JP2009528824A5 - - Google Patents
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- JP2009528824A5 JP2009528824A5 JP2008557434A JP2008557434A JP2009528824A5 JP 2009528824 A5 JP2009528824 A5 JP 2009528824A5 JP 2008557434 A JP2008557434 A JP 2008557434A JP 2008557434 A JP2008557434 A JP 2008557434A JP 2009528824 A5 JP2009528824 A5 JP 2009528824A5
- Authority
- JP
- Japan
- Prior art keywords
- modified
- amino acid
- coli
- aars
- translation system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 23
- 235000001014 amino acid Nutrition 0.000 claims 22
- 108020004566 Transfer RNA Proteins 0.000 claims 20
- 150000001413 amino acids Chemical class 0.000 claims 20
- 210000004027 cell Anatomy 0.000 claims 20
- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 108091033319 polynucleotide Proteins 0.000 claims 10
- 239000002157 polynucleotide Substances 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 10
- 239000013598 vector Substances 0.000 claims 8
- 101000640990 Arabidopsis thaliana Tryptophan-tRNA ligase, chloroplastic/mitochondrial Proteins 0.000 claims 7
- 241000588724 Escherichia coli Species 0.000 claims 7
- 241000064099 Massilioclostridium coli Species 0.000 claims 7
- 108010003060 Methionine-tRNA ligase Proteins 0.000 claims 7
- 102100037206 Methionine-tRNA ligase, cytoplasmic Human genes 0.000 claims 7
- 102100034300 Tryptophan-tRNA ligase, cytoplasmic Human genes 0.000 claims 7
- -1 6-chloroindolyl Chemical group 0.000 claims 6
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 6
- 235000004279 alanine Nutrition 0.000 claims 6
- 101710146427 Probable tyrosine-tRNA ligase, cytoplasmic Proteins 0.000 claims 5
- 102100034298 Tyrosine-tRNA ligase, cytoplasmic Human genes 0.000 claims 5
- 101710107268 Tyrosine-tRNA ligase, mitochondrial Proteins 0.000 claims 5
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 claims 4
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 210000003527 eukaryotic cell Anatomy 0.000 claims 3
- ROEBGGKWVJLWSP-MRVPVSSYSA-N (2r)-2-amino-3-(4-ethynyl-1h-pyrrol-3-yl)propanoic acid Chemical compound OC(=O)[C@H](N)CC1=CNC=C1C#C ROEBGGKWVJLWSP-MRVPVSSYSA-N 0.000 claims 2
- PEMUHKUIQHFMTH-QMMMGPOBSA-N (2s)-2-amino-3-(4-bromophenyl)propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(Br)C=C1 PEMUHKUIQHFMTH-QMMMGPOBSA-N 0.000 claims 2
- PPDNGMUGVMESGE-JTQLQIEISA-N (2s)-2-amino-3-(4-ethynylphenyl)propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(C#C)C=C1 PPDNGMUGVMESGE-JTQLQIEISA-N 0.000 claims 2
- JSXMFBNJRFXRCX-NSHDSACASA-N (2s)-2-amino-3-(4-prop-2-ynoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(OCC#C)C=C1 JSXMFBNJRFXRCX-NSHDSACASA-N 0.000 claims 2
- FLHDTNWRXMTPMP-NSHDSACASA-N (2s)-2-amino-3-(5-ethynyl-1h-indol-3-yl)propanoic acid Chemical compound C1=C(C#C)C=C2C(C[C@H](N)C(O)=O)=CNC2=C1 FLHDTNWRXMTPMP-NSHDSACASA-N 0.000 claims 2
- UIKHEWRXMDFLKN-NSHDSACASA-N (2s)-2-amino-3-(6-ethynyl-1h-indol-3-yl)propanoic acid Chemical compound C#CC1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 UIKHEWRXMDFLKN-NSHDSACASA-N 0.000 claims 2
- HTFFMYRVHHNNBE-YFKPBYRVSA-N (2s)-2-amino-6-azidohexanoic acid Chemical compound OC(=O)[C@@H](N)CCCCN=[N+]=[N-] HTFFMYRVHHNNBE-YFKPBYRVSA-N 0.000 claims 2
- ZXSBHXZKWRIEIA-JTQLQIEISA-N (2s)-3-(4-acetylphenyl)-2-azaniumylpropanoate Chemical compound CC(=O)C1=CC=C(C[C@H](N)C(O)=O)C=C1 ZXSBHXZKWRIEIA-JTQLQIEISA-N 0.000 claims 2
- AKVBCGQVQXPRLD-UHFFFAOYSA-N 2-aminooctanoic acid Chemical compound CCCCCCC(N)C(O)=O AKVBCGQVQXPRLD-UHFFFAOYSA-N 0.000 claims 2
- OFYAYGJCPXRNBL-UHFFFAOYSA-N 2-azaniumyl-3-naphthalen-1-ylpropanoate Chemical compound C1=CC=C2C(CC(N)C(O)=O)=CC=CC2=C1 OFYAYGJCPXRNBL-UHFFFAOYSA-N 0.000 claims 2
