JP2008516637A5 - - Google Patents
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- Publication number
- JP2008516637A5 JP2008516637A5 JP2007538145A JP2007538145A JP2008516637A5 JP 2008516637 A5 JP2008516637 A5 JP 2008516637A5 JP 2007538145 A JP2007538145 A JP 2007538145A JP 2007538145 A JP2007538145 A JP 2007538145A JP 2008516637 A5 JP2008516637 A5 JP 2008516637A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- trna
- translation system
- acetylgalactosamine
- providing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001413 amino acids Chemical class 0.000 claims 27
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 239000004473 Threonine Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 108020004705 Codon Proteins 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 4
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 4
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical group CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 claims 4
- 241000203407 Methanocaldococcus jannaschii Species 0.000 claims 3
- 101710146427 Probable tyrosine-tRNA ligase, cytoplasmic Proteins 0.000 claims 3
- 102000018378 Tyrosine-tRNA ligase Human genes 0.000 claims 3
- 101710107268 Tyrosine-tRNA ligase, mitochondrial Proteins 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 102220538277 Modulator of macroautophagy TMEM150B_Y32Q_mutation Human genes 0.000 claims 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 1
- 108091060545 Nonsense suppressor Proteins 0.000 claims 1
- 102220607023 Ras-related protein Rap-1b_Y32A_mutation Human genes 0.000 claims 1
- 102220606964 Ras-related protein Rap-1b_Y32F_mutation Human genes 0.000 claims 1
- 230000000689 aminoacylating effect Effects 0.000 claims 1
- 102220360721 c.209A>C Human genes 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102200086203 rs104894623 Human genes 0.000 claims 1
- 102200086205 rs104894623 Human genes 0.000 claims 1
- 102220126055 rs201877419 Human genes 0.000 claims 1
- 102220187197 rs3809694 Human genes 0.000 claims 1
- 102200095038 rs4987076 Human genes 0.000 claims 1
- 102200053890 rs61222761 Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62089804P | 2004-10-20 | 2004-10-20 | |
| PCT/US2005/038250 WO2006045116A2 (en) | 2004-10-20 | 2005-10-20 | In vivo site-specific incorporation of n-acetyl-galactosamine amino acids in eubacteria |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008516637A JP2008516637A (ja) | 2008-05-22 |
| JP2008516637A5 true JP2008516637A5 (https=) | 2008-12-11 |
Family
ID=36203749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007538145A Abandoned JP2008516637A (ja) | 2004-10-20 | 2005-10-20 | 真正細菌へのｎ−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US20080064059A1 (https=) |
| EP (1) | EP1809758A4 (https=) |
| JP (1) | JP2008516637A (https=) |
| WO (1) | WO2006045116A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7083970B2 (en) * | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| MXPA05003978A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| WO2004094593A2 (en) | 2003-04-17 | 2004-11-04 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| US20050287639A1 (en) | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| EP1807515A4 (en) | 2004-10-27 | 2008-06-18 | Scripps Research Inst | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| US8367588B2 (en) * | 2005-10-12 | 2013-02-05 | The Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| EP1808442B1 (en) * | 2006-01-13 | 2011-05-11 | Institut Pasteur | Enzymatic large-scale synthesis of mucin glyconjugates, and immunogenic applications thereof |
| AU2007224019A1 (en) | 2006-03-03 | 2007-09-13 | California Institute Of Technology | Site-specific incorporation of amino acids into molecules |
| US7960141B2 (en) * | 2006-03-09 | 2011-06-14 | The Scripps Research Institute | Systems for the expression of orthogonal translation components in eubacterial host cells |
| KR20080113226A (ko) | 2006-03-16 | 2008-12-29 | 더 스크립스 리서치 인스티튜트 | 비천연 아미노산 페닐셀레노시스테인을 함유하는 단백질의 유전자적으로 프로그램된 발현 |
