JP2009529877A5 - - Google Patents
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- Publication number
- JP2009529877A5 JP2009529877A5 JP2009500449A JP2009500449A JP2009529877A5 JP 2009529877 A5 JP2009529877 A5 JP 2009529877A5 JP 2009500449 A JP2009500449 A JP 2009500449A JP 2009500449 A JP2009500449 A JP 2009500449A JP 2009529877 A5 JP2009529877 A5 JP 2009529877A5
- Authority
- JP
- Japan
- Prior art keywords
- trna
- amino acid
- protein
- phenylselenocysteine
- translation system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 claims 30
- 108090000623 proteins and genes Proteins 0.000 claims 29
- 102000004169 proteins and genes Human genes 0.000 claims 29
- FXTLFZWJXBBXGX-QMMMGPOBSA-N (2R)-2-anilino-3-selanylpropanoic acid Chemical compound OC(=O)[C@H](C[SeH])NC1=CC=CC=C1 FXTLFZWJXBBXGX-QMMMGPOBSA-N 0.000 claims 24
- 238000000034 method Methods 0.000 claims 15
- 108020004705 Codon Proteins 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 108091033319 polynucleotide Proteins 0.000 claims 12
- 102000040430 polynucleotide Human genes 0.000 claims 12
- 239000002157 polynucleotide Substances 0.000 claims 12
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 10
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 10
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 6
- UQBOJOOOTLPNST-UHFFFAOYSA-N Dehydroalanine Chemical compound NC(=C)C(O)=O UQBOJOOOTLPNST-UHFFFAOYSA-N 0.000 claims 5
- 241000588724 Escherichia coli Species 0.000 claims 3
- 125000003473 lipid group Chemical group 0.000 claims 3
- 238000007248 oxidative elimination reaction Methods 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 241001112695 Clostridiales Species 0.000 claims 2
- 108700025695 Suppressor Genes Proteins 0.000 claims 2
- 230000000689 aminoacylating effect Effects 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 238000002741 site-directed mutagenesis Methods 0.000 claims 2
- CJWPDADGDASKGI-YFVJMOTDSA-N (2e,6e)-3,7,11-trimethyldodeca-2,6,10-triene-1-thiol Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CS CJWPDADGDASKGI-YFVJMOTDSA-N 0.000 claims 1
- CFISTOPZXSTQOS-SFHVURJKSA-N (2r)-2-amino-3-hexadecylsulfanylpropanoic acid Chemical compound CCCCCCCCCCCCCCCCSC[C@H](N)C(O)=O CFISTOPZXSTQOS-SFHVURJKSA-N 0.000 claims 1
- 238000006845 Michael addition reaction Methods 0.000 claims 1
- YYHOQQKJSHXDEN-KRWDZBQOSA-N N-palmitoyl-L-cysteine Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CS)C(O)=O YYHOQQKJSHXDEN-KRWDZBQOSA-N 0.000 claims 1
- SYSLNQMKLROGCL-BCYUYYMPSA-N S-[(2E,6E)-farnesyl]-L-cysteine zwitterion Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CSC[C@H](N)C(O)=O SYSLNQMKLROGCL-BCYUYYMPSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- ORTRWBYBJVGVQC-UHFFFAOYSA-N hexadecane-1-thiol Chemical compound CCCCCCCCCCCCCCCCS ORTRWBYBJVGVQC-UHFFFAOYSA-N 0.000 claims 1
- KPUXJBYSYFEKKB-UHFFFAOYSA-N hexadecanethioic s-acid Chemical compound CCCCCCCCCCCCCCCC(S)=O KPUXJBYSYFEKKB-UHFFFAOYSA-N 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78327206P | 2006-03-16 | 2006-03-16 | |
| US60/783,272 | 2006-03-16 | ||
| US86145606P | 2006-11-28 | 2006-11-28 | |
| US60/861,456 | 2006-11-28 | ||
| PCT/US2007/006382 WO2007109035A2 (en) | 2006-03-16 | 2007-03-13 | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009529877A JP2009529877A (ja) | 2009-08-27 |
| JP2009529877A5 true JP2009529877A5 (https=) | 2010-04-30 |
| JP5249194B2 JP5249194B2 (ja) | 2013-07-31 |
Family
ID=38522926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500449A Expired - Fee Related JP5249194B2 (ja) | 2006-03-16 | 2007-03-13 | 非天然アミノ酸フェニルセレノシステインを含有するタンパク質の遺伝的にプログラムされた発現 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7790847B2 (https=) |
| EP (1) | EP1994165B1 (https=) |
| JP (1) | JP5249194B2 (https=) |