- PZNQZSRPDOEBMS-QMMMGPOBSA-N 4-iodo-L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(I)C=C1 PZNQZSRPDOEBMS-QMMMGPOBSA-N 0.000 claims 2
- 241001112695 Clostridiales Species 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 2
- NIGWMJHCCYYCSF-UHFFFAOYSA-N Fenclonine Chemical compound OC(=O)C(N)CC1=CC=C(Cl)C=C1 NIGWMJHCCYYCSF-UHFFFAOYSA-N 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 2
- 102000002265 Human Growth Hormone Human genes 0.000 claims 2
- 108010000521 Human Growth Hormone Proteins 0.000 claims 2
- 239000000854 Human Growth Hormone Substances 0.000 claims 2
- 102000003960 Ligases Human genes 0.000 claims 2
- 108090000364 Ligases Proteins 0.000 claims 2
- 241000589516 Pseudomonas Species 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
- 239000004473 Threonine Substances 0.000 claims 2
- 230000002538 fungal effect Effects 0.000 claims 2
- 238000010348 incorporation Methods 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 210000005253 yeast cell Anatomy 0.000 claims 2
- JPZXHKDZASGCLU-LBPRGKRZSA-N β-(2-naphthyl)-alanine Chemical compound C1=CC=CC2=CC(C[C@H](N)C(O)=O)=CC=C21 JPZXHKDZASGCLU-LBPRGKRZSA-N 0.000 claims 2
- XHBJLKMBAFTWJD-JTQLQIEISA-N (2s)-2-amino-3-(3-ethynylphenyl)propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=CC(C#C)=C1 XHBJLKMBAFTWJD-JTQLQIEISA-N 0.000 claims 1
- NEMHIKRLROONTL-QMMMGPOBSA-N (2s)-2-azaniumyl-3-(4-azidophenyl)propanoate Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N=[N+]=[N-])C=C1 NEMHIKRLROONTL-QMMMGPOBSA-N 0.000 claims 1
- NNWQLZWAZSJGLY-VKHMYHEASA-N (2s)-2-azaniumyl-4-azidobutanoate Chemical compound OC(=O)[C@@H](N)CCN=[N+]=[N-] NNWQLZWAZSJGLY-VKHMYHEASA-N 0.000 claims 1
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 1
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 1
- 108020005098 Anticodon Proteins 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- QWCKQJZIFLGMSD-VKHMYHEASA-N L-alpha-aminobutyric acid Chemical compound CC[C@H](N)C(O)=O QWCKQJZIFLGMSD-VKHMYHEASA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77937506P | 2006-03-03 | 2006-03-03 | |
| US77937606P | 2006-03-03 | 2006-03-03 | |
| US60/779,376 | 2006-03-03 | ||
| US60/779,375 | 2006-03-03 | ||
| PCT/US2007/005581 WO2007103307A2 (en) | 2006-03-03 | 2007-03-05 | Site-specific incorporation of amino acids into molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013095341A Division JP2013146274A (ja) | 2006-03-03 | 2013-04-30 | 分子へのアミノ酸の部位特異的な組み込み |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009528824A JP2009528824A (ja) | 2009-08-13 |
| JP2009528824A5 true JP2009528824A5 (https=) | 2011-04-14 |
| JP5808882B2 JP5808882B2 (ja) | 2015-11-10 |
Family
ID=38462077
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557434A Active JP5808882B2 (ja) | 2006-03-03 | 2007-03-05 | 分子へのアミノ酸の部位特異的な組み込み |
| JP2013095341A Pending JP2013146274A (ja) | 2006-03-03 | 2013-04-30 | 分子へのアミノ酸の部位特異的な組み込み |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013095341A Pending JP2013146274A (ja) | 2006-03-03 | 2013-04-30 | 分子へのアミノ酸の部位特異的な組み込み |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8518666B2 (https=) |
| EP (1) | EP1999259B1 (https=) |
| JP (2) | JP5808882B2 (https=) |
| AU (2) | AU2007224019A1 (https=) |
| CA (1) | CA2644474A1 (https=) |
| DK (1) | DK1999259T3 (https=) |
| ES (1) | ES2504521T3 (https=) |
| PL (1) | PL1999259T3 (https=) |
| PT (1) | PT1999259E (https=) |
| SI (1) | SI1999259T1 (https=) |
