-09-03 1988-04-26 The Dow Chemical Company Method for allylating aromatic hydroxyl-containing compounds
US4835202A (en) 1987-11-20 1989-05-30 Ciba-Geigy Corporation (Hydroxyphenyl) phosphine stabilized compositions
US4783495A (en) * 1987-11-20 1988-11-08 Ciba-Geigy Corporation (Hydroxyphenyl) silane stabilizers
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
JPH02121941A (ja) * 1988-10-28 1990-05-09 Teijin Chem Ltd ハロゲン化トリスフェニル誘導体および難燃性熱可塑性樹脂組成物
IE61928B1 (en) 1988-11-29 1994-11-30 Boots Co Plc Treatment of obesity
US5219727A (en) * 1989-08-21 1993-06-15 Hoffmann-Laroche Inc. Quantitation of nucleic acids using the polymerase chain reaction
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5399363A (en) 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
JPH04268328A (ja) * 1991-02-22 1992-09-24 Idemitsu Petrochem Co Ltd 分岐ポリカーボネート
JPH04328555A (ja) * 1991-04-26 1992-11-17 Fuji Photo Film Co Ltd ポジ型フオトレジスト組成物
US5198531A (en) * 1991-06-14 1993-03-30 Research Diagnostic Antibodies Polymeric resin for peptide synthesis
WO1993015063A1 (en) * 1992-02-03 1993-08-05 Hoechst Celanese Corporation Uv light stabilizing, antioxidant and colorant compounds
US6007989A (en) 1992-05-13 1999-12-28 Board Of Regents, The University Of Texas System Methods of screening for compounds that derepress or increase telomerase activity
US5629154A (en) 1993-11-12 1997-05-13 Geron Corporation Telomerase activity assays
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
GB9218830D0 (en) 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
JP2845743B2 (ja) 1992-12-28 1999-01-13 三菱化学株式会社 新規なナフタレン誘導体
JP3534787B2 (ja) * 1993-05-06 2004-06-07 本州化学工業株式会社 トリスフェノールへのヒドロキシベンジル基付加体
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
JP3026707B2 (ja) * 1993-10-05 2000-03-27 出光石油化学株式会社 分岐状ポリカーボネートの製造方法
US5863726A (en) 1993-11-12 1999-01-26 Geron Corporation Telomerase activity assays
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
US6028103A (en) * 1994-09-16 2000-02-22 Children's Medical Center Corporation Triaryl methane compounds and analogues thereof useful for the treatment or prevention of sickle cell disease or diseases characterized by abnormal cell proliferation
CA2200084C (en) * 1994-09-16 2007-03-27 Jose Halperin Use of aromatic halides for treating mammalian cell proliferation
DE4439947A1 (de) 1994-11-09 1996-05-15 Boehringer Mannheim Gmbh 2,2-Dichloralkancarbonsäuren, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US5571825A (en) * 1995-03-31 1996-11-05 Warner-Lambert Company Method of selectively inhibiting prostaglandin G/H synthase-2
IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
CZ293016B6 (cs) 1995-06-01 2004-01-14 Sankyo Company Limited Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem
US5880146A (en) * 1995-06-07 1999-03-09 Fuji Immunopharmaceuticals Corporation Inhibition of IL-12-induced IFN-γ synthesis by specific bis-phenol compounds as a method of immune modulation
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
US5889038A (en) * 1996-03-20 1999-03-30 Children's Hospital Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds
JP4376970B2 (ja) * 1996-03-20 2009-12-02 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 鎌状赤血球症のためのトリアリールメタン化合物
US6191165B1 (en) * 1996-05-31 2001-02-20 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders
ES2283025T3 (es) 1996-08-30 2007-10-16 Novo Nordisk A/S Derivados de glp-1.1.
