JP2009528843A5 - - Google Patents
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- Publication number
- JP2009528843A5 JP2009528843A5 JP2008558377A JP2008558377A JP2009528843A5 JP 2009528843 A5 JP2009528843 A5 JP 2009528843A5 JP 2008558377 A JP2008558377 A JP 2008558377A JP 2008558377 A JP2008558377 A JP 2008558377A JP 2009528843 A5 JP2009528843 A5 JP 2009528843A5
- Authority
- JP
- Japan
- Prior art keywords
- thrombin
- human
- prothrombin
- recombinant human
- hek
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 11
- 108090000190 Thrombin Proteins 0.000 claims 8
- 108010094028 Prothrombin Proteins 0.000 claims 6
- 102100027378 Prothrombin Human genes 0.000 claims 6
- 229940039716 prothrombin Drugs 0.000 claims 6
- 108010049003 Fibrinogen Proteins 0.000 claims 4
- 102000008946 Fibrinogen Human genes 0.000 claims 4
- 101000651439 Homo sapiens Prothrombin Proteins 0.000 claims 4
- 229940012952 fibrinogen Drugs 0.000 claims 4
- 229940039715 human prothrombin Drugs 0.000 claims 4
- 229960004072 thrombin Drugs 0.000 claims 4
- 229960003766 thrombin (human) Drugs 0.000 claims 4
- 230000037048 polymerization activity Effects 0.000 claims 3
- 108010015680 recombinant human thrombin Proteins 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 108010085662 ecarin Proteins 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 230000009851 immunogenic response Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- AEMBWNDIEFEPTH-UHFFFAOYSA-N n-tert-butyl-n-ethylnitrous amide Chemical compound CCN(N=O)C(C)(C)C AEMBWNDIEFEPTH-UHFFFAOYSA-N 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77947406P | 2006-03-06 | 2006-03-06 | |
| US84394506P | 2006-09-12 | 2006-09-12 | |
| PCT/US2007/005845 WO2007103447A2 (en) | 2006-03-06 | 2007-03-06 | A method for the preparation of recombinant human thrombin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009528843A JP2009528843A (ja) | 2009-08-13 |
| JP2009528843A5 true JP2009528843A5 (enExample) | 2010-04-22 |
Family
ID=38475538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008558377A Pending JP2009528843A (ja) | 2006-03-06 | 2007-03-06 | 組換えヒトトロンビンおよびフィブリノゲンの調製法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20100159512A1 (enExample) |
| EP (2) | EP1996186A4 (enExample) |
| JP (1) | JP2009528843A (enExample) |
| CN (1) | CN101501216B (enExample) |
| AU (1) | AU2007223880A1 (enExample) |
| CA (1) | CA2644926A1 (enExample) |
| RU (1) | RU2008139428A (enExample) |
| WO (1) | WO2007103447A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009223115B2 (en) | 2008-03-14 | 2015-09-24 | Humanzyme, Inc. | Recombinant production of authentic human proteins using human cell expression systems |
| US8557773B2 (en) | 2008-05-02 | 2013-10-15 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Treatment of bleeding with low half-life fibrinogen |
| JP5819725B2 (ja) * | 2008-07-09 | 2015-11-24 | プロフィブリックス ビーブイ | 組換えフィブリノゲン |
| FR2942232B1 (fr) * | 2009-02-19 | 2015-03-13 | Lfb Biotechnologies | Moyens pour la purification d'une proteine de la coagulation et procedes pour sa mise en oeuvre |
| WO2010119036A1 (en) | 2009-04-14 | 2010-10-21 | Humagene Inc. | Novel post-translational fibrinogen variants |
| WO2012045569A1 (en) * | 2010-10-06 | 2012-04-12 | Medimmune Limited | Factor ii and fibrinogen for treatment of haemostatic disorders |
