MX2013008367A - Firmas de esxpresion genetica de cancer de colon y metodos de uso. - Google Patents
Firmas de esxpresion genetica de cancer de colon y metodos de uso.Info
- Publication number
- MX2013008367A MX2013008367A MX2013008367A MX2013008367A MX2013008367A MX 2013008367 A MX2013008367 A MX 2013008367A MX 2013008367 A MX2013008367 A MX 2013008367A MX 2013008367 A MX2013008367 A MX 2013008367A MX 2013008367 A MX2013008367 A MX 2013008367A
- Authority
- MX
- Mexico
- Prior art keywords
- colon cancer
- gene expression
- methods
- cancer gene
- expression signatures
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57419—Specifically defined cancers of colon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se provee una firma de expresión genética de cáncer de colon, microarreglos que la incluyen y métodos de uso de la firma de expresión genética de colon. La firma de expresión genética es especialmente útil para determinar la prognosis de un paciente diagnosticado con cáncer de colon, tal como cáncer de colon etapa II. La firma genética descrita en la presente es también útil para determinar la efectividad de resección quirúrgica con o sin quimioterapia adyuvante y determinar la posibilidad de recurrencia de cáncer en pacientes con cáncer de colon.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161435922P | 2011-01-25 | 2011-01-25 | |
PCT/US2012/022594 WO2012103250A2 (en) | 2011-01-25 | 2012-01-25 | Colon cancer gene expression signatures and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013008367A true MX2013008367A (es) | 2013-08-12 |
Family
ID=46581385
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013008367A MX2013008367A (es) | 2011-01-25 | 2012-01-25 | Firmas de esxpresion genetica de cancer de colon y metodos de uso. |
Country Status (14)
Country | Link |
---|---|
US (1) | US10196691B2 (es) |
EP (1) | EP2668296B1 (es) |
JP (1) | JP2014509189A (es) |
KR (1) | KR20140006898A (es) |
CN (1) | CN103403543B9 (es) |
AU (1) | AU2012209074A1 (es) |
BR (1) | BR112013018924A2 (es) |
CA (1) | CA2825218A1 (es) |
EA (1) | EA201391074A1 (es) |
IL (1) | IL227643A0 (es) |
MX (1) | MX2013008367A (es) |
SG (1) | SG192108A1 (es) |
WO (1) | WO2012103250A2 (es) |
ZA (1) | ZA201305024B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
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US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
RS54482B1 (en) | 2010-04-05 | 2016-06-30 | Prognosys Biosciences, Inc. | SPATIAL CODING BIOLOGICAL TESTING |
US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
US20130074201A1 (en) * | 2011-09-16 | 2013-03-21 | The Johns Hopkins University | Cancer-specific genetic rearrangements |
DK3511423T4 (da) * | 2012-10-17 | 2024-07-29 | Spatial Transcriptomics Ab | Fremgangsmåder og produkt til optimering af lokaliseret eller rumlig detektion af genekspression i en vævsprøve |
EP4234716A3 (en) | 2013-06-25 | 2023-12-06 | Prognosys Biosciences, Inc. | Methods for determining spatial patterns of biological targets in a sample |
US9652722B1 (en) * | 2013-12-05 | 2017-05-16 | The Mathworks, Inc. | Methods and systems for robust supervised machine learning |
AU2015216886A1 (en) * | 2014-02-17 | 2016-08-25 | F. Hoffmann-La Roche Ag | G-alpha, interacting vesicle associated protein (GIV) as a predictive marker in stage II colorectal cancer |
WO2015155765A1 (en) * | 2014-04-10 | 2015-10-15 | Bio-Marcare Technologies Ltd. | Methods and kits for identifying pre-cancerous colorectal polyps and colorectal cancer |
EP3530752B1 (en) | 2015-04-10 | 2021-03-24 | Spatial Transcriptomics AB | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
CN108020672A (zh) * | 2016-11-03 | 2018-05-11 | 中国医学科学院基础医学研究所 | 检测rhbdd1蛋白的elisa方法及试剂盒 |
WO2018107023A1 (en) * | 2016-12-08 | 2018-06-14 | Dana-Farber Cancer Institute, Inc. | Metabolic profiling of fixed samples |
CN107158388B (zh) * | 2017-07-11 | 2021-03-23 | 上海市第一人民医院 | MIIP pS303阻断剂在制备抗肿瘤药物中的应用 |
SG11202006974WA (en) * | 2018-01-22 | 2020-08-28 | Liquid Biopsy Res Llc | Methods for colon cancer detection and treatment monitoring |
US20210148912A1 (en) * | 2018-04-12 | 2021-05-20 | Board Of Regents, The University Of Texas System | Biomarker for detecting cancer |
JP2020028278A (ja) * | 2018-08-24 | 2020-02-27 | 国立大学法人九州大学 | 被検体に生じるイベントを予測するための判別器の生成方法、及び前記判別器を用いた被検体の層別化方法 |
CN111321220A (zh) * | 2018-12-14 | 2020-06-23 | 中国医学科学院肿瘤医院 | 用于检测直肠癌放化疗敏感性的组合物、微阵列和计算机系统 |
CN110079607B (zh) * | 2019-04-04 | 2022-08-02 | 陕西师范大学 | 一种引物组、检测血液样品种属的方法及应用 |
EP3976820A1 (en) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
CN116249785A (zh) | 2020-06-02 | 2023-06-09 | 10X基因组学有限公司 | 用于抗原-受体的空间转录组学 |
AU2021283174A1 (en) | 2020-06-02 | 2023-01-05 | 10X Genomics, Inc. | Nucleic acid library methods |
ES2981265T3 (es) | 2020-06-08 | 2024-10-08 | 10X Genomics Inc | Métodos para determinar un margen quirúrgico y métodos de uso del mismo |
