|
US7485420B2
(en)
*
|
2003-08-14 |
2009-02-03 |
Case Western Reserve University |
Methods and compositions for detecting colon cancers
|
|
US8415100B2
(en)
|
2003-08-14 |
2013-04-09 |
Case Western Reserve University |
Methods and compositions for detecting gastrointestinal and other cancers
|
|
US12366585B2
(en)
|
2006-05-18 |
2025-07-22 |
Caris Mpi, Inc. |
Molecular profiling of tumors
|
|
GB0700374D0
(en)
|
2007-01-09 |
2007-02-14 |
Oncomethylome Sciences S A |
NDRG family methylation markers
|
|
WO2008100913A2
(en)
*
|
2007-02-12 |
2008-08-21 |
The Johns Hopkins University |
Early detection and prognosis of colon cancers
|
|
NZ596545A
(en)
|
2007-09-17 |
2013-05-31 |
Glaxosmithkline Biolog Sa |
Improved detection of mage-a expression
|
|
US8673555B2
(en)
|
2008-02-15 |
2014-03-18 |
Mayo Foundation For Medical Education And Research |
Detecting neoplasm
|
|
EP2250287B1
(en)
*
|
2008-02-19 |
2013-09-18 |
MDxHealth SA |
Detection and prognosis of lung cancer
|
|
CA2718092C
(en)
*
|
2008-03-21 |
2019-03-19 |
Oncomethylome Sciences S.A. |
Detection and prognosis of cervical cancer
|
|
US20110160080A1
(en)
|
2008-05-14 |
2011-06-30 |
Chang Sherman H |
Diagnosis of Melanoma and Solar Lentigo by Nucleic Acid Analysis
|
|
EP2329040B1
(en)
*
|
2008-09-22 |
2017-10-11 |
ADVPharma, Inc. |
Molecular markers for lung and colorectal carcinomas
|
|
WO2010089538A2
(en)
|
2009-02-03 |
2010-08-12 |
Oncomethylome Sciences Sa |
Methods of detecting colorectal cancer
|
|
WO2010102823A1
(en)
*
|
2009-03-13 |
2010-09-16 |
Oncomethylome Sciences Sa |
Novel markers for bladder cancer detection
|
|
CA2779223A1
(en)
|
2009-10-27 |
2011-05-12 |
Caris Mpi, Inc. |
Molecular profiling for personalized medicine
|
|
EP2354242A1
(en)
*
|
2010-02-03 |
2011-08-10 |
Epiontis GmbH |
Assay for determining the type and/or status of a cell based on the epigenetic pattern and the chromatin structure
|
|
EP2553463B1
(en)
|
2010-03-26 |
2017-05-03 |
Hongzhi Zou |
Methods and materials for detecting colorectal neoplasm
|
|
WO2011135058A2
(en)
|
2010-04-30 |
2011-11-03 |
Mdxhealth Sa |
Methods for detecting epigenetic modifications
|
|
US9309565B2
(en)
*
|
2010-05-14 |
2016-04-12 |
Life Technologies Corporation |
Karyotyping assay
|
|
JP6222202B2
(ja)
*
|
2010-07-05 |
2017-11-01 |
ソニー株式会社 |
生体情報処理方法および装置、並びに記録媒体
|
|
JP5838557B2
(ja)
*
|
2010-07-05 |
2016-01-06 |
ソニー株式会社 |
生体情報処理方法および装置、並びに記録媒体
|
|
US8916344B2
(en)
|
2010-11-15 |
2014-12-23 |
Exact Sciences Corporation |
Methylation assay
|
|
US8361720B2
(en)
|
2010-11-15 |
2013-01-29 |
Exact Sciences Corporation |
Real time cleavage assay
|
|
EP3441479B1
(en)
*
|
2011-02-02 |
2020-09-02 |
Exact Sciences Development Company, LLC |
Digital sequence analysis of dna methylation
|
|
CN103649298A
(zh)
*
|
2011-05-12 |
2014-03-19 |
精密科学公司 |
核酸的分离
|
|
US8993341B2
(en)
|
2011-05-12 |
2015-03-31 |
Exact Sciences Corporation |
