AU2012209074A1 - Colon cancer gene expression signatures and methods of use - Google Patents

Colon cancer gene expression signatures and methods of use Download PDF

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Publication number
AU2012209074A1
AU2012209074A1 AU2012209074A AU2012209074A AU2012209074A1 AU 2012209074 A1 AU2012209074 A1 AU 2012209074A1 AU 2012209074 A AU2012209074 A AU 2012209074A AU 2012209074 A AU2012209074 A AU 2012209074A AU 2012209074 A1 AU2012209074 A1 AU 2012209074A1
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AU
Australia
Prior art keywords
colon cancer
transcripts
nucleic acid
sample
expression level
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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AU2012209074A
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English (en)
Inventor
Julie BLACK
Max Bylesjo
Timothy Davison
Vadim FARZTDINOV
Denis Paul Harkin
Robert James Holt
Richard Kennedy
Peter Kerr
Vitali Proutski
Claire WILSON
Andreas Winter
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Almac Diagnostics Ltd
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Almac Diagnostics Ltd
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Filing date
Publication date
Application filed by Almac Diagnostics Ltd filed Critical Almac Diagnostics Ltd
Publication of AU2012209074A1 publication Critical patent/AU2012209074A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2012209074A 2011-01-25 2012-01-25 Colon cancer gene expression signatures and methods of use Abandoned AU2012209074A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161435922P 2011-01-25 2011-01-25
US61/435,922 2011-01-25
PCT/US2012/022594 WO2012103250A2 (en) 2011-01-25 2012-01-25 Colon cancer gene expression signatures and methods of use

Publications (1)

Publication Number Publication Date
AU2012209074A1 true AU2012209074A1 (en) 2013-07-11

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Family Applications (1)

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AU2012209074A Abandoned AU2012209074A1 (en) 2011-01-25 2012-01-25 Colon cancer gene expression signatures and methods of use

Country Status (14)