CN111951883A (zh) * | 2020-08-04 | 2020-11-17 | 广东省第二人民医院(广东省卫生应急医院) | 一种特征mRNA表达谱组合及结肠癌早期预测方法 |
CN115786518A (zh) * | 2022-11-29 | 2023-03-14 | 广东医科大学附属医院 | 嗅素结构域家族蛋白4(olfm4)在结肠癌检测产品中的应用 |
Family Cites Families (34)
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DE3481060D1 (de) | 1983-09-02 | 1990-02-22 | Molecular Biosystems Inc | Oligonukleotid-polymer-tragsystem. |
CA1323293C (en) | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
WO1990001069A1 (en) | 1988-07-20 | 1990-02-08 | Segev Diagnostics, Inc. | Process for amplifying and detecting nucleic acid sequences |
US5219727A (en) | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
US5427930A (en) | 1990-01-26 | 1995-06-27 | Abbott Laboratories | Amplification of target nucleic acids using gap filling ligase chain reaction |
US5554501A (en) | 1992-10-29 | 1996-09-10 | Beckman Instruments, Inc. | Biopolymer synthesis using surface activated biaxially oriented polypropylene |
US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
US5648211A (en) | 1994-04-18 | 1997-07-15 | Becton, Dickinson And Company | Strand displacement amplification using thermophilic enzymes |
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AT402203B (de) | 1995-06-13 | 1997-03-25 | Himmler Gottfried Dipl Ing Dr | Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren |
US5716784A (en) | 1996-02-05 | 1998-02-10 | The Perkin-Elmer Corporation | Fluorescence detection assay for homogeneous PCR hybridization systems |
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KR20070052694A (ko) | 2004-01-09 | 2007-05-22 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 유전자 발현을 위한 세포-유형-특이적 패턴 |
WO2005083128A2 (en) | 2004-02-25 | 2005-09-09 | University Of South Florida | Methods for predicting cancer outcome and gene signatures for use therein |
US20060195266A1 (en) | 2005-02-25 | 2006-08-31 | Yeatman Timothy J | Methods for predicting cancer outcome and gene signatures for use therein |
CA2569079A1 (en) | 2004-06-03 | 2005-12-15 | The Johns Hopkins University | Methods of screening for cell proliferation or neoplastic disorders |
CA2586201A1 (en) | 2004-11-03 | 2006-05-11 | Almac Diagnostics Limited | Transcriptome microarray technology and methods of using the same |
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NZ593228A (en) * | 2006-01-11 | 2012-10-26 | Genomic Health Inc | Gene expression markers (inhba) for colorectal cancer prognosis |
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US20100261169A1 (en) * | 2007-01-29 | 2010-10-14 | Shira Wallach | Novel nucleotide and amino acid sequences, and methods of use thereof for diagnosis |
NZ562237A (en) | 2007-10-05 | 2011-02-25 | Pacific Edge Biotechnology Ltd | Proliferation signature and prognosis for gastrointestinal cancer |
ES2610588T3 (es) * | 2008-05-27 | 2017-04-28 | Dako Denmark A/S | Composiciones y métodos para la detección de aberraciones cromosómicas con tampones de hibridación novedosos |
WO2010060055A1 (en) | 2008-11-21 | 2010-05-27 | Duke University | Predicting cancer risk and treatment success |
-
2012
- 2012-01-25 MX MX2013008367A patent/MX2013008367A/es unknown
- 2012-01-25 CN CN201280010123.2A patent/CN103403543B9/zh not_active Expired - Fee Related
- 2012-01-25 SG SG2013056254A patent/SG192108A1/en unknown
- 2012-01-25 WO PCT/US2012/022594 patent/WO2012103250A2/en active Application Filing
- 2012-01-25 EP EP12739742.0A patent/EP2668296B1/en not_active Not-in-force
- 2012-01-25 AU AU2012209074A patent/AU2012209074A1/en not_active Abandoned
- 2012-01-25 EA EA201391074A patent/EA201391074A1/ru unknown
- 2012-01-25 KR KR1020137021973A patent/KR20140006898A/ko not_active Application Discontinuation
- 2012-01-25 CA CA2825218A patent/CA2825218A1/en not_active Abandoned
- 2012-01-25 BR BR112013018924A patent/BR112013018924A2/pt not_active IP Right Cessation
- 2012-01-25 US US13/981,601 patent/US10196691B2/en not_active Expired - Fee Related
- 2012-01-25 JP JP2013551314A patent/JP2014509189A/ja active Pending
-
2013
- 2013-07-04 ZA ZA2013/05024A patent/ZA201305024B/en unknown
- 2013-07-24 IL IL227643A patent/IL227643A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2014509189A (ja) | 2014-04-17 |
WO2012103250A3 (en) | 2012-10-11 |
US10196691B2 (en) | 2019-02-05 |
EP2668296A2 (en) | 2013-12-04 |
NZ612471A (en) | 2015-11-27 |
ZA201305024B (en) | 2014-03-26 |
KR20140006898A (ko) | 2014-01-16 |
US20140094379A1 (en) | 2014-04-03 |
AU2012209074A1 (en) | 2013-07-11 |
CA2825218A1 (en) | 2012-08-02 |
BR112013018924A2 (pt) | 2018-05-08 |
CN103403543A (zh) | 2013-11-20 |
CN103403543B (zh) | 2016-11-09 |
WO2012103250A2 (en) | 2012-08-02 |
EP2668296A4 (en) | 2015-09-02 |
IL227643A0 (en) | 2013-09-30 |
EP2668296B1 (en) | 2018-08-15 |
SG192108A1 (en) | 2013-08-30 |
CN103403543B9 (zh) | 2017-05-17 |
EA201391074A1 (ru) | 2013-12-30 |
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