| WO (1) | WO2007103307A2 (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050287639A1 (en) | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| US20080096819A1 (en) * | 2006-05-02 | 2008-04-24 | Allozyne, Inc. | Amino acid substituted molecules |
| EP2444499A3 (en) * | 2006-05-02 | 2012-05-09 | Allozyne, Inc. | Amino acid substituted molecules |
| CA2707840A1 (en) * | 2007-08-20 | 2009-02-26 | Allozyne, Inc. | Amino acid substituted molecules |
| WO2009059056A2 (en) * | 2007-11-02 | 2009-05-07 | The Scripps Research Institute | A genetically encoded boronate amino acid |
| CN102348807B (zh) | 2009-01-12 | 2015-04-15 | 苏特罗生物制药公司 | 利用体外蛋白合成体系将非天然氨基酸引入蛋白的单装载体系 |
| WO2010099477A2 (en) | 2009-02-27 | 2010-09-02 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
| EA201200717A1 (ru) * | 2009-12-11 | 2013-03-29 | Кейз Вестерн Ризев Юнивесити | Аналоги инсулина, содержащие хлорированные аминокислоты |
| US8980253B2 (en) | 2010-04-26 | 2015-03-17 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase |
| EP2563382B1 (en) | 2010-04-27 | 2017-06-07 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl trna synthetases |
| CA2797362C (en) | 2010-04-27 | 2020-12-08 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases |
| WO2011139853A2 (en) | 2010-04-28 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases |
| CA2797393C (en) | 2010-04-29 | 2020-03-10 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases |
| CA2797374C (en) | 2010-04-29 | 2021-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases |
| CA2797799C (en) | 2010-05-03 | 2020-12-08 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases |
| CN103096912A (zh) | 2010-05-03 | 2013-05-08 | Atyr医药公司 | 与苯丙氨酰-α-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
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| CN103140233B (zh) | 2010-05-03 | 2017-04-05 | Atyr 医药公司 | 与甲硫氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现 |
| US9062301B2 (en) | 2010-05-04 | 2015-06-23 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases |
| JP6008844B2 (ja) | 2010-05-04 | 2016-10-19 | エータイアー ファーマ， インコーポレイテッド | ｐ３８ＭＵＬＴＩ−ｔＲＮＡ合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| EP2568996B1 (en) | 2010-05-14 | 2017-10-04 | aTyr Pharma, Inc. | Therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases |
| CN103096914B (zh) | 2010-05-17 | 2015-08-12 | Atyr医药公司 | 与亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CA2800375C (en) | 2010-05-27 | 2021-03-09 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases |
| EP2575857B1 (en) | 2010-06-01 | 2018-01-24 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
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| WO2012009289A2 (en) | 2010-07-12 | 2012-01-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases |
| US20130202576A1 (en) | 2010-07-12 | 2013-08-08 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
| AU2011293294B2 (en) | 2010-08-25 | 2016-03-24 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases |
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| CA2812795C (en) | 2010-10-06 | 2021-08-31 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases |
| US20140140962A1 (en) * | 2011-04-29 | 2014-05-22 | The Research Foundation Of State University Of New York | Viruses modified with unnatural moieties and methods of use thereof |
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| JP2024500284A (ja) | 2020-11-19 | 2024-01-09 | プロトマー・テクノロジーズ・インコーポレイテッド | 芳香族ホウ素含有化合物及びインスリン類似体 |
| WO2023069816A2 (en) | 2021-09-20 | 2023-04-27 | The Broad Institute, Inc. | Compositions and methods for multiplex decoding of quadruplet codons |
| WO2023225534A1 (en) | 2022-05-18 | 2023-11-23 | Protomer Technologies Inc. | Aromatic boron-containing compounds and related insulin analogs |
