JP2008517631A5 - - Google Patents
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- Publication number
- JP2008517631A5 JP2008517631A5 JP2007539228A JP2007539228A JP2008517631A5 JP 2008517631 A5 JP2008517631 A5 JP 2008517631A5 JP 2007539228 A JP2007539228 A JP 2007539228A JP 2007539228 A JP2007539228 A JP 2007539228A JP 2008517631 A5 JP2008517631 A5 JP 2008517631A5
- Authority
- JP
- Japan
- Prior art keywords
- trna
- amino acid
- providing
- translation system
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62273804P | 2004-10-27 | 2004-10-27 | |
| US60/622,738 | 2004-10-27 | ||
| PCT/US2005/039210 WO2006110182A2 (en) | 2004-10-27 | 2005-10-27 | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011255180A Division JP5539948B2 (ja) | 2004-10-27 | 2011-11-22 | 非天然アミノ酸のインビボ組込み用直交翻訳成分 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008517631A JP2008517631A (ja) | 2008-05-29 |
| JP2008517631A5 true JP2008517631A5 (https=) | 2008-12-04 |
| JP5135504B2 JP5135504B2 (ja) | 2013-02-06 |
Family
ID=37087466
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007539228A Expired - Fee Related JP5135504B2 (ja) | 2004-10-27 | 2005-10-27 | 非天然アミノ酸のインビボ組込み用直交翻訳成分 |
| JP2011255180A Expired - Fee Related JP5539948B2 (ja) | 2004-10-27 | 2011-11-22 | 非天然アミノ酸のインビボ組込み用直交翻訳成分 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011255180A Expired - Fee Related JP5539948B2 (ja) | 2004-10-27 | 2011-11-22 | 非天然アミノ酸のインビボ組込み用直交翻訳成分 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8216804B2 (https=) |
| EP (3) | EP1807515A4 (https=) |
| JP (2) | JP5135504B2 (https=) |
| CN (2) | CN102827827B (https=) |
| AU (1) | AU2005330514B2 (https=) |
| BR (1) | BRPI0517381A (https=) |
| CA (1) | CA2583735A1 (https=) |
| IL (2) | IL182495A0 (https=) |
| MX (1) | MX2007004892A (https=) |
| WO (1) | WO2006110182A2 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7083970B2 (en) * | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| MXPA05003978A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| WO2004094593A2 (en) | 2003-04-17 | 2004-11-04 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| CA2580840A1 (en) | 2004-09-21 | 2006-03-30 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| WO2006136197A1 (en) * | 2005-06-21 | 2006-12-28 | V. Mane Fils | Smoking device incorporating a breakable capsule, breakable capsule and process for manufacturing said capsule |
| US8367588B2 (en) | 2005-10-12 | 2013-02-05 | The Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| US7960141B2 (en) * | 2006-03-09 | 2011-06-14 | The Scripps Research Institute | Systems for the expression of orthogonal translation components in eubacterial host cells |
| KR20080113226A (ko) | 2006-03-16 | 2008-12-29 | 더 스크립스 리서치 인스티튜트 | 비천연 아미노산 페닐셀레노시스테인을 함유하는 단백질의 유전자적으로 프로그램된 발현 |
| US7807411B2 (en) | 2006-05-23 | 2010-10-05 | The Scripps Research Institute | Genetically encoded fluorescent coumarin amino acids |
| EP2052083B1 (en) | 2006-09-21 | 2014-01-08 | The Scripps Research Institute | Genetically programmed expression of selectively sulfated proteins in eubacteria |
| JP2010506591A (ja) | 2006-10-18 | 2010-03-04 | ザ スクリップス リサーチ インスティテュート | 哺乳動物細胞中の蛋白質への非天然アミノ酸の遺伝的組込み |
| WO2009049223A2 (en) * | 2007-10-10 | 2009-04-16 | Irm Llc | Methods and compositions for the site-selective incorporation of fluorinated amino acids into polypeptides |
| MX2010004464A (es) | 2007-10-25 | 2010-06-07 | Scripps Research Inst | Incorporacion genetica de 3-aminotirosina a reductasas. |
| US8940506B2 (en) | 2008-03-21 | 2015-01-27 | The Regents Of The University Of California | High-sensitive fluorescent energy transfer assay using fluoresent amino acids and fluorescent proteins |
