JP2014509189A5 - - Google Patents
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- JP2014509189A5 JP2014509189A5 JP2013551314A JP2013551314A JP2014509189A5 JP 2014509189 A5 JP2014509189 A5 JP 2014509189A5 JP 2013551314 A JP2013551314 A JP 2013551314A JP 2013551314 A JP2013551314 A JP 2013551314A JP 2014509189 A5 JP2014509189 A5 JP 2014509189A5
- Authority
- JP
- Japan
- Prior art keywords
- colon cancer
- nucleic acid
- subject
- threshold
- expression level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 206010009944 Colon cancer Diseases 0.000 claims 39
- 208000029742 colonic neoplasm Diseases 0.000 claims 39
- 238000000034 method Methods 0.000 claims 37
- 230000014509 gene expression Effects 0.000 claims 34
- 150000007523 nucleic acids Chemical class 0.000 claims 27
- 108020004707 nucleic acids Proteins 0.000 claims 21
- 102000039446 nucleic acids Human genes 0.000 claims 21
- 239000000523 sample Substances 0.000 claims 21
- 230000004083 survival effect Effects 0.000 claims 10
- 230000007774 longterm Effects 0.000 claims 9
- 230000000295 complement effect Effects 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 238000003745 diagnosis Methods 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 102100033887 Arylsulfatase D Human genes 0.000 claims 2
- 101000925559 Homo sapiens Arylsulfatase D Proteins 0.000 claims 2
- 101001011441 Homo sapiens Interferon regulatory factor 4 Proteins 0.000 claims 2
- 101001131670 Homo sapiens PWWP domain-containing DNA repair factor 3A Proteins 0.000 claims 2
- 102100030126 Interferon regulatory factor 4 Human genes 0.000 claims 2
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 2
- 108091006298 SLC2A3 Proteins 0.000 claims 2
- 102100022722 Solute carrier family 2, facilitated glucose transporter member 3 Human genes 0.000 claims 2
- 238000011226 adjuvant chemotherapy Methods 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 239000002853 nucleic acid probe Substances 0.000 claims 2
- 102100032424 B-cell CLL/lymphoma 9-like protein Human genes 0.000 claims 1
- 102100036170 C-X-C motif chemokine 9 Human genes 0.000 claims 1
- 101000798491 Homo sapiens B-cell CLL/lymphoma 9-like protein Proteins 0.000 claims 1
- 101000947172 Homo sapiens C-X-C motif chemokine 9 Proteins 0.000 claims 1
- 101000913082 Homo sapiens IgGFc-binding protein Proteins 0.000 claims 1
- 101001064542 Homo sapiens Liprin-beta-1 Proteins 0.000 claims 1
- 101000972284 Homo sapiens Mucin-3A Proteins 0.000 claims 1
- 101001120760 Homo sapiens Olfactomedin-4 Proteins 0.000 claims 1
- 101000609959 Homo sapiens Protein piccolo Proteins 0.000 claims 1
- 101000692683 Homo sapiens RING finger protein 39 Proteins 0.000 claims 1
- 101000836994 Homo sapiens Sigma non-opioid intracellular receptor 1 Proteins 0.000 claims 1
- 101000826406 Homo sapiens Sulfotransferase 1C2 Proteins 0.000 claims 1
- 101000585332 Homo sapiens Sulfotransferase 1C4 Proteins 0.000 claims 1
- 102100026103 IgGFc-binding protein Human genes 0.000 claims 1
- 102100031961 Liprin-beta-1 Human genes 0.000 claims 1
- 102100022497 Mucin-3A Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102100026071 Olfactomedin-4 Human genes 0.000 claims 1
- 102100039154 Protein piccolo Human genes 0.000 claims 1
- 102100026465 RING finger protein 39 Human genes 0.000 claims 1
- 108091006302 SLC2A14 Proteins 0.000 claims 1
- 102100028656 Sigma non-opioid intracellular receptor 1 Human genes 0.000 claims 1
- 102100039672 Solute carrier family 2, facilitated glucose transporter member 14 Human genes 0.000 claims 1
- 102100023985 Sulfotransferase 1C2 Human genes 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 238000010195 expression analysis Methods 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 238000003499 nucleic acid array Methods 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161435922P | 2011-01-25 | 2011-01-25 | |
