CN103403543B9 - 结肠癌基因表达签名及使用方法 - Google Patents

结肠癌基因表达签名及使用方法 Download PDF

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CN103403543B9
CN103403543B9 CN201280010123.2A CN201280010123A CN103403543B9 CN 103403543 B9 CN103403543 B9 CN 103403543B9 CN 201280010123 A CN201280010123 A CN 201280010123A CN 103403543 B9 CN103403543 B9 CN 103403543B9
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colon cancer
expression
nucleic acid
sample
transcript
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CN103403543B (zh
CN103403543A (zh
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D·P·哈金
V·普鲁特斯基
J·布莱克
P·科尔
R·肯尼迪
A·温特
T·达维森
M·柏莱斯周
V·法尔滋特迪诺夫
C·威尔森
R·J·霍尔特
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Almac Diagnostics Ltd
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Almac Diagnostics Ltd
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57419Specifically defined cancers of colon
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Wood Science & Technology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
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  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201280010123.2A 2011-01-25 2012-01-25 结肠癌基因表达签名及使用方法 Expired - Fee Related CN103403543B9 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161435922P 2011-01-25 2011-01-25
US61/435,922 2011-01-25
PCT/US2012/022594 WO2012103250A2 (en) 2011-01-25 2012-01-25 Colon cancer gene expression signatures and methods of use

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CN103403543A CN103403543A (zh) 2013-11-20
CN103403543B CN103403543B (zh) 2016-11-09
CN103403543B9 true CN103403543B9 (zh) 2017-05-17

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US (1) US10196691B2 (enExample)
EP (1) EP2668296B1 (enExample)
JP (1) JP2014509189A (enExample)
KR (1) KR20140006898A (enExample)
CN (1) CN103403543B9 (enExample)
AU (1) AU2012209074A1 (enExample)
BR (1) BR112013018924A2 (enExample)
CA (1) CA2825218A1 (enExample)
EA (1) EA201391074A1 (enExample)
IL (1) IL227643A0 (enExample)
MX (1) MX2013008367A (enExample)
SG (1) SG192108A1 (enExample)
WO (1) WO2012103250A2 (enExample)
ZA (1) ZA201305024B (enExample)

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WO2015121465A1 (en) * 2014-02-17 2015-08-20 Ventana Medical Systems, Inc. G-alpha, interacting vesicle associated protein (giv) as a predictive marker in stage ii colorectal cancer
CN106460047B (zh) * 2014-04-10 2019-11-26 比奥马卡尔技术有限公司 用于鉴定癌前结肠直肠息肉和结肠直肠癌的方法及试剂盒
EP4119677B1 (en) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
CN108020672A (zh) * 2016-11-03 2018-05-11 中国医学科学院基础医学研究所 检测rhbdd1蛋白的elisa方法及试剂盒
WO2018107023A1 (en) * 2016-12-08 2018-06-14 Dana-Farber Cancer Institute, Inc. Metabolic profiling of fixed samples
CN107158388B (zh) * 2017-07-11 2021-03-23 上海市第一人民医院 MIIP pS303阻断剂在制备抗肿瘤药物中的应用
EP3743534B1 (en) * 2018-01-22 2022-03-23 Liquid Biopsy Research LLC Methods for colon cancer detection and treatment monitoring
AU2019252672B2 (en) * 2018-04-12 2025-08-14 Board Of Regents, The University Of Texas System Biomarker for detecting cancer
JP2020028278A (ja) * 2018-08-24 2020-02-27 国立大学法人九州大学 被検体に生じるイベントを予測するための判別器の生成方法、及び前記判別器を用いた被検体の層別化方法
CN111321220A (zh) * 2018-12-14 2020-06-23 中国医学科学院肿瘤医院 用于检测直肠癌放化疗敏感性的组合物、微阵列和计算机系统
CN110079607B (zh) * 2019-04-04 2022-08-02 陕西师范大学 一种引物组、检测血液样品种属的方法及应用
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WO2022002873A1 (en) * 2020-06-30 2022-01-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies
CN111951883A (zh) * 2020-08-04 2020-11-17 广东省第二人民医院(广东省卫生应急医院) 一种特征mRNA表达谱组合及结肠癌早期预测方法
CN115786518A (zh) * 2022-11-29 2023-03-14 广东医科大学附属医院 嗅素结构域家族蛋白4(olfm4)在结肠癌检测产品中的应用
WO2024206495A2 (en) * 2023-03-27 2024-10-03 Immunis.Ai, Inc. Active surveillance and risk stratification for prostate cancer
CN119372311A (zh) * 2024-09-30 2025-01-28 东南大学 基于成纤维细胞相关基因的结肠癌预后和治疗抵抗预测模型的构建方法和应用
CN120009551B (zh) * 2025-02-27 2025-08-15 西南医科大学 剪接因子wbp11及其抑制剂的用途、预防或治疗结直肠癌的药物

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Also Published As

Publication number Publication date
EP2668296A4 (en) 2015-09-02
CN103403543B (zh) 2016-11-09
AU2012209074A1 (en) 2013-07-11
EA201391074A1 (ru) 2013-12-30
IL227643A0 (en) 2013-09-30
US10196691B2 (en) 2019-02-05
BR112013018924A2 (pt) 2018-05-08
SG192108A1 (en) 2013-08-30
ZA201305024B (en) 2014-03-26
WO2012103250A3 (en) 2012-10-11
EP2668296B1 (en) 2018-08-15
EP2668296A2 (en) 2013-12-04
US20140094379A1 (en) 2014-04-03
JP2014509189A (ja) 2014-04-17
CA2825218A1 (en) 2012-08-02
CN103403543A (zh) 2013-11-20
MX2013008367A (es) 2013-08-12
KR20140006898A (ko) 2014-01-16
NZ612471A (en) 2015-11-27
WO2012103250A2 (en) 2012-08-02

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