JP2006507814A5 - - Google Patents
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- Publication number
- JP2006507814A5 JP2006507814A5 JP2004545280A JP2004545280A JP2006507814A5 JP 2006507814 A5 JP2006507814 A5 JP 2006507814A5 JP 2004545280 A JP2004545280 A JP 2004545280A JP 2004545280 A JP2004545280 A JP 2004545280A JP 2006507814 A5 JP2006507814 A5 JP 2006507814A5
- Authority
- JP
- Japan
- Prior art keywords
- trna
- cell
- phenylalanine
- acetyl
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 20
- 108091033319 polynucleotide Proteins 0.000 claims 13
- 102000040430 polynucleotide Human genes 0.000 claims 13
- 239000002157 polynucleotide Substances 0.000 claims 13
- ZXSBHXZKWRIEIA-JTQLQIEISA-N (2s)-3-(4-acetylphenyl)-2-azaniumylpropanoate Chemical compound CC(=O)C1=CC=C(C[C@H](N)C(O)=O)C=C1 ZXSBHXZKWRIEIA-JTQLQIEISA-N 0.000 claims 12
- 150000001413 amino acids Chemical group 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 6
- 108020004705 Codon Proteins 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 4
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 4
- 241000588724 Escherichia coli Species 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
- 210000003527 eukaryotic cell Anatomy 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 3
- 229960005190 phenylalanine Drugs 0.000 claims 2
- 241000203407 Methanocaldococcus jannaschii Species 0.000 claims 1
- CBQJSKKFNMDLON-JTQLQIEISA-N N-acetyl-L-phenylalanine Chemical compound CC(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 CBQJSKKFNMDLON-JTQLQIEISA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41926502P | 2002-10-16 | 2002-10-16 | |
| US42099002P | 2002-10-23 | 2002-10-23 | |
| PCT/US2003/032576 WO2004035743A2 (en) | 2002-10-16 | 2003-10-15 | Site specific incorporation of keto amino acids into proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006507814A JP2006507814A (ja) | 2006-03-09 |
| JP2006507814A5 true JP2006507814A5 (https=) | 2007-08-30 |
| JP4444113B2 JP4444113B2 (ja) | 2010-03-31 |
Family
ID=32110229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004545280A Expired - Lifetime JP4444113B2 (ja) | 2002-10-16 | 2003-10-15 | ケトアミノ酸の部位特異的蛋白質組込み方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7432092B2 (https=) |
| EP (2) | EP2062976B1 (https=) |
| JP (1) | JP4444113B2 (https=) |
| KR (1) | KR20050072441A (https=) |
| AT (2) | ATE429500T1 (https=) |
| AU (2) | AU2003277373B2 (https=) |
| CA (1) | CA2502029C (https=) |
| CY (1) | CY1110483T1 (https=) |
| DE (1) | DE60327369D1 (https=) |
| DK (1) | DK1578949T3 (https=) |
| ES (1) | ES2324608T3 (https=) |
| IL (3) | IL167715A (https=) |
| MX (1) | MXPA05003983A (https=) |
| PT (1) | PT1578949E (https=) |
| SI (1) | SI1578949T1 (https=) |
| WO (1) | WO2004035743A2 (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7083970B2 (en) * | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| MXPA05003978A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| WO2004094593A2 (en) | 2003-04-17 | 2004-11-04 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
| JP5275566B2 (ja) | 2003-06-18 | 2013-08-28 | ザ スクリプス リサーチ インスティチュート | 反応性非天然アミノ酸遺伝コード付加 |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| JP5657850B2 (ja) | 2003-10-14 | 2015-01-21 | ザ スクリプス リサーチ インスティテュート | 酸化還元機能性アミノ酸のタンパク質への部位特異的組み入れ |
