GB0700374D0 - NDRG family methylation markers - Google Patents

NDRG family methylation markers

Info

Publication number
GB0700374D0
GB0700374D0 GBGB0700374.2A GB0700374A GB0700374D0 GB 0700374 D0 GB0700374 D0 GB 0700374D0 GB 0700374 A GB0700374 A GB 0700374A GB 0700374 D0 GB0700374 D0 GB 0700374D0
Authority
GB
United Kingdom
Prior art keywords
methylation markers
ndrg family
ndrg
family
methylation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0700374.2A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MDxHealth SA
Original Assignee
OncoMethylome Sciences SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37801915&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB0700374(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by OncoMethylome Sciences SA filed Critical OncoMethylome Sciences SA
Priority to GBGB0700374.2A priority Critical patent/GB0700374D0/en
Publication of GB0700374D0 publication Critical patent/GB0700374D0/en
Priority to CN200880007698A priority patent/CN101680025A/zh
Priority to JP2009545222A priority patent/JP5721950B2/ja
Priority to US12/522,648 priority patent/US8969046B2/en
Priority to EP13156618.4A priority patent/EP2650377B1/en
Priority to EP08700153.3A priority patent/EP2069527B1/en
Priority to PCT/GB2008/000056 priority patent/WO2008084219A1/en
Priority to EP18176135.4A priority patent/EP3434791B1/en
Priority to CA2674988A priority patent/CA2674988C/en
Priority to US14/613,574 priority patent/US9982308B2/en
Priority to JP2015062366A priority patent/JP6141896B2/ja
Priority to US15/971,461 priority patent/US10808286B2/en
Priority to US16/154,023 priority patent/US11149317B2/en
Priority to US17/475,584 priority patent/US12215389B2/en
Priority to US19/002,264 priority patent/US20250137070A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
GBGB0700374.2A 2007-01-09 2007-01-09 NDRG family methylation markers Ceased GB0700374D0 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
GBGB0700374.2A GB0700374D0 (en) 2007-01-09 2007-01-09 NDRG family methylation markers
CA2674988A CA2674988C (en) 2007-01-09 2008-01-09 Epigenetic change in the ndrg4 gene and cancer
JP2009545222A JP5721950B2 (ja) 2007-01-09 2008-01-09 選択された遺伝子のエピジェネティックな変化及び癌
EP08700153.3A EP2069527B1 (en) 2007-01-09 2008-01-09 Epigenetic change in selected genes and cancer
EP18176135.4A EP3434791B1 (en) 2007-01-09 2008-01-09 Epigenetic change in selected genes and cancer
US12/522,648 US8969046B2 (en) 2007-01-09 2008-01-09 Methods for detecting epigenetic modifications
EP13156618.4A EP2650377B1 (en) 2007-01-09 2008-01-09 Epigenetic change in selected genes and cancer
CN200880007698A CN101680025A (zh) 2007-01-09 2008-01-09 选定基因中的表观遗传变化和癌症
PCT/GB2008/000056 WO2008084219A1 (en) 2007-01-09 2008-01-09 Epigenetic change in selected genes and cancer
US14/613,574 US9982308B2 (en) 2007-01-09 2015-02-04 Methods for amplifying DNA from the promoter of the NDRG4 gene DNA obtained from a fecal sample
JP2015062366A JP6141896B2 (ja) 2007-01-09 2015-03-25 選択された遺伝子のエピジェネティックな変化及び癌
US15/971,461 US10808286B2 (en) 2007-01-09 2018-05-04 Methods for detecting epigenetic modifications
US16/154,023 US11149317B2 (en) 2007-01-09 2018-10-08 Methods for detecting epigenetic modifications
US17/475,584 US12215389B2 (en) 2007-01-09 2021-09-15 Compositions for detecting epigenetic modifications
US19/002,264 US20250137070A1 (en) 2007-01-09 2024-12-26 Methods for detecting epigenetic modifications

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0700374.2A GB0700374D0 (en) 2007-01-09 2007-01-09 NDRG family methylation markers

Publications (1)

Publication Number Publication Date
GB0700374D0 true GB0700374D0 (en) 2007-02-14

Family

ID=37801915

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0700374.2A Ceased GB0700374D0 (en) 2007-01-09 2007-01-09 NDRG family methylation markers

Country Status (7)

