JP2013524837A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013524837A5 JP2013524837A5 JP2013508153A JP2013508153A JP2013524837A5 JP 2013524837 A5 JP2013524837 A5 JP 2013524837A5 JP 2013508153 A JP2013508153 A JP 2013508153A JP 2013508153 A JP2013508153 A JP 2013508153A JP 2013524837 A5 JP2013524837 A5 JP 2013524837A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- reprogramming
- poly
- postnatal
- genetically modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000008672 reprogramming Effects 0.000 claims 17
- 210000002950 fibroblast Anatomy 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 15
- 210000004413 cardiac myocyte Anatomy 0.000 claims 8
- 101150107475 MEF2C gene Proteins 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 101150003286 gata4 gene Proteins 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 101150115978 tbx5 gene Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 101001053263 Homo sapiens Insulin gene enhancer protein ISL-1 Proteins 0.000 claims 4
- 102100024392 Insulin gene enhancer protein ISL-1 Human genes 0.000 claims 4
- 101150078445 MYOCD gene Proteins 0.000 claims 4
- -1 Mesp1 Proteins 0.000 claims 4
- 101150114527 Nkx2-5 gene Proteins 0.000 claims 4
- 229920002678 cellulose Polymers 0.000 claims 4
- 239000001913 cellulose Substances 0.000 claims 4
- 239000011159 matrix material Substances 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 102000016942 Elastin Human genes 0.000 claims 2
- 108010014258 Elastin Proteins 0.000 claims 2
- 102000009123 Fibrin Human genes 0.000 claims 2
- 108010073385 Fibrin Proteins 0.000 claims 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 2
- 108010049003 Fibrinogen Proteins 0.000 claims 2
- 102000008946 Fibrinogen Human genes 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 2
- 102000007547 Laminin Human genes 0.000 claims 2
- 108010085895 Laminin Proteins 0.000 claims 2
- 229920000881 Modified starch Polymers 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 241000283984 Rodentia Species 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- 108700029229 Transcriptional Regulatory Elements Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 229960005188 collagen Drugs 0.000 claims 2
- 238000005138 cryopreservation Methods 0.000 claims 2
- 229920002549 elastin Polymers 0.000 claims 2
- 229950003499 fibrin Drugs 0.000 claims 2
- 229940012952 fibrinogen Drugs 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 229940014259 gelatin Drugs 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 235000019426 modified starch Nutrition 0.000 claims 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims 2
- 229920001610 polycaprolactone Polymers 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000026683 transduction Effects 0.000 claims 1
- 238000010361 transduction Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32898810P | 2010-04-28 | 2010-04-28 | |
| US61/328,988 | 2010-04-28 | ||
| US36429510P | 2010-07-14 | 2010-07-14 | |
| US61/364,295 | 2010-07-14 | ||
| PCT/US2011/033938 WO2011139688A2 (en) | 2010-04-28 | 2011-04-26 | Methods for generating cardiomyocytes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013524837A JP2013524837A (ja) | 2013-06-20 |
| JP2013524837A5 true JP2013524837A5 (enExample) | 2015-05-28 |
| JP5988961B2 JP5988961B2 (ja) | 2016-09-07 |
Family
ID=44904333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013508153A Active JP5988961B2 (ja) | 2010-04-28 | 2011-04-26 | 心筋細胞を発生させるための方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US9517250B2 (enExample) |
| EP (1) | EP2563907B1 (enExample) |
| JP (1) | JP5988961B2 (enExample) |
| WO (1) | WO2011139688A2 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| US11769398B2 (en) | 2005-09-08 | 2023-09-26 | Universal Electronics Inc. | System and method for widget-assisted setup of a universal remote control |
| US7907222B2 (en) | 2005-09-08 | 2011-03-15 | Universal Electronics Inc. | System and method for simplified setup of a universal remote control |
| US9852615B2 (en) | 2011-03-25 | 2017-12-26 | Universal Electronics Inc. | System and method for facilitating appliance control via a smart device |
| EP2563907B1 (en) | 2010-04-28 | 2019-06-19 | The J. David Gladstone Institutes | Methods for generating cardiomyocytes |
| CN102947444A (zh) * | 2010-06-23 | 2013-02-27 | 帷幄生物技术公司 | 用于治疗心血管疾病的非遗传修饰性重编程细胞的组合物和方法 |
| EP2678354A1 (en) * | 2011-02-22 | 2014-01-01 | The Board of Regents of The University of Texas System | Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes |
| CN103857797A (zh) * | 2011-07-19 | 2014-06-11 | 帷幄生物技术公司 | 用于修复软骨损伤的非遗传修饰性重编程细胞的组合物和方法 |
| EP2750509B1 (en) * | 2011-08-30 | 2016-12-28 | The J. David Gladstone Institutes | Methods for generating cardiomyocytes |
