JP2010504096A5 - - Google Patents
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- Publication number
- JP2010504096A5 JP2010504096A5 JP2009529249A JP2009529249A JP2010504096A5 JP 2010504096 A5 JP2010504096 A5 JP 2010504096A5 JP 2009529249 A JP2009529249 A JP 2009529249A JP 2009529249 A JP2009529249 A JP 2009529249A JP 2010504096 A5 JP2010504096 A5 JP 2010504096A5
- Authority
- JP
- Japan
- Prior art keywords
- trna
- amino acid
- seq
- host cell
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 claims 25
- 235000001014 amino acid Nutrition 0.000 claims 12
- 108091033319 polynucleotide Proteins 0.000 claims 11
- 102000040430 polynucleotide Human genes 0.000 claims 11
- 239000002157 polynucleotide Substances 0.000 claims 11
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 7
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 6
- CIQHWLTYGMYQQR-QMMMGPOBSA-N O(4')-sulfo-L-tyrosine Chemical group OC(=O)[C@@H](N)CC1=CC=C(OS(O)(=O)=O)C=C1 CIQHWLTYGMYQQR-QMMMGPOBSA-N 0.000 claims 6
- 235000018102 proteins Nutrition 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 108020004705 Codon Proteins 0.000 claims 4
- 241000203407 Methanocaldococcus jannaschii Species 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- 239000004472 Lysine Substances 0.000 claims 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 3
- 239000004473 Threonine Substances 0.000 claims 3
- 235000018417 cysteine Nutrition 0.000 claims 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
- 235000013922 glutamic acid Nutrition 0.000 claims 3
- 239000004220 glutamic acid Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 241001112695 Clostridiales Species 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 101710146427 Probable tyrosine-tRNA ligase, cytoplasmic Proteins 0.000 claims 2
- 102000018378 Tyrosine-tRNA ligase Human genes 0.000 claims 2
- 101710107268 Tyrosine-tRNA ligase, mitochondrial Proteins 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 230000000689 aminoacylating effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84651906P | 2006-09-21 | 2006-09-21 | |
| US60/846,519 | 2006-09-21 | ||
| US85521006P | 2006-10-28 | 2006-10-28 | |
| US60/855,210 | 2006-10-28 | ||
| PCT/US2007/020459 WO2008036392A2 (en) | 2006-09-21 | 2007-09-20 | Genetically programmed expression of selectively sulfated proteins in eubacteria |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010504096A JP2010504096A (ja) | 2010-02-12 |
| JP2010504096A5 true JP2010504096A5 (https=) | 2010-12-09 |
| JP5385143B2 JP5385143B2 (ja) | 2014-01-08 |
Family
ID=39201110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009529249A Expired - Fee Related JP5385143B2 (ja) | 2006-09-21 | 2007-09-20 | 真正細菌における選択的に硫酸化された蛋白質の遺伝的にプログラムされた発現 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8114627B2 (https=) |
| EP (1) | EP2052083B1 (https=) |
| JP (1) | JP5385143B2 (https=) |
| KR (1) | KR20090074765A (https=) |
| CN (1) | CN101516901B (https=) |
| AU (1) | AU2007297610A1 (https=) |
| BR (1) | BRPI0716963A2 (https=) |
| CA (1) | CA2663052A1 (https=) |
| ES (1) | ES2456331T3 (https=) |
| IL (1) | IL197531A0 (https=) |
| MX (1) | MX2009002987A (https=) |
| PL (1) | PL2052083T3 (https=) |
| PT (1) | PT2052083E (https=) |
| RU (1) | RU2009110152A (https=) |
| WO (1) | WO2008036392A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7083970B2 (en) * | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| MXPA05003978A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| WO2004094593A2 (en) | 2003-04-17 | 2004-11-04 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| US9150849B2 (en) * | 2007-11-02 | 2015-10-06 | The Scripps Research Institute | Directed evolution using proteins comprising unnatural amino acids |
| US8658394B2 (en) * | 2011-02-02 | 2014-02-25 | Waterstone Pharmaceuticals | Methods, cells and systems for incorporating non-canonical amino acids into proteins |
| CN102888387B (zh) * | 2011-07-21 | 2015-03-18 | 中国科学院生物物理研究所 | 3-氯代酪氨酸翻译系统及其应用 |
| CN103571804B (zh) * | 2012-08-10 | 2015-08-12 | 中国科学院生物物理研究所 | 3-吡唑基酪氨酸翻译系统及其应用 |
| WO2015120287A2 (en) | 2014-02-06 | 2015-08-13 | Yale University | Compositions and methods of use thereof for making polypeptides with many instances of nonstandard amino acids |
| US11408007B2 (en) | 2014-09-26 | 2022-08-09 | Yale University | Compositions and methods for biocontainment of microorganisms |