Country Link
US (6) US8969046B2 (enExample)
EP (3) EP2650377B1 (enExample)
JP (2) JP5721950B2 (enExample)
CN (1) CN101680025A (enExample)
CA (1) CA2674988C (enExample)
GB (1) GB0700374D0 (enExample)
WO (1) WO2008084219A1 (enExample)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005017207A2 (en) * 2003-08-14 2005-02-24 Case Western Reserve University Methods and compositions for detecting colon cancers
US8415100B2 (en) 2003-08-14 2013-04-09 Case Western Reserve University Methods and compositions for detecting gastrointestinal and other cancers
US12366585B2 (en) 2006-05-18 2025-07-22 Caris Mpi, Inc. Molecular profiling of tumors
GB0700374D0 (en) 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
CA2676227A1 (en) * 2007-02-12 2008-08-21 The Johns Hopkins University Early detection and prognosis of colon cancers
CN101932723B (zh) * 2007-09-17 2014-09-10 肿瘤甲基化科学公司 改进的对mage-a表达的检测
WO2009102788A2 (en) 2008-02-15 2009-08-20 Mayo Foundation For Medical Education And Research Detecting neoplasm
WO2009105549A2 (en) * 2008-02-19 2009-08-27 Oncomethylome Sciences Sa Detection and prognosis of lung cancer
EP2271774B1 (en) * 2008-03-21 2018-03-07 MDxHealth Detection and prognosis of cervical cancer
EP2294216A4 (en) 2008-05-14 2011-11-23 Dermtech Int DIAGNOSIS OF MELANOMA AND SOLAR LENTIGO BY ANALYSIS OF NUCLEIC ACIDS
US9249465B2 (en) * 2008-09-22 2016-02-02 Advpharma, Inc. Molecular markers for lung and colorectal carcinomas
US20120164238A1 (en) 2009-02-03 2012-06-28 Mdxhealth Sa Methods of detecting colorectal cancer
WO2010102823A1 (en) * 2009-03-13 2010-09-16 Oncomethylome Sciences Sa Novel markers for bladder cancer detection
WO2011056688A2 (en) 2009-10-27 2011-05-12 Caris Life Sciences, Inc. Molecular profiling for personalized medicine
EP2354242A1 (en) * 2010-02-03 2011-08-10 Epiontis GmbH Assay for determining the type and/or status of a cell based on the epigenetic pattern and the chromatin structure
WO2011119934A2 (en) 2010-03-26 2011-09-29 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal neoplasm
WO2011135058A2 (en) 2010-04-30 2011-11-03 Mdxhealth Sa Methods for detecting epigenetic modifications
EP2569452B1 (en) * 2010-05-14 2020-03-25 Life Technologies Corporation Karyotyping assay
JP5838557B2 (ja) * 2010-07-05 2016-01-06 ソニー株式会社 生体情報処理方法および装置、並びに記録媒体
JP6222202B2 (ja) * 2010-07-05 2017-11-01 ソニー株式会社 生体情報処理方法および装置、並びに記録媒体
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
WO2012106525A2 (en) * 2011-02-02 2012-08-09 Exact Sciences Corporation Digital sequence analysis of dna methylation
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
CN103649298A (zh) * 2011-05-12 2014-03-19 精密科学公司 核酸的分离
US10308980B2 (en) * 2011-11-04 2019-06-04 Oslo Universitetssykehus Hf Methods and biomarkers for analysis of colorectal cancer
CA2858144C (en) 2011-12-06 2021-05-04 Mdxhealth Sa Methods of detecting mutations and epigenetic changes
US9744155B2 (en) 2012-03-28 2017-08-29 Ixcela, Inc. IPA as a therapeutic agent, as a protective agent, and as a biomarker of disease risk
CA2874407A1 (en) 2012-05-24 2013-11-28 Fundacio Institut D'investigacio Biomedica De Bellvitge (Idibell) Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis
SG11201501465SA (en) 2012-08-31 2015-05-28 Nat Defense Medical Ct Method for screening cancer