| EP2327724A3 (en) | 2004-02-02 | 2011-07-27 | Ambrx, Inc. | Modified human growth hormone polypeptides and their uses |
| AU2005248392A1 (en) | 2004-05-25 | 2005-12-08 | Irm, Llc | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination |
| KR101699142B1 (ko) | 2004-06-18 | 2017-01-23 | 암브룩스, 인코포레이티드 | 신규 항원-결합 폴리펩티드 및 이의 용도 |
| JP2008507280A (ja) | 2004-07-21 | 2008-03-13 | アンブレツクス・インコーポレイテツド | 非天然コードアミノ酸を用いた生合成ポリペプチド |
| CA2580840A1 (en) | 2004-09-21 | 2006-03-30 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| US20080171317A1 (en) * | 2004-09-22 | 2008-07-17 | The Scripps Research Institute | Site-Specific Labeling of Proteins for Nmr Studies |
| JP2008516637A (ja) | 2004-10-20 | 2008-05-22 | ザ スクリップス リサーチ インスティテュート | 真正細菌へのｎ−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み |
| EP1807515A4 (en) * | 2004-10-27 | 2008-06-18 | Scripps Research Inst | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| JP2008525473A (ja) | 2004-12-22 | 2008-07-17 | アンブレツクス・インコーポレイテツド | 修飾されたヒト成長ホルモン |
| GB2438760A (en) | 2004-12-22 | 2007-12-05 | Ambrx Inc | Methods for expression and purification of recombinant human growth hormone |
| EP1828224B1 (en) | 2004-12-22 | 2016-04-06 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| CN102732588B (zh) | 2004-12-22 | 2015-01-07 | Ambrx公司 | 氨酰基-tRNA合成酶的组合物及其用途 |
| US7816320B2 (en) | 2004-12-22 | 2010-10-19 | Ambrx, Inc. | Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35 |
| WO2006133089A2 (en) | 2005-06-03 | 2006-12-14 | Ambrx, Inc. | Improved human interferon molecules and their uses |
| US20090306023A1 (en) * | 2005-06-29 | 2009-12-10 | Ramirez Jose E | Stable organic peroxide compositions |
| US8367588B2 (en) * | 2005-10-12 | 2013-02-05 | The Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| EP1951890A4 (en) | 2005-11-16 | 2009-06-24 | Ambrx Inc | PROCESSES AND COMPOSITIONS WITH NON-NATURAL AMINO ACIDS |
| DK1968635T3 (en) | 2005-12-14 | 2014-12-15 | Ambrx Inc | Compositions and Methods of, and uses of non-natural amino acids and polypeptides |
| WO2007092475A2 (en) * | 2006-02-06 | 2007-08-16 | Franklin And Marshall College | Site-specific incorporation of fluorinated amino acids into proteins |
| US7960141B2 (en) * | 2006-03-09 | 2011-06-14 | The Scripps Research Institute | Systems for the expression of orthogonal translation components in eubacterial host cells |
| KR20080113226A (ko) * | 2006-03-16 | 2008-12-29 | 더 스크립스 리서치 인스티튜트 | 비천연 아미노산 페닐셀레노시스테인을 함유하는 단백질의 유전자적으로 프로그램된 발현 |
| US7807411B2 (en) * | 2006-05-23 | 2010-10-05 | The Scripps Research Institute | Genetically encoded fluorescent coumarin amino acids |
| EP2064333B1 (en) | 2006-09-08 | 2014-02-26 | Ambrx, Inc. | Suppressor trna transcription in vertebrate cells |
| CN106008699A (zh) | 2006-09-08 | 2016-10-12 | Ambrx公司 | 经修饰的人类血浆多肽或Fc骨架和其用途 |
| MX2009002460A (es) * | 2006-09-08 | 2009-03-20 | Ambrx Inc | Arnt supresor hibrido para celulas de vertebrados. |
| EP2052083B1 (en) * | 2006-09-21 | 2014-01-08 | The Scripps Research Institute | Genetically programmed expression of selectively sulfated proteins in eubacteria |
| US20100055725A1 (en) * | 2006-10-17 | 2010-03-04 | Zymera, Inc. | System for assays of aminotransferase |