| CN102307905B (zh) | 2008-12-10 | 2015-11-25 | 斯克利普斯研究院 | 利用化学反应性非天然氨基酸产生载体-肽偶联物 |
| JP5725467B2 (ja) * | 2010-08-27 | 2015-05-27 | 国立大学法人 東京大学 | 新規人工翻訳合成系 |
| US8658394B2 (en) * | 2011-02-02 | 2014-02-25 | Waterstone Pharmaceuticals | Methods, cells and systems for incorporating non-canonical amino acids into proteins |
| CN102888387B (zh) * | 2011-07-21 | 2015-03-18 | 中国科学院生物物理研究所 | 3-氯代酪氨酸翻译系统及其应用 |
| CN103215235B (zh) * | 2012-01-18 | 2014-11-05 | 中国科学院生物物理研究所 | 3-咪唑基酪氨酸翻译系统及其应用 |
| IN2014DN09922A (https=) | 2012-05-18 | 2015-08-14 | Medical Res Council | |
| PL2859017T3 (pl) | 2012-06-08 | 2019-07-31 | Sutro Biopharma, Inc. | Przeciwciała zawierające swoiste dla miejsca, niewystępujące naturalnie reszty aminokwasowe, sposoby ich wytwarzania i sposoby ich zastosowania |
| WO2014004639A1 (en) | 2012-06-26 | 2014-01-03 | Sutro Biopharma, Inc. | Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use |
| CN103571804B (zh) * | 2012-08-10 | 2015-08-12 | 中国科学院生物物理研究所 | 3-吡唑基酪氨酸翻译系统及其应用 |
| HRP20220455T1 (hr) | 2012-08-31 | 2022-05-27 | Sutro Biopharma, Inc. | Modificirane aminokiseline koje sadrže azid grupu |
| CN104004723B (zh) * | 2013-02-22 | 2016-08-17 | 中国科学院生物物理研究所 | 3,5-二氟代酪氨酸翻译系统及其应用 |
| JO3564B1 (ar) | 2013-03-08 | 2020-07-05 | Novartis Ag | ببتيدات وتركيبات لعلاج ضرر المفاصل |
| CN104059891B (zh) * | 2013-03-22 | 2016-08-17 | 中国科学院生物物理研究所 | 8-羟基喹啉丙氨酸翻译系统及其应用 |
| ES2865473T3 (es) | 2013-07-10 | 2021-10-15 | Sutro Biopharma Inc | Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso |
| US10005838B2 (en) | 2013-07-19 | 2018-06-26 | The Regents Of The University Of California | Milk fat globule epidermal growth factor 8 regulates fatty acid uptake |
| PL3055321T3 (pl) | 2013-10-11 | 2019-02-28 | Sutro Biopharma, Inc. | SYNTETAZY tRNA DOŁĄCZAJĄCE AMINOKWAS NIENATURALNY DLA PARA-METYLOAZYDO-L-FENYLOALANINY |
| WO2015054590A2 (en) * | 2013-10-11 | 2015-04-16 | Sutro Biopharma, Inc. | NON-NATURAL AMINO ACID tRNA SYNTHETASES FOR PYRIDYL TETRAZINE |
| EP3055298B1 (en) | 2013-10-11 | 2020-04-29 | Sutro Biopharma, Inc. | Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use |
| GB2528227A (en) | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
| GB201419109D0 (en) * | 2014-10-27 | 2014-12-10 | Medical Res Council | Incorporation of unnatural amino acids into proteins |
| WO2016176689A1 (en) * | 2015-04-30 | 2016-11-03 | Oregon State University | Reagents and methods for bioorthogonal labeling of biomolecules in living cells |
| SG11201806419RA (en) | 2016-01-27 | 2018-08-30 | Sutro Biopharma Inc | Anti-cd74 antibody conjugates, compositions comprising anti-cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates |
| WO2018031531A1 (en) * | 2016-08-08 | 2018-02-15 | President And Fellows Of Harvard College | Engineered bacteria for non-invasive imaging and therapeutic applications |
| EP3538546B1 (en) | 2016-11-14 | 2025-01-08 | Novartis AG | Compositions, methods, and therapeutic uses related to fusogenic protein minion |
| CN109963579A (zh) | 2016-11-14 | 2019-07-02 | 诺华股份有限公司 | 用于治疗软骨损伤和关节炎的方法和组合物 |
| WO2019005973A1 (en) * | 2017-06-30 | 2019-01-03 | President And Fellows Of Harvard College | SYNTHASE VARIANTS FOR INCORPORATING BIPHENYLALANINE INTO A PEPTIDE |
| US11364275B2 (en) * | 2017-08-04 | 2022-06-21 | Bioventures, Llc | Linear lipopeptide paenipeptins and methods of using the same |
| CN112673109A (zh) * | 2018-09-07 | 2021-04-16 | 免疫医疗有限责任公司 | 细胞选择方法 |
| GB201817444D0 (en) | 2018-10-26 | 2018-12-12 | Res & Innovation Uk | Methods and compositions |
| WO2020169658A2 (en) | 2019-02-20 | 2020-08-27 | Novo Nordisk A/S | Aminoacyl-trna synthetases and uses hereof |
