JP2009528843A - 組換えヒトトロンビンおよびフィブリノゲンの調製法 - Google Patents

組換えヒトトロンビンおよびフィブリノゲンの調製法 Download PDF

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JP2009528843A
JP2009528843A JP2008558377A JP2008558377A JP2009528843A JP 2009528843 A JP2009528843 A JP 2009528843A JP 2008558377 A JP2008558377 A JP 2008558377A JP 2008558377 A JP2008558377 A JP 2008558377A JP 2009528843 A JP2009528843 A JP 2009528843A
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human
recombinant
thrombin
fibrinogen
prothrombin
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Pending
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JP2008558377A
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Japanese (ja)
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JP2009528843A5 (enExample
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カート・オスサー
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Humagene Inc
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Humagene Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
JP2008558377A 2006-03-06 2007-03-06 組換えヒトトロンビンおよびフィブリノゲンの調製法 Pending JP2009528843A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77947406P 2006-03-06 2006-03-06
US84394506P 2006-09-12 2006-09-12
PCT/US2007/005845 WO2007103447A2 (en) 2006-03-06 2007-03-06 A method for the preparation of recombinant human thrombin

Publications (2)

Publication Number Publication Date
JP2009528843A true JP2009528843A (ja) 2009-08-13
JP2009528843A5 JP2009528843A5 (enExample) 2010-04-22

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JP2008558377A Pending JP2009528843A (ja) 2006-03-06 2007-03-06 組換えヒトトロンビンおよびフィブリノゲンの調製法

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Country Link
US (2) US20100159512A1 (enExample)
EP (2) EP2407561A3 (enExample)
JP (1) JP2009528843A (enExample)
CN (1) CN101501216B (enExample)
AU (1) AU2007223880A1 (enExample)
CA (1) CA2644926A1 (enExample)
RU (1) RU2008139428A (enExample)
WO (1) WO2007103447A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9447167B2 (en) 2011-03-03 2016-09-20 Immuno-Biological Laboratories Co., Ltd Fibrinogen-producing transgenic silkworm

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US8236527B2 (en) 2008-03-14 2012-08-07 Humanzyme Limited Recombinant production of authentic human proteins using human cell expression systems
US8557773B2 (en) 2008-05-02 2013-10-15 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Treatment of bleeding with low half-life fibrinogen
AU2009268052B2 (en) * 2008-07-09 2015-05-28 Mallinckrodt Pharma Ip Trading D.A.C. Recombinant fibrinogen
FR2942232B1 (fr) * 2009-02-19 2015-03-13 Lfb Biotechnologies Moyens pour la purification d'une proteine de la coagulation et procedes pour sa mise en oeuvre
CN102481346A (zh) * 2009-04-14 2012-05-30 胡玛基因公司 新颖的翻译后纤维蛋白原变体
DK2624859T3 (en) * 2010-10-06 2017-06-06 Medimmune Ltd FACTOR II ALONE OR IN COMBINATION WITH OTHER FACTORS FOR TREATMENT OF REDUCED HEMOSTASE IN CONNECTION WITH DILUTION COAGULOPATHY
CN102690803B (zh) * 2011-03-24 2015-04-29 苏州泽璟生物制药有限公司 一种重组人凝血酶在动物细胞内的高效表达和生产方法
EP2556842A1 (en) 2011-08-11 2013-02-13 Bioftalmik, S.L. Composition in the form of film comprising fibrinogen and a fibrinogen activator and the applications thereof
US9598687B2 (en) 2011-09-06 2017-03-21 Medimmune, Llc Methods for processing coagulation factors
WO2014115087A2 (en) * 2013-01-22 2014-07-31 Cencor Biotech Ltd. A method for the preparation of recombinant human prothrombin and fibrinogen
WO2016150449A1 (en) * 2015-03-23 2016-09-29 Dana Genetic A/S Recombinant soluble human tissue factor, method of its production and uses thereof
US10954502B2 (en) 2015-04-28 2021-03-23 Saint Louis University Thrombin-thrombomodulin fusion proteins as protein C activators
US11085031B2 (en) 2016-04-28 2021-08-10 Saint Louis University Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant
BR102017004788B1 (pt) * 2017-03-09 2021-03-23 Instituto De Biologia Molecular Do Paraná - Ibmp. Método de produção de cola de fibrina de origem recombinante
ES2832881T3 (es) * 2018-04-24 2021-06-11 Fibriant B V Variantes de fibrinógeno gamma prima para su uso en el tratamiento de una infección
JP2025519280A (ja) 2022-05-17 2025-06-25 ユリウス－マキシミリアンズ－ユニヴァーシタエト ビュルツブルク 手術創ケア用のフィブリンシーラントのための新規組換えフィブリノーゲンバリアント
CN116333094B (zh) * 2023-02-04 2024-03-29 山东多美康生物医药有限公司 一种重组人源化I型胶原蛋白α1及表达载体和应用
CN116218864B (zh) * 2023-04-10 2024-01-09 山东多美康生物医药有限公司 一种重组Ⅲ型人源化胶原蛋白α1及其表达载体和应用

