JPWO2021261577A1 - - Google Patents
Info
- Publication number
- JPWO2021261577A1 JPWO2021261577A1 JP2022532551A JP2022532551A JPWO2021261577A1 JP WO2021261577 A1 JPWO2021261577 A1 JP WO2021261577A1 JP 2022532551 A JP2022532551 A JP 2022532551A JP 2022532551 A JP2022532551 A JP 2022532551A JP WO2021261577 A1 JPWO2021261577 A1 JP WO2021261577A1
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020109576 | 2020-06-25 | ||
| PCT/JP2021/024075 WO2021261577A1 (ja) | 2020-06-25 | 2021-06-25 | 改変された遺伝暗号表を有する翻訳系 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2021261577A1 true JPWO2021261577A1 (https=) | 2021-12-30 |
| JPWO2021261577A5 JPWO2021261577A5 (https=) | 2024-05-30 |
Family
ID=79281398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022532551A Pending JPWO2021261577A1 (https=) | 2020-06-25 | 2021-06-25 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240052340A1 (https=) |
| EP (1) | EP4166675A4 (https=) |
| JP (1) | JPWO2021261577A1 (https=) |
| KR (1) | KR20230028363A (https=) |
| CN (1) | CN115667539A (https=) |
| TW (1) | TW202208623A (https=) |
| WO (1) | WO2021261577A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202446781A (zh) | 2011-12-28 | 2024-12-01 | 日商中外製藥股份有限公司 | 胜肽化合物之製造方法 |
| EP4166664A1 (en) | 2015-03-13 | 2023-04-19 | Chugai Seiyaku Kabushiki Kaisha | Modified aminoacyl-trna synthetase and use thereof |
| JP7187323B2 (ja) | 2017-01-31 | 2022-12-12 | 中外製薬株式会社 | 無細胞翻訳系におけるペプチドの合成方法 |
| KR20250007021A (ko) | 2017-06-09 | 2025-01-13 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| EP3878836B1 (en) | 2018-11-07 | 2025-07-23 | Chugai Seiyaku Kabushiki Kaisha | O-substituted serine derivative production method |
| EP3939962A4 (en) | 2019-03-15 | 2022-12-28 | Chugai Seiyaku Kabushiki Kaisha | PROCESS FOR PREPARING AN AROMATIC AMINO ACID DERIVATIVE |
| BR112022007535A2 (pt) | 2019-11-07 | 2022-07-12 | Chugai Pharmaceutical Co Ltd | Composto peptídico cíclico tendo ação inibitória de kras |
| JP7823181B2 (ja) | 2022-05-06 | 2026-03-03 | 中外製薬株式会社 | Ｈｒａｓおよびｎｒａｓに対して選択的なｋｒａｓ阻害作用を有する環状化合物 |
| JPWO2024128195A1 (https=) * | 2022-12-12 | 2024-06-20 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018509172A (ja) * | 2015-03-27 | 2018-04-05 | ザ ユニバーシティ オブ クィーンズランド | タンパク質への非天然アミノ酸組込みのためのプラットフォーム |
| WO2018143145A1 (ja) * | 2017-01-31 | 2018-08-09 | 中外製薬株式会社 | 無細胞翻訳系におけるペプチドの合成方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006135096A1 (ja) | 2005-06-14 | 2006-12-21 | Gifu University | 部位特異的にタンパク質にチロシンアナログを導入する方法 |
| WO2007061136A1 (ja) | 2005-11-24 | 2007-05-31 | Riken | 非天然型アミノ酸を組み込んだタンパク質の製造方法 |
| WO2007066627A1 (ja) | 2005-12-06 | 2007-06-14 | The University Of Tokyo | 多目的アシル化触媒とその用途 |
| AU2007224019A1 (en) | 2006-03-03 | 2007-09-13 | California Institute Of Technology | Site-specific incorporation of amino acids into molecules |