| US7807411B2 (en) * | 2006-05-23 | 2010-10-05 | The Scripps Research Institute | Genetically encoded fluorescent coumarin amino acids |
| EP2052083B1 (en) * | 2006-09-21 | 2014-01-08 | The Scripps Research Institute | Genetically programmed expression of selectively sulfated proteins in eubacteria |
| JP2010506591A (ja) | 2006-10-18 | 2010-03-04 | ザ スクリップス リサーチ インスティテュート | 哺乳動物細胞中の蛋白質への非天然アミノ酸の遺伝的組込み |
| GB0716719D0 (en) * | 2007-08-29 | 2007-10-10 | Chromatide Ltd | Process for carrying out a chemical reaction |
| MX2010004464A (es) | 2007-10-25 | 2010-06-07 | Scripps Research Inst | Incorporacion genetica de 3-aminotirosina a reductasas. |
| US9150849B2 (en) | 2007-11-02 | 2015-10-06 | The Scripps Research Institute | Directed evolution using proteins comprising unnatural amino acids |
| WO2009059056A2 (en) * | 2007-11-02 | 2009-05-07 | The Scripps Research Institute | A genetically encoded boronate amino acid |
| AU2008335778B2 (en) | 2007-12-11 | 2014-04-10 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast Pichia pastoris |
| CN101970005A (zh) * | 2008-02-08 | 2011-02-09 | 斯克利普斯研究院 | 用遗传编码的非天然氨基酸打破免疫耐受 |
| US20090197339A1 (en) * | 2008-12-10 | 2009-08-06 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris |
| CN102307905B (zh) | 2008-12-10 | 2015-11-25 | 斯克利普斯研究院 | 利用化学反应性非天然氨基酸产生载体-肽偶联物 |
| WO2011078987A1 (en) | 2009-12-21 | 2011-06-30 | Trustees Of Dartmouth College | Recombinant prokaryotes and use thereof for production of o-glycosylated proteins |
| US12359192B2 (en) * | 2013-12-23 | 2025-07-15 | University Of Rochester | Methods and compositions for display of macrocyclic peptides |
| EP3087088B1 (en) * | 2013-12-23 | 2022-05-25 | University Of Rochester | Methods and compositions for ribosomal synthesis of macrocyclic peptides |
| US11085045B2 (en) * | 2015-11-17 | 2021-08-10 | Anima Biotech Inc. | Functional tRNA-aptamer molecules |
| US20200317708A1 (en) * | 2017-10-09 | 2020-10-08 | Indiana University Research And Technology Corporation | Sugar-linked amino acids for solid-phase peptide synthesis |
| US20220299522A1 (en) * | 2019-08-26 | 2022-09-22 | The Johns Hopkins University | Compositions and methods for identifying o-linked glycosylation sites in proteins |
| WO2021165968A1 (en) * | 2020-02-20 | 2021-08-26 | B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Mutant aminoacyl-trna synthetases |
| IL303886A (en) * | 2020-12-23 | 2023-08-01 | Flagship Pioneering Inc | Compositions of modified trems and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991016449A1 (en) * | 1990-04-16 | 1991-10-31 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
| US5369017A (en) * | 1994-02-04 | 1994-11-29 | The Scripps Research Institute | Process for solid phase glycopeptide synthesis |
| US7083970B2 (en) | 2001-04-19 | 2006-08-01 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs |
| EP2042196B1 (en) | 2001-10-10 | 2016-07-13 | ratiopharm GmbH | Remodelling and glycoconjugation of Granulocyte Colony Stimulating Factor (G-CSF) |
| ES2324608T3 (es) | 2002-10-16 | 2009-08-11 | The Scripps Research Institute | Incorporacion especifica de sitio de cetoaminoacidos en proteinas. |
| MXPA05003978A (es) | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| JP5319863B2 (ja) | 2002-12-26 | 2013-10-16 | 独立行政法人理化学研究所 | 体細胞相同組換えの誘発方法 |
| WO2004094593A2 (en) | 2003-04-17 | 2004-11-04 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| US20060160175A1 (en) | 2003-07-07 | 2006-07-20 | The Scripps Research Institute | Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
-
2005
- 2005-10-20 JP JP2007538145A patent/JP2008516637A/ja not_active Abandoned
- 2005-10-20 US US11/664,898 patent/US20080064059A1/en not_active Abandoned
- 2005-10-20 US US11/255,601 patent/US7378263B2/en not_active Expired - Fee Related
- 2005-10-20 WO PCT/US2005/038250 patent/WO2006045116A2/en not_active Ceased
- 2005-10-20 EP EP05811879A patent/EP1809758A4/en not_active Withdrawn
-
2008
- 2008-04-08 US US12/082,214 patent/US20080241903A1/en not_active Abandoned
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