RU2008139428A - Способ получения рекомбинантного тромбина и фибриногена человека - Google Patents
Способ получения рекомбинантного тромбина и фибриногена человека Download PDFInfo
- Publication number
- RU2008139428A RU2008139428A RU2008139428/13A RU2008139428A RU2008139428A RU 2008139428 A RU2008139428 A RU 2008139428A RU 2008139428/13 A RU2008139428/13 A RU 2008139428/13A RU 2008139428 A RU2008139428 A RU 2008139428A RU 2008139428 A RU2008139428 A RU 2008139428A
- Authority
- RU
- Russia
- Prior art keywords
- human
- thrombin
- prothrombin
- hek
- recombinant
- Prior art date
Links
- 108090000190 Thrombin Proteins 0.000 title claims abstract 6
- 229960004072 thrombin Drugs 0.000 title claims abstract 3
- 229940106780 human fibrinogen Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 19
- 229960003766 thrombin (human) Drugs 0.000 claims abstract 12
- 108010094028 Prothrombin Proteins 0.000 claims abstract 9
- 102100027378 Prothrombin Human genes 0.000 claims abstract 9
- 229940039716 prothrombin Drugs 0.000 claims abstract 9
- 210000004027 cell Anatomy 0.000 claims abstract 7
- 101000651439 Homo sapiens Prothrombin Proteins 0.000 claims abstract 6
- 229940039715 human prothrombin Drugs 0.000 claims abstract 6
- 108090000623 proteins and genes Proteins 0.000 claims abstract 4
- 108010015680 recombinant human thrombin Proteins 0.000 claims abstract 4
- 108010049003 Fibrinogen Proteins 0.000 claims abstract 3
- 102000008946 Fibrinogen Human genes 0.000 claims abstract 3
- 229940012952 fibrinogen Drugs 0.000 claims abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 2
- 230000013595 glycosylation Effects 0.000 claims abstract 2
- 238000006206 glycosylation reaction Methods 0.000 claims abstract 2
- 230000005847 immunogenicity Effects 0.000 claims abstract 2
- 210000003292 kidney cell Anatomy 0.000 claims abstract 2
- AEMBWNDIEFEPTH-UHFFFAOYSA-N n-tert-butyl-n-ethylnitrous amide Chemical compound CCN(N=O)C(C)(C)C AEMBWNDIEFEPTH-UHFFFAOYSA-N 0.000 claims abstract 2
- 150000007523 nucleic acids Chemical group 0.000 claims abstract 2
- 102000004169 proteins and genes Human genes 0.000 claims abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108010085662 ecarin Proteins 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77947406P | 2006-03-06 | 2006-03-06 | |
| US60/779,474 | 2006-03-06 | ||
| US84394506P | 2006-09-12 | 2006-09-12 | |
| US60/843,945 | 2006-09-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2008139428A true RU2008139428A (ru) | 2010-05-20 |
Family
ID=38475538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008139428/13A RU2008139428A (ru) | 2006-03-06 | 2007-03-06 | Способ получения рекомбинантного тромбина и фибриногена человека |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20100159512A1 (enExample) |
| EP (2) | EP2407561A3 (enExample) |
| JP (1) | JP2009528843A (enExample) |
| CN (1) | CN101501216B (enExample) |
| AU (1) | AU2007223880A1 (enExample) |
| CA (1) | CA2644926A1 (enExample) |
| RU (1) | RU2008139428A (enExample) |
| WO (1) | WO2007103447A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8236527B2 (en) | 2008-03-14 | 2012-08-07 | Humanzyme Limited | Recombinant production of authentic human proteins using human cell expression systems |
| US8557773B2 (en) | 2008-05-02 | 2013-10-15 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Treatment of bleeding with low half-life fibrinogen |
| AU2009268052B2 (en) * | 2008-07-09 | 2015-05-28 | Mallinckrodt Pharma Ip Trading D.A.C. | Recombinant fibrinogen |
| FR2942232B1 (fr) * | 2009-02-19 | 2015-03-13 | Lfb Biotechnologies | Moyens pour la purification d'une proteine de la coagulation et procedes pour sa mise en oeuvre |
