AU2007223880A1 - A method for the preparation of recombinant human thrombin and fibrinogen - Google Patents

A method for the preparation of recombinant human thrombin and fibrinogen Download PDF

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Publication number
AU2007223880A1
AU2007223880A1 AU2007223880A AU2007223880A AU2007223880A1 AU 2007223880 A1 AU2007223880 A1 AU 2007223880A1 AU 2007223880 A AU2007223880 A AU 2007223880A AU 2007223880 A AU2007223880 A AU 2007223880A AU 2007223880 A1 AU2007223880 A1 AU 2007223880A1
Authority
AU
Australia
Prior art keywords
human
thrombin
recombinant
fibrinogen
prothrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2007223880A
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English (en)
Inventor
Kurt Osther
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Humagene Inc
Original Assignee
Humagene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Humagene Inc filed Critical Humagene Inc
Publication of AU2007223880A1 publication Critical patent/AU2007223880A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
AU2007223880A 2006-03-06 2007-03-06 A method for the preparation of recombinant human thrombin and fibrinogen Abandoned AU2007223880A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US77947406P 2006-03-06 2006-03-06
US60/779,474 2006-03-06
US84394506P 2006-09-12 2006-09-12
US60/843,945 2006-09-12
PCT/US2007/005845 WO2007103447A2 (en) 2006-03-06 2007-03-06 A method for the preparation of recombinant human thrombin

Publications (1)

Publication Number Publication Date
AU2007223880A1 true AU2007223880A1 (en) 2007-09-13

Family

ID=38475538

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007223880A Abandoned AU2007223880A1 (en) 2006-03-06 2007-03-06 A method for the preparation of recombinant human thrombin and fibrinogen

Country Status (8)

Country Link
US (2) US20100159512A1 (enExample)
EP (2) EP2407561A3 (enExample)
JP (1) JP2009528843A (enExample)
CN (1) CN101501216B (enExample)
AU (1) AU2007223880A1 (enExample)
CA (1) CA2644926A1 (enExample)
RU (1) RU2008139428A (enExample)
WO (1) WO2007103447A2 (enExample)

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US8557773B2 (en) 2008-05-02 2013-10-15 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Treatment of bleeding with low half-life fibrinogen
AU2009268052B2 (en) * 2008-07-09 2015-05-28 Mallinckrodt Pharma Ip Trading D.A.C. Recombinant fibrinogen
FR2942232B1 (fr) * 2009-02-19 2015-03-13 Lfb Biotechnologies Moyens pour la purification d'une proteine de la coagulation et procedes pour sa mise en oeuvre
CN102481346A (zh) * 2009-04-14 2012-05-30 胡玛基因公司 新颖的翻译后纤维蛋白原变体
DK2624859T3 (en) * 2010-10-06 2017-06-06 Medimmune Ltd FACTOR II ALONE OR IN COMBINATION WITH OTHER FACTORS FOR TREATMENT OF REDUCED HEMOSTASE IN CONNECTION WITH DILUTION COAGULOPATHY
JP5839810B2 (ja) 2011-03-03 2016-01-06 日本製粉株式会社 フィブリノゲンを産生するトランスジェニックカイコ
CN102690803B (zh) * 2011-03-24 2015-04-29 苏州泽璟生物制药有限公司 一种重组人凝血酶在动物细胞内的高效表达和生产方法
EP2556842A1 (en) 2011-08-11 2013-02-13 Bioftalmik, S.L. Composition in the form of film comprising fibrinogen and a fibrinogen activator and the applications thereof
US9598687B2 (en) 2011-09-06 2017-03-21 Medimmune, Llc Methods for processing coagulation factors
WO2014115087A2 (en) * 2013-01-22 2014-07-31 Cencor Biotech Ltd. A method for the preparation of recombinant human prothrombin and fibrinogen
WO2016150449A1 (en) * 2015-03-23 2016-09-29 Dana Genetic A/S Recombinant soluble human tissue factor, method of its production and uses thereof
US10954502B2 (en) 2015-04-28 2021-03-23 Saint Louis University Thrombin-thrombomodulin fusion proteins as protein C activators
US11085031B2 (en) 2016-04-28 2021-08-10 Saint Louis University Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant
BR102017004788B1 (pt) * 2017-03-09 2021-03-23 Instituto De Biologia Molecular Do Paraná - Ibmp. Método de produção de cola de fibrina de origem recombinante
ES2832881T3 (es) * 2018-04-24 2021-06-11 Fibriant B V Variantes de fibrinógeno gamma prima para su uso en el tratamiento de una infección
JP2025519280A (ja) 2022-05-17 2025-06-25 ユリウス－マキシミリアンズ－ユニヴァーシタエト ビュルツブルク 手術創ケア用のフィブリンシーラントのための新規組換えフィブリノーゲンバリアント
CN116333094B (zh) * 2023-02-04 2024-03-29 山东多美康生物医药有限公司 一种重组人源化I型胶原蛋白α1及表达载体和应用
CN116218864B (zh) * 2023-04-10 2024-01-09 山东多美康生物医药有限公司 一种重组Ⅲ型人源化胶原蛋白α1及其表达载体和应用

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US4546082A (en) 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
US4870008A (en) 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
US4613572A (en) 1983-08-15 1986-09-23 Kansas State University Research Foundation Yeast BAR1 gene plasmid
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DE19605126A1 (de) * 1996-02-12 1997-08-14 Basf Ag Thrombinmuteine als Antidot für Thrombininhibitoren
US6037457A (en) * 1997-01-31 2000-03-14 The University Of North Carolina At Chapel Hill Method for recombinant fibrinogen production
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JP4150814B2 (ja) * 2001-07-06 2008-09-17 財団法人化学及血清療法研究所 遺伝子組換えエカリン及びその製造方法
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Also Published As

Publication number Publication date
WO2007103447A3 (en) 2008-12-11
US20130017591A1 (en) 2013-01-17
US20100159512A1 (en) 2010-06-24
EP1996186A2 (en) 2008-12-03
EP2407561A3 (en) 2012-05-30
RU2008139428A (ru) 2010-05-20
JP2009528843A (ja) 2009-08-13
CN101501216A (zh) 2009-08-05
WO2007103447A2 (en) 2007-09-13
CN101501216B (zh) 2013-10-02
EP1996186A4 (en) 2009-07-22
WO2007103447A8 (en) 2008-05-15
CA2644926A1 (en) 2007-09-13
EP2407561A2 (en) 2012-01-18

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