JPWO2021261577A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2021261577A5
JPWO2021261577A5 JP2022532551A JP2022532551A JPWO2021261577A5 JP WO2021261577 A5 JPWO2021261577 A5 JP WO2021261577A5 JP 2022532551 A JP2022532551 A JP 2022532551A JP 2022532551 A JP2022532551 A JP 2022532551A JP WO2021261577 A5 JPWO2021261577 A5 JP WO2021261577A5
Authority
JP
Japan
Prior art keywords
translation system
trna
adenosine
amino acid
codon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022532551A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2021261577A1 (https=
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/JP2021/024075 external-priority patent/WO2021261577A1/ja
Publication of JPWO2021261577A1 publication Critical patent/JPWO2021261577A1/ja
Publication of JPWO2021261577A5 publication Critical patent/JPWO2021261577A5/ja
Pending legal-status Critical Current

Links

JP2022532551A 2020-06-25 2021-06-25 Pending JPWO2021261577A1 (https=)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020109576 2020-06-25
PCT/JP2021/024075 WO2021261577A1 (ja) 2020-06-25 2021-06-25 改変された遺伝暗号表を有する翻訳系

Publications (2)

Publication Number Publication Date
JPWO2021261577A1 JPWO2021261577A1 (https=) 2021-12-30
JPWO2021261577A5 true JPWO2021261577A5 (https=) 2024-05-30

Family

ID=79281398

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022532551A Pending JPWO2021261577A1 (https=) 2020-06-25 2021-06-25

Country Status (7)

Country Link
US (1) US20240052340A1 (https=)
EP (1) EP4166675A4 (https=)
JP (1) JPWO2021261577A1 (https=)
KR (1) KR20230028363A (https=)
CN (1) CN115667539A (https=)
TW (1) TW202208623A (https=)
WO (1) WO2021261577A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
EP4166664A1 (en) 2015-03-13 2023-04-19 Chugai Seiyaku Kabushiki Kaisha Modified aminoacyl-trna synthetase and use thereof
JP7187323B2 (ja) 2017-01-31 2022-12-12 中外製薬株式会社 無細胞翻訳系におけるペプチドの合成方法
KR20250007021A (ko) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
EP3878836B1 (en) 2018-11-07 2025-07-23 Chugai Seiyaku Kabushiki Kaisha O-substituted serine derivative production method
EP3939962A4 (en) 2019-03-15 2022-12-28 Chugai Seiyaku Kabushiki Kaisha PROCESS FOR PREPARING AN AROMATIC AMINO ACID DERIVATIVE
BR112022007535A2 (pt) 2019-11-07 2022-07-12 Chugai Pharmaceutical Co Ltd Composto peptídico cíclico tendo ação inibitória de kras
JP7823181B2 (ja) 2022-05-06 2026-03-03 中外製薬株式会社 Hrasおよびnrasに対して選択的なkras阻害作用を有する環状化合物
JPWO2024128195A1 (https=) * 2022-12-12 2024-06-20

