JP2010506591A5 - - Google Patents
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- Publication number
- JP2010506591A5 JP2010506591A5 JP2009533372A JP2009533372A JP2010506591A5 JP 2010506591 A5 JP2010506591 A5 JP 2010506591A5 JP 2009533372 A JP2009533372 A JP 2009533372A JP 2009533372 A JP2009533372 A JP 2009533372A JP 2010506591 A5 JP2010506591 A5 JP 2010506591A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- trna
- amino acid
- unnatural amino
- aminoacyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85300806P | 2006-10-18 | 2006-10-18 | |
| US92345807P | 2007-04-12 | 2007-04-12 | |
| PCT/US2007/022232 WO2008073184A2 (en) | 2006-10-18 | 2007-10-17 | Genetic incorporation of unnatural amino acids into proteins in mammalian cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010506591A JP2010506591A (ja) | 2010-03-04 |
| JP2010506591A5 true JP2010506591A5 (https=) | 2010-12-09 |
Family
ID=39512252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533372A Pending JP2010506591A (ja) | 2006-10-18 | 2007-10-17 | 哺乳動物細胞中の蛋白質への非天然アミノ酸の遺伝的組込み |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20080166766A1 (https=) |
| EP (1) | EP2069481A4 (https=) |
| JP (1) | JP2010506591A (https=) |
| KR (1) | KR20090094812A (https=) |
| CN (1) | CN101535338A (https=) |
| AU (1) | AU2007333010A1 (https=) |
| BR (1) | BRPI0718389A2 (https=) |
| CA (1) | CA2665678A1 (https=) |
| IL (1) | IL197917A0 (https=) |
| MX (1) | MX2009004043A (https=) |
| RU (1) | RU2009112104A (https=) |
| WO (1) | WO2008073184A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7083970B2 (en) * | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| MXPA05003978A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| WO2004094593A2 (en) | 2003-04-17 | 2004-11-04 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| WO2010114615A2 (en) * | 2009-04-03 | 2010-10-07 | The Scripps Research Institute | A facile system for encoding unnatural amino acids in mammalian cells |
| CN103328648B (zh) * | 2010-12-03 | 2015-11-25 | 国立大学法人东京大学 | 具有稳定的二级结构的肽和肽库以及它们的制造方法 |
| DE102010056289A1 (de) | 2010-12-24 | 2012-06-28 | Geneart Ag | Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken |
| SG10201702387YA (en) * | 2012-09-24 | 2017-04-27 | Medimmune Ltd | Cell lines |
| BR112015022641B1 (pt) * | 2013-03-15 | 2023-02-28 | Medimmune Limited | Construção de dna e processo de preparação de uma proteína-alvo |
| CN109295025B (zh) * | 2014-09-03 | 2021-04-02 | 中国科学院生物物理研究所 | 酪氨酸类似物翻译系统和基因编码的蛋白质光致电子转移荧光传感器蛋白家族 |
| CN105400816A (zh) * | 2015-11-24 | 2016-03-16 | 深圳市第二人民医院 | 用于膀胱癌检测的逻辑与门基因线路的构建方法 |
| GB201600512D0 (en) | 2016-01-12 | 2016-02-24 | Univ York | Recombinant protein production |
| CN112725282A (zh) * | 2016-01-27 | 2021-04-30 | 北京大学 | 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建 |
| CN110520522A (zh) | 2017-02-17 | 2019-11-29 | 鲁比厄斯治疗法股份有限公司 | 功能化红系细胞 |
| EP3630977B1 (en) * | 2017-06-02 | 2024-02-21 | Ambrx, Inc. | Methods and compositions for promoting non-natural amino acid-containing protein production |
| JP2020522263A (ja) | 2017-06-06 | 2020-07-30 | キンドレッド バイオサイエンシズ インコーポレイテッド | 獣医学的使用のためのエリスロポエチンおよびアナログ |
| JP2021520828A (ja) | 2018-04-19 | 2021-08-26 | キンドレッド バイオサイエンシズ インコーポレイテッド | 医療用の変異体アスパラギナーゼポリペプチド |
| CN112673109A (zh) * | 2018-09-07 | 2021-04-16 | 免疫医疗有限责任公司 | 细胞选择方法 |
| US12565646B2 (en) | 2019-06-21 | 2026-03-03 | Trustees Of Boston College | Enhanced platforms for unnatural amino acid incorporation in mammalian cells |
| CN114729334A (zh) * | 2019-08-08 | 2022-07-08 | 布里克生物公司 | 用于非天然氨基酸的位点特异性掺入的氨酰tRNA合成酶和细胞系 |
| KR20220080101A (ko) * | 2019-10-15 | 2022-06-14 | 트러스티스 오브 보스톤 칼리지 | 향상된 비천연 아미노산 혼입을 위한 키메라 열안정성 아미노아실-tRNA 합성효소 |
| US20230069218A1 (en) * | 2019-12-12 | 2023-03-02 | Chugai Seiyaku Kabushiki Kaisha | Method for producing peptide containing non-natural amino acid |
