WO2008006680A8 - Verfahren zur herstellung von l-aminosäuren mittels mutanten des glta-gens kodierend für citratsynthase - Google Patents

Verfahren zur herstellung von l-aminosäuren mittels mutanten des glta-gens kodierend für citratsynthase

Info

Publication number
WO2008006680A8
WO2008006680A8 PCT/EP2007/056153 EP2007056153W WO2008006680A8 WO 2008006680 A8 WO2008006680 A8 WO 2008006680A8 EP 2007056153 W EP2007056153 W EP 2007056153W WO 2008006680 A8 WO2008006680 A8 WO 2008006680A8
Authority
WO
WIPO (PCT)
Prior art keywords
citrate synthase
producing
amino acids
mutants
gene coding
Prior art date
Application number
PCT/EP2007/056153
Other languages
English (en)
French (fr)
Other versions
WO2008006680A2 (de
WO2008006680A3 (de
Inventor
Brigitte Bathe
Wilfried Claes
Original Assignee
Evonik Degussa Gmbh
Brigitte Bathe
Wilfried Claes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Degussa Gmbh, Brigitte Bathe, Wilfried Claes filed Critical Evonik Degussa Gmbh
Priority to ES07786778T priority Critical patent/ES2382363T3/es
Priority to PL07786778T priority patent/PL2041276T3/pl
Priority to AT07786778T priority patent/ATE547516T1/de
Priority to DK07786778.6T priority patent/DK2041276T3/da
Priority to EP07786778A priority patent/EP2041276B1/de
Publication of WO2008006680A2 publication Critical patent/WO2008006680A2/de
Publication of WO2008006680A3 publication Critical patent/WO2008006680A3/de
Publication of WO2008006680A8 publication Critical patent/WO2008006680A8/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
    • C12Y203/03001—Citrate (Si)-synthase (2.3.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02004—Aspartate kinase (2.7.2.4)

Abstract

Gegenstand der Erfindung sind neue, für ein Polypeptid mit Citratsynthase Aktivität kodierende Polynukleotide, Bakterien die diese enthalten, bevorzugt der Gattung Corynebacterium und Escherichia, und Verfahren zur Herstellung von Aminosäuren unter Verwendung dieser Bakterien. Gegenstand der Erfindung ist dabei insbesondere ein isoliertes Polynukleotid, das für ein Polypeptid kodiert, welches die Aminosäuresequenz von SEQ ID NO:2 umfasst, wobei die L-Asparaginsäure an Position 5 der Aminosäuresequenz durch eine andere proteinogene Aminosäure ersetzt ist und wobei das Polypeptid Citratsynthase Aktivität besitzt.
PCT/EP2007/056153 2006-07-13 2007-06-20 Verfahren zur herstellung von l-aminosäuren mittels mutanten des glta-gens kodierend für citratsynthase WO2008006680A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES07786778T ES2382363T3 (es) 2006-07-13 2007-06-20 Procedimiento para la producción de l-aminoácidos mediante mutantes del gen glta que codifica la citrato sintasa
PL07786778T PL2041276T3 (pl) 2006-07-13 2007-06-20 Sposób wytwarzania L-aminokwasów za pomocą mutantów genu gltA kodującego syntazę cytranianową
AT07786778T ATE547516T1 (de) 2006-07-13 2007-06-20 Verfahren zur herstellung von l-aminosäuren mittels mutanten des glta-gens kodierend für citratsynthase
DK07786778.6T DK2041276T3 (da) 2006-07-13 2007-06-20 Fremgangsmåde til fremstilling af l-aminosyrer ved hjælp af mutanter af glta-genet kodende for citrat synthase
EP07786778A EP2041276B1 (de) 2006-07-13 2007-06-20 Verfahren zur herstellung von l-aminosäuren mittels mutanten des glta-gens kodierend für citratsynthase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006032634A DE102006032634A1 (de) 2006-07-13 2006-07-13 Verfahren zur Herstellung von L-Aminosäuren
DE102006032634.2 2006-07-13

Publications (3)

Publication Number Publication Date
WO2008006680A2 WO2008006680A2 (de) 2008-01-17
WO2008006680A3 WO2008006680A3 (de) 2008-07-03
WO2008006680A8 true WO2008006680A8 (de) 2008-09-25

Family

ID=38825283

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/056153 WO2008006680A2 (de) 2006-07-13 2007-06-20 Verfahren zur herstellung von l-aminosäuren mittels mutanten des glta-gens kodierend für citratsynthase

Country Status (8)

Country Link
US (3) US7785840B2 (de)
EP (1) EP2041276B1 (de)
AT (1) ATE547516T1 (de)
DE (1) DE102006032634A1 (de)
DK (1) DK2041276T3 (de)
ES (1) ES2382363T3 (de)
PL (1) PL2041276T3 (de)
WO (1) WO2008006680A2 (de)

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KR102525072B1 (ko) * 2021-03-10 2023-04-24 씨제이제일제당 주식회사 신규한 시트레이트 신타아제 변이체 및 이를 이용한 l-아미노산 생산 방법
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Also Published As

Publication number Publication date
EP2041276A2 (de) 2009-04-01
ATE547516T1 (de) 2012-03-15
DE102006032634A1 (de) 2008-01-17
US8202706B2 (en) 2012-06-19
WO2008006680A2 (de) 2008-01-17
EP2041276B1 (de) 2012-02-29
US20080014618A1 (en) 2008-01-17
DK2041276T3 (da) 2012-05-29
US7785840B2 (en) 2010-08-31
US8119372B2 (en) 2012-02-21
ES2382363T3 (es) 2012-06-07
PL2041276T3 (pl) 2012-07-31
WO2008006680A3 (de) 2008-07-03
US20100261257A1 (en) 2010-10-14
US20090280542A1 (en) 2009-11-12

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