Removal of PCR inhibitors
|
|
US10308980B2
(en)
*
|
2011-11-04 |
2019-06-04 |
Oslo Universitetssykehus Hf |
Methods and biomarkers for analysis of colorectal cancer
|
|
EP2788505B1
(en)
*
|
2011-12-06 |
2017-08-23 |
MDxHealth SA |
Methods of detecting mutations and epigenetic changes
|
|
US9744155B2
(en)
|
2012-03-28 |
2017-08-29 |
Ixcela, Inc. |
IPA as a therapeutic agent, as a protective agent, and as a biomarker of disease risk
|
|
CA2874407A1
(en)
|
2012-05-24 |
2013-11-28 |
Fundacio Institut D'investigacio Biomedica De Bellvitge (Idibell) |
Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis
|
|
EP2891720B1
(en)
*
|
2012-08-31 |
2020-04-08 |
National Defense Medical Center |
Method for screening cancer
|
|
CN102787174B
(zh)
*
|
2012-09-06 |
2013-08-07 |
南京大学 |
胃肠肿瘤发病相关抑癌基因表观突变检测试剂盒及其用途
|
|
AU2013355260B2
(en)
*
|
2012-12-04 |
2019-07-25 |
Caris Mpi, Inc. |
Molecular profiling for cancer
|
|
EP2971179B1
(en)
|
2013-03-14 |
2019-01-09 |
Mayo Foundation for Medical Education and Research |
Detecting neoplasm
|
|
US9644232B2
(en)
|
2013-07-26 |
2017-05-09 |
General Electric Company |
Method and device for collection and amplification of circulating nucleic acids
|
|
US10253358B2
(en)
|
2013-11-04 |
2019-04-09 |
Exact Sciences Development Company, Llc |
Multiple-control calibrators for DNA quantitation
|
|
EP2886659A1
(en)
*
|
2013-12-20 |
2015-06-24 |
AIT Austrian Institute of Technology GmbH |
Gene methylation based colorectal cancer diagnosis
|
|
CN105934520A
(zh)
*
|
2014-01-31 |
2016-09-07 |
伊克斯塞拉有限公司 |
作为生物标志物的共价键代谢物
|
|
JP2015177745A
(ja)
*
|
2014-03-18 |
2015-10-08 |
愛知県 |
肺癌の検査方法
|
|
US10301680B2
(en)
|
2014-03-31 |
2019-05-28 |
Mayo Foundation For Medical Education And Research |
Detecting colorectal neoplasm
|
|
US10184154B2
(en)
|
2014-09-26 |
2019-01-22 |
Mayo Foundation For Medical Education And Research |
Detecting cholangiocarcinoma
|
|
CN104561258B
(zh)
*
|
2014-10-08 |
2016-08-24 |
王红卫 |
一种用于直结肠癌早期诊断的检测试剂盒及其应用
|
|
GB201418965D0
(enExample)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
|
EP3225630B1
(en)
|
2014-11-27 |
2021-05-12 |
Public University Corporation Yokohama City University |
Method and reagent for detecting ovarian clear cell adenocarcinoma
|
|
US9984201B2
(en)
|
2015-01-18 |
2018-05-29 |
Youhealth Biotech, Limited |
Method and system for determining cancer status
|
|
US10030272B2
(en)
|
2015-02-27 |
2018-07-24 |
Mayo Foundation For Medical Education And Research |
Detecting gastrointestinal neoplasms
|
|
WO2016160454A1
(en)
|
2015-03-27 |
2016-10-06 |
Exact Sciences Corporation |
Detecting esophageal disorders
|
|
JP2016192909A
(ja)
*
|
2015-03-31 |
2016-11-17 |
シスメックス株式会社 |
胃癌に関する情報の取得方法、ならびに胃癌に関する情報を取得するためのマーカーおよび胃癌検出用キット
|
|
JP6871926B2
(ja)
|
2015-08-31 |
2021-05-19 |
マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチＭａｙｏ Ｆｏｕｎｄａｔｉｏｎ ｆｏｒ Ｍｅｄｉｃａｌ Ｅｄｕｃａｔｉｏｎ ａｎｄ Ｒｅｓｅａｒｃｈ |