CN102787174B (zh) * 2012-09-06 2013-08-07 南京大学 胃肠肿瘤发病相关抑癌基因表观突变检测试剂盒及其用途
EP2929350A4 (en) * 2012-12-04 2016-11-16 Caris Mpi Inc MOLECULAR PROFILING OF CANCER
CA2902916C (en) 2013-03-14 2018-08-28 Mayo Foundation For Medical Education And Research Detecting neoplasm
US9644232B2 (en) * 2013-07-26 2017-05-09 General Electric Company Method and device for collection and amplification of circulating nucleic acids
US10253358B2 (en) 2013-11-04 2019-04-09 Exact Sciences Development Company, Llc Multiple-control calibrators for DNA quantitation
EP2886659A1 (en) * 2013-12-20 2015-06-24 AIT Austrian Institute of Technology GmbH Gene methylation based colorectal cancer diagnosis
JP6830355B2 (ja) * 2014-01-31 2021-02-17 イクセラ，インコーポレイテッド バイオマーカーとしての共有結合した代謝物質
US11578373B2 (en) 2019-03-26 2023-02-14 Dermtech, Inc. Gene classifiers and uses thereof in skin cancers
JP2015177745A (ja) * 2014-03-18 2015-10-08 愛知県 肺癌の検査方法
ES2812753T3 (es) 2014-03-31 2021-03-18 Mayo Found Medical Education & Res Detección de neoplasma colorectal
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
CN104561258B (zh) * 2014-10-08 2016-08-24 王红卫 一种用于直结肠癌早期诊断的检测试剂盒及其应用
GB201418965D0 (enExample) 2014-10-24 2014-12-10 Ospedale San Raffaele And Fond Telethon
EP3225630B1 (en) 2014-11-27 2021-05-12 Public University Corporation Yokohama City University Method and reagent for detecting ovarian clear cell adenocarcinoma
US9984201B2 (en) 2015-01-18 2018-05-29 Youhealth Biotech, Limited Method and system for determining cancer status
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
CN107532124B (zh) 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
JP2016192909A (ja) * 2015-03-31 2016-11-17 シスメックス株式会社 胃癌に関する情報の取得方法、ならびに胃癌に関する情報を取得するためのマーカーおよび胃癌検出用キット
AU2016315924B2 (en) 2015-08-31 2022-08-25 Exact Sciences Corporation Detecting gastric neoplasm
ES2912965T3 (es) 2015-09-09 2022-05-30 Drawbridge Health Inc Dispositivos para la recopilación, estabilización y conservación de muestras
CN105177163B (zh) * 2015-10-21 2018-04-13 山东大学齐鲁医院 一种用于宫颈癌早期筛查的试剂盒
CN108350485A (zh) 2015-10-30 2018-07-31 精密科学发展有限责任公司 血浆dna的多重扩增检测测定以及分离和检测
AU2017250663B2 (en) 2016-04-14 2023-06-15 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
US10202650B2 (en) 2016-05-31 2019-02-12 Youhealth Biotech, Limited Methods for monitoring ELOVL2, KLF14 and PENK gene expression following treatment with vitamin C
CN106011263B (zh) * 2016-06-28 2020-01-07 宁波大学 用于检测与胃癌相关的ndrg4基因甲基化程度的试剂盒及其应用
CN106119361B (zh) * 2016-06-28 2020-01-07 宁波思锐生物科技有限公司 用于胃癌早期诊断及预后评估的ndrg4基因甲基化检测的试剂盒及其应用
CN113151458A (zh) 2016-07-06 2021-07-23 优美佳肿瘤技术有限公司 实体瘤甲基化标志物及其用途
EP3481953A4 (en) 2016-07-06 2020-04-15 Youhealth Biotech, Limited SPECIFIC METHYLATION MARKERS OF LIVER CANCER AND USES THEREOF
EP3481951A4 (en) 2016-07-06 2020-08-05 Youhealth Biotech, Limited COLON CANCER SPECIFIC METHYLATION MARKERS AND USES OF THESE MARKERS
US11396678B2 (en) 2016-07-06 2022-07-26 The Regent Of The University Of California Breast and ovarian cancer methylation markers and uses thereof
US10093986B2 (en) 2016-07-06 2018-10-09 Youhealth Biotech, Limited Leukemia methylation markers and uses thereof
WO2018008740A1 (ja) * 2016-07-08 2018-01-11 有限会社ハヌマット 大腸癌発症可能性の判定方法
CN106521006A (zh) * 2016-12-27 2017-03-22 刘鹏飞 Ndrg4基因甲基化检测用试剂体系和试剂盒及其应用