| CN102481346A (zh) * | 2009-04-14 | 2012-05-30 | 胡玛基因公司 | 新颖的翻译后纤维蛋白原变体 |
| DK2624859T3 (en) * | 2010-10-06 | 2017-06-06 | Medimmune Ltd | FACTOR II ALONE OR IN COMBINATION WITH OTHER FACTORS FOR TREATMENT OF REDUCED HEMOSTASE IN CONNECTION WITH DILUTION COAGULOPATHY |
| JP5839810B2 (ja) | 2011-03-03 | 2016-01-06 | 日本製粉株式会社 | フィブリノゲンを産生するトランスジェニックカイコ |
| CN102690803B (zh) * | 2011-03-24 | 2015-04-29 | 苏州泽璟生物制药有限公司 | 一种重组人凝血酶在动物细胞内的高效表达和生产方法 |
| EP2556842A1 (en) | 2011-08-11 | 2013-02-13 | Bioftalmik, S.L. | Composition in the form of film comprising fibrinogen and a fibrinogen activator and the applications thereof |
| US9598687B2 (en) | 2011-09-06 | 2017-03-21 | Medimmune, Llc | Methods for processing coagulation factors |
| WO2014115087A2 (en) * | 2013-01-22 | 2014-07-31 | Cencor Biotech Ltd. | A method for the preparation of recombinant human prothrombin and fibrinogen |
| WO2016150449A1 (en) * | 2015-03-23 | 2016-09-29 | Dana Genetic A/S | Recombinant soluble human tissue factor, method of its production and uses thereof |
| US10954502B2 (en) | 2015-04-28 | 2021-03-23 | Saint Louis University | Thrombin-thrombomodulin fusion proteins as protein C activators |
| US11085031B2 (en) | 2016-04-28 | 2021-08-10 | Saint Louis University | Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant |
| BR102017004788B1 (pt) * | 2017-03-09 | 2021-03-23 | Instituto De Biologia Molecular Do Paraná - Ibmp. | Método de produção de cola de fibrina de origem recombinante |
| ES2832881T3 (es) * | 2018-04-24 | 2021-06-11 | Fibriant B V | Variantes de fibrinógeno gamma prima para su uso en el tratamiento de una infección |
| JP2025519280A (ja) | 2022-05-17 | 2025-06-25 | ユリウス－マキシミリアンズ－ユニヴァーシタエト ビュルツブルク | 手術創ケア用のフィブリンシーラントのための新規組換えフィブリノーゲンバリアント |
| CN116333094B (zh) * | 2023-02-04 | 2024-03-29 | 山东多美康生物医药有限公司 | 一种重组人源化I型胶原蛋白α1及表达载体和应用 |
| CN116218864B (zh) * | 2023-04-10 | 2024-01-09 | 山东多美康生物医药有限公司 | 一种重组Ⅲ型人源化胶原蛋白α1及其表达载体和应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US722366A (en) | 1901-09-09 | 1903-03-10 | Lars Peter Larsen | Regenerative apparatus for the simultaneous warming and cooling of milk. |
| ATE20824T1 (de) | 1981-06-25 | 1986-08-15 | Serapharm Gmbh & Co Kg | Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung. |
| US4442655A (en) | 1981-06-25 | 1984-04-17 | Serapharm Michael Stroetmann | Fibrinogen-containing dry preparation, manufacture and use thereof |
| US4546082A (en) | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
| US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
| US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| US4613572A (en) | 1983-08-15 | 1986-09-23 | Kansas State University Research Foundation | Yeast BAR1 gene plasmid |
| US4931373A (en) | 1984-05-25 | 1990-06-05 | Zymogenetics, Inc. | Stable DNA constructs for expression of α-1 antitrypsin |
| JPS61502655A (ja) | 1984-07-09 | 1986-11-20 | インテグレ−テッド・ジェネティックス・インコ−ポレ−テッド | 酵母クロ−ニングビヒクル |
| JPS6144825A (ja) | 1984-08-09 | 1986-03-04 | Unitika Ltd | 止血剤 |
| JP2523562B2 (ja) | 1985-10-25 | 1996-08-14 | ザイモジェネティックス インコーポレーテッド | 外来タンパク質を分泌することを目的としたｂａｒ１の使用法 |
| US4965203A (en) | 1987-01-28 | 1990-10-23 | Warner-Lambert Company | Purified thrombin preparations |
| CZ333492A3 (en) * | 1991-11-12 | 1993-09-15 | Lilly Co Eli | Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised |
| US5572692A (en) | 1991-12-24 | 1996-11-05 | Intel Corporation | Memory configuration decoding system having automatic row base address generation mechanism for variable memory devices with row access interleaving |
| US5527692A (en) | 1991-12-31 | 1996-06-18 | Zymogenetics, Inc. | Methods for producing thrombin |