Country Link
US (1) US10196691B2 (enExample)
EP (1) EP2668296B1 (enExample)
JP (1) JP2014509189A (enExample)
KR (1) KR20140006898A (enExample)
CN (1) CN103403543B9 (enExample)
AU (1) AU2012209074A1 (enExample)
BR (1) BR112013018924A2 (enExample)
CA (1) CA2825218A1 (enExample)
EA (1) EA201391074A1 (enExample)
IL (1) IL227643A0 (enExample)
MX (1) MX2013008367A (enExample)
SG (1) SG192108A1 (enExample)
WO (1) WO2012103250A2 (enExample)
ZA (1) ZA201305024B (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011237729B2 (en) 2010-04-05 2014-04-03 Prognosys Biosciences, Inc. Spatially encoded biological assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US20130074201A1 (en) * 2011-09-16 2013-03-21 The Johns Hopkins University Cancer-specific genetic rearrangements
US9593365B2 (en) * 2012-10-17 2017-03-14 Spatial Transcriptions Ab Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
DK3013983T3 (da) 2013-06-25 2023-03-06 Prognosys Biosciences Inc Spatialt kodede biologiske assays ved brug af en mikrofluidisk anordning
US9652722B1 (en) * 2013-12-05 2017-05-16 The Mathworks, Inc. Methods and systems for robust supervised machine learning
EP3108254B8 (en) * 2014-02-17 2019-06-12 Ventana Medical Systems, Inc. G-alpha, interacting vesicle associated protein (giv) as a predictive marker in stage ii colorectal cancer
JP6608424B2 (ja) 2014-04-10 2019-11-20 バイオ−マルケア テクノロジーズ リミテッド 前癌性結腸直腸ポリープおよび結腸直腸癌を特定するための方法およびキット
CN120425026A (zh) 2015-04-10 2025-08-05 十程基因技术瑞典公司 生物样本的空间区别、多重核酸分析
CN108020672A (zh) * 2016-11-03 2018-05-11 中国医学科学院基础医学研究所 检测rhbdd1蛋白的elisa方法及试剂盒
WO2018107023A1 (en) * 2016-12-08 2018-06-14 Dana-Farber Cancer Institute, Inc. Metabolic profiling of fixed samples
CN107158388B (zh) * 2017-07-11 2021-03-23 上海市第一人民医院 MIIP pS303阻断剂在制备抗肿瘤药物中的应用
BR112020014737A2 (pt) * 2018-01-22 2020-12-08 Liquid Biopsy Research LLC Métodos para detecção e tratamento do câncer de cólon com monitoramento
WO2019200177A1 (en) * 2018-04-12 2019-10-17 Board Of Regents, The University Of Texas System Biomarker for detecting cancer
JP2020028278A (ja) * 2018-08-24 2020-02-27 国立大学法人九州大学 被検体に生じるイベントを予測するための判別器の生成方法、及び前記判別器を用いた被検体の層別化方法
CN111321220A (zh) * 2018-12-14 2020-06-23 中国医学科学院肿瘤医院 用于检测直肠癌放化疗敏感性的组合物、微阵列和计算机系统
CN110079607B (zh) * 2019-04-04 2022-08-02 陕西师范大学 一种引物组、检测血液样品种属的方法及应用
EP3976820A1 (en) 2019-05-30 2022-04-06 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
EP4158054B1 (en) 2020-06-02 2025-04-16 10X Genomics, Inc. Spatial transcriptomics for antigen-receptors
WO2021247543A2 (en) 2020-06-02 2021-12-09 10X Genomics, Inc. Nucleic acid library methods
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
EP4172621A1 (en) * 2020-06-30 2023-05-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies
CN111951883A (zh) * 2020-08-04 2020-11-17 广东省第二人民医院（广东省卫生应急医院） 一种特征mRNA表达谱组合及结肠癌早期预测方法
AU2022256363A1 (en) * 2021-04-14 2023-11-02 Amgen Inc. Automated outlier removal for multivariate modeling
CN115786518A (zh) * 2022-11-29 2023-03-14 广东医科大学附属医院 嗅素结构域家族蛋白4（olfm4）在结肠癌检测产品中的应用
WO2024206495A2 (en) * 2023-03-27 2024-10-03 Immunis.Ai, Inc. Active surveillance and risk stratification for prostate cancer
CN119372311A (zh) * 2024-09-30 2025-01-28 东南大学 基于成纤维细胞相关基因的结肠癌预后和治疗抵抗预测模型的构建方法和应用
CN120009551B (zh) * 2025-02-27 2025-08-15 西南医科大学 剪接因子wbp11及其抑制剂的用途、预防或治疗结直肠癌的药物

