JP2008513040A - 光調節型アミノ酸の遺伝コード付加 - Google Patents

光調節型アミノ酸の遺伝コード付加 Download PDF

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Publication number
JP2008513040A
JP2008513040A JP2007533630A JP2007533630A JP2008513040A JP 2008513040 A JP2008513040 A JP 2008513040A JP 2007533630 A JP2007533630 A JP 2007533630A JP 2007533630 A JP2007533630 A JP 2007533630A JP 2008513040 A JP2008513040 A JP 2008513040A
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JP
Japan
Prior art keywords
trna
amino acid
protein
phe
azobenzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2007533630A
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English (en)
Japanese (ja)
Other versions
JP2008513040A5 (https=
Inventor
アレキサンダー・ディーターズ
ニング・ウー
ピーター・ジー．・シュルツ
デヴィッド・キング
アシュトン・クロップ・ティー．
モフア・ボース
ダン・グロフ
ジアンミング・ズィー
エリック・ブルッスタッド
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Scripps Research Institute
Original Assignee
Scripps Research Institute
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Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of JP2008513040A publication Critical patent/JP2008513040A/ja
Publication of JP2008513040A5 publication Critical patent/JP2008513040A5/ja
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2007533630A 2004-09-21 2005-09-21 光調節型アミノ酸の遺伝コード付加 Abandoned JP2008513040A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61222304P 2004-09-21 2004-09-21
US62062504P 2004-10-19 2004-10-19
PCT/US2005/034002 WO2006034410A2 (en) 2004-09-21 2005-09-21 Adding photoregulated amino acids to the genetic code

Publications (2)

Publication Number Publication Date
JP2008513040A true JP2008513040A (ja) 2008-05-01
JP2008513040A5 JP2008513040A5 (https=) 2008-11-13

Family

ID=36090678

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007533630A Abandoned JP2008513040A (ja) 2004-09-21 2005-09-21 光調節型アミノ酸の遺伝コード付加

Country Status (4)

Country Link
US (2) US20090181858A1 (https=)
EP (1) EP1797177A4 (https=)
JP (1) JP2008513040A (https=)
WO (1) WO2006034410A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013521269A (ja) * 2010-03-05 2013-06-10 メディカル リサーチ カウンシル 遺伝的にコードされた光制御
JP2020520348A (ja) * 2017-05-10 2020-07-09 テクニッシェ ウニベルシタット ミュンヘン 光切替可能ポリペプチドおよびその使用
JP2022523055A (ja) * 2019-01-25 2022-04-21 シンテゴ コーポレイション Ｃｒｉｓｐｒ活性をモジュレートするための系および方法

