CN101501216B - 制备重组人凝血酶的方法 - Google Patents

制备重组人凝血酶的方法 Download PDF

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Publication number
CN101501216B
CN101501216B CN2007800143376A CN200780014337A CN101501216B CN 101501216 B CN101501216 B CN 101501216B CN 2007800143376 A CN2007800143376 A CN 2007800143376A CN 200780014337 A CN200780014337 A CN 200780014337A CN 101501216 B CN101501216 B CN 101501216B
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human
gly
thrombin
glu
ser
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CN101501216A (zh
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K·奥斯瑟
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Humagene Inc
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Humagene Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
CN2007800143376A 2006-03-06 2007-03-06 制备重组人凝血酶的方法 Expired - Fee Related CN101501216B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US77947406P 2006-03-06 2006-03-06
US60/779,474 2006-03-06
US84394506P 2006-09-12 2006-09-12
US60/843,945 2006-09-12
PCT/US2007/005845 WO2007103447A2 (en) 2006-03-06 2007-03-06 A method for the preparation of recombinant human thrombin

Publications (2)

Publication Number Publication Date
CN101501216A CN101501216A (zh) 2009-08-05
CN101501216B true CN101501216B (zh) 2013-10-02

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CN2007800143376A Expired - Fee Related CN101501216B (zh) 2006-03-06 2007-03-06 制备重组人凝血酶的方法

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US (2) US20100159512A1 (enExample)
EP (2) EP2407561A3 (enExample)
JP (1) JP2009528843A (enExample)
CN (1) CN101501216B (enExample)
AU (1) AU2007223880A1 (enExample)
CA (1) CA2644926A1 (enExample)
RU (1) RU2008139428A (enExample)
WO (1) WO2007103447A2 (enExample)

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US8236527B2 (en) 2008-03-14 2012-08-07 Humanzyme Limited Recombinant production of authentic human proteins using human cell expression systems
US8557773B2 (en) 2008-05-02 2013-10-15 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Treatment of bleeding with low half-life fibrinogen
AU2009268052B2 (en) * 2008-07-09 2015-05-28 Mallinckrodt Pharma Ip Trading D.A.C. Recombinant fibrinogen
FR2942232B1 (fr) * 2009-02-19 2015-03-13 Lfb Biotechnologies Moyens pour la purification d'une proteine de la coagulation et procedes pour sa mise en oeuvre
CN102481346A (zh) * 2009-04-14 2012-05-30 胡玛基因公司 新颖的翻译后纤维蛋白原变体
DK2624859T3 (en) * 2010-10-06 2017-06-06 Medimmune Ltd FACTOR II ALONE OR IN COMBINATION WITH OTHER FACTORS FOR TREATMENT OF REDUCED HEMOSTASE IN CONNECTION WITH DILUTION COAGULOPATHY
JP5839810B2 (ja) 2011-03-03 2016-01-06 日本製粉株式会社 フィブリノゲンを産生するトランスジェニックカイコ
CN102690803B (zh) * 2011-03-24 2015-04-29 苏州泽璟生物制药有限公司 一种重组人凝血酶在动物细胞内的高效表达和生产方法
EP2556842A1 (en) 2011-08-11 2013-02-13 Bioftalmik, S.L. Composition in the form of film comprising fibrinogen and a fibrinogen activator and the applications thereof
US9598687B2 (en) 2011-09-06 2017-03-21 Medimmune, Llc Methods for processing coagulation factors
WO2014115087A2 (en) * 2013-01-22 2014-07-31 Cencor Biotech Ltd. A method for the preparation of recombinant human prothrombin and fibrinogen
WO2016150449A1 (en) * 2015-03-23 2016-09-29 Dana Genetic A/S Recombinant soluble human tissue factor, method of its production and uses thereof
US10954502B2 (en) 2015-04-28 2021-03-23 Saint Louis University Thrombin-thrombomodulin fusion proteins as protein C activators
US11085031B2 (en) 2016-04-28 2021-08-10 Saint Louis University Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant
BR102017004788B1 (pt) * 2017-03-09 2021-03-23 Instituto De Biologia Molecular Do Paraná - Ibmp. Método de produção de cola de fibrina de origem recombinante
ES2832881T3 (es) * 2018-04-24 2021-06-11 Fibriant B V Variantes de fibrinógeno gamma prima para su uso en el tratamiento de una infección
JP2025519280A (ja) 2022-05-17 2025-06-25 ユリウス－マキシミリアンズ－ユニヴァーシタエト ビュルツブルク 手術創ケア用のフィブリンシーラントのための新規組換えフィブリノーゲンバリアント
CN116333094B (zh) * 2023-02-04 2024-03-29 山东多美康生物医药有限公司 一种重组人源化I型胶原蛋白α1及表达载体和应用
CN116218864B (zh) * 2023-04-10 2024-01-09 山东多美康生物医药有限公司 一种重组Ⅲ型人源化胶原蛋白α1及其表达载体和应用

Citations (4)

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CN1074438A (zh) * 1991-11-12 1993-07-21 伊莱利利公司 抗血栓剂
US5476777A (en) * 1991-12-31 1995-12-19 Zymogenetics, Inc. Methods for producing thrombin
CN1127509A (zh) * 1993-06-03 1996-07-24 阿斯特拉公司 新的肽衍生物
CN1139455A (zh) * 1993-11-12 1997-01-01 吉里德科学公司 凝血酶突变体

