JP2009529877A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009529877A5 JP2009529877A5 JP2009500449A JP2009500449A JP2009529877A5 JP 2009529877 A5 JP2009529877 A5 JP 2009529877A5 JP 2009500449 A JP2009500449 A JP 2009500449A JP 2009500449 A JP2009500449 A JP 2009500449A JP 2009529877 A5 JP2009529877 A5 JP 2009529877A5
- Authority
- JP
- Japan
- Prior art keywords
- trna
- amino acid
- protein
- phenylselenocysteine
- translation system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 claims 30
- 108090000623 proteins and genes Proteins 0.000 claims 29
- 102000004169 proteins and genes Human genes 0.000 claims 29
- FXTLFZWJXBBXGX-QMMMGPOBSA-N (2R)-2-anilino-3-selanylpropanoic acid Chemical compound OC(=O)[C@H](C[SeH])NC1=CC=CC=C1 FXTLFZWJXBBXGX-QMMMGPOBSA-N 0.000 claims 24
- 238000000034 method Methods 0.000 claims 15
- 108020004705 Codon Proteins 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 108091033319 polynucleotide Proteins 0.000 claims 12
- 102000040430 polynucleotide Human genes 0.000 claims 12
- 239000002157 polynucleotide Substances 0.000 claims 12
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 10
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 10
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 6
- UQBOJOOOTLPNST-UHFFFAOYSA-N Dehydroalanine Chemical compound NC(=C)C(O)=O UQBOJOOOTLPNST-UHFFFAOYSA-N 0.000 claims 5
- 241000588724 Escherichia coli Species 0.000 claims 3
- 125000003473 lipid group Chemical group 0.000 claims 3
- 238000007248 oxidative elimination reaction Methods 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 241001112695 Clostridiales Species 0.000 claims 2
- 108700025695 Suppressor Genes Proteins 0.000 claims 2
- 230000000689 aminoacylating effect Effects 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 238000002741 site-directed mutagenesis Methods 0.000 claims 2
- CJWPDADGDASKGI-YFVJMOTDSA-N (2e,6e)-3,7,11-trimethyldodeca-2,6,10-triene-1-thiol Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CS CJWPDADGDASKGI-YFVJMOTDSA-N 0.000 claims 1
- CFISTOPZXSTQOS-SFHVURJKSA-N (2r)-2-amino-3-hexadecylsulfanylpropanoic acid Chemical compound CCCCCCCCCCCCCCCCSC[C@H](N)C(O)=O CFISTOPZXSTQOS-SFHVURJKSA-N 0.000 claims 1
- 238000006845 Michael addition reaction Methods 0.000 claims 1
- YYHOQQKJSHXDEN-KRWDZBQOSA-N N-palmitoyl-L-cysteine Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CS)C(O)=O YYHOQQKJSHXDEN-KRWDZBQOSA-N 0.000 claims 1
- SYSLNQMKLROGCL-BCYUYYMPSA-N S-[(2E,6E)-farnesyl]-L-cysteine zwitterion Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CSC[C@H](N)C(O)=O SYSLNQMKLROGCL-BCYUYYMPSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- ORTRWBYBJVGVQC-UHFFFAOYSA-N hexadecane-1-thiol Chemical compound CCCCCCCCCCCCCCCCS ORTRWBYBJVGVQC-UHFFFAOYSA-N 0.000 claims 1
- KPUXJBYSYFEKKB-UHFFFAOYSA-N hexadecanethioic s-acid Chemical compound CCCCCCCCCCCCCCCC(S)=O KPUXJBYSYFEKKB-UHFFFAOYSA-N 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78327206P | 2006-03-16 | 2006-03-16 | |
| US60/783,272 | 2006-03-16 | ||
| US86145606P | 2006-11-28 | 2006-11-28 | |
| US60/861,456 | 2006-11-28 | ||
| PCT/US2007/006382 WO2007109035A2 (en) | 2006-03-16 | 2007-03-13 | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009529877A JP2009529877A (ja) | 2009-08-27 |