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985001051A1 (en) 1983-09-02 1985-03-14 Molecular Biosystems, Inc. Oligonucleotide polymeric support system
AU622426B2 (en) 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
WO1990001069A1 (en) 1988-07-20 1990-02-08 Segev Diagnostics, Inc. Process for amplifying and detecting nucleic acid sequences
US5219727A (en) 1989-08-21 1993-06-15 Hoffmann-Laroche Inc. Quantitation of nucleic acids using the polymerase chain reaction
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
US5554501A (en) 1992-10-29 1996-09-10 Beckman Instruments, Inc. Biopolymer synthesis using surface activated biaxially oriented polypropylene
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
WO1995030774A1 (en) 1994-05-05 1995-11-16 Beckman Instruments, Inc. Oligonucleotide repeat arrays
EP0776376B1 (en) 1994-07-15 2001-11-21 Akzo Nobel N.V. Use of rna polymerase to improve nucleic acid amplification process
AT402203B (de) 1995-06-13 1997-03-25 Himmler Gottfried Dipl Ing Dr Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren
US5716784A (en) 1996-02-05 1998-02-10 The Perkin-Elmer Corporation Fluorescence detection assay for homogeneous PCR hybridization systems
CA2255774C (en) 1996-05-29 2008-03-18 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US5985567A (en) 1997-08-15 1999-11-16 Beckman Coulter, Inc. Hybridization detection by pretreating bound single-stranded probes
US6013789A (en) 1998-02-20 2000-01-11 Beckman Coulter, Inc. Covalent attachment of biomolecules to derivatized polypropylene supports
WO2001073027A2 (en) 2000-03-24 2001-10-04 Corixa Corporation Compositions and methods for therapy and diagnosis of colon cancer
JP2005523688A (ja) 2002-01-18 2005-08-11 ブリストル−マイヤーズ　スクイブ　カンパニー タンパク質チロシンキナーゼおよび／またはタンパク質チロシンキナーゼ経路と相互作用する化合物の活性を予測するためのポリヌクレオチドおよびポリペプチドの同定
JP2006507841A (ja) 2002-11-14 2006-03-09 ダーマコン， インコーポレイテッド 機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ
US7250496B2 (en) 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
WO2004066941A2 (en) 2003-01-24 2004-08-12 Bayer Pharmaceuticals Corporation Expression profiles for colon cancer and methods of use
WO2005054508A2 (en) 2003-12-01 2005-06-16 Ipsogen Gene expression profiling of colon cancer by dna microarrays and correlation with survival and histoclinical parameters
JP2008504803A (ja) 2004-01-09 2008-02-21 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 遺伝子発現の細胞型特異的パターン
WO2005083128A2 (en) 2004-02-25 2005-09-09 University Of South Florida Methods for predicting cancer outcome and gene signatures for use therein
US20060195266A1 (en) 2005-02-25 2006-08-31 Yeatman Timothy J Methods for predicting cancer outcome and gene signatures for use therein
EP1774044A4 (en) 2004-06-03 2009-06-10 Univ Johns Hopkins METHOD FOR CHECKING CELL PROLIFERATION OR NEOPLASTIC INTERFERENCE
US20060134663A1 (en) 2004-11-03 2006-06-22 Paul Harkin Transcriptome microarray technology and methods of using the same
JP5237817B2 (ja) 2005-10-21 2013-07-17 ジーンニュース インコーポレーティッド バイオマーカー産物レベルを疾患に相関させるための方法および装置
CA2636984A1 (en) * 2006-01-11 2007-07-19 Genomic Health, Inc. Gene expression markers for colorectal cancer prognosis
US20100009905A1 (en) * 2006-03-24 2010-01-14 Macina Roberto A Compositions and Methods for Detection, Prognosis and Treatment of Colon Cancer
WO2008093323A2 (en) * 2007-01-29 2008-08-07 Compugen Ltd. Novel nucleotide and amino acid sequences, and methods of use thereof for diagnosis
NZ562237A (en) 2007-10-05 2011-02-25 Pacific Edge Biotechnology Ltd Proliferation signature and prognosis for gastrointestinal cancer
EP2636757B1 (en) * 2008-05-27 2016-11-23 Dako Denmark A/S Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers
WO2010060055A1 (en) 2008-11-21 2010-05-27 Duke University Predicting cancer risk and treatment success

Also Published As

Publication number Publication date
EP2668296B1 (en) 2018-08-15
US10196691B2 (en) 2019-02-05
MX2013008367A (es) 2013-08-12
ZA201305024B (en) 2014-03-26
NZ612471A (en) 2015-11-27
WO2012103250A2 (en) 2012-08-02
EP2668296A2 (en) 2013-12-04
US20140094379A1 (en) 2014-04-03
CA2825218A1 (en) 2012-08-02
EA201391074A1 (ru) 2013-12-30
KR20140006898A (ko) 2014-01-16
EP2668296A4 (en) 2015-09-02
CN103403543A (zh) 2013-11-20
JP2014509189A (ja) 2014-04-17
WO2012103250A3 (en) 2012-10-11
CN103403543B (zh) 2016-11-09
IL227643A0 (en) 2013-09-30
BR112013018924A2 (en) 2018-05-08
CN103403543B9 (zh) 2017-05-17
SG192108A1 (en) 2013-08-30

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