| EP4544047A2 (en) * | 2022-06-22 | 2025-04-30 | The University of Chicago | Engineered trna and methods of use |
| CN116376851A (zh) * | 2022-08-25 | 2023-07-04 | 凯莱英医药集团（天津）股份有限公司 | 氨酰tRNA合酶突变体及其应用 |
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| ATE193551T1 (de) | 1991-03-18 | 2000-06-15 | Scripps Research Inst | Oligosaccharide als enzymsubstrate und - inhibitoren: verfahren und zusammensetzungen |
| EP0974111B1 (en) | 1997-04-11 | 2003-01-08 | California Institute Of Technology | Apparatus and method for automated protein design |
| US7449443B2 (en) | 2000-03-23 | 2008-11-11 | California Institute Of Technology | Method for stabilization of proteins using non-natural amino acids |
| US7083970B2 (en) | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| US7139665B2 (en) * | 2002-02-27 | 2006-11-21 | California Institute Of Technology | Computational method for designing enzymes for incorporation of non natural amino acids into proteins |
| MXPA05003978A (es) | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| EP2327724A3 (en) | 2004-02-02 | 2011-07-27 | Ambrx, Inc. | Modified human growth hormone polypeptides and their uses |
| US20050260711A1 (en) | 2004-03-30 | 2005-11-24 | Deepshikha Datta | Modulating pH-sensitive binding using non-natural amino acids |
| US20050287639A1 (en) | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| JP2008507280A (ja) | 2004-07-21 | 2008-03-13 | アンブレツクス・インコーポレイテツド | 非天然コードアミノ酸を用いた生合成ポリペプチド |
| US20090181858A1 (en) | 2004-09-21 | 2009-07-16 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
| JP2008516637A (ja) | 2004-10-20 | 2008-05-22 | ザ スクリップス リサーチ インスティテュート | 真正細菌へのｎ−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み |
| EP1828224B1 (en) | 2004-12-22 | 2016-04-06 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| CN102732588B (zh) | 2004-12-22 | 2015-01-07 | Ambrx公司 | 氨酰基-tRNA合成酶的组合物及其用途 |
| JP2008541766A (ja) | 2005-06-03 | 2008-11-27 | アンブレツクス・インコーポレイテツド | タンパク質中への天然にコードされないアミノ酸の取り込み |
| MX2008002149A (es) | 2005-08-18 | 2008-04-22 | Ambrx Inc | Composiciones de arnt y sus usos. |
| DK1968635T3 (en) | 2005-12-14 | 2014-12-15 | Ambrx Inc | Compositions and Methods of, and uses of non-natural amino acids and polypeptides |
| AU2007215566A1 (en) | 2006-01-19 | 2007-08-23 | Ambrx, Inc. | Non-natural amino acid polypeptides having modulated immunogenicity |
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2007
- 2007-03-05 AU AU2007224019A patent/AU2007224019A1/en not_active Abandoned
- 2007-03-05 PT PT77522951T patent/PT1999259E/pt unknown
- 2007-03-05 US US11/682,272 patent/US8518666B2/en not_active Expired - Fee Related
- 2007-03-05 CA CA002644474A patent/CA2644474A1/en not_active Abandoned
- 2007-03-05 ES ES07752295.1T patent/ES2504521T3/es active Active
- 2007-03-05 WO PCT/US2007/005581 patent/WO2007103307A2/en not_active Ceased
- 2007-03-05 PL PL07752295T patent/PL1999259T3/pl unknown
- 2007-03-05 SI SI200731519T patent/SI1999259T1/sl unknown
- 2007-03-05 DK DK07752295.1T patent/DK1999259T3/da active
- 2007-03-05 JP JP2008557434A patent/JP5808882B2/ja active Active
- 2007-03-05 EP EP07752295.1A patent/EP1999259B1/en not_active Not-in-force
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2013
- 2013-04-30 JP JP2013095341A patent/JP2013146274A/ja active Pending
- 2013-08-16 US US13/969,368 patent/US8980581B2/en active Active
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2014
- 2014-05-20 AU AU2014202733A patent/AU2014202733A1/en not_active Abandoned
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