JP2008513040A5 - - Google Patents
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- Publication number
- JP2008513040A5 JP2008513040A5 JP2007533630A JP2007533630A JP2008513040A5 JP 2008513040 A5 JP2008513040 A5 JP 2008513040A5 JP 2007533630 A JP2007533630 A JP 2007533630A JP 2007533630 A JP2007533630 A JP 2007533630A JP 2008513040 A5 JP2008513040 A5 JP 2008513040A5
- Authority
- JP
- Japan
- Prior art keywords
- trna
- amino acid
- seq
- phe
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001413 amino acids Chemical class 0.000 claims 52
- 210000004027 cell Anatomy 0.000 claims 36
- 235000001014 amino acid Nutrition 0.000 claims 34
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 21
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 21
- 108091033319 polynucleotide Proteins 0.000 claims 21
- 102000040430 polynucleotide Human genes 0.000 claims 21
- 239000002157 polynucleotide Substances 0.000 claims 21
- DOCYTUNUHIGJTI-QMMMGPOBSA-N (2r)-2-[(2-nitrophenyl)methylamino]-3-sulfanylpropanoic acid Chemical compound OC(=O)[C@H](CS)NCC1=CC=CC=C1[N+]([O-])=O DOCYTUNUHIGJTI-QMMMGPOBSA-N 0.000 claims 20
- 108020004705 Codon Proteins 0.000 claims 17
- 235000018102 proteins Nutrition 0.000 claims 17
- 102000004169 proteins and genes Human genes 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 17
- AKVBCGQVQXPRLD-UHFFFAOYSA-N 2-aminooctanoic acid Chemical compound CCCCCCC(N)C(O)=O AKVBCGQVQXPRLD-UHFFFAOYSA-N 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 238000000034 method Methods 0.000 claims 11
- 241000588724 Escherichia coli Species 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- GEYBMYRBIABFTA-VIFPVBQESA-N O-methyl-L-tyrosine Chemical compound COC1=CC=C(C[C@H](N)C(O)=O)C=C1 GEYBMYRBIABFTA-VIFPVBQESA-N 0.000 claims 5
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 4
- 125000001295 dansyl group Chemical group [H]C1=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C2C([H])=C([H])C([H])=C(C2=C1[H])S(*)(=O)=O 0.000 claims 4
- 239000003550 marker Substances 0.000 claims 4
- 150000003355 serines Chemical class 0.000 claims 4
- 241001112695 Clostridiales Species 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 210000005253 yeast cell Anatomy 0.000 claims 3
- 241000203407 Methanocaldococcus jannaschii Species 0.000 claims 2
- 108020005038 Terminator Codon Proteins 0.000 claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000004952 protein activity Effects 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- ZCIVZGYOBRGUMA-VIFPVBQESA-N (2r)-2-[benzyl(nitro)amino]-3-sulfanylpropanoic acid Chemical compound OC(=O)[C@H](CS)N([N+]([O-])=O)CC1=CC=CC=C1 ZCIVZGYOBRGUMA-VIFPVBQESA-N 0.000 claims 1
- KLSJWNVTNUYHDU-UHFFFAOYSA-N Amitrole Chemical compound NC1=NC=NN1 KLSJWNVTNUYHDU-UHFFFAOYSA-N 0.000 claims 1
- 108010016529 Bacillus amyloliquefaciens ribonuclease Proteins 0.000 claims 1
- 108010035563 Chloramphenicol O-acetyltransferase Proteins 0.000 claims 1
- 108010001515 Galectin 4 Proteins 0.000 claims 1
- 102100039556 Galectin-4 Human genes 0.000 claims 1
- 101100246753 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) pyrF gene Proteins 0.000 claims 1
- 108010071170 Leucine-tRNA ligase Proteins 0.000 claims 1
- 102100023339 Leucine-tRNA ligase, cytoplasmic Human genes 0.000 claims 1
- 241000203353 Methanococcus Species 0.000 claims 1
- 101150050575 URA3 gene Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000000689 aminoacylating effect Effects 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 claims 1
- 229960005091 chloramphenicol Drugs 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 229940035893 uracil Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61222304P | 2004-09-21 | 2004-09-21 | |
| US62062504P | 2004-10-19 | 2004-10-19 | |
| PCT/US2005/034002 WO2006034410A2 (en) | 2004-09-21 | 2005-09-21 | Adding photoregulated amino acids to the genetic code |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008513040A JP2008513040A (ja) | 2008-05-01 |
| JP2008513040A5 true JP2008513040A5 (https=) | 2008-11-13 |
Family
ID=36090678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007533630A Abandoned JP2008513040A (ja) | 2004-09-21 | 2005-09-21 | 光調節型アミノ酸の遺伝コード付加 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20090181858A1 (https=) |
| EP (1) | EP1797177A4 (https=) |