| CN110117580B (zh) * | 2018-02-05 | 2021-12-14 | 中国科学院生物物理研究所 | 硒代酪氨酸翻译系统及其应用 |
| IL280198B2 (en) * | 2018-07-18 | 2026-01-01 | Regenxbio Inc | Treatment of mucopolysaccharidosis I with fully glycosylated human iduronidase-alpha-L (idus) |
| CN113785058B (zh) * | 2019-03-04 | 2024-12-24 | 得克萨斯A&M大学系统 | 制作和利用琥珀专性的噬菌体展示文库的方法 |
| US11149280B2 (en) | 2019-10-29 | 2021-10-19 | Yale University | Engineering organisms resistant to viruses and horizontally transferred genetic elements |
| CN111304234A (zh) * | 2020-02-27 | 2020-06-19 | 江南大学 | 一种适用于枯草芽孢杆菌的非天然氨基酸利用工具 |
| CN113789335B (zh) * | 2021-11-16 | 2022-03-15 | 江苏省中国科学院植物研究所 | 一种水蛭酪氨酸磺酸转移酶基因及其应用 |
| CN118389493B (zh) * | 2024-05-10 | 2025-04-11 | 北京大学 | 一种定点修饰的工程化tRNA及其应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204016B1 (en) | 1998-01-29 | 2001-03-20 | The Board Of Regents Of The University Of Oklahoma | Tyrosylprotein sulfotransferases and methods of use thereof |
| US7083970B2 (en) * | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| MXPA05003978A (es) | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| ES2324608T3 (es) | 2002-10-16 | 2009-08-11 | The Scripps Research Institute | Incorporacion especifica de sitio de cetoaminoacidos en proteinas. |
| WO2004058946A2 (en) | 2002-12-22 | 2004-07-15 | The Scripps Research Institute | Protein arrays |
| WO2004094593A2 (en) | 2003-04-17 | 2004-11-04 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
| JP5275566B2 (ja) | 2003-06-18 | 2013-08-28 | ザ スクリプス リサーチ インスティチュート | 反応性非天然アミノ酸遺伝コード付加 |
| US20060160175A1 (en) | 2003-07-07 | 2006-07-20 | The Scripps Research Institute | Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| JP5657850B2 (ja) | 2003-10-14 | 2015-01-21 | ザ スクリプス リサーチ インスティテュート | 酸化還元機能性アミノ酸のタンパク質への部位特異的組み入れ |
| AU2004321117B2 (en) | 2003-12-18 | 2010-09-02 | The Scripps Research Institute | Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells |
| AU2005248392A1 (en) | 2004-05-25 | 2005-12-08 | Irm, Llc | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination |
| CA2580840A1 (en) | 2004-09-21 | 2006-03-30 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| US20090181858A1 (en) | 2004-09-21 | 2009-07-16 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
| US20080171317A1 (en) | 2004-09-22 | 2008-07-17 | The Scripps Research Institute | Site-Specific Labeling of Proteins for Nmr Studies |
| JP2008516637A (ja) | 2004-10-20 | 2008-05-22 | ザ スクリップス リサーチ インスティテュート | 真正細菌へのｎ−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み |
| EP1807515A4 (en) | 2004-10-27 | 2008-06-18 | Scripps Research Inst | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| US8367588B2 (en) | 2005-10-12 | 2013-02-05 | The Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| US7960141B2 (en) | 2006-03-09 | 2011-06-14 | The Scripps Research Institute | Systems for the expression of orthogonal translation components in eubacterial host cells |
| KR20080113226A (ko) | 2006-03-16 | 2008-12-29 | 더 스크립스 리서치 인스티튜트 | 비천연 아미노산 페닐셀레노시스테인을 함유하는 단백질의 유전자적으로 프로그램된 발현 |
-
2007
- 2007-09-20 EP EP07861356.9A patent/EP2052083B1/en not_active Not-in-force
- 2007-09-20 ES ES07861356.9T patent/ES2456331T3/es active Active
- 2007-09-20 CA CA002663052A patent/CA2663052A1/en not_active Abandoned
- 2007-09-20 CN CN200780035189.6A patent/CN101516901B/zh not_active Expired - Fee Related
- 2007-09-20 RU RU2009110152/10A patent/RU2009110152A/ru not_active Application Discontinuation
- 2007-09-20 WO PCT/US2007/020459 patent/WO2008036392A2/en not_active Ceased
- 2007-09-20 JP JP2009529249A patent/JP5385143B2/ja not_active Expired - Fee Related
- 2007-09-20 KR KR1020097007574A patent/KR20090074765A/ko not_active Ceased
- 2007-09-20 US US11/903,499 patent/US8114627B2/en active Active
- 2007-09-20 MX MX2009002987A patent/MX2009002987A/es not_active Application Discontinuation
- 2007-09-20 PL PL07861356T patent/PL2052083T3/pl unknown
- 2007-09-20 PT PT78613569T patent/PT2052083E/pt unknown
- 2007-09-20 US US12/311,169 patent/US8114652B2/en active Active
- 2007-09-20 BR BRPI0716963-9A patent/BRPI0716963A2/pt not_active IP Right Cessation
- 2007-09-20 AU AU2007297610A patent/AU2007297610A1/en not_active Abandoned
-
2009
- 2009-03-11 IL IL197531A patent/IL197531A0/en unknown
-
2011
- 2011-12-14 US US13/326,143 patent/US8361770B2/en not_active Expired - Fee Related
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