| US61/435,922 | 2011-01-25 | ||
| PCT/US2012/022594 WO2012103250A2 (en) | 2011-01-25 | 2012-01-25 | Colon cancer gene expression signatures and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014509189A JP2014509189A (ja) | 2014-04-17 |
| JP2014509189A5 true JP2014509189A5 (enExample) | 2015-03-05 |
Family
ID=46581385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013551314A Pending JP2014509189A (ja) | 2011-01-25 | 2012-01-25 | 結腸ガン遺伝子発現シグネチャーおよび使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10196691B2 (enExample) |
| EP (1) | EP2668296B1 (enExample) |
| JP (1) | JP2014509189A (enExample) |
| KR (1) | KR20140006898A (enExample) |
| CN (1) | CN103403543B9 (enExample) |
| AU (1) | AU2012209074A1 (enExample) |
| BR (1) | BR112013018924A2 (enExample) |
| CA (1) | CA2825218A1 (enExample) |
| EA (1) | EA201391074A1 (enExample) |
| IL (1) | IL227643A0 (enExample) |
| MX (1) | MX2013008367A (enExample) |
| SG (1) | SG192108A1 (enExample) |
| WO (1) | WO2012103250A2 (enExample) |
| ZA (1) | ZA201305024B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| HRP20151294T1 (hr) | 2010-04-05 | 2016-03-11 | Prognosys Biosciences, Inc. | Biološka testiranja sa prostornim kodiranjem |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| US20130074201A1 (en) * | 2011-09-16 | 2013-03-21 | The Johns Hopkins University | Cancer-specific genetic rearrangements |
| EP3511423B2 (en) * | 2012-10-17 | 2024-05-29 | Spatial Transcriptomics AB | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| LT3013984T (lt) | 2013-06-25 | 2023-06-12 | Prognosys Biosciences, Inc. | Biologinių taikinių erdvinių modelių mėginyje nustatymo būdai |
| US9652722B1 (en) * | 2013-12-05 | 2017-05-16 | The Mathworks, Inc. | Methods and systems for robust supervised machine learning |
| ES2713240T3 (es) * | 2014-02-17 | 2019-05-20 | Ventana Med Syst Inc | Proteína asociada a vesícula que interacciona con G-alfa (GIV) como marcador predictivo en cáncer colorrectal de estadio II |
| US10407737B2 (en) | 2014-04-10 | 2019-09-10 | Bio-Marcare Technologies Ltd. | Methods and kits for identifying pre-cancerous colorectal polyps and colorectal cancer |
| CN120425026A (zh) | 2015-04-10 | 2025-08-05 | 十程基因技术瑞典公司 | 生物样本的空间区别、多重核酸分析 |
| CN108020672A (zh) * | 2016-11-03 | 2018-05-11 | 中国医学科学院基础医学研究所 | 检测rhbdd1蛋白的elisa方法及试剂盒 |
| US20200088748A1 (en) * | 2016-12-08 | 2020-03-19 | Dana-Farber Cancer Institute, Inc. | Metabolic profiling of fixed samples |
| CN107158388B (zh) * | 2017-07-11 | 2021-03-23 | 上海市第一人民医院 | MIIP pS303阻断剂在制备抗肿瘤药物中的应用 |
| US11414707B2 (en) * | 2018-01-22 | 2022-08-16 | Liquid Biopsy Research LLC | Methods for colon cancer detection and treatment |
| US12498372B2 (en) | 2018-04-12 | 2025-12-16 | Board Of Regents, The University Of Texas System | Biomarker for detecting cancer |
| JP2020028278A (ja) * | 2018-08-24 | 2020-02-27 | 国立大学法人九州大学 | 被検体に生じるイベントを予測するための判別器の生成方法、及び前記判別器を用いた被検体の層別化方法 |
| CN111321220A (zh) * | 2018-12-14 | 2020-06-23 | 中国医学科学院肿瘤医院 | 用于检测直肠癌放化疗敏感性的组合物、微阵列和计算机系统 |
| CN110079607B (zh) * | 2019-04-04 | 2022-08-02 | 陕西师范大学 | 一种引物组、检测血液样品种属的方法及应用 |
| WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| EP4025692A2 (en) | 2020-06-02 | 2022-07-13 | 10X Genomics, Inc. | Nucleic acid library methods |
| EP4600376A3 (en) | 2020-06-02 | 2025-10-22 | 10X Genomics, Inc. | Spatial transcriptomics for antigen-receptors |
| EP4421186B1 (en) | 2020-06-08 | 2025-08-13 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
| EP4172621A1 (en) * | 2020-06-30 | 2023-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies |
| CN111951883A (zh) * | 2020-08-04 | 2020-11-17 | 广东省第二人民医院（广东省卫生应急医院） | 一种特征mRNA表达谱组合及结肠癌早期预测方法 |
| CN115786518A (zh) * | 2022-11-29 | 2023-03-14 | 广东医科大学附属医院 | 嗅素结构域家族蛋白4（olfm4）在结肠癌检测产品中的应用 |