CN210383905U (zh) 2017-01-10 2020-04-24 集联健康有限公司 一种用于从受试者收集流体样品的装置以及运输套筒
CN108300783A (zh) * 2017-01-11 2018-07-20 上海易毕恩基因科技有限公司 用于筛选肠癌和/或胃癌的基因标志物的方法、用该方法筛选的基因标志物及其用途
CN110475875B (zh) 2017-01-27 2024-06-25 精密科学公司 通过分析甲基化dna检测结肠瘤形成
CA3054836A1 (en) 2017-02-28 2018-09-07 Mayo Foundation For Medical Education And Research Detecting prostate cancer
EP3589371A4 (en) 2017-03-02 2020-11-25 Youhealth Oncotech, Limited METHYLATION MARKERS FOR DIAGNOSING HEPATOCELLULAR CARCINOMA AND LUNG CANCER
EP3631461A1 (en) * 2017-06-02 2020-04-08 Verhaert, Peter Dominiek Emiel Maria Mass spectrometry histochemistry of peptides from formaldehyde-fixed, paraffin-embedded tissue
CN107177679A (zh) * 2017-06-07 2017-09-19 北京呈诺医学科技有限公司 一种检测食管鳞癌相关基因tfpi2和hspb2启动子甲基化程度的试剂盒
WO2018237327A1 (en) 2017-06-22 2018-12-27 Triact Therapeutics, Inc. Methods of treating glioblastoma
IT201700072650A1 (it) * 2017-06-28 2018-12-28 Univ Degli Studi Cagliari Metodo per rilevare e/o per la prognosi di neoplasie del colon-retto
US11628144B2 (en) 2017-09-29 2023-04-18 Triact Therapeutics, Inc. Iniparib formulations and uses thereof
US20200277677A1 (en) 2017-10-06 2020-09-03 Youhealth Oncotech, Limited Methylation markers for diagnosing cancer
KR102052089B1 (ko) * 2017-11-22 2019-12-05 연세대학교 산학협력단 유전자의 CpG 메틸화 변화를 이용한 간암의 위험도를 평가하는 방법
CN111655869B (zh) 2017-11-30 2024-06-28 梅约医学教育与研究基金会 检测乳腺癌
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
US11976332B2 (en) 2018-02-14 2024-05-07 Dermtech, Inc. Gene classifiers and uses thereof in non-melanoma skin cancers
US12027237B2 (en) 2018-03-13 2024-07-02 Grail, Llc Anomalous fragment detection and classification
CN108460247B (zh) * 2018-03-29 2022-06-07 上海锐翌生物科技有限公司 基于kras和ndrg4基因确定结直肠肿瘤细胞的方法和系统
WO2019195268A2 (en) 2018-04-02 2019-10-10 Grail, Inc. Methylation markers and targeted methylation probe panels
CN108707667B (zh) * 2018-06-01 2021-10-26 安徽达健医学科技有限公司 一种用于结直肠癌早期诊断的试剂盒及其使用方法
CA3136405A1 (en) * 2018-06-01 2019-12-05 Geneoscopy, Inc. Detection method for cancer using rna biomarkers
CN108796078B (zh) * 2018-06-05 2022-07-26 苏州唯善生物科技有限公司 一种用于消化道癌诊断、检测或筛查的引物和探针组
CN108977543B (zh) * 2018-08-06 2021-12-14 上海锐翌生物科技有限公司 一种基于联合检测sdc2和sfrp2基因甲基化水平的结直肠癌早期诊断试剂
US11441182B2 (en) * 2018-08-08 2022-09-13 Virginia Commonwealth University Multiplexed and recyclable single-molecule sensors for quantitative analysis of nucleic-acid biomarkers
AU2019351130B2 (en) 2018-09-27 2025-10-23 GRAIL, Inc Methylation markers and targeted methylation probe panel
EP3867405A4 (en) 2018-10-17 2022-07-20 The University of Queensland Epigenetic biomarker and uses therefor
IL311084A (en) 2018-11-30 2024-04-01 Caris Mpi Inc New generation molecular characterization
US12234514B2 (en) 2018-12-21 2025-02-25 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free DNA samples
US11041847B1 (en) 2019-01-25 2021-06-22 Ixcela, Inc. Detection and modification of gut microbial population
CN109943638A (zh) * 2019-05-08 2019-06-28 湖南百伯基因技术有限公司 一种检测ndrg4、sdc2和bmp3基因甲基化的引物探针组合及其应用和试剂盒
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
CN110283911A (zh) * 2019-06-28 2019-09-27 四川沃文特生物技术有限公司 用于粪便样本进行早期结直肠癌基因甲基化检测的引物对和探针及试剂盒
CN110343764B (zh) * 2019-07-22 2020-05-26 武汉艾米森生命科技有限公司 检测结直肠癌相关基因甲基化的检测试剂的应用和试剂盒
US11427874B1 (en) 2019-08-26 2022-08-30 Epi One Inc. Methods and systems for detection of prostate cancer by DNA methylation analysis
