PL3458074T3 - KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIA - Google Patents
KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIAInfo
- Publication number
- PL3458074T3 PL3458074T3 PL17800042.8T PL17800042T PL3458074T3 PL 3458074 T3 PL3458074 T3 PL 3458074T3 PL 17800042 T PL17800042 T PL 17800042T PL 3458074 T3 PL3458074 T3 PL 3458074T3
- Authority
- PL
- Poland
- Prior art keywords
- trna
- nanoparticles
- delivery
- compositions
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Dispersion Chemistry (AREA)
- Optics & Photonics (AREA)
- Neurology (AREA)
- Inorganic Chemistry (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662337096P | 2016-05-16 | 2016-05-16 | |
| PCT/US2017/032967 WO2017201091A1 (en) | 2016-05-16 | 2017-05-16 | COMPOSITIONS FOR THE DELIVERY OF tRNA AS NANOPARTICLES AND METHODS OF USE THEREWITH |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3458074T3 true PL3458074T3 (pl) | 2024-11-12 |
Family
ID=60326616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17800042.8T PL3458074T3 (pl) | 2016-05-16 | 2017-05-16 | KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIA |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20170354672A1 (pl) |
| EP (2) | EP4393549A3 (pl) |
| JP (1) | JP7312552B2 (pl) |
| CN (2) | CN115919769A (pl) |
| AU (3) | AU2017268272C1 (pl) |
| CA (1) | CA3024135C (pl) |
| DK (1) | DK3458074T3 (pl) |
| ES (1) | ES2985317T3 (pl) |
| PL (1) | PL3458074T3 (pl) |
| PT (1) | PT3458074T (pl) |
| WO (1) | WO2017201091A1 (pl) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7041616B2 (ja) * | 2015-09-14 | 2022-03-24 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | リポカチオン性デンドリマーおよびその使用 |
| CN110612353A (zh) | 2017-03-03 | 2019-12-24 | 加利福尼亚大学董事会 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
| EP3703701A4 (en) | 2017-11-02 | 2022-02-09 | University of Iowa Research Foundation | Methods of rescuing stop codons via genetic reassignment with ace-trna |
| US12357580B2 (en) | 2018-06-19 | 2025-07-15 | The Board Of Regents Of The University Of Texas System | Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids |
| CN112996519B (zh) | 2018-09-04 | 2025-02-28 | 德克萨斯大学系统董事会 | 用于核酸的器官特异性递送的组合物和方法 |
| AU2019335055B2 (en) | 2018-09-04 | 2025-05-29 | The Board Of Regents Of The University Of Texas System | Compositions and methods for organ specific delivery of nucleic acids |
| CN109266734A (zh) * | 2018-09-25 | 2019-01-25 | 深圳市人民医院 | 自身免疫性疾病诊断试剂盒和应用 |
| AU2019350869A1 (en) * | 2018-09-26 | 2021-05-20 | Case Western Reserve University | Methods and compositions for treating a premature stop codon-mediated disorder |
| US10905778B2 (en) * | 2018-09-26 | 2021-02-02 | Case Western Reserve University | Methods and compositions for treating a premature stop codon-mediated disorder |
| US12281314B2 (en) * | 2018-09-26 | 2025-04-22 | Case Western Reserve University | Methods and compositions for increasing protein expression and/or treating a haploinsufficiency disorder |
| WO2020243560A1 (en) * | 2019-05-31 | 2020-12-03 | Flagship Pioneering, Inc. | Uses of trem compositions to modulate trna pools |
| CN115038789A (zh) | 2019-12-02 | 2022-09-09 | 塑造治疗公司 | 治疗性编辑 |
| JP2023533174A (ja) * | 2020-06-12 | 2023-08-02 | ユニバーシティ オブ ロチェスター | ＡＣＥ－ｔＲＮＡのコード化及び発現 |
| BR112023019229A2 (pt) | 2021-03-22 | 2023-11-28 | Recode Therapeutics Inc | Composições e métodos para a liberação direcionada às células |
| IL306007A (en) | 2021-03-23 | 2023-11-01 | Recode Therapeutics Inc | Polynucleotide preparations, related formulations and methods of using them |
| WO2022261185A1 (en) * | 2021-06-09 | 2022-12-15 | Recode Therapeutics, Inc. | Polynucleotide compositions, related formulations, and methods of use thereof |