JP4128247B2 (ja) 1996-11-01 2008-07-30 株式会社リコー フェノール系化合物及び電子写真感光体
JPH10153884A (ja) * 1996-11-25 1998-06-09 Minolta Co Ltd 静電潜像現像用トナー
JP2001512307A (ja) 1997-02-05 2001-08-21 １１４９３３６ オンタリオ インコーポレーテッド プロエキセンジンをコードするポリヌクレオチドならびにその作製方法および使用
DE19711617A1 (de) 1997-03-20 1998-09-24 Boehringer Mannheim Gmbh Neue Thiazolidindione, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE19823831A1 (de) 1998-05-28 1999-12-02 Probiodrug Ges Fuer Arzneim Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
JP3728205B2 (ja) 1998-07-02 2005-12-21 マイクロリス・コーポレイション 固体表面を液状配合物で被覆する方法
FR2783246B1 (fr) 1998-09-11 2000-11-17 Aventis Pharma Sa Derives d'azetidine, leur preparation et les medicaments les contenant
DE19844547C2 (de) 1998-09-29 2002-11-07 Aventis Pharma Gmbh Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
KR100353014B1 (ko) 1998-11-11 2002-09-18 동아제약 주식회사 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물
CO5150173A1 (es) 1998-12-10 2002-04-29 Novartis Ag Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
US6380378B1 (en) 1998-12-24 2002-04-30 Toagosei Company, Ltd. Nucleotide compound, nucleotide block oligonucleotide, and method for producing them
GB9900416D0 (en) 1999-01-08 1999-02-24 Alizyme Therapeutics Ltd Inhibitors
FR2789079B3 (fr) 1999-02-01 2001-03-02 Sanofi Synthelabo Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
US6417208B1 (en) 1999-02-05 2002-07-09 Albert Einstein College Of Medicine Of Yeshiva University Method of identification of inhibitors of PDE1C
JP4195145B2 (ja) * 1999-04-01 2008-12-10 出光興産株式会社 ポリカーボネートの製造方法
US6262118B1 (en) 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
EP1076066A1 (en) 1999-07-12 2001-02-14 Zealand Pharmaceuticals A/S Peptides for lowering blood glucose levels
EP1207873B1 (en) * 1999-07-28 2009-11-18 The Trustees Of The University Of Pennsylvania Methods of inhibiting osteoclast activity
IL148291A0 (en) 1999-09-16 2002-09-12 Tanabe Seiyaku Co Aromatic nitrogen-containing 6-membered cyclic compounds
TW200514783A (en) 1999-09-22 2005-05-01 Bristol Myers Squibb Co Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method
WO2001030771A1 (en) * 1999-10-28 2001-05-03 Kyowa Hakko Kogyo Co., Ltd. Thiazolidinedione derivatives
SE9904413D0 (sv) 1999-12-03 1999-12-03 Astra Ab Comminuted form
AU784370B2 (en) 1999-12-22 2006-03-23 Metabasis Therapeutics, Inc. Novel bisamidate phosphonate prodrugs
US6803375B1 (en) * 2000-01-06 2004-10-12 The Regents Of The University Of California Non-peptide inhibition of T-lymphocyte activation and therapies related thereto
JP4187934B2 (ja) * 2000-02-18 2008-11-26 富士フイルム株式会社 ポジ型レジスト組成物
US6395767B2 (en) 2000-03-10 2002-05-28 Bristol-Myers Squibb Company Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
KR20030023747A (ko) 2000-08-11 2003-03-19 화이자 인코포레이티드 인슐린 저항성 증후군의 치료
US7115619B2 (en) * 2000-10-12 2006-10-03 Cancer Research Technology Limited N8, N13 -disubstituted quino[4,3,2-kl]acridinium salts as therapeutic agents
GB0031103D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
US20040132830A1 (en) * 2001-01-19 2004-07-08 Finer Jeffrey T Triphenylmethane kinesin inhibitors
BR0206847A (pt) 2001-02-02 2004-02-25 Pfizer Tratamento do diabete melito
EA200400010A1 (ru) 2001-06-07 2004-06-24 Эли Лилли Энд Компани Модуляторы рецепторов активаторов пролиферации пероксисом
ES2296979T3 (es) 2001-06-27 2008-05-01 Smithkline Beecham Corporation Fluoropirrolidinas como inhibidores de dipeptidil peptidasa.