胃の新生物を検出すること
|
|
HK1258397A1
(zh)
|
2015-09-09 |
2019-11-08 |
Drawbridge Health, Inc. |
用於样品收集、稳定化和保存的系统、方法和装置
|
|
CN105177163B
(zh)
*
|
2015-10-21 |
2018-04-13 |
山东大学齐鲁医院 |
一种用于宫颈癌早期筛查的试剂盒
|
|
CA3002196C
(en)
|
2015-10-30 |
2024-05-14 |
Exact Sciences Development Company, Llc |
Multiplex amplification detection assay and isolation and detection of dna from plasma
|
|
CN109153993B
(zh)
|
2016-04-14 |
2023-02-17 |
梅约医学教育与研究基金会 |
检测胰腺高度异型增生
|
|
US10370726B2
(en)
|
2016-04-14 |
2019-08-06 |
Mayo Foundation For Medical Education And Research |
Detecting colorectal neoplasia
|
|
AU2017260630B2
(en)
|
2016-05-05 |
2023-07-13 |
Exact Sciences Corporation |
Detection of lung neoplasia by analysis of methylated DNA
|
|
WO2017210341A1
(en)
|
2016-05-31 |
2017-12-07 |
The Regents Of The University Of California |
Methods for evaluating, monitoring, and modulating aging process
|
|
CN106119361B
(zh)
*
|
2016-06-28 |
2020-01-07 |
宁波思锐生物科技有限公司 |
用于胃癌早期诊断及预后评估的ndrg4基因甲基化检测的试剂盒及其应用
|
|
CN106011263B
(zh)
*
|
2016-06-28 |
2020-01-07 |
宁波大学 |
用于检测与胃癌相关的ndrg4基因甲基化程度的试剂盒及其应用
|
|
EP3481941A4
(en)
|
2016-07-06 |
2020-04-15 |
Youhealth Biotech, Limited |
METHYLIZATION MARKERS FOR BREAST AND OVARIAL CANCER AND THEIR USE
|
|
US10093986B2
(en)
|
2016-07-06 |
2018-10-09 |
Youhealth Biotech, Limited |
Leukemia methylation markers and uses thereof
|
|
WO2018009705A1
(en)
|
2016-07-06 |
2018-01-11 |
Youhealth Biotech, Limited |
Liver cancer methylation markers and uses thereof
|
|
EP3481403B1
(en)
|
2016-07-06 |
2022-02-09 |
Youhealth Biotech, Limited |
Solid tumor methylation markers and uses thereof
|
|
WO2018009696A1
(en)
|
2016-07-06 |
2018-01-11 |
Youhealth Biotech, Limited |
Colon cancer methylation markers and uses thereof
|
|
US20190241970A1
(en)
*
|
2016-07-08 |
2019-08-08 |
Hanumat Co., Ltd. |
Method for determining likelihood of colorectal cancer development
|
|
CN106521006A
(zh)
*
|
2016-12-27 |
2017-03-22 |
刘鹏飞 |
Ndrg4基因甲基化检测用试剂体系和试剂盒及其应用
|
|
SG10201911879UA
(en)
|
2017-01-10 |
2020-01-30 |
Drawbridge Health Inc |
Devices, systems, and methods for sample collection
|
|
CN108300783A
(zh)
*
|
2017-01-11 |
2018-07-20 |
上海易毕恩基因科技有限公司 |
用于筛选肠癌和/或胃癌的基因标志物的方法、用该方法筛选的基因标志物及其用途
|
|
AU2018211956B2
(en)
|
2017-01-27 |
2024-06-20 |
Exact Sciences Corporation |
Detection of colon neoplasia by analysis of methylated DNA
|
|
US10934592B2
(en)
|
2017-02-28 |
2021-03-02 |
Mayo Foundation For Medical Education And Research |
Detecting prostate cancer
|
|
BR112019018272A2
(pt)
|
2017-03-02 |
2020-07-28 |
Youhealth Oncotech, Limited |
marcadores metilação para diagnosticar hepatocelular carcinoma e câncer
|
|
WO2018220151A1
(en)
*
|
2017-06-02 |
2018-12-06 |
Verhaert Peter Dominiek Emiel Maria |
Mass spectrometry histochemistry of peptides from formaldehyde-fixed, paraffin-embedded tissue
|
|
CN107177679A
(zh)
*
|
2017-06-07 |
2017-09-19 |