| CN113416784A (zh) * | 2021-07-18 | 2021-09-21 | 南京中医药大学 | 一种与乳腺癌诊断相关的血清外泌体tsRNA标志物及其应用 |
| EP4522743A1 (en) * | 2022-05-09 | 2025-03-19 | Flagship Pioneering Innovations VI, LLC | Trem compositions and methods of use for treating proliferative disorders |
| WO2023218420A1 (en) | 2022-05-13 | 2023-11-16 | Janssen Pharmaceuticals, Inc. | Mrna compositions for inducing latent hiv-1 reversal |
| CN115851911B (zh) * | 2022-11-25 | 2025-10-24 | 南京鼓楼医院 | 一种用于鉴别狼疮性肾炎的尿液外泌体tsRNA标志物和探针及其应用 |
| WO2024123633A1 (en) | 2022-12-08 | 2024-06-13 | Recode Therapeutics, Inc. | Lipid nanoparticle compositions and uses thereof |
| CN116515827B (zh) * | 2023-03-20 | 2024-12-10 | 复旦大学附属眼耳鼻喉科医院 | 用于治疗年龄相关性黄斑变性的活性成分、药物组合物和应用 |
| US12364773B2 (en) | 2023-12-01 | 2025-07-22 | Recode Therapeutics, Inc. | Lipid nanoparticle compositions and uses thereof |
| WO2025137646A1 (en) | 2023-12-22 | 2025-06-26 | Recode Therapeutics, Inc. | Gene editing methods and compositions for treating cystic fibrosis |
| CN117965718B (zh) * | 2024-02-02 | 2024-09-06 | 江苏省中医院 | 一种与脓毒症相关的生物标志物及其应用 |
| CN118178452A (zh) * | 2024-02-23 | 2024-06-14 | 山东大学 | 小分子RNA tRF-1:29-Gly-CCC-1-M4在制备抗间充质干细胞衰老药物中的应用 |
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| US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
| US5846945A (en) | 1993-02-16 | 1998-12-08 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
| GB9506466D0 (en) | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| US5739169A (en) | 1996-05-31 | 1998-04-14 | Procept, Incorporated | Aromatic compounds for inhibiting immune response |
| AU2003212089B2 (en) * | 2002-03-14 | 2008-08-21 | Commonwealth Scientific And Industrial Research Organisation | Methods and means for monitoring and modulating gene silencing |
| US7404969B2 (en) * | 2005-02-14 | 2008-07-29 | Sirna Therapeutics, Inc. | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules |
| EP2295570A1 (en) * | 2005-07-27 | 2011-03-16 | Oncotherapy Science, Inc. | Method of diagnosing small cell lung cancer |
| RU2464315C2 (ru) * | 2006-03-16 | 2012-10-20 | Зе Скрипс Ресеч Инститьют | Генетически запрограммированная экспрессия белков, содержащих не встречающуюся в природе аминокислоту фенилселеноцистеин |
| US8071082B2 (en) * | 2006-07-21 | 2011-12-06 | Massachusetts Institute Of Technology | End-modified poly(beta-amino esters) and uses thereof |
| WO2008045486A2 (en) * | 2006-10-09 | 2008-04-17 | The University Of North Carolina At Chapel Hill | Nanoparticle compositions for controlled delivery of nucleic acids |
| CN101595215A (zh) * | 2006-10-30 | 2009-12-02 | 普罗梅加公司 | 具有增强的动力学和功能性表达的突变水解酶蛋白 |
| CN101849005A (zh) * | 2007-11-05 | 2010-09-29 | 普罗梅加公司 | 杂合融合报道子及其应用 |
| KR101620642B1 (ko) * | 2007-11-07 | 2016-05-12 | 제넨테크, 인크. | 항-ｃｄ４０ 항체를 사용한 치료에 대한 ｂ-세포 림프종의 반응성 평가를 위한 방법 및 조성물 |
| WO2010042877A1 (en) * | 2008-10-09 | 2010-04-15 | Tekmira Pharmaceuticals Corporation | Improved amino lipids and methods for the delivery of nucleic acids |
| JP6087504B2 (ja) | 2008-11-07 | 2017-03-01 | マサチューセッツ インスティテュート オブ テクノロジー | アミノアルコールリピドイドおよびその使用 |
| KR100909786B1 (ko) * | 2008-11-10 | 2009-07-29 | 고려대학교 산학협력단 | 올리고 펩티드를 수식한 신규한 양이온성 지질, 그의 제조 방법 및 그를 포함하는 전달체 |
| AU2010257181A1 (en) | 2009-06-02 | 2012-01-12 | Brian Charles Keller | Pure PEG-lipid conjugates |
| CN101591428B (zh) * | 2009-06-29 | 2011-05-25 | 浙江大学 | 一种聚酯树枝状大分子的制备方法 |
| US20120237589A1 (en) * | 2009-07-09 | 2012-09-20 | Marina Biotech, Inc. | Amphoteric liposomes comprising imino lipids |
| EP2496700B1 (en) * | 2009-11-04 | 2017-03-01 | The University Of British Columbia | Nucleic acid-containing lipid particles and related methods |
| KR101183989B1 (ko) * | 2010-02-04 | 2012-09-19 | 전남대학교산학협력단 | 세포내 유전자 전달용 복합체, 이의 제조 방법 및 이를 이용한 세포내로의 유전자 전달 방법 |