| JP2009529877A5 true JP2009529877A5 (https=) | 2010-04-30 |
| JP5249194B2 JP5249194B2 (ja) | 2013-07-31 |
Family
ID=38522926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500449A Expired - Fee Related JP5249194B2 (ja) | 2006-03-16 | 2007-03-13 | 非天然アミノ酸フェニルセレノシステインを含有するタンパク質の遺伝的にプログラムされた発現 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7790847B2 (https=) |
| EP (1) | EP1994165B1 (https=) |
| JP (1) | JP5249194B2 (https=) |
| KR (1) | KR20080113226A (https=) |
| CN (1) | CN101405401B (https=) |
| AU (1) | AU2007227592B2 (https=) |
| BR (1) | BRPI0709603A2 (https=) |
| CA (1) | CA2638772A1 (https=) |
| IL (1) | IL193722A0 (https=) |
| MX (1) | MX2008011669A (https=) |
| RU (1) | RU2464315C2 (https=) |
| WO (1) | WO2007109035A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002085923A2 (en) * | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| MXPA05003978A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| EP1649004A4 (en) * | 2003-07-07 | 2008-04-09 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| CN101048506B (zh) | 2004-10-27 | 2013-06-26 | 斯克利普斯研究院 | 体内掺入非天然氨基酸的正交翻译组分 |
| KR20080106430A (ko) * | 2006-03-09 | 2008-12-05 | 더 스크립스 리서치 인스티튜트 | 진정 세균 숙주 세포 내에서의 직교형 번역 성분의 발현을 위한 시스템 |
| WO2007109035A2 (en) | 2006-03-16 | 2007-09-27 | The Scripps Research Institute | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
| AU2007267950B2 (en) * | 2006-05-23 | 2012-08-16 | The Scripps Research Institute | Genetically encoded fluorescent coumarin amino acids |
| JP5385143B2 (ja) * | 2006-09-21 | 2014-01-08 | ザ スクリプス リサーチ インスティチュート | 真正細菌における選択的に硫酸化された蛋白質の遺伝的にプログラムされた発現 |
| WO2008073184A2 (en) | 2006-10-18 | 2008-06-19 | The Scripps Research Institute | Genetic incorporation of unnatural amino acids into proteins in mammalian cells |
| US8673591B2 (en) | 2007-10-25 | 2014-03-18 | The Scripps Research Institute | Genetic incorporation of 3-aminotyrosine into reductases |
| WO2009059056A2 (en) * | 2007-11-02 | 2009-05-07 | The Scripps Research Institute | A genetically encoded boronate amino acid |
| JP5513398B2 (ja) * | 2007-11-02 | 2014-06-04 | ザ スクリプス リサーチ インスティチュート | 非天然アミノ酸を含有する蛋白質を使用する指向的進化 |
| CN101939410A (zh) | 2007-12-11 | 2011-01-05 | 斯克利普斯研究院 | 甲基营养酵母菌巴斯德毕赤酵母中的体内非天然氨基酸表达 |
| WO2009086497A2 (en) * | 2007-12-28 | 2009-07-09 | Ardell David H | Genetic encryption |
| CN104651381A (zh) | 2008-01-03 | 2015-05-27 | 巴斯夫酶有限责任公司 | 转移酶和氧化还原酶、编码它们的核酸以及其制备和应用方法 |
| EP2249865A4 (en) * | 2008-02-08 | 2012-04-04 | Scripps Research Inst | BREAKING IMMUNOLOGICAL TOLERANCE WITH A GENETICALLY ENCODED UNNATURAL AMINO ACID |
| US20090197339A1 (en) * | 2008-12-10 | 2009-08-06 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris |
| US8609383B2 (en) | 2008-12-10 | 2013-12-17 | The Scripps Research Institute | Production of carrier-peptide conjugates using chemically reactive unnatural amino acids |
| US8658394B2 (en) * | 2011-02-02 | 2014-02-25 | Waterstone Pharmaceuticals | Methods, cells and systems for incorporating non-canonical amino acids into proteins |
| CN103215235B (zh) * | 2012-01-18 | 2014-11-05 | 中国科学院生物物理研究所 | 3-咪唑基酪氨酸翻译系统及其应用 |
| CN103571804B (zh) * | 2012-08-10 | 2015-08-12 | 中国科学院生物物理研究所 | 3-吡唑基酪氨酸翻译系统及其应用 |
