JP2009538136A5 - - Google Patents
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- Publication number
- JP2009538136A5 JP2009538136A5 JP2009512140A JP2009512140A JP2009538136A5 JP 2009538136 A5 JP2009538136 A5 JP 2009538136A5 JP 2009512140 A JP2009512140 A JP 2009512140A JP 2009512140 A JP2009512140 A JP 2009512140A JP 2009538136 A5 JP2009538136 A5 JP 2009538136A5
- Authority
- JP
- Japan
- Prior art keywords
- trna
- amino acid
- unnatural amino
- translation system
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001413 amino acids Chemical class 0.000 claims 19
- 108091033319 polynucleotide Proteins 0.000 claims 14
- 102000040430 polynucleotide Human genes 0.000 claims 14
- 239000002157 polynucleotide Substances 0.000 claims 14
- 108020004705 Codon Proteins 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 5
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 241000203407 Methanocaldococcus jannaschii Species 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- QEQAKQQRJFWPOR-JTQLQIEISA-N (2s)-2-amino-4-(7-hydroxy-2-oxochromen-4-yl)butanoic acid Chemical compound C1=C(O)C=CC2=C1OC(=O)C=C2CC[C@H](N)C(O)=O QEQAKQQRJFWPOR-JTQLQIEISA-N 0.000 claims 2
- 241001112695 Clostridiales Species 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 108091060545 Nonsense suppressor Proteins 0.000 claims 2
- 101710146427 Probable tyrosine-tRNA ligase, cytoplasmic Proteins 0.000 claims 2
- 102000018378 Tyrosine-tRNA ligase Human genes 0.000 claims 2
- 101710107268 Tyrosine-tRNA ligase, mitochondrial Proteins 0.000 claims 2
- 230000006229 amino acid addition Effects 0.000 claims 1
- 230000000689 aminoacylating effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80809906P | 2006-05-23 | 2006-05-23 | |
| US81385606P | 2006-06-14 | 2006-06-14 | |
| PCT/US2007/012361 WO2007139870A1 (en) | 2006-05-23 | 2007-05-21 | Genetically encoded fluorescent coumarin amino acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009538136A JP2009538136A (ja) | 2009-11-05 |
| JP2009538136A5 true JP2009538136A5 (https=) | 2010-07-15 |
Family
ID=38778978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009512140A Pending JP2009538136A (ja) | 2006-05-23 | 2007-05-21 | 遺伝的にコードされた蛍光クマリンアミノ酸 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US8192952B2 (https=) |
| EP (1) | EP2018429A4 (https=) |
| JP (1) | JP2009538136A (https=) |
| KR (1) | KR20090024706A (https=) |
| AU (1) | AU2007267950B2 (https=) |
| BR (1) | BRPI0711811A2 (https=) |
| CA (1) | CA2652894A1 (https=) |
| IL (1) | IL195250A0 (https=) |
| MX (1) | MX2008014776A (https=) |
| RU (1) | RU2473690C2 (https=) |
| WO (1) | WO2007139870A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002085923A2 (en) * | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| MXPA05003978A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| EP1649004A4 (en) * | 2003-07-07 | 2008-04-09 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| WO2009117726A2 (en) | 2008-03-21 | 2009-09-24 | The Regents Of The University Of California | High-sensitive fluorescent energy transfer assay using fluorescent amino acids and fluoresent proteins |
| WO2011119771A2 (en) * | 2010-03-23 | 2011-09-29 | The Salk Institute For Biological Studies | Methods and compositions for detecting protein modifications |
| FR2972114B1 (fr) | 2011-03-01 | 2013-03-15 | Univ Grenoble 1 | Un nouveau leurre moleculaire procoagulant pour le traitement des hemophiles a ou b avec ou sans inhibiteur |
| CN105541962B (zh) * | 2015-12-19 | 2021-04-02 | 深圳市贝沃德克生物技术研究院有限公司 | 基于7-羟基香豆素的定点荧光标记方法 |
| CN105524167A (zh) * | 2016-01-30 | 2016-04-27 | 深圳市贝沃德克生物技术研究院有限公司 | 抗乙肝e抗原的绿色荧光抗体的制备方法 |
