JP2008516637A5 - - Google Patents
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- Publication number
- JP2008516637A5 JP2008516637A5 JP2007538145A JP2007538145A JP2008516637A5 JP 2008516637 A5 JP2008516637 A5 JP 2008516637A5 JP 2007538145 A JP2007538145 A JP 2007538145A JP 2007538145 A JP2007538145 A JP 2007538145A JP 2008516637 A5 JP2008516637 A5 JP 2008516637A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- trna
- translation system
- acetylgalactosamine
- providing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001413 amino acids Chemical class 0.000 claims 27
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 239000004473 Threonine Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 108020004705 Codon Proteins 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 4
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 4
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical group CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 claims 4
- 241000203407 Methanocaldococcus jannaschii Species 0.000 claims 3
- 101710146427 Probable tyrosine-tRNA ligase, cytoplasmic Proteins 0.000 claims 3
- 102000018378 Tyrosine-tRNA ligase Human genes 0.000 claims 3
- 101710107268 Tyrosine-tRNA ligase, mitochondrial Proteins 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 102220538277 Modulator of macroautophagy TMEM150B_Y32Q_mutation Human genes 0.000 claims 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 1
- 108091060545 Nonsense suppressor Proteins 0.000 claims 1
- 102220607023 Ras-related protein Rap-1b_Y32A_mutation Human genes 0.000 claims 1
- 102220606964 Ras-related protein Rap-1b_Y32F_mutation Human genes 0.000 claims 1
- 230000000689 aminoacylating effect Effects 0.000 claims 1
- 102220360721 c.209A>C Human genes 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102200086203 rs104894623 Human genes 0.000 claims 1
- 102200086205 rs104894623 Human genes 0.000 claims 1
- 102220126055 rs201877419 Human genes 0.000 claims 1
- 102220187197 rs3809694 Human genes 0.000 claims 1
- 102200095038 rs4987076 Human genes 0.000 claims 1
- 102200053890 rs61222761 Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62089804P | 2004-10-20 | 2004-10-20 | |
| PCT/US2005/038250 WO2006045116A2 (en) | 2004-10-20 | 2005-10-20 | In vivo site-specific incorporation of n-acetyl-galactosamine amino acids in eubacteria |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008516637A JP2008516637A (ja) | 2008-05-22 |
| JP2008516637A5 true JP2008516637A5 (https=) | 2008-12-11 |
Family
ID=36203749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007538145A Abandoned JP2008516637A (ja) | 2004-10-20 | 2005-10-20 | 真正細菌へのｎ−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US20080064059A1 (https=) |
| EP (1) | EP1809758A4 (https=) |
| JP (1) | JP2008516637A (https=) |
| WO (1) | WO2006045116A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002085923A2 (en) * | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| MXPA05003978A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| EP1649004A4 (en) * | 2003-07-07 | 2008-04-09 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| US20050287639A1 (en) | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| CN101048506B (zh) | 2004-10-27 | 2013-06-26 | 斯克利普斯研究院 | 体内掺入非天然氨基酸的正交翻译组分 |
| BRPI0617191A2 (pt) * | 2005-10-12 | 2011-07-19 | Scripps Research Inst | modificação pós-traducional de polipeptìdeos expressos em fagos |
| ATE509027T1 (de) * | 2006-01-13 | 2011-05-15 | Pasteur Institut | Enzymatische synthese von grossen mengen von mucin glyconjugaten und deren immunogenische anwendungen |
| AU2007224019A1 (en) | 2006-03-03 | 2007-09-13 | California Institute Of Technology | Site-specific incorporation of amino acids into molecules |
| KR20080106430A (ko) * | 2006-03-09 | 2008-12-05 | 더 스크립스 리서치 인스티튜트 | 진정 세균 숙주 세포 내에서의 직교형 번역 성분의 발현을 위한 시스템 |
| WO2007109035A2 (en) | 2006-03-16 | 2007-09-27 | The Scripps Research Institute | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