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US722366A (en) 1901-09-09 1903-03-10 Lars Peter Larsen Regenerative apparatus for the simultaneous warming and cooling of milk.
ATE20824T1 (de) 1981-06-25 1986-08-15 Serapharm Gmbh & Co Kg Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung.
US4442655A (en) 1981-06-25 1984-04-17 Serapharm Michael Stroetmann Fibrinogen-containing dry preparation, manufacture and use thereof
US4546082A (en) 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
US4870008A (en) 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
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US4931373A (en) 1984-05-25 1990-06-05 Zymogenetics, Inc. Stable DNA constructs for expression of α-1 antitrypsin
JPS61502655A (ja) 1984-07-09 1986-11-20 インテグレ−テッド・ジェネティックス・インコ−ポレ−テッド 酵母クロ−ニングビヒクル
JPS6144825A (ja) 1984-08-09 1986-03-04 Unitika Ltd 止血剤
JP2523562B2 (ja) 1985-10-25 1996-08-14 ザイモジェネティックス インコーポレーテッド 外来タンパク質を分泌することを目的としたｂａｒ１の使用法
US4965203A (en) 1987-01-28 1990-10-23 Warner-Lambert Company Purified thrombin preparations
US5572692A (en) 1991-12-24 1996-11-05 Intel Corporation Memory configuration decoding system having automatic row base address generation mechanism for variable memory devices with row access interleaving
US5527692A (en) 1991-12-31 1996-06-18 Zymogenetics, Inc. Methods for producing thrombin
IL102929A (en) * 1992-08-24 1996-11-14 Interpharm Lab Ltd Serum-free medium for mammalian cells
US5968817A (en) * 1993-03-15 1999-10-19 The Scripps Research Institute DNA encoding serotonin receptors
US5639940A (en) 1994-03-03 1997-06-17 Pharmaceutical Proteins Ltd. Production of fibrinogen in transgenic animals
DE19605126A1 (de) * 1996-02-12 1997-08-14 Basf Ag Thrombinmuteine als Antidot für Thrombininhibitoren
US6037457A (en) * 1997-01-31 2000-03-14 The University Of North Carolina At Chapel Hill Method for recombinant fibrinogen production
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AT409379B (de) * 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
AU2002257440A1 (en) * 2001-05-07 2002-11-18 National Research Council Of Canada Enhanced production of recombinant proteins by transient transfection of suspension-growing mammalian cells
DE60231210D1 (de) * 2001-07-06 2009-04-02 Chemo Sero Therapeut Res Inst Verfahren zur herstelllung von menschlichem thrombin mittels genmodifikationstechnik
JP4150814B2 (ja) * 2001-07-06 2008-09-17 財団法人化学及血清療法研究所 遺伝子組換えエカリン及びその製造方法
CA2467509A1 (en) * 2001-12-14 2003-06-26 Eli Lilly And Company Recombinant bovine thrombin
AU2003280993A1 (en) * 2002-07-17 2004-02-02 Asahi Kasei Pharma Corporation Human prothrombin analog and human meizothrombin analog
JP3994159B2 (ja) * 2003-03-24 2007-10-17 農林水産省動物医薬品検査所長 動物由来成分無添加培養液およびそれを用いる細胞系の作出方法
GB0324044D0 (en) * 2003-10-14 2003-11-19 Astrazeneca Ab Protein
EP2180045B1 (en) * 2003-10-24 2015-12-23 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Novel protein highly producing recombinant animal cell, method for preparing the same and method for mass-producing protein using the same
RU2396347C2 (ru) * 2004-08-17 2010-08-10 Ксл Бехринг Гмбх Модифицированные витамин к-зависимые полипептиды
US20080145885A1 (en) * 2006-07-11 2008-06-19 Invitrogen Corporation Proteome Standards for Mass Spectrometry

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1074438A (zh) * 1991-11-12 1993-07-21 伊莱利利公司 抗血栓剂
US5476777A (en) * 1991-12-31 1995-12-19 Zymogenetics, Inc. Methods for producing thrombin
CN1127509A (zh) * 1993-06-03 1996-07-24 阿斯特拉公司 新的肽衍生物
CN1139455A (zh) * 1993-11-12 1997-01-01 吉里德科学公司 凝血酶突变体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
第6栏第50-54段.

Also Published As

Publication number Publication date
WO2007103447A3 (en) 2008-12-11
US20130017591A1 (en) 2013-01-17
US20100159512A1 (en) 2010-06-24
EP1996186A2 (en) 2008-12-03
EP2407561A3 (en) 2012-05-30
RU2008139428A (ru) 2010-05-20
JP2009528843A (ja) 2009-08-13
CN101501216A (zh) 2009-08-05
WO2007103447A2 (en) 2007-09-13
AU2007223880A1 (en) 2007-09-13
EP1996186A4 (en) 2009-07-22
WO2007103447A8 (en) 2008-05-15
CA2644926A1 (en) 2007-09-13
EP2407561A2 (en) 2012-01-18

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Termination date: 20160306