| PL2906592T3 (pl) * | 2012-10-12 | 2019-07-31 | Sutro Biopharma, Inc. | Proteolityczna inaktywacja wybranych białek w ekstraktach bakteryjnych dla ulepszonej ekspresji |
| CN103820410B (zh) * | 2012-11-16 | 2016-03-30 | 中国科学院生物物理研究所 | 3-甲硫酪氨酸翻译系统及其应用 |
| CN104004723B (zh) * | 2013-02-22 | 2016-08-17 | 中国科学院生物物理研究所 | 3,5-二氟代酪氨酸翻译系统及其应用 |
| CN104059891B (zh) * | 2013-03-22 | 2016-08-17 | 中国科学院生物物理研究所 | 8-羟基喹啉丙氨酸翻译系统及其应用 |
| JP6822839B2 (ja) * | 2013-09-13 | 2021-01-27 | ザ・スクリップス・リサーチ・インスティテュート | 修飾された治療剤、及びその組成物 |
| KR102455171B1 (ko) | 2013-12-18 | 2022-10-14 | 더 스크립스 리서치 인스티튜트 | 변형된 치료제, 스테이플드 펩티드 지질 접합체, 및 이의 조성물 |
| PL3458074T3 (pl) * | 2016-05-16 | 2024-11-12 | Board Of Regents Of The University Of Texas System | KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIA |
| JP7234114B2 (ja) | 2016-12-29 | 2023-03-07 | イルミナ インコーポレイテッド | 細胞区画内の生体分子への直交アクセスおよび細胞区画内の生体分子のタグ付けのための分析システム |
| MX2022006861A (es) | 2019-12-04 | 2022-07-11 | Scripps Research Inst | Agonistas del receptor glp2 y metodos de uso. |
| CN114644581B (zh) * | 2021-01-04 | 2024-07-16 | 北京惠大生物科技有限公司 | 含芳基硫酚或芳基硒酚经修饰的氨基酸、重组蛋白及其生物合成方法及应用 |
| KR20240032010A (ko) | 2021-06-09 | 2024-03-08 | 더 스크립스 리서치 인스티튜트 | 장기 지속형 이중 gip/glp-1 펩타이드 접합체 및 사용 방법 |
| CN118389493B (zh) * | 2024-05-10 | 2025-04-11 | 北京大学 | 一种定点修饰的工程化tRNA及其应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2118586A1 (en) * | 1992-07-13 | 1994-01-20 | Bernard Malfroy-Camine | Transvascular and intracellular delivery of lipidized proteins |
| WO2002085923A2 (en) * | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| MXPA05003978A (es) | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| JP4444113B2 (ja) * | 2002-10-16 | 2010-03-31 | ザ スクリップス リサーチ インスティテュート | ケトアミノ酸の部位特異的蛋白質組込み方法 |
| CA2508939A1 (en) | 2002-12-22 | 2004-07-15 | The Scripps Research Institute | Protein arrays |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| EP2410331B1 (en) | 2003-06-18 | 2015-09-23 | The Scripps Research Institute | Aminoacyl-tRNA synthetase for aminoacylation tRNA with unnatural amino acids |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| EP1649004A4 (en) | 2003-07-07 | 2008-04-09 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| US20060160175A1 (en) | 2003-07-07 | 2006-07-20 | The Scripps Research Institute | Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| PT1687401E (pt) | 2003-10-14 | 2013-02-26 | Scripps Research Inst | Incorporação de aminoácidos activos em oxidação-redução específica do local em proteínas |
| US7741071B2 (en) | 2003-12-18 | 2010-06-22 | The Scripps Research Institute | Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells |
| US20050287639A1 (en) * | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| JP2008500050A (ja) | 2004-05-25 | 2008-01-10 | ザ スクリップス リサーチ インスティテュート | 結晶構造決定のための重原子含有非天然アミノ酸の部位特異的蛋白質組込み |
| US20090181858A1 (en) | 2004-09-21 | 2009-07-16 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
| AU2005286722B2 (en) * | 2004-09-21 | 2010-12-02 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| US20080171317A1 (en) | 2004-09-22 | 2008-07-17 | The Scripps Research Institute | Site-Specific Labeling of Proteins for Nmr Studies |
| JP2008516637A (ja) | 2004-10-20 | 2008-05-22 | ザ スクリップス リサーチ インスティテュート | 真正細菌へのｎ−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み |
