JP2013501523A5 - - Google Patents

Info

Publication number

JP2013501523A5

JP2013501523A5 JP2012524782A JP2012524782A JP2013501523A5 JP 2013501523 A5 JP2013501523 A5 JP 2013501523A5 JP 2012524782 A JP2012524782 A JP 2012524782A JP 2012524782 A JP2012524782 A JP 2012524782A JP 2013501523 A5 JP2013501523 A5 JP 2013501523A5

Authority

JP

Japan

Prior art keywords

seq

braf

sample

sequence

amplification reaction

Prior art date

2010-08-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims 47
• 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims 47
• 239000000523 sample Substances 0.000 claims 42
• 230000003321 amplification Effects 0.000 claims 36
• 238000003199 nucleic acid amplification method Methods 0.000 claims 36
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 34
• 238000006243 chemical reaction Methods 0.000 claims 22
• 239000013615 primer Substances 0.000 claims 19
• 230000035772 mutation Effects 0.000 claims 16
• 238000000034 method Methods 0.000 claims 14
• 238000000137 annealing Methods 0.000 claims 8
• 102220197820 rs121913227 Human genes 0.000 claims 7
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
• 108020004999 messenger RNA Proteins 0.000 claims 6
• 150000007523 nucleic acids Chemical class 0.000 claims 6
• 238000001514 detection method Methods 0.000 claims 5
• 206010028980 Neoplasm Diseases 0.000 claims 4
• 108091034117 Oligonucleotide Proteins 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 239000003155 DNA primer Substances 0.000 claims 3
• 101150048834 braF gene Proteins 0.000 claims 3
• 102200055464 rs113488022 Human genes 0.000 claims 3
• 102220198068 rs113488022 Human genes 0.000 claims 3
• 102200055469 rs121913377 Human genes 0.000 claims 3
• 102220014069 rs121913378 Human genes 0.000 claims 3
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
• 108020004414 DNA Proteins 0.000 claims 2
• 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 2
• 108020004711 Nucleic Acid Probes Proteins 0.000 claims 2
• 238000002512 chemotherapy Methods 0.000 claims 2
• 230000014509 gene expression Effects 0.000 claims 2
• 208000021039 metastatic melanoma Diseases 0.000 claims 2
• 239000002853 nucleic acid probe Substances 0.000 claims 2
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1