RU2464315C2 - Генетически запрограммированная экспрессия белков, содержащих не встречающуюся в природе аминокислоту фенилселеноцистеин - Google Patents

Генетически запрограммированная экспрессия белков, содержащих не встречающуюся в природе аминокислоту фенилселеноцистеин Download PDF

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RU2464315C2
RU2464315C2 RU2008135114/10A RU2008135114A RU2464315C2 RU 2464315 C2 RU2464315 C2 RU 2464315C2 RU 2008135114/10 A RU2008135114/10 A RU 2008135114/10A RU 2008135114 A RU2008135114 A RU 2008135114A RU 2464315 C2 RU2464315 C2 RU 2464315C2
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trna
protein
amino acid
phenylselenocysteine
sequence
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Джиангюн ВАНГ (US)
Джиангюн ВАНГ
Питер Г. ШУЛЬЦ (US)
Питер Г. ШУЛЬЦ
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Зе Скрипс Ресеч Инститьют
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

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  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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RU2008135114/10A 2006-03-16 2007-03-13 Генетически запрограммированная экспрессия белков, содержащих не встречающуюся в природе аминокислоту фенилселеноцистеин RU2464315C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78327206P 2006-03-16 2006-03-16
US60/783,272 2006-03-16
US86145606P 2006-11-28 2006-11-28
US60/861,456 2006-11-28

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RU2008135114A RU2008135114A (ru) 2010-04-27
RU2464315C2 true RU2464315C2 (ru) 2012-10-20

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US (3) US7790847B2 (https=)
EP (1) EP1994165B1 (https=)
JP (1) JP5249194B2 (https=)
KR (1) KR20080113226A (https=)
CN (1) CN101405401B (https=)
AU (1) AU2007227592B2 (https=)
BR (1) BRPI0709603A2 (https=)
CA (1) CA2638772A1 (https=)
IL (1) IL193722A0 (https=)
MX (1) MX2008011669A (https=)
RU (1) RU2464315C2 (https=)
WO (1) WO2007109035A2 (https=)

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RU2771892C2 (ru) * 2016-12-29 2022-05-13 Иллумина, Инк. Система анализа для ортогонального доступа к биомолекулам и их мечения в клеточных компартментах
US12416002B2 (en) 2016-12-29 2025-09-16 Illumina, Inc. Analysis system for orthogonal access to and tagging of biomolecules in cellular compartments