| US20240327927A1 (en) * | 2023-03-27 | 2024-10-03 | Immunis.Ai, Inc. | Active surveillance and risk stratification for prostate cancer |
| CN119372311A (zh) * | 2024-09-30 | 2025-01-28 | 东南大学 | 基于成纤维细胞相关基因的结肠癌预后和治疗抵抗预测模型的构建方法和应用 |
| CN120009551B (zh) * | 2025-02-27 | 2025-08-15 | 西南医科大学 | 剪接因子wbp11及其抑制剂的用途、预防或治疗结直肠癌的药物 |
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| AU575586B2 (en) | 1983-09-02 | 1988-08-04 | Syngene, Inc. | Oligonucleotide synthesis employing primer with oxidzable substituents in system |
| AU622426B2 (en) | 1987-12-11 | 1992-04-09 | Abbott Laboratories | Assay using template-dependent nucleic acid probe reorganization |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| DE68926504T2 (de) | 1988-07-20 | 1996-09-12 | David Segev | Verfahren zur amplifizierung und zum nachweis von nukleinsäuresequenzen |
| US5219727A (en) | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
| US5427930A (en) | 1990-01-26 | 1995-06-27 | Abbott Laboratories | Amplification of target nucleic acids using gap filling ligase chain reaction |
| US5554501A (en) | 1992-10-29 | 1996-09-10 | Beckman Instruments, Inc. | Biopolymer synthesis using surface activated biaxially oriented polypropylene |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US5648211A (en) | 1994-04-18 | 1997-07-15 | Becton, Dickinson And Company | Strand displacement amplification using thermophilic enzymes |
| DE69503126T2 (de) | 1994-05-05 | 1998-11-12 | Beckman Instruments Inc | Repetitive oligonukleotide matrix |
| CA2195209C (en) | 1994-07-15 | 2008-09-23 | Roy R. Sooknanan | Use of rna polymerase to improve nucleic acid amplification process |
| AT402203B (de) | 1995-06-13 | 1997-03-25 | Himmler Gottfried Dipl Ing Dr | Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren |
| US5716784A (en) | 1996-02-05 | 1998-02-10 | The Perkin-Elmer Corporation | Fluorescence detection assay for homogeneous PCR hybridization systems |
| JP4468488B2 (ja) | 1996-05-29 | 2010-05-26 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 組み合せたリガーゼ検出およびポリメラーゼ連鎖反応を用いる核酸配列相違の検出 |
| US5985567A (en) | 1997-08-15 | 1999-11-16 | Beckman Coulter, Inc. | Hybridization detection by pretreating bound single-stranded probes |
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| WO2005083128A2 (en) | 2004-02-25 | 2005-09-09 | University Of South Florida | Methods for predicting cancer outcome and gene signatures for use therein |
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| WO2009144581A1 (en) | 2008-05-27 | 2009-12-03 | Dako Denmark A/S | Hybridization compositions and methods |
| WO2010060055A1 (en) | 2008-11-21 | 2010-05-27 | Duke University | Predicting cancer risk and treatment success |
-
2012
- 2012-01-25 EA EA201391074A patent/EA201391074A1/ru unknown
- 2012-01-25 US US13/981,601 patent/US10196691B2/en not_active Expired - Fee Related
- 2012-01-25 CN CN201280010123.2A patent/CN103403543B9/zh not_active Expired - Fee Related
- 2012-01-25 WO PCT/US2012/022594 patent/WO2012103250A2/en not_active Ceased
- 2012-01-25 SG SG2013056254A patent/SG192108A1/en unknown
- 2012-01-25 MX MX2013008367A patent/MX2013008367A/es unknown
- 2012-01-25 AU AU2012209074A patent/AU2012209074A1/en not_active Abandoned
- 2012-01-25 JP JP2013551314A patent/JP2014509189A/ja active Pending
- 2012-01-25 EP EP12739742.0A patent/EP2668296B1/en not_active Not-in-force
- 2012-01-25 KR KR1020137021973A patent/KR20140006898A/ko not_active Withdrawn
- 2012-01-25 CA CA2825218A patent/CA2825218A1/en not_active Abandoned
- 2012-01-25 BR BR112013018924-0A patent/BR112013018924A2/en not_active IP Right Cessation
-
2013
- 2013-07-04 ZA ZA2013/05024A patent/ZA201305024B/en unknown
- 2013-07-24 IL IL227643A patent/IL227643A0/en unknown
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