JP2008513040A - 光調節型アミノ酸の遺伝コード付加 - Google Patents

光調節型アミノ酸の遺伝コード付加 Download PDF

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Publication number
JP2008513040A
JP2008513040A JP2007533630A JP2007533630A JP2008513040A JP 2008513040 A JP2008513040 A JP 2008513040A JP 2007533630 A JP2007533630 A JP 2007533630A JP 2007533630 A JP2007533630 A JP 2007533630A JP 2008513040 A JP2008513040 A JP 2008513040A
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JP
Japan
Prior art keywords
trna
amino acid
protein
phe
azobenzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2007533630A
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English (en)
Japanese (ja)
Other versions
JP2008513040A5 (https=
Inventor
アレキサンダー・ディーターズ
ニング・ウー
ピーター・ジー．・シュルツ
デヴィッド・キング
アシュトン・クロップ・ティー．
モフア・ボース
ダン・グロフ
ジアンミング・ズィー
エリック・ブルッスタッド
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Scripps Research Institute
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Scripps Research Institute
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Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of JP2008513040A publication Critical patent/JP2008513040A/ja
Publication of JP2008513040A5 publication Critical patent/JP2008513040A5/ja
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2007533630A 2004-09-21 2005-09-21 光調節型アミノ酸の遺伝コード付加 Abandoned JP2008513040A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61222304P 2004-09-21 2004-09-21
US62062504P 2004-10-19 2004-10-19
PCT/US2005/034002 WO2006034410A2 (en) 2004-09-21 2005-09-21 Adding photoregulated amino acids to the genetic code

Publications (2)

Publication Number Publication Date
JP2008513040A true JP2008513040A (ja) 2008-05-01
JP2008513040A5 JP2008513040A5 (https=) 2008-11-13

Family

ID=36090678

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007533630A Abandoned JP2008513040A (ja) 2004-09-21 2005-09-21 光調節型アミノ酸の遺伝コード付加

Country Status (4)

Country Link
US (2) US20090181858A1 (https=)
EP (1) EP1797177A4 (https=)
JP (1) JP2008513040A (https=)
WO (1) WO2006034410A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013521269A (ja) * 2010-03-05 2013-06-10 メディカル リサーチ カウンシル 遺伝的にコードされた光制御
JP2020520348A (ja) * 2017-05-10 2020-07-09 テクニッシェ ウニベルシタット ミュンヘン 光切替可能ポリペプチドおよびその使用
JP2022523055A (ja) * 2019-01-25 2022-04-21 シンテゴ コーポレイション Ｃｒｉｓｐｒ活性をモジュレートするための系および方法

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7083970B2 (en) * 2001-04-19 2006-08-01 The Scripps Research Institute Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
MXPA05003978A (es) * 2002-10-16 2005-06-22 Scripps Research Inst Sintesis de glicoproteinas.
WO2004094593A2 (en) 2003-04-17 2004-11-04 The Scripps Research Institute Expanding the eukaryotic genetic code
WO2005019415A2 (en) 2003-07-07 2005-03-03 The Scripps Research Institute Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof
US20050287639A1 (en) 2004-05-17 2005-12-29 California Institute Of Technology Methods of incorporating amino acid analogs into proteins
US20080171317A1 (en) * 2004-09-22 2008-07-17 The Scripps Research Institute Site-Specific Labeling of Proteins for Nmr Studies
EP1807515A4 (en) 2004-10-27 2008-06-18 Scripps Research Inst Orthogonal translation components for the in vivo incorporation of unnatural amino acids
US8367588B2 (en) * 2005-10-12 2013-02-05 The Scripps Research Institute Selective posttranslational modification of phage-displayed polypeptides
AU2007224019A1 (en) 2006-03-03 2007-09-13 California Institute Of Technology Site-specific incorporation of amino acids into molecules
US7960141B2 (en) * 2006-03-09 2011-06-14 The Scripps Research Institute Systems for the expression of orthogonal translation components in eubacterial host cells
KR20080113226A (ko) 2006-03-16 2008-12-29 더 스크립스 리서치 인스티튜트 비천연 아미노산 페닐셀레노시스테인을 함유하는 단백질의 유전자적으로 프로그램된 발현
US7807411B2 (en) * 2006-05-23 2010-10-05 The Scripps Research Institute Genetically encoded fluorescent coumarin amino acids
EP2052083B1 (en) * 2006-09-21 2014-01-08 The Scripps Research Institute Genetically programmed expression of selectively sulfated proteins in eubacteria
JP2010506591A (ja) * 2006-10-18 2010-03-04 ザ スクリップス リサーチ インスティテュート 哺乳動物細胞中の蛋白質への非天然アミノ酸の遺伝的組込み
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
WO2009049223A2 (en) * 2007-10-10 2009-04-16 Irm Llc Methods and compositions for the site-selective incorporation of fluorinated amino acids into polypeptides
MX2010004464A (es) 2007-10-25 2010-06-07 Scripps Research Inst Incorporacion genetica de 3-aminotirosina a reductasas.
US9150849B2 (en) 2007-11-02 2015-10-06 The Scripps Research Institute Directed evolution using proteins comprising unnatural amino acids
WO2009059056A2 (en) * 2007-11-02 2009-05-07 The Scripps Research Institute A genetically encoded boronate amino acid
AU2008335778B2 (en) 2007-12-11 2014-04-10 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast Pichia pastoris
CN101970005A (zh) * 2008-02-08 2011-02-09 斯克利普斯研究院 用遗传编码的非天然氨基酸打破免疫耐受
US20090197339A1 (en) * 2008-12-10 2009-08-06 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
CN102307905B (zh) 2008-12-10 2015-11-25 斯克利普斯研究院 利用化学反应性非天然氨基酸产生载体-肽偶联物
EP3381932A1 (en) * 2017-03-28 2018-10-03 Technische Universität Berlin Modified mussel proteins, uses thereof and related compounds
CN114729334A (zh) * 2019-08-08 2022-07-08 布里克生物公司 用于非天然氨基酸的位点特异性掺入的氨酰tRNA合成酶和细胞系
EP4192943A4 (en) * 2020-08-07 2025-02-12 Brickbio, Inc. Stable cell lines for site-specific incorporation of unnatural amino acids
WO2025212981A1 (en) * 2024-04-05 2025-10-09 President And Fellows Of Harvard College Orthogonal aminoacyl trna synthetase pairs for protein production
CN119219791B (zh) * 2024-09-29 2025-08-12 西湖大学 光响应组装蛋白及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05003978A (es) * 2002-10-16 2005-06-22 Scripps Research Inst Sintesis de glicoproteinas.

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013521269A (ja) * 2010-03-05 2013-06-10 メディカル リサーチ カウンシル 遺伝的にコードされた光制御
JP2020520348A (ja) * 2017-05-10 2020-07-09 テクニッシェ ウニベルシタット ミュンヘン 光切替可能ポリペプチドおよびその使用
JP7221537B2 (ja) 2017-05-10 2023-02-14 テクニッシェ ウニベルシタット ミュンヘン 光切替可能ポリペプチドおよびその使用
JP2022523055A (ja) * 2019-01-25 2022-04-21 シンテゴ コーポレイション Ｃｒｉｓｐｒ活性をモジュレートするための系および方法

Also Published As

Publication number Publication date
US20090181858A1 (en) 2009-07-16
EP1797177A2 (en) 2007-06-20
EP1797177A4 (en) 2008-07-09
WO2006034410A2 (en) 2006-03-30
US20060134746A1 (en) 2006-06-22
WO2006034410A3 (en) 2006-08-03

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