| KR (1) | KR20080113226A (https=) |
| CN (1) | CN101405401B (https=) |
| AU (1) | AU2007227592B2 (https=) |
| BR (1) | BRPI0709603A2 (https=) |
| CA (1) | CA2638772A1 (https=) |
| IL (1) | IL193722A0 (https=) |
| MX (1) | MX2008011669A (https=) |
| RU (1) | RU2464315C2 (https=) |
| WO (1) | WO2007109035A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7083970B2 (en) * | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| MXPA05003978A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| WO2004094593A2 (en) | 2003-04-17 | 2004-11-04 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| EP1807515A4 (en) | 2004-10-27 | 2008-06-18 | Scripps Research Inst | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| US7960141B2 (en) * | 2006-03-09 | 2011-06-14 | The Scripps Research Institute | Systems for the expression of orthogonal translation components in eubacterial host cells |
| KR20080113226A (ko) | 2006-03-16 | 2008-12-29 | 더 스크립스 리서치 인스티튜트 | 비천연 아미노산 페닐셀레노시스테인을 함유하는 단백질의 유전자적으로 프로그램된 발현 |
| US7807411B2 (en) * | 2006-05-23 | 2010-10-05 | The Scripps Research Institute | Genetically encoded fluorescent coumarin amino acids |
| EP2052083B1 (en) * | 2006-09-21 | 2014-01-08 | The Scripps Research Institute | Genetically programmed expression of selectively sulfated proteins in eubacteria |
| JP2010506591A (ja) | 2006-10-18 | 2010-03-04 | ザ スクリップス リサーチ インスティテュート | 哺乳動物細胞中の蛋白質への非天然アミノ酸の遺伝的組込み |
| MX2010004464A (es) | 2007-10-25 | 2010-06-07 | Scripps Research Inst | Incorporacion genetica de 3-aminotirosina a reductasas. |
| WO2009059056A2 (en) * | 2007-11-02 | 2009-05-07 | The Scripps Research Institute | A genetically encoded boronate amino acid |
| US9150849B2 (en) | 2007-11-02 | 2015-10-06 | The Scripps Research Institute | Directed evolution using proteins comprising unnatural amino acids |
| AU2008335778B2 (en) | 2007-12-11 | 2014-04-10 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast Pichia pastoris |
| US8592199B2 (en) | 2007-12-28 | 2013-11-26 | David H. Ardell | Genetic encryption |
| CA2710683A1 (en) | 2008-01-03 | 2009-07-16 | Verenium Corporation | Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them |
| CN101970005A (zh) * | 2008-02-08 | 2011-02-09 | 斯克利普斯研究院 | 用遗传编码的非天然氨基酸打破免疫耐受 |
| CN102307905B (zh) | 2008-12-10 | 2015-11-25 | 斯克利普斯研究院 | 利用化学反应性非天然氨基酸产生载体-肽偶联物 |
| US20090197339A1 (en) * | 2008-12-10 | 2009-08-06 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris |
| US8658394B2 (en) * | 2011-02-02 | 2014-02-25 | Waterstone Pharmaceuticals | Methods, cells and systems for incorporating non-canonical amino acids into proteins |
| CN103215235B (zh) * | 2012-01-18 | 2014-11-05 | 中国科学院生物物理研究所 | 3-咪唑基酪氨酸翻译系统及其应用 |
| CN103571804B (zh) * | 2012-08-10 | 2015-08-12 | 中国科学院生物物理研究所 | 3-吡唑基酪氨酸翻译系统及其应用 |
| JP6421122B2 (ja) | 2012-10-12 | 2018-11-07 | ストロ バイオファーマ， インコーポレイテッド | 改善された発現のための、細菌抽出物中の選択タンパク質のタンパク質分解不活性化 |
| CN103820410B (zh) * | 2012-11-16 | 2016-03-30 | 中国科学院生物物理研究所 | 3-甲硫酪氨酸翻译系统及其应用 |
| CN104004723B (zh) * | 2013-02-22 | 2016-08-17 | 中国科学院生物物理研究所 | 3,5-二氟代酪氨酸翻译系统及其应用 |
| CN104059891B (zh) * | 2013-03-22 | 2016-08-17 | 中国科学院生物物理研究所 | 8-羟基喹啉丙氨酸翻译系统及其应用 |
| CN105792851B (zh) * | 2013-09-13 | 2023-10-10 | 斯克利普斯研究所 | 修饰的治疗剂及其组合物 |
| AU2014364589B2 (en) | 2013-12-18 | 2020-02-27 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| CN109414451B (zh) * | 2016-05-16 | 2022-08-12 | 德克萨斯大学系统董事会 | 用于作为纳米粒递送tRNA的组合物及其使用方法 |
| AU2017386533B2 (en) | 2016-12-29 | 2024-05-09 | Illumina, Inc. | Analysis system for orthogonal access to and tagging of biomolecules in cellular compartments |
| AU2020397917A1 (en) | 2019-12-04 | 2022-06-23 | The Scripps Research Institute | GLP2 receptor agonists and methods of use |
| CN114644581B (zh) * | 2021-01-04 | 2024-07-16 | 北京惠大生物科技有限公司 | 含芳基硫酚或芳基硒酚经修饰的氨基酸、重组蛋白及其生物合成方法及应用 |