| JP2010506591A (ja) | 2006-10-18 | 2010-03-04 | ザ スクリップス リサーチ インスティテュート | 哺乳動物細胞中の蛋白質への非天然アミノ酸の遺伝的組込み |
| GB0623974D0 (en) * | 2006-11-30 | 2007-01-10 | Medical Res Council | Evolved orthogonal ribosomes |
| CA2682147C (en) | 2007-03-30 | 2017-08-08 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
| MX2009011870A (es) | 2007-05-02 | 2009-11-12 | Ambrx Inc | Polipeptidos de interferon beta modificados y usos de los mismos. |
| MX2010005317A (es) | 2007-11-20 | 2010-06-02 | Ambrx Inc | Polipeptidos de insulina modificados y sus usos. |
| NZ586947A (en) | 2008-02-08 | 2012-11-30 | Ambrx Inc | Modified leptin polypeptides and their uses |
| PT2318029T (pt) | 2008-07-23 | 2018-01-10 | Ambrx Inc | Polipéptidos de g-csf bovino modificados e suas utilizações |
| MX2011003272A (es) | 2008-09-26 | 2011-04-28 | Ambrx Inc | Polipeptidos de eritropoyetina animal modificados y sus usos. |
| PE20110480A1 (es) | 2008-09-26 | 2011-07-01 | Ambrx Inc | Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales |
| WO2011073738A1 (en) | 2009-12-14 | 2011-06-23 | Metabolic Explorer | Use of inducible promoters in the production of methionine |
| JP2013515081A (ja) | 2009-12-21 | 2013-05-02 | アンブルックス，インコーポレイテッド | 修飾されているブタのソマトトロピンポリペプチドおよびそれらの使用 |
| NZ600361A (en) | 2009-12-21 | 2014-06-27 | Ambrx Inc | Modified bovine somatotropin polypeptides and their uses |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| MA34521B1 (fr) | 2010-08-17 | 2013-09-02 | Ambrx Inc | Polypeptides de relaxine modifiés et leurs utilisations |
| TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
| CN102888387B (zh) * | 2011-07-21 | 2015-03-18 | 中国科学院生物物理研究所 | 3-氯代酪氨酸翻译系统及其应用 |
| JO3564B1 (ar) | 2013-03-08 | 2020-07-05 | Novartis Ag | ببتيدات وتركيبات لعلاج ضرر المفاصل |
| AU2014248617B2 (en) * | 2013-03-13 | 2016-05-19 | Ambrx, Inc. | Modified canine leptin polypeptides |
| US10005838B2 (en) | 2013-07-19 | 2018-06-26 | The Regents Of The University Of California | Milk fat globule epidermal growth factor 8 regulates fatty acid uptake |
| US10011649B2 (en) | 2013-08-26 | 2018-07-03 | Arizona Board Of Regents On Behalf Of Arizona State University | High affinity synbodies for influenza |
| US10316322B2 (en) | 2014-07-02 | 2019-06-11 | Sutro Biopharma, Inc. | High growth capacity auxotrophic Escherichia coli and methods of use |
| SMT202100388T1 (it) | 2014-10-24 | 2021-09-14 | Bristol Myers Squibb Co | Polipeptidi fgf-21 modificati e loro usi |
| WO2016090157A1 (en) | 2014-12-04 | 2016-06-09 | Celgene Corporation | Biomolecule conjugates |
| US9744624B2 (en) * | 2015-06-17 | 2017-08-29 | Kinsus Interconnect Technology Corp. | Method for manufacturing circuit board |
| EP3538546B1 (en) | 2016-11-14 | 2025-01-08 | Novartis AG | Compositions, methods, and therapeutic uses related to fusogenic protein minion |
| CN109963579A (zh) | 2016-11-14 | 2019-07-02 | 诺华股份有限公司 | 用于治疗软骨损伤和关节炎的方法和组合物 |
| CN110637027B (zh) | 2017-02-08 | 2024-08-30 | 百时美施贵宝公司 | 包含药代动力学增强子的修饰的松弛素多肽及其用途 |
| TW202128996A (zh) * | 2019-10-10 | 2021-08-01 | 美商史基普研究協會 | 用於活體內合成非天然多肽的組合物及方法 |
| JP2025535713A (ja) | 2022-10-07 | 2025-10-28 | アンブレツクス・インコーポレイテツド | 薬物リンカー及びその抗体コンジュゲート |