北京呈诺医学科技有限公司 |
一种检测食管鳞癌相关基因tfpi2和hspb2启动子甲基化程度的试剂盒
|
|
WO2018237327A1
(en)
|
2017-06-22 |
2018-12-27 |
Triact Therapeutics, Inc. |
Methods of treating glioblastoma
|
|
IT201700072650A1
(it)
*
|
2017-06-28 |
2018-12-28 |
Univ Degli Studi Cagliari |
Metodo per rilevare e/o per la prognosi di neoplasie del colon-retto
|
|
EP3687501A4
(en)
|
2017-09-29 |
2021-06-23 |
Triact Therapeutics, Inc. |
INIPARIB FORMULATIONS AND THEIR USES
|
|
CN111742062B
(zh)
|
2017-10-06 |
2023-11-17 |
优美佳肿瘤技术有限公司 |
用于诊断癌症的甲基化标志物
|
|
KR102052089B1
(ko)
*
|
2017-11-22 |
2019-12-05 |
연세대학교 산학협력단 |
유전자의 CpG 메틸화 변화를 이용한 간암의 위험도를 평가하는 방법
|
|
AU2018374176B2
(en)
|
2017-11-30 |
2024-12-12 |
Exact Sciences Corporation |
Detecting breast cancer
|
|
US10648025B2
(en)
|
2017-12-13 |
2020-05-12 |
Exact Sciences Development Company, Llc |
Multiplex amplification detection assay II
|
|
US11976332B2
(en)
|
2018-02-14 |
2024-05-07 |
Dermtech, Inc. |
Gene classifiers and uses thereof in non-melanoma skin cancers
|
|
CN111989407B
(zh)
|
2018-03-13 |
2024-10-29 |
格里尔公司 |
异常的片段检测及分类
|
|
CN108460247B
(zh)
*
|
2018-03-29 |
2022-06-07 |
上海锐翌生物科技有限公司 |
基于kras和ndrg4基因确定结直肠肿瘤细胞的方法和系统
|
|
CA3302676A1
(en)
|
2018-04-02 |
2026-05-13 |
Grail, Inc. |
Methylation markers and targeted methylation probe panels
|
|
US20210214797A1
(en)
*
|
2018-06-01 |
2021-07-15 |
Geneoscopy, Llc |
Detection method
|
|
CN108707667B
(zh)
*
|
2018-06-01 |
2021-10-26 |
安徽达健医学科技有限公司 |
一种用于结直肠癌早期诊断的试剂盒及其使用方法
|
|
CN108796078B
(zh)
*
|
2018-06-05 |
2022-07-26 |
苏州唯善生物科技有限公司 |
一种用于消化道癌诊断、检测或筛查的引物和探针组
|
|
CN108977543B
(zh)
*
|
2018-08-06 |
2021-12-14 |
上海锐翌生物科技有限公司 |
一种基于联合检测sdc2和sfrp2基因甲基化水平的结直肠癌早期诊断试剂
|
|
US11441182B2
(en)
*
|
2018-08-08 |
2022-09-13 |
Virginia Commonwealth University |
Multiplexed and recyclable single-molecule sensors for quantitative analysis of nucleic-acid biomarkers
|
|
EP3856903A4
(en)
|
2018-09-27 |
2022-07-27 |
Grail, LLC |
METHYLATION MARKER AND TARGETED METHYLATION PROBE PANEL
|
|
EP3867405A4
(en)
|
2018-10-17 |
2022-07-20 |
The University of Queensland |
EPIGENETIC BIOMARKER AND USES THEREOF
|
|
KR20210111254A
(ko)
|
2018-11-30 |
2021-09-10 |
캐리스 엠피아이, 아이엔씨. |
차세대 분자 프로파일링
|
|
EP3899953A1
(en)
|
2018-12-21 |
2021-10-27 |
Grail, Inc. |
Source of origin deconvolution based on methylation fragments in cell-free-dna samples
|
|
CA3127329A1
(en)
|
2019-01-24 |
2020-07-30 |
Mayo Foundation For Medical Education And Research |
Detecting endometrial cancer
|
|
US11041847B1
(en)
|
2019-01-25 |
2021-06-22 |
Ixcela, Inc. |
Detection and modification of gut microbial population
|
|
CA3134936A1
(en)
|
2019-03-26 |
2020-10-01 |
Dermtech, Inc. |
Novel gene classifiers and uses thereof in skin cancers
|
|
CN109943638A
(zh)
*
|
2019-05-08 |
2019-06-28 |
湖南百伯基因技术有限公司 |
一种检测ndrg4、sdc2和bmp3基因甲基化的引物探针组合及其应用和试剂盒
|
|
US11396679B2
(en)
|
2019-05-31 |
2022-07-26 |
Universal Diagnostics, S.L. |