| MX2023014771A (es) | 2021-06-09 | 2024-03-19 | Scripps Research Inst | Conjugados peptidicos duales gip/glp-1 de accion prolongada y metodos de uso. |
| CN118389493B (zh) * | 2024-05-10 | 2025-04-11 | 北京大学 | 一种定点修饰的工程化tRNA及其应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI941169L (fi) * | 1992-07-13 | 1994-05-04 | Eukarion Inc | Lipidisoitujen proteiinien transvaskulaarinen ja intracellulaarinen antaminen |
| US7083970B2 (en) | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| MXPA05003978A (es) | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| ES2324608T3 (es) * | 2002-10-16 | 2009-08-11 | The Scripps Research Institute | Incorporacion especifica de sitio de cetoaminoacidos en proteinas. |
| WO2004058946A2 (en) | 2002-12-22 | 2004-07-15 | The Scripps Research Institute | Protein arrays |
| WO2004094593A2 (en) | 2003-04-17 | 2004-11-04 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
| JP5275566B2 (ja) | 2003-06-18 | 2013-08-28 | ザ スクリプス リサーチ インスティチュート | 反応性非天然アミノ酸遺伝コード付加 |
| US20060160175A1 (en) | 2003-07-07 | 2006-07-20 | The Scripps Research Institute | Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| JP5657850B2 (ja) * | 2003-10-14 | 2015-01-21 | ザ スクリプス リサーチ インスティテュート | 酸化還元機能性アミノ酸のタンパク質への部位特異的組み入れ |
| AU2004321117B2 (en) | 2003-12-18 | 2010-09-02 | The Scripps Research Institute | Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells |
| US20050287639A1 (en) * | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| AU2005248392A1 (en) | 2004-05-25 | 2005-12-08 | Irm, Llc | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination |
| CA2580840A1 (en) | 2004-09-21 | 2006-03-30 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| US20090181858A1 (en) | 2004-09-21 | 2009-07-16 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
| US20080171317A1 (en) | 2004-09-22 | 2008-07-17 | The Scripps Research Institute | Site-Specific Labeling of Proteins for Nmr Studies |
| JP2008516637A (ja) | 2004-10-20 | 2008-05-22 | ザ スクリップス リサーチ インスティテュート | 真正細菌へのｎ−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み |
| EP1807515A4 (en) | 2004-10-27 | 2008-06-18 | Scripps Research Inst | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| US8367588B2 (en) | 2005-10-12 | 2013-02-05 | The Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| US7960141B2 (en) | 2006-03-09 | 2011-06-14 | The Scripps Research Institute | Systems for the expression of orthogonal translation components in eubacterial host cells |
| KR20080113226A (ko) | 2006-03-16 | 2008-12-29 | 더 스크립스 리서치 인스티튜트 | 비천연 아미노산 페닐셀레노시스테인을 함유하는 단백질의 유전자적으로 프로그램된 발현 |
-
2007
- 2007-03-13 KR KR1020087024575A patent/KR20080113226A/ko not_active Ceased
- 2007-03-13 US US11/724,039 patent/US7790847B2/en active Active
- 2007-03-13 MX MX2008011669A patent/MX2008011669A/es active IP Right Grant
- 2007-03-13 RU RU2008135114/10A patent/RU2464315C2/ru not_active IP Right Cessation
- 2007-03-13 WO PCT/US2007/006382 patent/WO2007109035A2/en not_active Ceased
- 2007-03-13 AU AU2007227592A patent/AU2007227592B2/en not_active Ceased
- 2007-03-13 EP EP07753037.6A patent/EP1994165B1/en not_active Not-in-force
- 2007-03-13 CN CN2007800092529A patent/CN101405401B/zh not_active Expired - Fee Related
- 2007-03-13 JP JP2009500449A patent/JP5249194B2/ja not_active Expired - Fee Related
- 2007-03-13 BR BRPI0709603-8A patent/BRPI0709603A2/pt not_active Application Discontinuation
- 2007-03-13 US US12/225,261 patent/US8217145B2/en active Active
- 2007-03-13 CA CA002638772A patent/CA2638772A1/en not_active Abandoned
-
2008
- 2008-08-27 IL IL193722A patent/IL193722A0/en unknown
-
2012
- 2012-06-08 US US13/492,240 patent/US8394605B2/en not_active Expired - Fee Related
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