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002085923A2 (en) * 2001-04-19 2002-10-31 The Scripps Research Institute In vivo incorporation of unnatural amino acids
MXPA05003978A (es) * 2002-10-16 2005-06-22 Scripps Research Inst Sintesis de glicoproteinas.
JP5642916B2 (ja) 2003-04-17 2014-12-17 ザ スクリプス リサーチ インスティテュート 真核遺伝コードの拡張
EP1649004A4 (en) * 2003-07-07 2008-04-09 Scripps Research Inst COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF
US20050287639A1 (en) 2004-05-17 2005-12-29 California Institute Of Technology Methods of incorporating amino acid analogs into proteins
US20080171317A1 (en) * 2004-09-22 2008-07-17 The Scripps Research Institute Site-Specific Labeling of Proteins for Nmr Studies
CN101048506B (zh) 2004-10-27 2013-06-26 斯克利普斯研究院 体内掺入非天然氨基酸的正交翻译组分
BRPI0617191A2 (pt) * 2005-10-12 2011-07-19 Scripps Research Inst modificação pós-traducional de polipeptìdeos expressos em fagos
AU2007224019A1 (en) 2006-03-03 2007-09-13 California Institute Of Technology Site-specific incorporation of amino acids into molecules
KR20080106430A (ko) * 2006-03-09 2008-12-05 더 스크립스 리서치 인스티튜트 진정 세균 숙주 세포 내에서의 직교형 번역 성분의 발현을 위한 시스템
WO2007109035A2 (en) 2006-03-16 2007-09-27 The Scripps Research Institute Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
AU2007267950B2 (en) * 2006-05-23 2012-08-16 The Scripps Research Institute Genetically encoded fluorescent coumarin amino acids
JP5385143B2 (ja) * 2006-09-21 2014-01-08 ザ スクリプス リサーチ インスティチュート 真正細菌における選択的に硫酸化された蛋白質の遺伝的にプログラムされた発現
WO2008073184A2 (en) * 2006-10-18 2008-06-19 The Scripps Research Institute Genetic incorporation of unnatural amino acids into proteins in mammalian cells
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
WO2009049223A2 (en) * 2007-10-10 2009-04-16 Irm Llc Methods and compositions for the site-selective incorporation of fluorinated amino acids into polypeptides
US8673591B2 (en) 2007-10-25 2014-03-18 The Scripps Research Institute Genetic incorporation of 3-aminotyrosine into reductases
WO2009059056A2 (en) * 2007-11-02 2009-05-07 The Scripps Research Institute A genetically encoded boronate amino acid
JP5513398B2 (ja) 2007-11-02 2014-06-04 ザ スクリプス リサーチ インスティチュート 非天然アミノ酸を含有する蛋白質を使用する指向的進化
CN101939410A (zh) 2007-12-11 2011-01-05 斯克利普斯研究院 甲基营养酵母菌巴斯德毕赤酵母中的体内非天然氨基酸表达
EP2249865A4 (en) * 2008-02-08 2012-04-04 Scripps Research Inst BREAKING IMMUNOLOGICAL TOLERANCE WITH A GENETICALLY ENCODED UNNATURAL AMINO ACID
US8609383B2 (en) 2008-12-10 2013-12-17 The Scripps Research Institute Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
US20090197339A1 (en) * 2008-12-10 2009-08-06 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
EP3381932A1 (en) * 2017-03-28 2018-10-03 Technische Universität Berlin Modified mussel proteins, uses thereof and related compounds
US20220325269A1 (en) * 2019-08-08 2022-10-13 Brickbio, Inc. Aminoacyl-trna synthetases and cell lines for site-specific incorporation of unnatural amino acids
EP4192943A4 (en) * 2020-08-07 2025-02-12 Brickbio, Inc. Stable cell lines for site-specific incorporation of unnatural amino acids
WO2025212981A1 (en) * 2024-04-05 2025-10-09 President And Fellows Of Harvard College Orthogonal aminoacyl trna synthetase pairs for protein production
CN119219791B (zh) * 2024-09-29 2025-08-12 西湖大学 光响应组装蛋白及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05003978A (es) * 2002-10-16 2005-06-22 Scripps Research Inst Sintesis de glicoproteinas.

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013521269A (ja) * 2010-03-05 2013-06-10 メディカル リサーチ カウンシル 遺伝的にコードされた光制御
JP2020520348A (ja) * 2017-05-10 2020-07-09 テクニッシェ ウニベルシタット ミュンヘン 光切替可能ポリペプチドおよびその使用
JP7221537B2 (ja) 2017-05-10 2023-02-14 テクニッシェ ウニベルシタット ミュンヘン 光切替可能ポリペプチドおよびその使用
JP2022523055A (ja) * 2019-01-25 2022-04-21 シンテゴ コーポレイション Ｃｒｉｓｐｒ活性をモジュレートするための系および方法

Also Published As

Publication number Publication date
WO2006034410A3 (en) 2006-08-03
WO2006034410A2 (en) 2006-03-30
US20090181858A1 (en) 2009-07-16
US20060134746A1 (en) 2006-06-22
EP1797177A4 (en) 2008-07-09
EP1797177A2 (en) 2007-06-20

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