KR20220092561A (ko) 2019-10-31 2022-07-01 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 난소암 검출
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
WO2021112918A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
CN111549129B (zh) * 2020-03-30 2023-08-29 宁波美康盛德医学检验所有限公司 用于检测胃癌的试剂盒及其应用
WO2021222828A1 (en) * 2020-04-30 2021-11-04 Guardant Health, Inc. Methods for sequence determination using partitioned nucleic acids
US12467096B2 (en) 2020-05-15 2025-11-11 Universal Diagnostics, S.A. Methods and systems for identifying methylation biomarkers
WO2022002424A1 (en) 2020-06-30 2022-01-06 Universal Diagnostics, S.L. Systems and methods for detection of multiple cancer types
CN113699237A (zh) * 2020-07-29 2021-11-26 上海吉凯医学检验所有限公司 一种检测早期结直肠癌和腺瘤的dna甲基化标志物的试剂盒
CN112941162A (zh) * 2020-12-30 2021-06-11 昆明理工大学 一种dna端粒长度和基因甲基化程度相关性的检测方法
US20240159742A1 (en) * 2021-03-10 2024-05-16 University Of Cincinnati Epigenetic quantification using dna hybridization-based single-molecule immunofluorescent imaging
CN113234821B (zh) * 2021-04-29 2022-09-16 北京艾克伦医疗科技有限公司 鉴定食管癌状态的方法和试剂盒
WO2022238560A1 (en) * 2021-05-14 2022-11-17 Universal Diagnostics Sl Methods for disease detection
TW202307218A (zh) * 2021-05-14 2023-02-16 西班牙商通用診斷公司 用於疾病偵測的方法
WO2023052640A1 (en) 2021-09-30 2023-04-06 Tivenix Sa A method for diagnosing and predicting progression of neurodegenerative diseases or disorders
TWI839307B (zh) * 2023-05-06 2024-04-11 華聯生物科技股份有限公司 利用電腦評估肝癌患者治療後病變進展及預後的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03001834A (es) * 2000-09-01 2003-08-01 Epigenomics Ag Metodo para determinar el grado de metilacion de determinadas citocinas en adn genomico en el contexto de secuencia 5'-cpg-3'.
EP1497462A4 (en) 2002-03-07 2007-11-07 Univ Johns Hopkins Med GENOMIC SCREEN ON EPIGENETIC MUTED CANCER ASSOCIATED GENES
CA2519456A1 (en) * 2003-03-17 2004-09-30 Michael G. Goggins Aberrantly methylated genes in pancreatic cancer
EP1636381B1 (en) * 2003-06-23 2011-01-05 Epigenomics AG Methods and nucleic acids for the analysis of colon cell proliferative disorders
JP2005110645A (ja) 2003-09-16 2005-04-28 National Cancer Center-Japan 哺乳動物由来の検体の癌化度を評価する方法
US20080118926A1 (en) 2004-12-13 2008-05-22 National University Corporation Okayama University Method For Detecting Methylation In Genes And Method For Examining Neoplasm Through Detecting Methylation In Genes
JP2006166732A (ja) 2004-12-13 2006-06-29 Okayama Univ 消化器中の新生物の検出方法
US20060171952A1 (en) * 2005-02-02 2006-08-03 Mather Jennie P JAM-3 and antibodies that bind thereto
PT1871912E (pt) * 2005-04-15 2012-05-25 Epigenomics Ag Método para determinar metilação de adn em amostras de sangue ou urina
US20120196827A1 (en) 2006-06-12 2012-08-02 Oncomethylome Sciences S.A. Methylation markers for early detection and prognosis of colon cancers
GB0614567D0 (en) 2006-07-21 2006-08-30 Snell & Wilcox Ltd Motion vector interpolation
GB0700374D0 (en) * 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
CA2676227A1 (en) 2007-02-12 2008-08-21 The Johns Hopkins University Early detection and prognosis of colon cancers
EP3230476B1 (en) * 2014-12-12 2020-02-05 Exact Sciences Development Company, LLC Zdhhc1 for normalizing methylation detection assays

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