DE60327369D1 - Stellenspezifischer einbau von ketoaminosäuren in proteine - Google Patents

Stellenspezifischer einbau von ketoaminosäuren in proteine

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Publication number
DE60327369D1
DE60327369D1 DE60327369T DE60327369T DE60327369D1 DE 60327369 D1 DE60327369 D1 DE 60327369D1 DE 60327369 T DE60327369 T DE 60327369T DE 60327369 T DE60327369 T DE 60327369T DE 60327369 D1 DE60327369 D1 DE 60327369D1
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Germany
Prior art keywords
proteins
location
orthogonal
specific installation
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE60327369T
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English (en)
Inventor
Peter G Schultz
Lei Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
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Scripps Research Institute
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE60327369T 2002-10-16 2003-10-15 Stellenspezifischer einbau von ketoaminosäuren in proteine Expired - Lifetime DE60327369D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41926502P 2002-10-16 2002-10-16
US42099002P 2002-10-23 2002-10-23
PCT/US2003/032576 WO2004035743A2 (en) 2002-10-16 2003-10-15 Site specific incorporation of keto amino acids into proteins

Publications (1)

Publication Number Publication Date
DE60327369D1 true DE60327369D1 (de) 2009-06-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE60327369T Expired - Lifetime DE60327369D1 (de) 2002-10-16 2003-10-15 Stellenspezifischer einbau von ketoaminosäuren in proteine

Country Status (17)

Country Link
US (5) US7432092B2 (de)
EP (2) EP1578949B1 (de)
JP (1) JP4444113B2 (de)
KR (1) KR20050072441A (de)
AT (2) ATE526414T1 (de)
AU (2) AU2003277373B2 (de)
CA (1) CA2502029C (de)
CY (1) CY1110483T1 (de)
DE (1) DE60327369D1 (de)
DK (1) DK1578949T3 (de)
ES (1) ES2324608T3 (de)
HK (1) HK1083351A1 (de)
IL (3) IL167715A (de)
MX (1) MXPA05003983A (de)
PT (1) PT1578949E (de)
SI (1) SI1578949T1 (de)
WO (1) WO2004035743A2 (de)

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AU2003286436B2 (en) 2002-10-16 2010-08-19 The Scripps Research Institute Glycoprotein synthesis
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EP2793027B1 (de) 2003-06-18 2019-11-13 The Scripps Research Institute Unnatürliche reaktive Aminosäurengencodehinzufügungen
US7527943B2 (en) 2003-07-07 2009-05-05 The Scripps Research Institute Compositions of orthogonal glutamyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
PT1914314E (pt) 2003-07-07 2010-09-08 Scripps Research Inst Composições de pares ortogonais de lisil-arnt e aminoacil-arnt-sintetase e suas utilizações
EP1687401B1 (de) 2003-10-14 2012-11-21 The Scripps Research Institute Stellenspezifischer einbau redoxaktiver aminosäuren in proteine
WO2005074524A2 (en) 2004-02-02 2005-08-18 Ambrx, Inc. Modified human interferon polypeptides and their uses
CA2567624A1 (en) 2004-05-25 2005-12-08 The Scripps Research Institute Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination
US7632924B2 (en) 2004-06-18 2009-12-15 Ambrx, Inc. Antigen-binding polypeptides and their uses
CA2569381A1 (en) * 2004-07-21 2006-08-31 Ambrx, Inc. Biosynthetic polypeptides utilizing non-naturally encoded amino acids
CN101151366B (zh) 2004-09-21 2012-12-19 斯克利普斯研究院 将炔基氨基酸体内掺入真细菌的蛋白
US20080171317A1 (en) * 2004-09-22 2008-07-17 The Scripps Research Institute Site-Specific Labeling of Proteins for Nmr Studies
JP2008516637A (ja) 2004-10-20 2008-05-22 ザ スクリップス リサーチ インスティテュート 真正細菌へのｎ−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み
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BRPI0519170A8 (pt) 2004-12-22 2018-05-08 Ambrx Inc formulações de hormônio de crescimento humano que compreendem um aminoácido não naturalmente codificado
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AU2007223830A1 (en) 2006-03-09 2007-09-13 The Scripps Research Institute System for the expression of orthogonal translation components in eubacterial host cells
US8217145B2 (en) 2006-03-16 2012-07-10 The Scrips Research Institute Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
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CA2662753C (en) * 2006-09-08 2016-02-23 Ambrx, Inc. Hybrid suppressor trna for vertebrate cells
WO2008030614A2 (en) 2006-09-08 2008-03-13 Ambrx, Inc. Suppressor trna transcription in vertebrate cells
MX2009002523A (es) 2006-09-08 2009-03-20 Ambrx Inc Polipeptido de plasma humano modificado o andamios fc y sus usos.
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US20100055725A1 (en) * 2006-10-17 2010-03-04 Zymera, Inc. System for assays of aminotransferase
JP2010506591A (ja) 2006-10-18 2010-03-04 ザ スクリップス リサーチ インスティテュート 哺乳動物細胞中の蛋白質への非天然アミノ酸の遺伝的組込み
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ATE554785T1 (de) 2007-03-30 2012-05-15 Ambrx Inc Modifizierte fgf-21 polypeptide und ihre verwendung
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Also Published As

Publication number Publication date
MXPA05003983A (es) 2005-06-22
ATE526414T1 (de) 2011-10-15
EP2062976A3 (de) 2010-04-07
WO2004035743A2 (en) 2004-04-29
US8071344B2 (en) 2011-12-06
CA2502029C (en) 2014-06-10
SI1578949T1 (sl) 2009-08-31
ATE429500T1 (de) 2009-05-15
AU2003277373B2 (en) 2009-05-07
IL201208A (en) 2011-02-28
JP4444113B2 (ja) 2010-03-31
KR20050072441A (ko) 2005-07-11
JP2006507814A (ja) 2006-03-09
IL167715A (en) 2010-11-30
AU2003277373A1 (en) 2004-05-04
CA2502029A1 (en) 2004-04-29
US8114629B2 (en) 2012-02-14
DK1578949T3 (da) 2009-07-27
EP1578949A2 (de) 2005-09-28
US20110318806A1 (en) 2011-12-29
US20060068478A1 (en) 2006-03-30
EP1578949A4 (de) 2006-12-20
EP1578949B1 (de) 2009-04-22
AU2009203098A1 (en) 2009-08-20
CY1110483T1 (el) 2015-04-29
US20080227153A1 (en) 2008-09-18
WO2004035743A8 (en) 2005-06-09
US7910345B2 (en) 2011-03-22
EP2062976B1 (de) 2011-09-28
ES2324608T3 (es) 2009-08-11
US20090215117A1 (en) 2009-08-27
US20080176284A1 (en) 2008-07-24
US7432092B2 (en) 2008-10-07
AU2009203098B2 (en) 2011-09-08
EP2062976A2 (de) 2009-05-27
IL210359A0 (en) 2011-03-31
HK1083351A1 (en) 2006-06-30
PT1578949E (pt) 2009-07-14
WO2004035743A3 (en) 2005-11-10
US7524647B2 (en) 2009-04-28

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