| US12565646B2 (en) | 2019-06-21 | 2026-03-03 | Trustees Of Boston College | Enhanced platforms for unnatural amino acid incorporation in mammalian cells |
| CN114729334A (zh) * | 2019-08-08 | 2022-07-08 | 布里克生物公司 | 用于非天然氨基酸的位点特异性掺入的氨酰tRNA合成酶和细胞系 |
| AU2020361533A1 (en) * | 2019-10-08 | 2022-04-28 | Trustees Of Boston College | Proteins containing multiple, different unnatural amino acids and methods of making and using such proteins |
| KR20220080101A (ko) * | 2019-10-15 | 2022-06-14 | 트러스티스 오브 보스톤 칼리지 | 향상된 비천연 아미노산 혼입을 위한 키메라 열안정성 아미노아실-tRNA 합성효소 |
| US20230069218A1 (en) * | 2019-12-12 | 2023-03-02 | Chugai Seiyaku Kabushiki Kaisha | Method for producing peptide containing non-natural amino acid |
| WO2021165968A1 (en) * | 2020-02-20 | 2021-08-26 | B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Mutant aminoacyl-trna synthetases |
| EP4146665A1 (en) | 2020-05-05 | 2023-03-15 | Genentech, Inc. | Systems and methods for tyrosinase-mediated site-specific protein conjugation |
| EP4192943A4 (en) * | 2020-08-07 | 2025-02-12 | Brickbio, Inc. | Stable cell lines for site-specific incorporation of unnatural amino acids |
| CN114250243B (zh) * | 2020-09-24 | 2024-05-03 | 深圳华大生命科学研究院 | 一种检测极端嗜盐生物中氨酰-tRNA合成酶和tRNA活性的系统及方法 |
| CN113481218B (zh) * | 2021-06-13 | 2024-06-14 | 中国药科大学 | 巨型病毒或巨型噬菌体来源氨酰tRNA合成酶/tRNA正交体系构建方法及正交体系 |
| WO2023069816A2 (en) | 2021-09-20 | 2023-04-27 | The Broad Institute, Inc. | Compositions and methods for multiplex decoding of quadruplet codons |
| US20250129132A1 (en) * | 2021-09-21 | 2025-04-24 | University Of Washington | Genetically encoded and exogenously triggered protein-protein ligation |
| CN114134141B (zh) * | 2021-11-03 | 2024-01-30 | 杭州嵌化合生医药科技有限公司 | 一种引入非天然氨基酸的嵌合体苯丙氨酸翻译系统及其构建方法 |
| CN116376947A (zh) * | 2021-12-24 | 2023-07-04 | 北京理工大学 | 一种适用于筛选高产非蛋白质氨基酸的菌株的方法 |
| CN115717130B (zh) * | 2022-09-02 | 2024-10-15 | 凯莱英医药集团（天津）股份有限公司 | 氨酰-tRNA合酶突变体及烯基酪氨酰-tRNA的制备方法 |
| WO2024091824A1 (en) | 2022-10-26 | 2024-05-02 | Ada Forsyth Institute, Inc. | Differentiation and reprogramming of chondrocyte |
| WO2024147130A1 (en) * | 2023-01-02 | 2024-07-11 | B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Mutant aminoacyl trna synthetase, compositions comprising same, and use thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5580953A (en) * | 1991-08-14 | 1996-12-03 | Amylin Pharmaceuticals, Inc. | Amylin antagonist peptides and uses therefor |
| US5635608A (en) | 1994-11-08 | 1997-06-03 | Molecular Probes, Inc. | α-carboxy caged compounds |
| KR100501838B1 (ko) | 1995-04-24 | 2005-07-21 | 큐비스트 파마슈티컬즈 인코포레이티드 | 새로운 대사 경로를 만들고 이를 스크리닝하는 방법 |
| US5958672A (en) | 1995-07-18 | 1999-09-28 | Diversa Corporation | Protein activity screening of clones having DNA from uncultivated microorganisms |
| CN1156180A (zh) * | 1995-09-05 | 1997-08-06 | 底古萨股份公司 | 用大肠杆菌生产色氨酸 |
| US5998580A (en) | 1995-10-13 | 1999-12-07 | Fay; Frederick F. | Photosensitive caged macromolecules |
| US5756316A (en) | 1995-11-02 | 1998-05-26 | Genencor International, Inc. | Molecular cloning by multimerization of plasmids |
| US6171820B1 (en) | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
| US6238884B1 (en) | 1995-12-07 | 2001-05-29 | Diversa Corporation | End selection in directed evolution |
| US5783431A (en) | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
| JP2000301808A (ja) * | 1999-04-19 | 2000-10-31 | Canon Inc | テストパターン記録方法、情報処理装置および記録装置 |
| CN1297999A (zh) * | 1999-11-24 | 2001-06-06 | 上海博容基因开发有限公司 | 一种新的多肽——人谷氨酰转移核糖核酸合成酶58和编码这种多肽的多核苷酸 |
| CA2403296A1 (en) * | 2000-04-10 | 2001-10-18 | Benjamin F. Cravatt | Proteomic analysis using activity-based probe libraries |