| CN101048506B (zh) | 2004-10-27 | 2013-06-26 | 斯克利普斯研究院 | 体内掺入非天然氨基酸的正交翻译组分 |
| BRPI0617191A2 (pt) | 2005-10-12 | 2011-07-19 | Scripps Research Inst | modificação pós-traducional de polipeptìdeos expressos em fagos |
| KR20080106430A (ko) | 2006-03-09 | 2008-12-05 | 더 스크립스 리서치 인스티튜트 | 진정 세균 숙주 세포 내에서의 직교형 번역 성분의 발현을 위한 시스템 |
| WO2007109035A2 (en) | 2006-03-16 | 2007-09-27 | The Scripps Research Institute | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
-
2007
- 2007-03-13 WO PCT/US2007/006382 patent/WO2007109035A2/en not_active Ceased
- 2007-03-13 US US11/724,039 patent/US7790847B2/en active Active
- 2007-03-13 AU AU2007227592A patent/AU2007227592B2/en not_active Ceased
- 2007-03-13 KR KR1020087024575A patent/KR20080113226A/ko not_active Ceased
- 2007-03-13 US US12/225,261 patent/US8217145B2/en active Active
- 2007-03-13 MX MX2008011669A patent/MX2008011669A/es active IP Right Grant
- 2007-03-13 RU RU2008135114/10A patent/RU2464315C2/ru not_active IP Right Cessation
- 2007-03-13 CN CN2007800092529A patent/CN101405401B/zh not_active Expired - Fee Related
- 2007-03-13 CA CA002638772A patent/CA2638772A1/en not_active Abandoned
- 2007-03-13 EP EP07753037.6A patent/EP1994165B1/en not_active Not-in-force
- 2007-03-13 BR BRPI0709603-8A patent/BRPI0709603A2/pt not_active Application Discontinuation
- 2007-03-13 JP JP2009500449A patent/JP5249194B2/ja not_active Expired - Fee Related
-
2008
- 2008-08-27 IL IL193722A patent/IL193722A0/en unknown
-
2012
- 2012-06-08 US US13/492,240 patent/US8394605B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009529877A5 (https=) | ||
| RU2008135114A (ru) | Генетически запрограммированная экспрессия белков, содержащих не встречающуюся в природе аминокислоту фенилселеноцистеин | |
| JP2008517631A5 (https=) | ||
| JP2008516637A5 (https=) | ||
| JP6239888B2 (ja) | 直交ｔＲＮＡ−アミノアシルｔＲＮＡシンテターゼ対を生産するための方法及び組成物 | |
| RU2009110152A (ru) | Генетически закодированная формула селективно-сульфатных белков в эубактерии | |
| JP2009538136A5 (https=) | ||
| Lennen et al. | Combinatorial strategies for improving multiple-stress resistance in industrially relevant Escherichia coli strains | |
| JP2010504096A5 (https=) | ||
| CA2442679A1 (en) | Methods for secretory production of proteins | |
| RU2007141683A (ru) | Вариантная форма урат-оксидазы и ее использование | |
| JP2010530223A5 (https=) | ||
| RU2009112104A (ru) | Генетическое встраивание не встречающихся в природе аминокислот в белки клеток млекопитающих | |
| JP2010501167A5 (https=) | ||
| WO2007005604A3 (en) | Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof | |
| EP3969582A1 (en) | Synthetic genome | |
| WO2021117848A1 (ja) | 非天然アミノ酸を含むペプチドの製造方法 | |
| JP4850064B2 (ja) | 無細胞タンパク質生合成用溶解物の産生法 | |
| US10480003B2 (en) | Constructs and systems and methods for engineering a CO2 fixing photorespiratory by-pass pathway | |
| KR101135647B1 (ko) | 메타게놈 유래 알칼린 포스파타아제 | |
| KR100750658B1 (ko) | 폴리믹신 생합성 효소 및 이를 코딩하는 유전자 군 | |
| WO2009038841A3 (en) | Portable, temperature and chemically inducible expression vector for high cell density expression of heterologous genes in escherichia coli | |
| JP4059398B2 (ja) | システイン合成酵素遺伝子を利用したセリン豊富な蛋白質の製造方法 | |
| JP2008517996A5 (https=) | ||
| US20240391961A1 (en) | Autonomous organisms for synthesis of permanently phosphorylated proteins |