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006135096A1 (ja) 2005-06-14 2006-12-21 Gifu University 部位特異的にタンパク質にチロシンアナログを導入する方法
WO2007061136A1 (ja) 2005-11-24 2007-05-31 Riken 非天然型アミノ酸を組み込んだタンパク質の製造方法
WO2007066627A1 (ja) 2005-12-06 2007-06-14 The University Of Tokyo 多目的アシル化触媒とその用途
AU2007224019A1 (en) 2006-03-03 2007-09-13 California Institute Of Technology Site-specific incorporation of amino acids into molecules
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
WO2008001947A1 (en) 2006-06-28 2008-01-03 Riken MUTANT SepRS, AND METHOD FOR SITE-SPECIFIC INTRODUCTION OF PHOSPHOSERINE INTO PROTEIN BY USING THE SAME
US20120077224A1 (en) 2009-06-05 2012-03-29 The Salk Institute For Biological Studies unnatural amino acid incorporation in eukaryotic cells
JP5725467B2 (ja) 2010-08-27 2015-05-27 国立大学法人 東京大学 新規人工翻訳合成系
JP5818237B2 (ja) 2010-09-09 2015-11-18 国立大学法人 東京大学 N−メチルアミノ酸およびその他の特殊アミノ酸を含む特殊ペプチド化合物ライブラリーの翻訳構築と活性種探索法
EP2647720B1 (en) 2010-12-03 2019-06-19 The University of Tokyo Peptide library production method, peptide library, and screening method
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
JP6754997B2 (ja) 2013-08-26 2020-09-16 国立大学法人 東京大学 大環状ペプチド、その製造方法、及び大環状ペプチドライブラリを用いるスクリーニング方法
WO2015120287A2 (en) 2014-02-06 2015-08-13 Yale University Compositions and methods of use thereof for making polypeptides with many instances of nonstandard amino acids
EP3274459A4 (en) 2015-03-27 2018-08-22 The University of Queensland Platform for non-natural amino acid incorporation into proteins
WO2018052002A1 (ja) 2016-09-13 2018-03-22 第一三共株式会社 Thrombospondin 1結合ペプチド
JP7187323B2 (ja) * 2017-01-31 2022-12-12 中外製薬株式会社 無細胞翻訳系におけるペプチドの合成方法
CN110869544B (zh) 2017-06-09 2024-03-08 中外制药株式会社 膜透过性高的环状肽化合物及包含其的文库
WO2019193416A1 (en) * 2018-04-03 2019-10-10 The University Of Queensland Oligonucleotide-mediated sense codon reassignment

Similar Documents

Publication Publication Date Title
JPWO2021261577A5 (https=)
US8299225B2 (en) Amidite for synthesizing modified nucleic acid and method for synthesizing modified nucleic acid
EP3878836A1 (en) O-substituted serine derivative production method
WO2018103509A1 (zh) 含连续季碳中心环丙烷氨基磷酸酯类化合物的合成方法
AU2015336857B2 (en) Genetic encoding of chemical post-translational modification for phage-displayed libraries
US8889843B2 (en) Nucleic acid synthesizing dimer amidite and nucleic acid synthesizing method
CN110950872A (zh) 制备靶向抗癌药avapritinib的方法
CN118048338B (zh) Sam类似物、sam依赖型甲基转移酶突变体及其应用
JP5750209B2 (ja) 機能性分子、機能性分子合成用アミダイド、及び標的物質解析方法
England et al. Incorporation of esters into proteins: Improved synthesis of hydroxyacyl tRNAs
US3137705A (en) Hydroxylamino compounds
JP5544833B2 (ja) インドール基用保護基
CN111808114A (zh) 基于级联巯基/溴代马来酰亚胺迈克尔加成的化合物及其应用
JP2014152158A (ja) アミン化合物の製造方法
CN113801020B (zh) 一种用于核酸液相合成载体的化合物及其制备方法和用途
Artman III et al. Preparation of N-Sulfonylimines Bearing Easily Removable Protecting Groups via the Hudson Reaction of Oximes with Sulfinyl Chlorides
OKADA et al. Amino Acids and Peptides. V. Synthesis of NL-and D-Alanyl-1-aminoethylphosphonic Acids
CN102603705A (zh) 取代基中α-碳上带活性官能团的手性五元环亚硫酸酯的制备方法
CN120608293A (zh) 一种1-吡咯啉的电合成方法
CN109651451B (zh) 阿扎胞苷衍生物的制备方法及其应用
CN121362135A (zh) 一种用于寡核苷酸制备的通用载体us ii的高效合成方法
JP4643156B2 (ja) N−アシルスルホンアミド結合を有する新規ホスミドシン類縁体
JP5795819B2 (ja) インドール基用保護基、並びに核酸自動合成用アミダイド及び核酸合成方法
Adams et al. Primary Amine-Functionalized Ligand Substitution and Biotinylation of Co (III) for Ligand-Anchored Artificial Metalloenzymes
EP0454385A1 (en) Process for preparing optically active isomers of 6-substituted purinyl piperazine derivatives