JP2013524837A5 - - Google Patents
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- JP2013524837A5 JP2013524837A5 JP2013508153A JP2013508153A JP2013524837A5 JP 2013524837 A5 JP2013524837 A5 JP 2013524837A5 JP 2013508153 A JP2013508153 A JP 2013508153A JP 2013508153 A JP2013508153 A JP 2013508153A JP 2013524837 A5 JP2013524837 A5 JP 2013524837A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- reprogramming
- poly
- postnatal
- genetically modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000008672 reprogramming Effects 0.000 claims 17
- 210000002950 fibroblast Anatomy 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 15
- 210000004413 cardiac myocyte Anatomy 0.000 claims 8
- 101150107475 MEF2C gene Proteins 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 101150003286 gata4 gene Proteins 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 101150115978 tbx5 gene Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 101001053263 Homo sapiens Insulin gene enhancer protein ISL-1 Proteins 0.000 claims 4
- 102100024392 Insulin gene enhancer protein ISL-1 Human genes 0.000 claims 4
- 101150078445 MYOCD gene Proteins 0.000 claims 4
- -1 Mesp1 Proteins 0.000 claims 4
- 101150114527 Nkx2-5 gene Proteins 0.000 claims 4
- 229920002678 cellulose Polymers 0.000 claims 4
- 239000001913 cellulose Substances 0.000 claims 4
- 239000011159 matrix material Substances 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 102000016942 Elastin Human genes 0.000 claims 2
- 108010014258 Elastin Proteins 0.000 claims 2
- 102000009123 Fibrin Human genes 0.000 claims 2
- 108010073385 Fibrin Proteins 0.000 claims 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 2
- 108010049003 Fibrinogen Proteins 0.000 claims 2
- 102000008946 Fibrinogen Human genes 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 2
- 102000007547 Laminin Human genes 0.000 claims 2
- 108010085895 Laminin Proteins 0.000 claims 2
- 229920000881 Modified starch Polymers 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 241000283984 Rodentia Species 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- 108700029229 Transcriptional Regulatory Elements Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 229960005188 collagen Drugs 0.000 claims 2
- 238000005138 cryopreservation Methods 0.000 claims 2
- 229920002549 elastin Polymers 0.000 claims 2
- 229950003499 fibrin Drugs 0.000 claims 2
- 229940012952 fibrinogen Drugs 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 229940014259 gelatin Drugs 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 235000019426 modified starch Nutrition 0.000 claims 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims 2
- 229920001610 polycaprolactone Polymers 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000026683 transduction Effects 0.000 claims 1
- 238000010361 transduction Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32898810P | 2010-04-28 | 2010-04-28 | |
| US61/328,988 | 2010-04-28 | ||
| US36429510P | 2010-07-14 | 2010-07-14 | |
| US61/364,295 | 2010-07-14 | ||
| PCT/US2011/033938 WO2011139688A2 (en) | 2010-04-28 | 2011-04-26 | Methods for generating cardiomyocytes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013524837A JP2013524837A (ja) | 2013-06-20 |
| JP2013524837A5 true JP2013524837A5 (enExample) | 2015-05-28 |
| JP5988961B2 JP5988961B2 (ja) | 2016-09-07 |
Family
ID=44904333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013508153A Active JP5988961B2 (ja) | 2010-04-28 | 2011-04-26 | 心筋細胞を発生させるための方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US9517250B2 (enExample) |
| EP (1) | EP2563907B1 (enExample) |
| JP (1) | JP5988961B2 (enExample) |
| WO (1) | WO2011139688A2 (enExample) |
Families Citing this family (54)
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| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| US7907222B2 (en) | 2005-09-08 | 2011-03-15 | Universal Electronics Inc. | System and method for simplified setup of a universal remote control |
| US11769398B2 (en) | 2005-09-08 | 2023-09-26 | Universal Electronics Inc. | System and method for widget-assisted setup of a universal remote control |
| US9852615B2 (en) | 2011-03-25 | 2017-12-26 | Universal Electronics Inc. | System and method for facilitating appliance control via a smart device |
| US9517250B2 (en) | 2010-04-28 | 2016-12-13 | The J. David Gladstone Institutes | Methods for generating cardiomyocytes |
| JP2013534525A (ja) * | 2010-06-23 | 2013-09-05 | ヴィヴォスクリプト，インコーポレイテッド | 心臓疾患の治療のために遺伝子改変を伴わずに細胞を再プログラミングするための組成物および方法 |
| AU2012220702B2 (en) * | 2011-02-22 | 2016-12-15 | The Board Of Regents Of The University Of Texas System | Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes |
| JP6113160B2 (ja) * | 2011-07-19 | 2017-04-12 | ヴィヴォスクリプト，インコーポレイテッド | 軟骨損傷を修復するために遺伝子改変を伴わずに細胞を再プログラミングするための組成物および方法 |
| US9828585B2 (en) | 2011-08-30 | 2017-11-28 | The J. David Gladstone Instututes | Methods for generating cardiomyocytes |
| US9019435B2 (en) | 2011-09-22 | 2015-04-28 | Universal Electronics Inc. | System and method for configuring controlling device functionality |
| US11295603B2 (en) | 2011-10-28 | 2022-04-05 | Universal Electronics Inc. | System and method for optimized appliance control |
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| US10593195B2 (en) | 2011-10-28 | 2020-03-17 | Universal Electronics Inc. | System and method for optimized appliance control |
| US10937308B2 (en) | 2011-10-28 | 2021-03-02 | Universal Electronics Inc. | System and method for optimized appliance control |
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| US10130637B2 (en) | 2012-11-02 | 2018-11-20 | Duke University | Inhibition of histone methyltransferase for cardiac reprogramming |
| US10383916B2 (en) | 2012-11-02 | 2019-08-20 | Cornell University | Angiogenic conditioning to enhance cardiac cellular reprogramming of fibroblasts of the infarcted myocardium |
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| EP3642328A4 (en) * | 2017-06-21 | 2021-03-31 | Mogrify Limited | Cell reprogramming to cardiomyocytes |
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| CN114615985A (zh) * | 2019-09-11 | 2022-06-10 | 西奈山伊坎医学院 | 包含修饰mRNA的分子的组合物及其使用方法 |
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| JP2013534525A (ja) * | 2010-06-23 | 2013-09-05 | ヴィヴォスクリプト，インコーポレイテッド | 心臓疾患の治療のために遺伝子改変を伴わずに細胞を再プログラミングするための組成物および方法 |
| US9828585B2 (en) | 2011-08-30 | 2017-11-28 | The J. David Gladstone Instututes | Methods for generating cardiomyocytes |
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2011
- 2011-04-26 US US13/642,391 patent/US9517250B2/en active Active
- 2011-04-26 JP JP2013508153A patent/JP5988961B2/ja active Active
- 2011-04-26 WO PCT/US2011/033938 patent/WO2011139688A2/en not_active Ceased
- 2011-04-26 EP EP11777910.8A patent/EP2563907B1/en active Active
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2014
- 2014-03-19 US US14/219,541 patent/US9517251B2/en active Active
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