Detection of colorectal cancer
|
|
CN110283911A
(zh)
*
|
2019-06-28 |
2019-09-27 |
四川沃文特生物技术有限公司 |
用于粪便样本进行早期结直肠癌基因甲基化检测的引物对和探针及试剂盒
|
|
CN110343764B
(zh)
*
|
2019-07-22 |
2020-05-26 |
武汉艾米森生命科技有限公司 |
检测结直肠癌相关基因甲基化的检测试剂的应用和试剂盒
|
|
US11427874B1
(en)
|
2019-08-26 |
2022-08-30 |
Epi One Inc. |
Methods and systems for detection of prostate cancer by DNA methylation analysis
|
|
JP7799607B2
(ja)
|
2019-10-31 |
2026-01-15 |
マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ |
卵巣癌の検出
|
|
US11898199B2
(en)
|
2019-11-11 |
2024-02-13 |
Universal Diagnostics, S.A. |
Detection of colorectal cancer and/or advanced adenomas
|
|
IL293489A
(en)
|
2019-12-02 |
2022-08-01 |
Caris Mpi Inc |
predictor of pan-cancer platinum response
|
|
US20230049979A1
(en)
*
|
2020-02-06 |
2023-02-16 |
OncoHost Ltd. |
Machine learning prediction of therapy response
|
|
MX2022009999A
(es)
|
2020-02-14 |
2023-01-19 |
Caris Mpi Inc |
Puntuacion de prevalencia genomica panomica.
|
|
CN111549129B
(zh)
*
|
2020-03-30 |
2023-08-29 |
宁波美康盛德医学检验所有限公司 |
用于检测胃癌的试剂盒及其应用
|
|
WO2021222828A1
(en)
*
|
2020-04-30 |
2021-11-04 |
Guardant Health, Inc. |
Methods for sequence determination using partitioned nucleic acids
|
|
WO2021228418A1
(en)
|
2020-05-15 |
2021-11-18 |
Universal Diagnostics, S.L. |
Methods and systems for identifying methylation biomarkers
|
|
EP4150121A1
(en)
|
2020-06-30 |
2023-03-22 |
Universal Diagnostics, S.A. |
Systems and methods for detection of multiple cancer types
|
|
CN113278693A
(zh)
*
|
2020-07-29 |
2021-08-20 |
上海吉凯医学检验所有限公司 |
早期结直肠癌和腺瘤的dna甲基化标志物、检测其的方法及其应用
|
|
CN112941162A
(zh)
*
|
2020-12-30 |
2021-06-11 |
昆明理工大学 |
一种dna端粒长度和基因甲基化程度相关性的检测方法
|
|
WO2022192510A1
(en)
*
|
2021-03-10 |
2022-09-15 |
University Of Cincinnati |
Epigenetic quantification using dna hybridization-based single-molecule immunofluorescent imaging
|
|
CN113234821B
(zh)
*
|
2021-04-29 |
2022-09-16 |
北京艾克伦医疗科技有限公司 |
鉴定食管癌状态的方法和试剂盒
|
|
EP4320276B1
(en)
*
|
2021-05-14 |
2025-04-23 |
Universal Diagnostics S.A. |
Methods for disease detection
|
|
TW202307218A
(zh)
*
|
2021-05-14 |
2023-02-16 |
西班牙商通用診斷公司 |
用於疾病偵測的方法
|
|
IL311764A
(en)
|
2021-09-30 |
2024-05-01 |
Tivenix Sa |
A method for diagnosing and predicting progression of neurodegenerative diseases or disorders
|
|
US20260110036A1
(en)
*
|
2022-06-17 |
2026-04-23 |
Korea Research Institute Of Bioscience And Biotechnology |
Marker for prognosis of diffuse type gastric cancer and treatment target
|
|
CN117343992A
(zh)
*
|
2022-06-29 |
2024-01-05 |
广州市基准医疗有限责任公司 |
一种多基因合并荧光通道检测的方法
|
|
CN117385028A
(zh)
*
|
2022-07-04 |
2024-01-12 |
江苏鹍远生物科技股份有限公司 |
结直肠癌特异性甲基化标志物及其应用
|
|
US12606872B2
(en)
|
2022-11-16 |
2026-04-21 |
Universal Diagnostics, S.A. |
Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using DNA methylation markers
|
|
TWI839307B
(zh)
*
|
2023-05-06 |
2024-04-11 |
華聯生物科技股份有限公司 |
利用電腦評估肝癌患者治療後病變進展及預後的方法
|