| US9274130B2 (en) | 2006-05-31 | 2016-03-01 | Lpath, Inc. | Prevention and treatment of pain using antibodies to lysophosphatidic acid |
| WO2008001947A1 (en) | 2006-06-28 | 2008-01-03 | Riken | MUTANT SepRS, AND METHOD FOR SITE-SPECIFIC INTRODUCTION OF PHOSPHOSERINE INTO PROTEIN BY USING THE SAME |
| US20120077224A1 (en) | 2009-06-05 | 2012-03-29 | The Salk Institute For Biological Studies | unnatural amino acid incorporation in eukaryotic cells |
| JP5725467B2 (ja) | 2010-08-27 | 2015-05-27 | 国立大学法人 東京大学 | 新規人工翻訳合成系 |
| JP5818237B2 (ja) | 2010-09-09 | 2015-11-18 | 国立大学法人 東京大学 | Ｎ−メチルアミノ酸およびその他の特殊アミノ酸を含む特殊ペプチド化合物ライブラリーの翻訳構築と活性種探索法 |
| EP2647720B1 (en) | 2010-12-03 | 2019-06-19 | The University of Tokyo | Peptide library production method, peptide library, and screening method |
| TW202446781A (zh) | 2011-12-28 | 2024-12-01 | 日商中外製藥股份有限公司 | 胜肽化合物之製造方法 |
| JP6754997B2 (ja) | 2013-08-26 | 2020-09-16 | 国立大学法人 東京大学 | 大環状ペプチド、その製造方法、及び大環状ペプチドライブラリを用いるスクリーニング方法 |
| WO2015120287A2 (en) | 2014-02-06 | 2015-08-13 | Yale University | Compositions and methods of use thereof for making polypeptides with many instances of nonstandard amino acids |
| WO2018052002A1 (ja) | 2016-09-13 | 2018-03-22 | 第一三共株式会社 | Ｔｈｒｏｍｂｏｓｐｏｎｄｉｎ １結合ペプチド |
| CN110869544B (zh) | 2017-06-09 | 2024-03-08 | 中外制药株式会社 | 膜透过性高的环状肽化合物及包含其的文库 |
| WO2019193416A1 (en) * | 2018-04-03 | 2019-10-10 | The University Of Queensland | Oligonucleotide-mediated sense codon reassignment |
-
2021
- 2021-06-25 JP JP2022532551A patent/JPWO2021261577A1/ja active Pending
- 2021-06-25 CN CN202180036193.4A patent/CN115667539A/zh active Pending
- 2021-06-25 US US18/010,608 patent/US20240052340A1/en active Pending
- 2021-06-25 KR KR1020237000660A patent/KR20230028363A/ko active Pending
- 2021-06-25 WO PCT/JP2021/024075 patent/WO2021261577A1/ja not_active Ceased
- 2021-06-25 TW TW110123326A patent/TW202208623A/zh unknown
- 2021-06-25 EP EP21828111.1A patent/EP4166675A4/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018509172A (ja) * | 2015-03-27 | 2018-04-05 | ザ ユニバーシティ オブ クィーンズランド | タンパク質への非天然アミノ酸組込みのためのプラットフォーム |
| WO2018143145A1 (ja) * | 2017-01-31 | 2018-08-09 | 中外製薬株式会社 | 無細胞翻訳系におけるペプチドの合成方法 |
Non-Patent Citations (2)
| Title |
|---|
| MURAMATSU, T., ET AL.: "A novel lysine-substituted nucleoside in the first position of the anticodon of minor isoleucine tRN", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 19, JPN6021035571, 1988, pages 9261 - 9267, ISSN: 0005651240 * |
| 鈴木勉: "アーキアにおける遺伝暗号解読機構 アグマチジンの生合成とＡＵＡコドンの解読", 化学と生物, vol. 50, no. 1, JPN6021035570, 2012, pages 36 - 43, ISSN: 0005727692 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4166675A1 (en) | 2023-04-19 |
| CN115667539A (zh) | 2023-01-31 |
| US20240052340A1 (en) | 2024-02-15 |
| KR20230028363A (ko) | 2023-02-28 |
| EP4166675A4 (en) | 2025-06-11 |
| TW202208623A (zh) | 2022-03-01 |
| WO2021261577A1 (ja) | 2021-12-30 |
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