| JP5839810B2 (ja) | 2011-03-03 | 2016-01-06 | 日本製粉株式会社 | フィブリノゲンを産生するトランスジェニックカイコ |
| CN102690803B (zh) * | 2011-03-24 | 2015-04-29 | 苏州泽璟生物制药有限公司 | 一种重组人凝血酶在动物细胞内的高效表达和生产方法 |
| EP2556842A1 (en) | 2011-08-11 | 2013-02-13 | Bioftalmik, S.L. | Composition in the form of film comprising fibrinogen and a fibrinogen activator and the applications thereof |
| EP2753706A4 (en) * | 2011-09-06 | 2015-08-12 | Medimmune Llc | METHODS OF TREATING COAGULATION FACTORS |
| RU2015135227A (ru) * | 2013-01-22 | 2018-12-25 | Кенкор Биотех Лтд. | Способ получения рекомбинантного человеческого протромбина и фибриногена |
| US20180111977A1 (en) * | 2015-03-23 | 2018-04-26 | Dana Genetic A/S | Recombinant soluble human tissue factor, method of its production and uses thereof |
| US10954502B2 (en) | 2015-04-28 | 2021-03-23 | Saint Louis University | Thrombin-thrombomodulin fusion proteins as protein C activators |
| WO2017189943A1 (en) * | 2016-04-28 | 2017-11-02 | Saint Louis University | Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant |
| BR102017004788B1 (pt) * | 2017-03-09 | 2021-03-23 | Instituto De Biologia Molecular Do Paraná - Ibmp. | Método de produção de cola de fibrina de origem recombinante |
| ES2832881T3 (es) * | 2018-04-24 | 2021-06-11 | Fibriant B V | Variantes de fibrinógeno gamma prima para su uso en el tratamiento de una infección |
| EP4526336A1 (en) | 2022-05-17 | 2025-03-26 | Julius-Maximilians-Universität Würzburg | Novel recombinant fibrinogen variants for fibrin sealants for surgical wound care |
| CN116333094B (zh) * | 2023-02-04 | 2024-03-29 | 山东多美康生物医药有限公司 | 一种重组人源化I型胶原蛋白α1及表达载体和应用 |
| CN116218864B (zh) * | 2023-04-10 | 2024-01-09 | 山东多美康生物医药有限公司 | 一种重组Ⅲ型人源化胶原蛋白α1及其表达载体和应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US722366A (en) | 1901-09-09 | 1903-03-10 | Lars Peter Larsen | Regenerative apparatus for the simultaneous warming and cooling of milk. |
| ATE20824T1 (de) | 1981-06-25 | 1986-08-15 | Serapharm Gmbh & Co Kg | Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung. |
| US4442655A (en) | 1981-06-25 | 1984-04-17 | Serapharm Michael Stroetmann | Fibrinogen-containing dry preparation, manufacture and use thereof |
| US4546082A (en) | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
| US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
| US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| US4613572A (en) | 1983-08-15 | 1986-09-23 | Kansas State University Research Foundation | Yeast BAR1 gene plasmid |
| US4931373A (en) | 1984-05-25 | 1990-06-05 | Zymogenetics, Inc. | Stable DNA constructs for expression of α-1 antitrypsin |
| JPS61502655A (ja) | 1984-07-09 | 1986-11-20 | インテグレ−テッド・ジェネティックス・インコ−ポレ−テッド | 酵母クロ−ニングビヒクル |
| JPS6144825A (ja) | 1984-08-09 | 1986-03-04 | Unitika Ltd | 止血剤 |
| AU6543286A (en) | 1985-10-25 | 1987-05-19 | Zymogenetics Inc. | Method of using bar1 for secreting foreign proteins |
| US4965203A (en) | 1987-01-28 | 1990-10-23 | Warner-Lambert Company | Purified thrombin preparations |
| CZ333492A3 (en) * | 1991-11-12 | 1993-09-15 | Lilly Co Eli | Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised |
| US5572692A (en) | 1991-12-24 | 1996-11-05 | Intel Corporation | Memory configuration decoding system having automatic row base address generation mechanism for variable memory devices with row access interleaving |