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JPH06153931A (ja) * 1992-08-24 1994-06-03 Interpharm Lab Ltd 無血清培地
WO2003004641A1 (en) * 2001-07-06 2003-01-16 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Process for producing human thrombin by gene modification technique
JP2003510070A (ja) * 1999-09-28 2003-03-18 バクスター アクチェンゲゼルシャフト 細胞の無タンパク質かつ無血清の培養のための培地
WO2004007714A1 (ja) * 2002-07-17 2004-01-22 Asahi Kasei Pharma Corporation ヒトプロトロンビン類似体およびヒトメゾトロンビン類似体
JP2004283097A (ja) * 2003-03-24 2004-10-14 National Veterinary Assay Laboratory Ministry Of Agriculture Forestry & Fisheries 動物由来成分無添加培養液およびそれを用いる細胞系の作出方法

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US6037457A (en) * 1997-01-31 2000-03-14 The University Of North Carolina At Chapel Hill Method for recombinant fibrinogen production
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AU2002257440A1 (en) * 2001-05-07 2002-11-18 National Research Council Of Canada Enhanced production of recombinant proteins by transient transfection of suspension-growing mammalian cells
JP4150814B2 (ja) * 2001-07-06 2008-09-17 財団法人化学及血清療法研究所 遺伝子組換えエカリン及びその製造方法
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JPH06153931A (ja) * 1992-08-24 1994-06-03 Interpharm Lab Ltd 無血清培地
JP2003510070A (ja) * 1999-09-28 2003-03-18 バクスター アクチェンゲゼルシャフト 細胞の無タンパク質かつ無血清の培養のための培地
WO2003004641A1 (en) * 2001-07-06 2003-01-16 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Process for producing human thrombin by gene modification technique
WO2004007714A1 (ja) * 2002-07-17 2004-01-22 Asahi Kasei Pharma Corporation ヒトプロトロンビン類似体およびヒトメゾトロンビン類似体
JP2004283097A (ja) * 2003-03-24 2004-10-14 National Veterinary Assay Laboratory Ministry Of Agriculture Forestry & Fisheries 動物由来成分無添加培養液およびそれを用いる細胞系の作出方法

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9447167B2 (en) 2011-03-03 2016-09-20 Immuno-Biological Laboratories Co., Ltd Fibrinogen-producing transgenic silkworm

Also Published As

Publication number Publication date
WO2007103447A3 (en) 2008-12-11
US20130017591A1 (en) 2013-01-17
US20100159512A1 (en) 2010-06-24
EP1996186A2 (en) 2008-12-03
EP2407561A3 (en) 2012-05-30
RU2008139428A (ru) 2010-05-20
CN101501216A (zh) 2009-08-05
WO2007103447A2 (en) 2007-09-13
AU2007223880A1 (en) 2007-09-13
CN101501216B (zh) 2013-10-02
EP1996186A4 (en) 2009-07-22
WO2007103447A8 (en) 2008-05-15
CA2644926A1 (en) 2007-09-13
EP2407561A2 (en) 2012-01-18

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