| US7083970B2 (en) * | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| AU2003250559A1 (en) | 2002-07-23 | 2004-02-09 | Yong-Seok Jeong | Beverage can |
| MXPA05003978A (es) | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| ES2324608T3 (es) | 2002-10-16 | 2009-08-11 | The Scripps Research Institute | Incorporacion especifica de sitio de cetoaminoacidos en proteinas. |
| WO2004058946A2 (en) | 2002-12-22 | 2004-07-15 | The Scripps Research Institute | Protein arrays |
| WO2004094593A2 (en) | 2003-04-17 | 2004-11-04 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
| JP5275566B2 (ja) | 2003-06-18 | 2013-08-28 | ザ スクリプス リサーチ インスティチュート | 反応性非天然アミノ酸遺伝コード付加 |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| US20060160175A1 (en) | 2003-07-07 | 2006-07-20 | The Scripps Research Institute | Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| US7134031B2 (en) | 2003-08-04 | 2006-11-07 | Arm Limited | Performance control within a multi-processor system |
| JP5657850B2 (ja) | 2003-10-14 | 2015-01-21 | ザ スクリプス リサーチ インスティテュート | 酸化還元機能性アミノ酸のタンパク質への部位特異的組み入れ |
| AU2004321117B2 (en) | 2003-12-18 | 2010-09-02 | The Scripps Research Institute | Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells |
| JP2005322288A (ja) * | 2004-05-07 | 2005-11-17 | Sony Corp | ディスク記録及び／又は再生装置 |
| JP2005321568A (ja) * | 2004-05-07 | 2005-11-17 | Canon Inc | 画像形成装置 |
| AU2005248392A1 (en) | 2004-05-25 | 2005-12-08 | Irm, Llc | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination |
| US20090181858A1 (en) | 2004-09-21 | 2009-07-16 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
| CA2580840A1 (en) | 2004-09-21 | 2006-03-30 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| US20080171317A1 (en) | 2004-09-22 | 2008-07-17 | The Scripps Research Institute | Site-Specific Labeling of Proteins for Nmr Studies |
| JP2008516637A (ja) | 2004-10-20 | 2008-05-22 | ザ スクリップス リサーチ インスティテュート | 真正細菌へのｎ−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み |
| US8367588B2 (en) | 2005-10-12 | 2013-02-05 | The Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| US7960141B2 (en) | 2006-03-09 | 2011-06-14 | The Scripps Research Institute | Systems for the expression of orthogonal translation components in eubacterial host cells |
| KR20080113226A (ko) | 2006-03-16 | 2008-12-29 | 더 스크립스 리서치 인스티튜트 | 비천연 아미노산 페닐셀레노시스테인을 함유하는 단백질의 유전자적으로 프로그램된 발현 |
-
2005
- 2005-10-27 EP EP05857733A patent/EP1807515A4/en not_active Ceased
- 2005-10-27 CN CN201210216741.4A patent/CN102827827B/zh not_active Expired - Fee Related
- 2005-10-27 AU AU2005330514A patent/AU2005330514B2/en not_active Ceased
- 2005-10-27 CA CA002583735A patent/CA2583735A1/en not_active Abandoned
- 2005-10-27 BR BRPI0517381-7A patent/BRPI0517381A/pt not_active Application Discontinuation
- 2005-10-27 CN CN2005800369829A patent/CN101048506B/zh not_active Expired - Fee Related
- 2005-10-27 WO PCT/US2005/039210 patent/WO2006110182A2/en not_active Ceased
- 2005-10-27 JP JP2007539228A patent/JP5135504B2/ja not_active Expired - Fee Related
- 2005-10-27 EP EP11164983.6A patent/EP2380982B1/en not_active Expired - Lifetime
- 2005-10-27 US US11/665,083 patent/US8216804B2/en active Active
- 2005-10-27 EP EP11165007.3A patent/EP2383340B1/en not_active Expired - Lifetime
- 2005-10-27 MX MX2007004892A patent/MX2007004892A/es active IP Right Grant
-
2007
- 2007-04-12 IL IL182495A patent/IL182495A0/en unknown
-
2011
- 2011-02-15 IL IL211229A patent/IL211229A0/en unknown
- 2011-11-22 JP JP2011255180A patent/JP5539948B2/ja not_active Expired - Fee Related
-
2012
- 2012-06-08 US US13/492,296 patent/US9102932B2/en not_active Expired - Lifetime
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