| JP3404038B2 (ja) * | 1991-12-31 | 2003-05-06 | ザイモジェネティクス，インコーポレイティド | トロンビンの製造方法 |
| US5527692A (en) | 1991-12-31 | 1996-06-18 | Zymogenetics, Inc. | Methods for producing thrombin |
| IL102929A (en) * | 1992-08-24 | 1996-11-14 | Interpharm Lab Ltd | Serum-free medium for mammalian cells |
| US5968817A (en) * | 1993-03-15 | 1999-10-19 | The Scripps Research Institute | DNA encoding serotonin receptors |
| SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| AU1096595A (en) * | 1993-11-12 | 1995-05-29 | Gilead Sciences, Inc. | Thrombin mutants |
| US5639940A (en) | 1994-03-03 | 1997-06-17 | Pharmaceutical Proteins Ltd. | Production of fibrinogen in transgenic animals |
| DE19605126A1 (de) * | 1996-02-12 | 1997-08-14 | Basf Ag | Thrombinmuteine als Antidot für Thrombininhibitoren |
| US6037457A (en) * | 1997-01-31 | 2000-03-14 | The University Of North Carolina At Chapel Hill | Method for recombinant fibrinogen production |
| US6780411B2 (en) * | 1998-05-01 | 2004-08-24 | Zymogenetics, Inc. | Tissue sealant compositions |
| AT409379B (de) * | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| EP1390511B1 (en) * | 2001-05-07 | 2008-03-12 | National Research Council Of Canada | Enhanced production of recombinant proteins by transient transfection of suspension-growing mammalian cells |
| CA2452767C (en) * | 2001-07-06 | 2013-03-19 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Genetic recombinant ecarin and process for preparing the same |
| CN100347297C (zh) * | 2001-07-06 | 2007-11-07 | 财团法人化学及血清疗法研究所 | 利用基因工程技术制备人凝血酶的方法 |
| AU2002350173A1 (en) * | 2001-12-14 | 2003-06-30 | Eli Lilly And Company | Recombinant bovine thrombin |
| JPWO2004007714A1 (ja) * | 2002-07-17 | 2005-11-10 | 旭化成ファーマ株式会社 | ヒトプロトロンビン類似体およびヒトメゾトロンビン類似体 |
| JP3994159B2 (ja) * | 2003-03-24 | 2007-10-17 | 農林水産省動物医薬品検査所長 | 動物由来成分無添加培養液およびそれを用いる細胞系の作出方法 |
| GB0324044D0 (en) * | 2003-10-14 | 2003-11-19 | Astrazeneca Ab | Protein |
| DE602004026759D1 (de) * | 2003-10-24 | 2010-06-02 | Chemo Sero Therapeut Res Inst | Neue rekombinante tierzellen mit hoher proteinproduktion, verfahren zur konstruktion davon sowie verfahren zur massenproduktion von protein unter verwendung davon |
| EP1781782B1 (en) * | 2004-08-17 | 2010-05-26 | CSL Behring GmbH | Modified vitamin k dependent polypeptides |
| WO2008008862A2 (en) * | 2006-07-11 | 2008-01-17 | Invitrogen Corporation | Proteome standards for mass spectrometry |
-
2007
- 2007-03-06 CN CN2007800143376A patent/CN101501216B/zh not_active Expired - Fee Related
- 2007-03-06 CA CA002644926A patent/CA2644926A1/en not_active Abandoned
- 2007-03-06 JP JP2008558377A patent/JP2009528843A/ja active Pending
- 2007-03-06 RU RU2008139428/13A patent/RU2008139428A/ru unknown
- 2007-03-06 AU AU2007223880A patent/AU2007223880A1/en not_active Abandoned
- 2007-03-06 US US12/281,877 patent/US20100159512A1/en not_active Abandoned
- 2007-03-06 WO PCT/US2007/005845 patent/WO2007103447A2/en not_active Ceased
- 2007-03-06 EP EP20070752537 patent/EP1996186A4/en not_active Withdrawn
- 2007-03-06 EP EP11181186A patent/EP2407561A3/en not_active Withdrawn
-
2012
- 2012-03-30 US US13/435,778 patent/US20130017591A1/en not_active Abandoned
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