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WO2005019415A2 (en) 2003-07-07 2005-03-03 The Scripps Research Institute Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof
EP1807515A4 (en) 2004-10-27 2008-06-18 Scripps Research Inst Orthogonal translation components for the in vivo incorporation of unnatural amino acids
US7960141B2 (en) * 2006-03-09 2011-06-14 The Scripps Research Institute Systems for the expression of orthogonal translation components in eubacterial host cells
KR20080113226A (ko) 2006-03-16 2008-12-29 더 스크립스 리서치 인스티튜트 비천연 아미노산 페닐셀레노시스테인을 함유하는 단백질의 유전자적으로 프로그램된 발현
US7807411B2 (en) * 2006-05-23 2010-10-05 The Scripps Research Institute Genetically encoded fluorescent coumarin amino acids
EP2052083B1 (en) * 2006-09-21 2014-01-08 The Scripps Research Institute Genetically programmed expression of selectively sulfated proteins in eubacteria
JP2010506591A (ja) 2006-10-18 2010-03-04 ザ スクリップス リサーチ インスティテュート 哺乳動物細胞中の蛋白質への非天然アミノ酸の遺伝的組込み
MX2010004464A (es) 2007-10-25 2010-06-07 Scripps Research Inst Incorporacion genetica de 3-aminotirosina a reductasas.
WO2009059056A2 (en) * 2007-11-02 2009-05-07 The Scripps Research Institute A genetically encoded boronate amino acid
US9150849B2 (en) 2007-11-02 2015-10-06 The Scripps Research Institute Directed evolution using proteins comprising unnatural amino acids
AU2008335778B2 (en) 2007-12-11 2014-04-10 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast Pichia pastoris
US8592199B2 (en) 2007-12-28 2013-11-26 David H. Ardell Genetic encryption
CA2710683A1 (en) 2008-01-03 2009-07-16 Verenium Corporation Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
CN101970005A (zh) * 2008-02-08 2011-02-09 斯克利普斯研究院 用遗传编码的非天然氨基酸打破免疫耐受
CN102307905B (zh) 2008-12-10 2015-11-25 斯克利普斯研究院 利用化学反应性非天然氨基酸产生载体-肽偶联物
US20090197339A1 (en) * 2008-12-10 2009-08-06 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
US8658394B2 (en) * 2011-02-02 2014-02-25 Waterstone Pharmaceuticals Methods, cells and systems for incorporating non-canonical amino acids into proteins
CN103215235B (zh) * 2012-01-18 2014-11-05 中国科学院生物物理研究所 3-咪唑基酪氨酸翻译系统及其应用
CN103571804B (zh) * 2012-08-10 2015-08-12 中国科学院生物物理研究所 3-吡唑基酪氨酸翻译系统及其应用
JP6421122B2 (ja) 2012-10-12 2018-11-07 ストロ バイオファーマ， インコーポレイテッド 改善された発現のための、細菌抽出物中の選択タンパク質のタンパク質分解不活性化
CN103820410B (zh) * 2012-11-16 2016-03-30 中国科学院生物物理研究所 3-甲硫酪氨酸翻译系统及其应用
CN104004723B (zh) * 2013-02-22 2016-08-17 中国科学院生物物理研究所 3,5-二氟代酪氨酸翻译系统及其应用
CN104059891B (zh) * 2013-03-22 2016-08-17 中国科学院生物物理研究所 8-羟基喹啉丙氨酸翻译系统及其应用
CN105792851B (zh) * 2013-09-13 2023-10-10 斯克利普斯研究所 修饰的治疗剂及其组合物
AU2014364589B2 (en) 2013-12-18 2020-02-27 The California Institute For Biomedical Research Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
CN109414451B (zh) * 2016-05-16 2022-08-12 德克萨斯大学系统董事会 用于作为纳米粒递送tRNA的组合物及其使用方法
AU2020397917A1 (en) 2019-12-04 2022-06-23 The Scripps Research Institute GLP2 receptor agonists and methods of use
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Cited By (2)

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Publication number Priority date Publication date Assignee Title
RU2771892C2 (ru) * 2016-12-29 2022-05-13 Иллумина, Инк. Система анализа для ортогонального доступа к биомолекулам и их мечения в клеточных компартментах
US12416002B2 (en) 2016-12-29 2025-09-16 Illumina, Inc. Analysis system for orthogonal access to and tagging of biomolecules in cellular compartments

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AU2007227592A1 (en) 2007-09-27
US7790847B2 (en) 2010-09-07
WO2007109035A2 (en) 2007-09-27
WO2007109035A3 (en) 2008-10-16
EP1994165A2 (en) 2008-11-26
CN101405401A (zh) 2009-04-08
US20120282668A1 (en) 2012-11-08
US20070238152A1 (en) 2007-10-11
KR20080113226A (ko) 2008-12-29
CA2638772A1 (en) 2007-09-27
US8217145B2 (en) 2012-07-10
JP2009529877A (ja) 2009-08-27
AU2007227592B2 (en) 2011-11-24
EP1994165B1 (en) 2014-11-05
US20090209000A1 (en) 2009-08-20
US8394605B2 (en) 2013-03-12
RU2008135114A (ru) 2010-04-27
MX2008011669A (es) 2008-09-22
IL193722A0 (en) 2011-08-01
EP1994165A4 (en) 2012-11-07
CN101405401B (zh) 2013-03-27
BRPI0709603A2 (pt) 2011-07-19
JP5249194B2 (ja) 2013-07-31

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