| AU2007267950B2 (en) * | 2006-05-23 | 2012-08-16 | The Scripps Research Institute | Genetically encoded fluorescent coumarin amino acids |
| JP5385143B2 (ja) * | 2006-09-21 | 2014-01-08 | ザ スクリプス リサーチ インスティチュート | 真正細菌における選択的に硫酸化された蛋白質の遺伝的にプログラムされた発現 |
| WO2008073184A2 (en) | 2006-10-18 | 2008-06-19 | The Scripps Research Institute | Genetic incorporation of unnatural amino acids into proteins in mammalian cells |
| GB0716719D0 (en) * | 2007-08-29 | 2007-10-10 | Chromatide Ltd | Process for carrying out a chemical reaction |
| US8673591B2 (en) | 2007-10-25 | 2014-03-18 | The Scripps Research Institute | Genetic incorporation of 3-aminotyrosine into reductases |
| WO2009059056A2 (en) * | 2007-11-02 | 2009-05-07 | The Scripps Research Institute | A genetically encoded boronate amino acid |
| JP5513398B2 (ja) * | 2007-11-02 | 2014-06-04 | ザ スクリプス リサーチ インスティチュート | 非天然アミノ酸を含有する蛋白質を使用する指向的進化 |
| CN101939410A (zh) | 2007-12-11 | 2011-01-05 | 斯克利普斯研究院 | 甲基营养酵母菌巴斯德毕赤酵母中的体内非天然氨基酸表达 |
| EP2249865A4 (en) * | 2008-02-08 | 2012-04-04 | Scripps Research Inst | BREAKING IMMUNOLOGICAL TOLERANCE WITH A GENETICALLY ENCODED UNNATURAL AMINO ACID |
| US8609383B2 (en) | 2008-12-10 | 2013-12-17 | The Scripps Research Institute | Production of carrier-peptide conjugates using chemically reactive unnatural amino acids |
| US20090197339A1 (en) * | 2008-12-10 | 2009-08-06 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris |
| US9051593B2 (en) | 2009-12-21 | 2015-06-09 | Trustees Of Dartmouth College | Recombinant prokaryotes and use thereof for production of O-glycosylated proteins |
| EP4122945A1 (en) * | 2013-12-23 | 2023-01-25 | University of Rochester | Methods and compositions for ribosomal synthesis of macrocyclic peptides |
| US12359192B2 (en) * | 2013-12-23 | 2025-07-15 | University Of Rochester | Methods and compositions for display of macrocyclic peptides |
| WO2017085718A1 (en) * | 2015-11-17 | 2017-05-26 | Anima Biotech Inc. | FUNCTIONAL TRANSFER tRNA-APTAMER MOLECULES |
| WO2019074833A1 (en) * | 2017-10-09 | 2019-04-18 | Indiana University Research And Technology Corporation | SUGAR-RELATED AMINO ACIDS FOR THE SYNTHESIS OF SOLID-STATE PEPTIDES |
| US20220299522A1 (en) * | 2019-08-26 | 2022-09-22 | The Johns Hopkins University | Compositions and methods for identifying o-linked glycosylation sites in proteins |
| EP4107258A4 (en) * | 2020-02-20 | 2024-04-17 | B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University | MUTANT AMINOACYL-ARNT SYNTHETASES |
| IL303886A (en) * | 2020-12-23 | 2023-08-01 | Flagship Pioneering Inc | Compositions of modified trems and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991016449A1 (en) | 1990-04-16 | 1991-10-31 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
| US5369017A (en) * | 1994-02-04 | 1994-11-29 | The Scripps Research Institute | Process for solid phase glycopeptide synthesis |
| WO2002085923A2 (en) | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| ES2411007T3 (es) | 2001-10-10 | 2013-07-04 | Novo Nordisk A/S | Remodelación y glicoconjugación de péptidos |
| MXPA05003978A (es) | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| JP4444113B2 (ja) | 2002-10-16 | 2010-03-31 | ザ スクリップス リサーチ インスティテュート | ケトアミノ酸の部位特異的蛋白質組込み方法 |
| JP5319863B2 (ja) | 2002-12-26 | 2013-10-16 | 独立行政法人理化学研究所 | 体細胞相同組換えの誘発方法 |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| EP1649004A4 (en) | 2003-07-07 | 2008-04-09 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| US20060160175A1 (en) | 2003-07-07 | 2006-07-20 | The Scripps Research Institute | Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
-
2005
- 2005-10-20 JP JP2007538145A patent/JP2008516637A/ja not_active Abandoned
- 2005-10-20 US US11/664,898 patent/US20080064059A1/en not_active Abandoned
- 2005-10-20 EP EP05811879A patent/EP1809758A4/en not_active Withdrawn
- 2005-10-20 WO PCT/US2005/038250 patent/WO2006045116A2/en not_active Ceased
- 2005-10-20 US US11/255,601 patent/US7378263B2/en not_active Expired - Fee Related
-
2008
- 2008-04-08 US US12/082,214 patent/US20080241903A1/en not_active Abandoned
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