| JP (1) | JP2008513040A (https=) |
| WO (1) | WO2006034410A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002085923A2 (en) * | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| MXPA05003978A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| EP1649004A4 (en) * | 2003-07-07 | 2008-04-09 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| US20050287639A1 (en) | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| US20080171317A1 (en) * | 2004-09-22 | 2008-07-17 | The Scripps Research Institute | Site-Specific Labeling of Proteins for Nmr Studies |
| CN101048506B (zh) | 2004-10-27 | 2013-06-26 | 斯克利普斯研究院 | 体内掺入非天然氨基酸的正交翻译组分 |
| BRPI0617191A2 (pt) * | 2005-10-12 | 2011-07-19 | Scripps Research Inst | modificação pós-traducional de polipeptìdeos expressos em fagos |
| AU2007224019A1 (en) | 2006-03-03 | 2007-09-13 | California Institute Of Technology | Site-specific incorporation of amino acids into molecules |
| KR20080106430A (ko) * | 2006-03-09 | 2008-12-05 | 더 스크립스 리서치 인스티튜트 | 진정 세균 숙주 세포 내에서의 직교형 번역 성분의 발현을 위한 시스템 |
| WO2007109035A2 (en) | 2006-03-16 | 2007-09-27 | The Scripps Research Institute | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
| AU2007267950B2 (en) * | 2006-05-23 | 2012-08-16 | The Scripps Research Institute | Genetically encoded fluorescent coumarin amino acids |
| JP5385143B2 (ja) * | 2006-09-21 | 2014-01-08 | ザ スクリプス リサーチ インスティチュート | 真正細菌における選択的に硫酸化された蛋白質の遺伝的にプログラムされた発現 |
| WO2008073184A2 (en) * | 2006-10-18 | 2008-06-19 | The Scripps Research Institute | Genetic incorporation of unnatural amino acids into proteins in mammalian cells |
| WO2008091863A1 (en) | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
| WO2009049223A2 (en) * | 2007-10-10 | 2009-04-16 | Irm Llc | Methods and compositions for the site-selective incorporation of fluorinated amino acids into polypeptides |
| US8673591B2 (en) | 2007-10-25 | 2014-03-18 | The Scripps Research Institute | Genetic incorporation of 3-aminotyrosine into reductases |
| WO2009059056A2 (en) * | 2007-11-02 | 2009-05-07 | The Scripps Research Institute | A genetically encoded boronate amino acid |
| JP5513398B2 (ja) | 2007-11-02 | 2014-06-04 | ザ スクリプス リサーチ インスティチュート | 非天然アミノ酸を含有する蛋白質を使用する指向的進化 |
| CN101939410A (zh) | 2007-12-11 | 2011-01-05 | 斯克利普斯研究院 | 甲基营养酵母菌巴斯德毕赤酵母中的体内非天然氨基酸表达 |
| EP2249865A4 (en) * | 2008-02-08 | 2012-04-04 | Scripps Research Inst | BREAKING IMMUNOLOGICAL TOLERANCE WITH A GENETICALLY ENCODED UNNATURAL AMINO ACID |
| US8609383B2 (en) | 2008-12-10 | 2013-12-17 | The Scripps Research Institute | Production of carrier-peptide conjugates using chemically reactive unnatural amino acids |
| US20090197339A1 (en) * | 2008-12-10 | 2009-08-06 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris |
| WO2011107747A2 (en) * | 2010-03-05 | 2011-09-09 | Medical Research Council | Genetically encoded photocontrol |
| EP3381932A1 (en) * | 2017-03-28 | 2018-10-03 | Technische Universität Berlin | Modified mussel proteins, uses thereof and related compounds |
| CA3060339A1 (en) * | 2017-05-10 | 2018-11-15 | Technische Universitat Munchen | Light-switchable polypeptide and uses thereof |
| CN113874503A (zh) * | 2019-01-25 | 2021-12-31 | 辛瑟高公司 | 用于调节crispr活性的系统和方法 |
| US20220325269A1 (en) * | 2019-08-08 | 2022-10-13 | Brickbio, Inc. | Aminoacyl-trna synthetases and cell lines for site-specific incorporation of unnatural amino acids |
| EP4192943A4 (en) * | 2020-08-07 | 2025-02-12 | Brickbio, Inc. | Stable cell lines for site-specific incorporation of unnatural amino acids |
| WO2025212981A1 (en) * | 2024-04-05 | 2025-10-09 | President And Fellows Of Harvard College | Orthogonal aminoacyl trna synthetase pairs for protein production |
| CN119219791B (zh) * | 2024-09-29 | 2025-08-12 | 西湖大学 | 光响应组装蛋白及其应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05003978A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
-
2005
- 2005-09-21 US US11/662,749 patent/US20090181858A1/en not_active Abandoned
- 2005-09-21 JP JP2007533630A patent/JP2008513040A/ja not_active Abandoned
- 2005-09-21 EP EP05815319A patent/EP1797177A4/en not_active Withdrawn
- 2005-09-21 US US11/233,508 patent/US20060134746A1/en not_active Abandoned
- 2005-09-21 WO PCT/US2005/034002 patent/WO2006034410A2/en not_active Ceased
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