JP2010504096A5 - - Google Patents

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Publication number

JP2010504096A5

JP2010504096A5 JP2009529249A JP2009529249A JP2010504096A5 JP 2010504096 A5 JP2010504096 A5 JP 2010504096A5 JP 2009529249 A JP2009529249 A JP 2009529249A JP 2009529249 A JP2009529249 A JP 2009529249A JP 2010504096 A5 JP2010504096 A5 JP 2010504096A5

Authority

JP

Japan

Prior art keywords

trna

amino acid

seq

host cell

preparing

Prior art date

2007-09-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 150000001413 amino acids Chemical class 0.000 claims 25
• 235000001014 amino acid Nutrition 0.000 claims 12
• 108091033319 polynucleotide Proteins 0.000 claims 11
• 102000040430 polynucleotide Human genes 0.000 claims 11
• 239000002157 polynucleotide Substances 0.000 claims 11
• 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 7
• 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 7
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 6
• CIQHWLTYGMYQQR-QMMMGPOBSA-N O(4')-sulfo-L-tyrosine Chemical group OC(=O)[C@@H](N)CC1=CC=C(OS(O)(=O)=O)C=C1 CIQHWLTYGMYQQR-QMMMGPOBSA-N 0.000 claims 6
• 235000018102 proteins Nutrition 0.000 claims 6
• 102000004169 proteins and genes Human genes 0.000 claims 6
• 108090000623 proteins and genes Proteins 0.000 claims 6
• 108020004705 Codon Proteins 0.000 claims 4
• 241000203407 Methanocaldococcus jannaschii Species 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• 150000007523 nucleic acids Chemical class 0.000 claims 4
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 3
• 239000004471 Glycine Substances 0.000 claims 3
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 3
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 3
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
• 239000004472 Lysine Substances 0.000 claims 3
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 3
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 3
• 239000004473 Threonine Substances 0.000 claims 3
• 235000018417 cysteine Nutrition 0.000 claims 3
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
• 235000013922 glutamic acid Nutrition 0.000 claims 3
• 239000004220 glutamic acid Substances 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 229920001184 polypeptide Polymers 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• 241001112695 Clostridiales Species 0.000 claims 2
• 241000588724 Escherichia coli Species 0.000 claims 2
• 101710146427 Probable tyrosine-tRNA ligase, cytoplasmic Proteins 0.000 claims 2
• 102000018378 Tyrosine-tRNA ligase Human genes 0.000 claims 2
• 101710107268 Tyrosine-tRNA ligase, mitochondrial Proteins 0.000 claims 2
• 239000002773 nucleotide Substances 0.000 claims 2
• 125000003729 nucleotide group Chemical group 0.000 claims 2
• 230000000689 aminoacylating effect Effects 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1