| JP3404038B2 (ja) | 1991-12-31 | 2003-05-06 | ザイモジェネティクス，インコーポレイティド | トロンビンの製造方法 |
| IL102929A (en) * | 1992-08-24 | 1996-11-14 | Interpharm Lab Ltd | Serum-free medium for mammalian cells |
| US5968817A (en) * | 1993-03-15 | 1999-10-19 | The Scripps Research Institute | DNA encoding serotonin receptors |
| SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| US6110721A (en) * | 1993-11-12 | 2000-08-29 | Gilead Sciences, Inc. | Polypeptides and coagulation therapy |
| US5639940A (en) | 1994-03-03 | 1997-06-17 | Pharmaceutical Proteins Ltd. | Production of fibrinogen in transgenic animals |
| DE19605126A1 (de) * | 1996-02-12 | 1997-08-14 | Basf Ag | Thrombinmuteine als Antidot für Thrombininhibitoren |
| US6037457A (en) * | 1997-01-31 | 2000-03-14 | The University Of North Carolina At Chapel Hill | Method for recombinant fibrinogen production |
| US6780411B2 (en) * | 1998-05-01 | 2004-08-24 | Zymogenetics, Inc. | Tissue sealant compositions |
| AT409379B (de) * | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| AU2002257440A1 (en) * | 2001-05-07 | 2002-11-18 | National Research Council Of Canada | Enhanced production of recombinant proteins by transient transfection of suspension-growing mammalian cells |
| DE60231210D1 (de) * | 2001-07-06 | 2009-04-02 | Chemo Sero Therapeut Res Inst | Verfahren zur herstelllung von menschlichem thrombin mittels genmodifikationstechnik |
| JP4150814B2 (ja) * | 2001-07-06 | 2008-09-17 | 財団法人化学及血清療法研究所 | 遺伝子組換えエカリン及びその製造方法 |
| CA2467509A1 (en) * | 2001-12-14 | 2003-06-26 | Eli Lilly And Company | Recombinant bovine thrombin |
| AU2003280993A1 (en) * | 2002-07-17 | 2004-02-02 | Asahi Kasei Pharma Corporation | Human prothrombin analog and human meizothrombin analog |
| JP3994159B2 (ja) * | 2003-03-24 | 2007-10-17 | 農林水産省動物医薬品検査所長 | 動物由来成分無添加培養液およびそれを用いる細胞系の作出方法 |
| GB0324044D0 (en) * | 2003-10-14 | 2003-11-19 | Astrazeneca Ab | Protein |
| EP2180045B1 (en) * | 2003-10-24 | 2015-12-23 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Novel protein highly producing recombinant animal cell, method for preparing the same and method for mass-producing protein using the same |
| RU2396347C2 (ru) * | 2004-08-17 | 2010-08-10 | Ксл Бехринг Гмбх | Модифицированные витамин к-зависимые полипептиды |
| US20080145885A1 (en) * | 2006-07-11 | 2008-06-19 | Invitrogen Corporation | Proteome Standards for Mass Spectrometry |
-
2007
- 2007-03-06 RU RU2008139428/13A patent/RU2008139428A/ru unknown
- 2007-03-06 EP EP11181186A patent/EP2407561A3/en not_active Withdrawn
- 2007-03-06 AU AU2007223880A patent/AU2007223880A1/en not_active Abandoned
- 2007-03-06 JP JP2008558377A patent/JP2009528843A/ja active Pending
- 2007-03-06 WO PCT/US2007/005845 patent/WO2007103447A2/en not_active Ceased
- 2007-03-06 US US12/281,877 patent/US20100159512A1/en not_active Abandoned
- 2007-03-06 CN CN2007800143376A patent/CN101501216B/zh not_active Expired - Fee Related
- 2007-03-06 CA CA002644926A patent/CA2644926A1/en not_active Abandoned
- 2007-03-06 EP EP20070752537 patent/EP1996186A4/en not_active Withdrawn
-
2012
- 2012-03-30 US US13/435,778 patent/US20130017591A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007103447A3 (en) | 2008-12-11 |
| US20130017591A1 (en) | 2013-01-17 |
| US20100159512A1 (en) | 2010-06-24 |
| EP1996186A2 (en) | 2008-12-03 |
| EP2407561A3 (en) | 2012-05-30 |
| JP2009528843A (ja) | 2009-08-13 |
| CN101501216A (zh) | 2009-08-05 |
| WO2007103447A2 (en) | 2007-09-13 |
| AU2007223880A1 (en) | 2007-09-13 |
| CN101501216B (zh) | 2013-10-02 |
| EP1996186A4 (en) | 2009-07-22 |
| WO2007103447A8 (en) | 2008-05-15 |
| CA2644926A1 (en) | 2007-09-13 |
| EP2407561A2 (en) | 2012-01-18 |
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