| CN111304234A (zh) * | 2020-02-27 | 2020-06-19 | 江南大学 | 一种适用于枯草芽孢杆菌的非天然氨基酸利用工具 |
| CN118359572B (zh) * | 2024-04-09 | 2024-12-13 | 北京大学深圳研究生院 | 一种基于硫代香豆素的非天然氨基酸及其制备方法、应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998593A (en) * | 1998-03-10 | 1999-12-07 | Abbott Laboratories | Fluorescent enzyme substrates |
| WO2002085923A2 (en) * | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| MXPA05003978A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| JP4444113B2 (ja) * | 2002-10-16 | 2010-03-31 | ザ スクリップス リサーチ インスティテュート | ケトアミノ酸の部位特異的蛋白質組込み方法 |
| CA2508939A1 (en) | 2002-12-22 | 2004-07-15 | The Scripps Research Institute | Protein arrays |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| EP2410331B1 (en) * | 2003-06-18 | 2015-09-23 | The Scripps Research Institute | Aminoacyl-tRNA synthetase for aminoacylation tRNA with unnatural amino acids |
| EP1649004A4 (en) * | 2003-07-07 | 2008-04-09 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| WO2005007624A2 (en) * | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| US20060160175A1 (en) * | 2003-07-07 | 2006-07-20 | The Scripps Research Institute | Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| PT1687401E (pt) * | 2003-10-14 | 2013-02-26 | Scripps Research Inst | Incorporação de aminoácidos activos em oxidação-redução específica do local em proteínas |
| US7741071B2 (en) | 2003-12-18 | 2010-06-22 | The Scripps Research Institute | Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells |
| JP2008500050A (ja) | 2004-05-25 | 2008-01-10 | ザ スクリップス リサーチ インスティテュート | 結晶構造決定のための重原子含有非天然アミノ酸の部位特異的蛋白質組込み |
| US20090181858A1 (en) * | 2004-09-21 | 2009-07-16 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
| AU2005286722B2 (en) | 2004-09-21 | 2010-12-02 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| US20080171317A1 (en) * | 2004-09-22 | 2008-07-17 | The Scripps Research Institute | Site-Specific Labeling of Proteins for Nmr Studies |
| JP2008516637A (ja) * | 2004-10-20 | 2008-05-22 | ザ スクリップス リサーチ インスティテュート | 真正細菌へのｎ−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み |
| CN101048506B (zh) | 2004-10-27 | 2013-06-26 | 斯克利普斯研究院 | 体内掺入非天然氨基酸的正交翻译组分 |
| BRPI0617191A2 (pt) * | 2005-10-12 | 2011-07-19 | Scripps Research Inst | modificação pós-traducional de polipeptìdeos expressos em fagos |
| KR20080106430A (ko) | 2006-03-09 | 2008-12-05 | 더 스크립스 리서치 인스티튜트 | 진정 세균 숙주 세포 내에서의 직교형 번역 성분의 발현을 위한 시스템 |
| WO2007109035A2 (en) | 2006-03-16 | 2007-09-27 | The Scripps Research Institute | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
-
2007
- 2007-05-21 AU AU2007267950A patent/AU2007267950B2/en not_active Ceased
- 2007-05-21 US US12/227,383 patent/US8192952B2/en not_active Expired - Fee Related
- 2007-05-21 KR KR1020087030491A patent/KR20090024706A/ko not_active Ceased
- 2007-05-21 US US11/805,247 patent/US7807411B2/en not_active Expired - Fee Related
- 2007-05-21 RU RU2008145487/10A patent/RU2473690C2/ru not_active IP Right Cessation
- 2007-05-21 BR BRPI0711811-2A patent/BRPI0711811A2/pt not_active IP Right Cessation
- 2007-05-21 JP JP2009512140A patent/JP2009538136A/ja active Pending
- 2007-05-21 WO PCT/US2007/012361 patent/WO2007139870A1/en not_active Ceased
- 2007-05-21 EP EP07777256A patent/EP2018429A4/en not_active Withdrawn
- 2007-05-21 MX MX2008014776A patent/MX2008014776A/es active IP Right Grant
- 2007-05-21 CA CA002652894A patent/CA2652894A1/en not_active Abandoned
-
2008
- 2008-11-12 IL IL195250A patent/IL195250A0/en unknown
-
2012
- 2012-04-30 US US13/460,174 patent/US20120329162A1/en not_active Abandoned
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