| WO2024091824A1 (en) | 2022-10-26 | 2024-05-02 | Ada Forsyth Institute, Inc. | Differentiation and reprogramming of chondrocyte |
| AU2024209360A1 (en) | 2023-01-16 | 2025-09-04 | Ambrx, Inc. | Anti-cd70 antibody-drug conjugates |
| WO2024178310A1 (en) | 2023-02-23 | 2024-08-29 | Ambrx, Inc. | Trop2-directed antibody-drug conjugates and uses thereof |
| WO2024241086A1 (en) | 2023-05-24 | 2024-11-28 | Ambrx, Inc. | Pegylated bovine interferon lambda and methods of use thereof |
| IL326709A (en) | 2023-08-22 | 2026-04-01 | Ambrx Inc | Anti-PSMA ADC conjugate compositions and methods of using them |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100501838B1 (ko) | 1995-04-24 | 2005-07-21 | 큐비스트 파마슈티컬즈 인코포레이티드 | 새로운 대사 경로를 만들고 이를 스크리닝하는 방법 |
| US5958672A (en) | 1995-07-18 | 1999-09-28 | Diversa Corporation | Protein activity screening of clones having DNA from uncultivated microorganisms |
| US5756316A (en) | 1995-11-02 | 1998-05-26 | Genencor International, Inc. | Molecular cloning by multimerization of plasmids |
| US6238884B1 (en) | 1995-12-07 | 2001-05-29 | Diversa Corporation | End selection in directed evolution |
| US5783431A (en) | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
| US7083970B2 (en) * | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| MXPA05003978A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
-
2003
- 2003-10-15 ES ES03809019T patent/ES2324608T3/es not_active Expired - Lifetime
- 2003-10-15 EP EP09003609A patent/EP2062976B1/en not_active Expired - Lifetime
- 2003-10-15 AT AT03809019T patent/ATE429500T1/de active
- 2003-10-15 JP JP2004545280A patent/JP4444113B2/ja not_active Expired - Lifetime
- 2003-10-15 CA CA2502029A patent/CA2502029C/en not_active Expired - Lifetime
- 2003-10-15 KR KR1020057006592A patent/KR20050072441A/ko not_active Ceased
- 2003-10-15 US US10/530,421 patent/US7432092B2/en not_active Expired - Lifetime
- 2003-10-15 SI SI200331612T patent/SI1578949T1/sl unknown
- 2003-10-15 DK DK03809019T patent/DK1578949T3/da active
- 2003-10-15 AU AU2003277373A patent/AU2003277373B2/en not_active Expired
- 2003-10-15 MX MXPA05003983A patent/MXPA05003983A/es active IP Right Grant
- 2003-10-15 DE DE60327369T patent/DE60327369D1/de not_active Expired - Lifetime
- 2003-10-15 WO PCT/US2003/032576 patent/WO2004035743A2/en not_active Ceased
- 2003-10-15 AT AT09003609T patent/ATE526414T1/de not_active IP Right Cessation
- 2003-10-15 PT PT03809019T patent/PT1578949E/pt unknown
- 2003-10-15 EP EP03809019A patent/EP1578949B1/en not_active Expired - Lifetime
-
2005
- 2005-03-29 IL IL167715A patent/IL167715A/en unknown
-
2007
- 2007-10-26 US US11/978,182 patent/US8071344B2/en not_active Expired - Lifetime
- 2007-10-26 US US11/978,160 patent/US7524647B2/en not_active Expired - Lifetime
- 2007-10-26 US US11/978,140 patent/US8114629B2/en not_active Expired - Lifetime
-
2008
- 2008-08-07 US US12/228,146 patent/US7910345B2/en not_active Expired - Lifetime
-
2009
- 2009-06-24 CY CY20091100664T patent/CY1110483T1/el unknown
- 2009-07-30 AU AU2009203098A patent/AU2009203098B2/en not_active Expired
- 2009-09-29 IL IL201208A patent/IL201208A/en active IP Right Grant
-
2010
- 2010-12-29 IL IL210359A patent/IL210359A0/en unknown
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