SI2152256T1 - Aktivirne spojine telomeraze in postopki za njihovo uporabo - Google Patents

Aktivirne spojine telomeraze in postopki za njihovo uporabo

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Publication number
SI2152256T1
SI2152256T1 SI200831358T SI200831358T SI2152256T1 SI 2152256 T1 SI2152256 T1 SI 2152256T1 SI 200831358 T SI200831358 T SI 200831358T SI 200831358 T SI200831358 T SI 200831358T SI 2152256 T1 SI2152256 T1 SI 2152256T1
Authority
SI
Slovenia
Prior art keywords
methods
activating compounds
telomerase activating
telomerase
compounds
Prior art date
Application number
SI200831358T
Other languages
English (en)
Inventor
Aviv Gazit
Shimon Slavin
Esther Priel
Sara Yitzchak
Original Assignee
Ben Gurion University Of The Negev Research And Development Authority
Shimon Slavin
Aviv Gazit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ben Gurion University Of The Negev Research And Development Authority, Shimon Slavin, Aviv Gazit filed Critical Ben Gurion University Of The Negev Research And Development Authority
Publication of SI2152256T1 publication Critical patent/SI2152256T1/sl

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    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
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    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
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    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5022—Aromatic phosphines (P-C aromatic linkage)
SI200831358T 2007-06-04 2008-06-04 Aktivirne spojine telomeraze in postopki za njihovo uporabo SI2152256T1 (sl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US92487507P 2007-06-04 2007-06-04
US92952507P 2007-07-02 2007-07-02
US92952407P 2007-07-02 2007-07-02
US692408P 2008-02-06 2008-02-06
EP08763514.0A EP2152256B1 (en) 2007-06-04 2008-06-04 Telomerase activating compounds and methods of use thereof
PCT/IL2008/000756 WO2008149353A2 (en) 2007-06-04 2008-06-04 Telomerase activating compounds and methods of use thereof

Publications (1)

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SI2152256T1 true SI2152256T1 (sl) 2015-04-30

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Family Applications (2)

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SI200831209T SI2152663T1 (sl) 2007-06-04 2008-06-03 Tri-arilne spojine in sestavki, ki vsebujejo isto
SI200831358T SI2152256T1 (sl) 2007-06-04 2008-06-04 Aktivirne spojine telomeraze in postopki za njihovo uporabo

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SI200831209T SI2152663T1 (sl) 2007-06-04 2008-06-03 Tri-arilne spojine in sestavki, ki vsebujejo isto

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EP (3) EP2152663B1 (sl)
JP (6) JP5508258B2 (sl)
KR (4) KR101560844B1 (sl)
CN (4) CN101742906A (sl)
AU (2) AU2008259342B2 (sl)
CA (4) CA2690004C (sl)
CY (1) CY1115919T1 (sl)
DK (2) DK2152663T3 (sl)
EA (4) EA021544B1 (sl)
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HR (2) HRP20140394T1 (sl)
IL (4) IL202425A (sl)
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PL (2) PL2152663T3 (sl)
PT (2) PT2152663E (sl)
SI (2) SI2152663T1 (sl)
TW (1) TWI430796B (sl)
WO (3) WO2008149345A2 (sl)

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* Cited by examiner, † Cited by third party
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PL2152663T3 (pl) 2007-06-04 2014-09-30 Ben Gurion Univ Of The Negev Research And Development Authority Związki triarylowe oraz kompozycje zawierające te związki
UA107784C2 (en) * 2008-12-22 2015-02-25 Pola Chem Ind Inc Inhibitor of melanin production
ES2596631T3 (es) 2009-05-18 2017-01-11 Telomerase Activation Sciences, Inc. Composiciones y métodos para aumentar la actividad telomerasa
JP6657101B2 (ja) 2013-11-05 2020-03-04 ベン グリオン ユニバーシティ オブ ザ ネガフ リサーチ アンド ディベロップメント オーソリティ 糖尿病及びそれから生じる疾患合併症の治療のための化合物
JP7114481B2 (ja) 2016-04-07 2022-08-08 ジェムバックス アンド カエル カンパニー，リミティド テロメラーゼ活性の増加及びテロメアの延長の効能を有するペプチド、及びこれを含む組成物
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