| WO2012011110A2 (en) * | 2010-07-22 | 2012-01-26 | Ramot At Tel Aviv University Ltd. | Systems and methods for detection of cellular stress |
| PT2694116T (pt) * | 2011-04-06 | 2018-10-12 | Univ Texas | Nanopartículas à base de lípidos |
| EP2532649B1 (en) * | 2011-06-07 | 2015-04-08 | Incella GmbH | Amino lipids, their synthesis and uses thereof |
| CN107082747B (zh) * | 2011-06-08 | 2020-11-20 | 日东电工株式会社 | 用于定向药物输送和增强siRNA活性的化合物 |
| US20150031864A1 (en) * | 2012-02-29 | 2015-01-29 | Ambrx, Inc. | Modified Adiponectin Polypeptides and Their Uses |
| CA2881602A1 (en) * | 2012-08-14 | 2014-02-20 | Angiochem Inc. | Peptide-dendrimer conjugates and uses thereof |
| KR20140048404A (ko) * | 2012-10-11 | 2014-04-24 | 포항공과대학교 산학협력단 | 저밀도 지단백질 유사 나노입자 및 이를 포함하는 간 표적 진단 및 치료용 조성물 |
| US20160151284A1 (en) * | 2013-07-23 | 2016-06-02 | Protiva Biotherapeutics, Inc. | Compositions and methods for delivering messenger rna |
| CN103999853B (zh) * | 2014-06-11 | 2015-07-22 | 中国农业大学 | 荧光树枝状纳米大分子在制备药物载体中的应用 |
| EP2966068A1 (en) * | 2014-07-08 | 2016-01-13 | Incella GmbH | Synthesis and use of amino lipids |
| CN104383596A (zh) * | 2014-10-24 | 2015-03-04 | 东华大学 | 一种tpgs载药脂质体-天然材料复合纳米纤维支架的制备方法 |
| AU2015360794B2 (en) | 2014-12-08 | 2021-07-08 | The Board Of Regents Of The University Of Texas System | Lipocationic polymers and uses thereof |
| JP7041616B2 (ja) | 2015-09-14 | 2022-03-24 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | リポカチオン性デンドリマーおよびその使用 |
| AU2017267634C1 (en) * | 2016-05-16 | 2022-05-26 | The Board Of Regents Of The University Of Texas System | Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids |
-
2017
- 2017-05-16 PL PL17800042.8T patent/PL3458074T3/pl unknown
- 2017-05-16 WO PCT/US2017/032967 patent/WO2017201091A1/en not_active Ceased
- 2017-05-16 EP EP24161024.5A patent/EP4393549A3/en active Pending
- 2017-05-16 ES ES17800042T patent/ES2985317T3/es active Active
- 2017-05-16 JP JP2018560153A patent/JP7312552B2/ja active Active
- 2017-05-16 CN CN202210856722.1A patent/CN115919769A/zh active Pending
- 2017-05-16 US US15/597,063 patent/US20170354672A1/en not_active Abandoned
- 2017-05-16 DK DK17800042.8T patent/DK3458074T3/da active
- 2017-05-16 PT PT178000428T patent/PT3458074T/pt unknown
- 2017-05-16 CN CN201780038893.0A patent/CN109414451B/zh active Active
- 2017-05-16 AU AU2017268272A patent/AU2017268272C1/en active Active
- 2017-05-16 CA CA3024135A patent/CA3024135C/en active Active
- 2017-05-16 EP EP17800042.8A patent/EP3458074B1/en active Active
-
2020
- 2020-10-06 US US17/064,505 patent/US20210023120A1/en not_active Abandoned
-
2021
- 2021-09-03 AU AU2021225244A patent/AU2021225244B2/en active Active
-
2023
- 2023-09-05 AU AU2023226641A patent/AU2023226641B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP4393549A3 (en) | 2024-10-09 |
| AU2023226641A1 (en) | 2023-09-21 |
| EP4393549A2 (en) | 2024-07-03 |
| JP7312552B2 (ja) | 2023-07-21 |
| DK3458074T3 (da) | 2024-07-29 |
| AU2023226641B2 (en) | 2025-06-26 |
| AU2021225244A1 (en) | 2021-09-30 |
| AU2021225244B2 (en) | 2023-09-28 |
| JP2023123863A (ja) | 2023-09-05 |
| PT3458074T (pt) | 2024-08-21 |
| EP3458074A4 (en) | 2020-01-22 |
| CN115919769A (zh) | 2023-04-07 |
| BR112018073671A2 (pt) | 2019-02-26 |
| US20170354672A1 (en) | 2017-12-14 |
| JP2019515016A (ja) | 2019-06-06 |
| WO2017201091A1 (en) | 2017-11-23 |
| EP3458074A1 (en) | 2019-03-27 |
| AU2017268272B2 (en) | 2021-09-23 |
| AU2017268272C1 (en) | 2022-05-05 |
| CA3024135A1 (en) | 2017-11-23 |
| CN109414451B (zh) | 2022-08-12 |
| US20210023120A1 (en) | 2021-01-28 |
| CA3024135C (en) | 2024-09-24 |
| EP3458074B1 (en) | 2024-04-17 |
| AU2017268272A1 (en) | 2018-11-29 |
| CN109414451A (zh) | 2019-03-01 |
| ES2985317T3 (es) | 2024-11-05 |
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