| CN113388654A (zh) * | 2021-06-04 | 2021-09-14 | 清华大学 | 一种基于线形模板无细胞体系非天然氨基酸嵌入方法 |
| CN114134141B (zh) * | 2021-11-03 | 2024-01-30 | 杭州嵌化合生医药科技有限公司 | 一种引入非天然氨基酸的嵌合体苯丙氨酸翻译系统及其构建方法 |
| CN119662697B (zh) * | 2024-12-20 | 2026-03-27 | 天津大学 | 缺失基因的酿酒酵母及在利用非天然氨基酸修饰蛋白质中的应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7083970B2 (en) | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| MXPA05003978A (es) | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| ES2324608T3 (es) | 2002-10-16 | 2009-08-11 | The Scripps Research Institute | Incorporacion especifica de sitio de cetoaminoacidos en proteinas. |
| WO2004039989A1 (ja) * | 2002-10-31 | 2004-05-13 | Riken | 非天然型アミノ酸組み込みタンパク質の発現方法 |
| WO2004058946A2 (en) | 2002-12-22 | 2004-07-15 | The Scripps Research Institute | Protein arrays |
| JP2006517802A (ja) * | 2003-02-14 | 2006-08-03 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 外来性分子の一過性の発現もしくは安定な発現のための発現カセットおよび発現ベクター |
| WO2004094593A2 (en) | 2003-04-17 | 2004-11-04 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
| JP5275566B2 (ja) | 2003-06-18 | 2013-08-28 | ザ スクリプス リサーチ インスティチュート | 反応性非天然アミノ酸遺伝コード付加 |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| US20060160175A1 (en) | 2003-07-07 | 2006-07-20 | The Scripps Research Institute | Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| JP5657850B2 (ja) | 2003-10-14 | 2015-01-21 | ザ スクリプス リサーチ インスティテュート | 酸化還元機能性アミノ酸のタンパク質への部位特異的組み入れ |
| AU2004321117B2 (en) | 2003-12-18 | 2010-09-02 | The Scripps Research Institute | Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells |
| EP2327724A3 (en) * | 2004-02-02 | 2011-07-27 | Ambrx, Inc. | Modified human growth hormone polypeptides and their uses |
| AU2005248392A1 (en) | 2004-05-25 | 2005-12-08 | Irm, Llc | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination |
| CA2580840A1 (en) | 2004-09-21 | 2006-03-30 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| US20090181858A1 (en) * | 2004-09-21 | 2009-07-16 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
| US20080171317A1 (en) | 2004-09-22 | 2008-07-17 | The Scripps Research Institute | Site-Specific Labeling of Proteins for Nmr Studies |
| JP2008516637A (ja) | 2004-10-20 | 2008-05-22 | ザ スクリップス リサーチ インスティテュート | 真正細菌へのｎ−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み |
| EP1807515A4 (en) | 2004-10-27 | 2008-06-18 | Scripps Research Inst | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| US8367588B2 (en) | 2005-10-12 | 2013-02-05 | The Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| US7960141B2 (en) | 2006-03-09 | 2011-06-14 | The Scripps Research Institute | Systems for the expression of orthogonal translation components in eubacterial host cells |
| KR20080113226A (ko) | 2006-03-16 | 2008-12-29 | 더 스크립스 리서치 인스티튜트 | 비천연 아미노산 페닐셀레노시스테인을 함유하는 단백질의 유전자적으로 프로그램된 발현 |
-
2007
- 2007-10-17 JP JP2009533372A patent/JP2010506591A/ja active Pending
- 2007-10-17 WO PCT/US2007/022232 patent/WO2008073184A2/en not_active Ceased
- 2007-10-17 EP EP07870795A patent/EP2069481A4/en not_active Withdrawn
- 2007-10-17 CA CA002665678A patent/CA2665678A1/en not_active Abandoned
- 2007-10-17 CN CNA2007800390157A patent/CN101535338A/zh active Pending
- 2007-10-17 US US11/975,351 patent/US20080166766A1/en not_active Abandoned
- 2007-10-17 AU AU2007333010A patent/AU2007333010A1/en not_active Abandoned
- 2007-10-17 KR KR1020097009346A patent/KR20090094812A/ko not_active Ceased
- 2007-10-17 MX MX2009004043A patent/MX2009004043A/es not_active Application Discontinuation
- 2007-10-17 US US12/311,545 patent/US9624485B2/en not_active Expired - Fee Related
- 2007-10-17 BR BRPI0718389-5A patent/BRPI0718389A2/pt not_active IP Right Cessation
- 2007-10-17 RU RU2009112104/10A patent/RU2009112104A/ru not_active Application Discontinuation
-
2009
- 2009-04-05 IL IL197917A patent/IL197917A0/en unknown
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