AU2007223880A1 - A method for the preparation of recombinant human thrombin and fibrinogen - Google Patents
A method for the preparation of recombinant human thrombin and fibrinogen Download PDFInfo
- Publication number
- AU2007223880A1 AU2007223880A1 AU2007223880A AU2007223880A AU2007223880A1 AU 2007223880 A1 AU2007223880 A1 AU 2007223880A1 AU 2007223880 A AU2007223880 A AU 2007223880A AU 2007223880 A AU2007223880 A AU 2007223880A AU 2007223880 A1 AU2007223880 A1 AU 2007223880A1
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- Prior art keywords
- human
- thrombin
- recombinant
- fibrinogen
- prothrombin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (5)
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| US77947406P | 2006-03-06 | 2006-03-06 | |
| US60/779,474 | 2006-03-06 | ||
| US84394506P | 2006-09-12 | 2006-09-12 | |
| US60/843,945 | 2006-09-12 | ||
| PCT/US2007/005845 WO2007103447A2 (en) | 2006-03-06 | 2007-03-06 | A method for the preparation of recombinant human thrombin |
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| AU2007223880A1 true AU2007223880A1 (en) | 2007-09-13 |
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| AU2007223880A Abandoned AU2007223880A1 (en) | 2006-03-06 | 2007-03-06 | A method for the preparation of recombinant human thrombin and fibrinogen |
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| US (2) | US20100159512A1 (enExample) |
| EP (2) | EP1996186A4 (enExample) |
| JP (1) | JP2009528843A (enExample) |
| CN (1) | CN101501216B (enExample) |
| AU (1) | AU2007223880A1 (enExample) |
| CA (1) | CA2644926A1 (enExample) |
| RU (1) | RU2008139428A (enExample) |
| WO (1) | WO2007103447A2 (enExample) |
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| AU2009223115B2 (en) | 2008-03-14 | 2015-09-24 | Humanzyme, Inc. | Recombinant production of authentic human proteins using human cell expression systems |
| EP3225252A1 (en) | 2008-05-02 | 2017-10-04 | Laboratoire Français du Fractionnement et des Biotechnologies | Treatment of bleeding with low half-life fibrinogen |
| NZ590871A (en) * | 2008-07-09 | 2012-07-27 | Profibrix Bv | Recombinant fibrinogen |
| FR2942232B1 (fr) * | 2009-02-19 | 2015-03-13 | Lfb Biotechnologies | Moyens pour la purification d'une proteine de la coagulation et procedes pour sa mise en oeuvre |
| US20120164111A1 (en) | 2009-04-14 | 2012-06-28 | Kurt Osther | Novel post-translational fibrinogen variants |
| PL2624859T3 (pl) * | 2010-10-06 | 2017-09-29 | Medimmune Limited | Czynnik ii samodzielnie lub w skojarzeniu z dalszymi czynnikami do leczenia zaburzeń hemostazy powiązanych z koagulopatią z rozcieńczenia |
| JP5839810B2 (ja) | 2011-03-03 | 2016-01-06 | 日本製粉株式会社 | フィブリノゲンを産生するトランスジェニックカイコ |
| CN102690803B (zh) * | 2011-03-24 | 2015-04-29 | 苏州泽璟生物制药有限公司 | 一种重组人凝血酶在动物细胞内的高效表达和生产方法 |
| EP2556842A1 (en) | 2011-08-11 | 2013-02-13 | Bioftalmik, S.L. | Composition in the form of film comprising fibrinogen and a fibrinogen activator and the applications thereof |
| HK1199908A1 (en) | 2011-09-06 | 2015-07-24 | Medimmune, Llc | Methods for processing coagulation factors |
| WO2014115087A2 (en) * | 2013-01-22 | 2014-07-31 | Cencor Biotech Ltd. | A method for the preparation of recombinant human prothrombin and fibrinogen |
| EP3274367A1 (en) * | 2015-03-23 | 2018-01-31 | Dana Genetic A/S | Recombinant soluble human tissue factor, method of its production and uses thereof |
| WO2016176440A2 (en) * | 2015-04-28 | 2016-11-03 | Saint Louis University | Thrombin-thrombomodulin fusion proteins as protein c activators |
| WO2017189943A1 (en) * | 2016-04-28 | 2017-11-02 | Saint Louis University | Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant |
| BR102017004788B1 (pt) * | 2017-03-09 | 2021-03-23 | Instituto De Biologia Molecular Do Paraná - Ibmp. | Método de produção de cola de fibrina de origem recombinante |
| EP3618853B1 (en) * | 2018-04-24 | 2020-09-09 | Fibriant B.V. | Fibrinogen gamma prime variants for use in treating an infection |
| JP2025519280A (ja) | 2022-05-17 | 2025-06-25 | ユリウス－マキシミリアンズ－ユニヴァーシタエト ビュルツブルク | 手術創ケア用のフィブリンシーラントのための新規組換えフィブリノーゲンバリアント |
| CN116333094B (zh) * | 2023-02-04 | 2024-03-29 | 山东多美康生物医药有限公司 | 一种重组人源化I型胶原蛋白α1及表达载体和应用 |
| CN116218864B (zh) * | 2023-04-10 | 2024-01-09 | 山东多美康生物医药有限公司 | 一种重组Ⅲ型人源化胶原蛋白α1及其表达载体和应用 |
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| US722366A (en) | 1901-09-09 | 1903-03-10 | Lars Peter Larsen | Regenerative apparatus for the simultaneous warming and cooling of milk. |
| ATE20824T1 (de) | 1981-06-25 | 1986-08-15 | Serapharm Gmbh & Co Kg | Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung. |
| US4442655A (en) | 1981-06-25 | 1984-04-17 | Serapharm Michael Stroetmann | Fibrinogen-containing dry preparation, manufacture and use thereof |
| US4546082A (en) | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
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-
2007
- 2007-03-06 CA CA002644926A patent/CA2644926A1/en not_active Abandoned
- 2007-03-06 AU AU2007223880A patent/AU2007223880A1/en not_active Abandoned
- 2007-03-06 US US12/281,877 patent/US20100159512A1/en not_active Abandoned
- 2007-03-06 CN CN2007800143376A patent/CN101501216B/zh not_active Expired - Fee Related
- 2007-03-06 JP JP2008558377A patent/JP2009528843A/ja active Pending
- 2007-03-06 EP EP20070752537 patent/EP1996186A4/en not_active Withdrawn
- 2007-03-06 WO PCT/US2007/005845 patent/WO2007103447A2/en not_active Ceased
- 2007-03-06 RU RU2008139428/13A patent/RU2008139428A/ru unknown
- 2007-03-06 EP EP11181186A patent/EP2407561A3/en not_active Withdrawn
-
2012
- 2012-03-30 US US13/435,778 patent/US20130017591A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009528843A (ja) | 2009-08-13 |
| US20100159512A1 (en) | 2010-06-24 |
| EP1996186A4 (en) | 2009-07-22 |
| EP2407561A2 (en) | 2012-01-18 |
| WO2007103447A2 (en) | 2007-09-13 |
| CN101501216A (zh) | 2009-08-05 |
| CA2644926A1 (en) | 2007-09-13 |
| US20130017591A1 (en) | 2013-01-17 |
| RU2008139428A (ru) | 2010-05-20 |
| WO2007103447A3 (en) | 2008-12-11 |
| EP2407561A3 (en) | 2012-05-30 |
| WO2007103447A8 (en) | 2008-05-15 |
| CN101501216B (zh) | 2013-10-02 |
| EP1996186A2 (en) | 2008-12-03 |
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