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
US7045523B2 (en) * 2001-10-18 2006-05-16 Novartis Ag Combination comprising N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and telomerase inhibitor
WO2003037432A1 (en) 2001-11-02 2003-05-08 Pfizer Products Inc. Treatment of insulin resistance syndrome and type 2 diabetes with pde9 inhibitors
CA2484556A1 (en) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
US20070042962A1 (en) * 2002-02-04 2007-02-22 Adams David S Peptide dependent upregulation of telomerase expression
WO2003077949A2 (en) 2002-03-14 2003-09-25 Bayer Pharmaceuticals Corporation Methods of treating diabetes using pde 11a inhibitors
WO2004082667A1 (en) 2003-03-17 2004-09-30 Pfizer Products Inc. Treatment of type 1 diabetes with pde5 inhibitors
US20040220186A1 (en) 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
JP4517723B2 (ja) 2003-05-22 2010-08-04 住友ベークライト株式会社 ナフトキノンジアジドスルホン酸エステル、それを用いたポジ型感光性樹脂組成物、半導体装置及び表示素子
DK1644009T3 (en) * 2003-06-23 2018-03-05 Telomerase Activation Sciences Inc Compositions for increasing telomerase activity and treating HIV infection
CA2530316A1 (en) 2003-06-30 2005-01-13 Altana Pharma Ag Pyrrolodihydroisoquinolines as pde10 inhibitors
US20070032404A1 (en) 2003-07-31 2007-02-08 Bayer Pharmaceuticals Corporation Methods for treating diabetes and related disorders using pde10a inhibitors
US20050049208A1 (en) 2003-09-03 2005-03-03 Kaufmann Doug A. Method of treating and method of preventing diabetes
EA013427B1 (ru) 2004-03-15 2010-04-30 Такеда Фармасьютикал Компани Лимитед Ингибиторы дипептидилпептидазы
JP2007532116A (ja) * 2004-04-07 2007-11-15 キアジェン ノース アメリカン ホールディングス，インコーポレイティド １成分型および２成分型のＤＮＡＰｏｌＩＩＩレプリカーゼとその使用
JP2008501776A (ja) 2004-06-07 2008-01-24 ファイザー・プロダクツ・インク 肥満に関連し、かつメタボリックシンドロームに関連する状態の治療としてのホスホジエステラーゼ１０の阻害
WO2006007864A1 (en) * 2004-07-17 2006-01-26 Max Planck Geselllschaft Zur Förderung Der Wissenschaft Treating neurodegenerative conditions
JP4929569B2 (ja) * 2004-08-20 2012-05-09 東レ株式会社 高分子電解質材、ならびにそれを用いた高分子電解質膜、膜電極複合体および高分子電解質型燃料電池
US7541392B2 (en) * 2004-09-14 2009-06-02 E.I. Du Pont De Nemours And Company Materials leading to improved dental composites and dental composites made therefrom
AU2006210778B2 (en) * 2005-01-31 2011-11-03 Trustees Of The University Of Pennsylvania Tumor necrosis factor inhibitors
AU2006210641A1 (en) * 2005-02-01 2006-08-10 Icagen, Inc. Imines as ion channel modulators
JP5211438B2 (ja) 2005-06-09 2013-06-12 東レ株式会社 樹脂組成物およびそれを用いた表示装置
NZ575904A (en) * 2006-09-28 2011-11-25 Univ Otago Triphenylphosphonium thionitrite nitric oxide donors
WO2008149346A2 (en) 2007-06-04 2008-12-11 Ben Gurion University Of The Negev Research And Development Authority Enhanced sensitivity polymerase chain reactions

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AU2008259342B2 (en) 2014-07-10
TWI430796B (zh) 2014-03-21
EP2152663A2 (en) 2010-02-17
AU2008259350A1 (en) 2008-12-11
CN103553939A (zh) 2014-02-05
EP2152663B1 (en) 2014-03-19
JP2010529107A (ja) 2010-08-26
ES2465216T3 (es) 2014-06-05
US20100256382A1 (en) 2010-10-07
AU2008259350B2 (en) 2013-06-06
EP2152663A4 (en) 2011-11-09
KR20100039828A (ko) 2010-04-16
CA2963857A1 (en) 2008-12-11
CN104000806A (zh) 2014-08-27
US20100267667A1 (en) 2010-10-21
DK2152663T3 (da) 2014-06-23

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