| US9019435B2 (en) | 2011-09-22 | 2015-04-28 | Universal Electronics Inc. | System and method for configuring controlling device functionality |
| US9449500B2 (en) | 2012-08-08 | 2016-09-20 | Universal Electronics Inc. | System and method for optimized appliance control |
| US10593195B2 (en) | 2011-10-28 | 2020-03-17 | Universal Electronics Inc. | System and method for optimized appliance control |
| US11295603B2 (en) | 2011-10-28 | 2022-04-05 | Universal Electronics Inc. | System and method for optimized appliance control |
| US11756412B2 (en) | 2011-10-28 | 2023-09-12 | Universal Electronics Inc. | Systems and methods for associating services and/or devices with a voice assistant |
| US10937308B2 (en) | 2011-10-28 | 2021-03-02 | Universal Electronics Inc. | System and method for optimized appliance control |
| JP6236393B2 (ja) * | 2011-11-09 | 2017-11-22 | セダーズ−シナイ メディカル センター | 転写因子に基づくペースメーカー細胞の生成およびその使用方法 |
| JP2013240308A (ja) * | 2012-05-23 | 2013-12-05 | Kagoshima Univ | ヒトＥＳ／ｉＰＳ細胞における遺伝子発現方法 |
| US9828603B2 (en) | 2012-08-13 | 2017-11-28 | Cedars Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| US10383916B2 (en) | 2012-11-02 | 2019-08-20 | Cornell University | Angiogenic conditioning to enhance cardiac cellular reprogramming of fibroblasts of the infarcted myocardium |
| WO2014071323A2 (en) | 2012-11-02 | 2014-05-08 | Duke University | Inhibition of histone methyltransferase for cardiac reprogramming |
| WO2015061568A1 (en) | 2013-10-23 | 2015-04-30 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Reprogramming cardiomyocytes with one transcription factor |
| US11377639B2 (en) | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
| DE102013114671B4 (de) * | 2013-12-20 | 2015-10-29 | Universität Rostock | Verfahren zur Erzeugung von Sinusknotenzellen ("Herz-Schrittmacherzellen") aus Stammzellen |
| JP2015213441A (ja) * | 2014-05-08 | 2015-12-03 | 学校法人慶應義塾 | 心筋様細胞の作製方法及びそれに用いる培地 |
| US10081816B1 (en) * | 2014-07-03 | 2018-09-25 | Nant Holdings Ip, Llc | Mechanical transfection devices and methods |
| US10760040B1 (en) | 2014-07-03 | 2020-09-01 | NanoCav, LLC | Mechanical transfection devices and methods |
| US11357799B2 (en) | 2014-10-03 | 2022-06-14 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| JPWO2016056438A1 (ja) * | 2014-10-06 | 2017-10-05 | 学校法人慶應義塾 | 心筋様細胞の作製方法及びそれに用いる心筋様細胞の作製用組成物 |
| EP3259346B1 (en) * | 2015-02-20 | 2024-08-07 | Baylor College of Medicine | P63 inactivation for the treatment of heart failure |
| CN107530476A (zh) * | 2015-03-12 | 2018-01-02 | 般财团法人化学及血清疗法研究所 | 使用脱细胞化组织的抗粘连材料和代用生物膜 |
| EP3402543B1 (en) | 2016-01-11 | 2021-09-08 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| WO2017151717A1 (en) * | 2016-03-01 | 2017-09-08 | French Brent A | Compositions and methods for adeno-associated virus mediated gene expression in myofibroblast-like cells |
| CN109072220A (zh) * | 2016-03-15 | 2018-12-21 | 学校法人庆应义塾 | 由成纤维细胞直接制造心脏祖细胞和心肌细胞的方法 |
| JP2019513366A (ja) * | 2016-03-30 | 2019-05-30 | ザ ジェイ． デビッド グラッドストーン インスティテューツ、 ア テスタメンタリー トラスト エスタブリッシュド アンダー ザ ウィル オブ ジェイ． デビッド グラッドストーン | 促進された直接心臓リプログラミング |
| WO2017180896A1 (en) * | 2016-04-14 | 2017-10-19 | Cedars-Sinai Medical Center | Gja1 isoforms protect against metabolic stress |
| US11351200B2 (en) | 2016-06-03 | 2022-06-07 | Cedars-Sinai Medical Center | CDC-derived exosomes for treatment of ventricular tachyarrythmias |
| WO2018005546A1 (en) * | 2016-06-27 | 2018-01-04 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Engineered cardiomyocytes and uses thereof |
| EP3515459A4 (en) | 2016-09-20 | 2020-08-05 | Cedars-Sinai Medical Center | CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS |
| WO2018055235A1 (en) | 2016-09-21 | 2018-03-29 | University Of Helsinki | Isoxazole-amides for treating cardiac diseases |
| US11759482B2 (en) | 2017-04-19 | 2023-09-19 | Cedars-Sinai Medical Center | Methods and compositions for treating skeletal muscular dystrophy |
| CN110997901A (zh) * | 2017-06-21 | 2020-04-10 | 重组生物科技有限公司 | 细胞重编程为心肌细胞 |
| US11660355B2 (en) | 2017-12-20 | 2023-05-30 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| US11834679B2 (en) | 2018-01-30 | 2023-12-05 | Kataoka Corporation | Method for producing cardiomyocytes |
| EP3749344A4 (en) | 2018-02-05 | 2022-01-26 | Cedars-Sinai Medical Center | METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS |
| AU2019333315B2 (en) | 2018-08-30 | 2022-09-29 | Tenaya Therapeutics, Inc. | Cardiac cell reprogramming with myocardin and ASCL1 |
| SG11202110607WA (en) | 2019-04-01 | 2021-10-28 | Tenaya Therapeutics Inc | Adeno-associated virus with engineered capsid |
| EP3965800A4 (en) * | 2019-05-08 | 2023-02-15 | Cedars-Sinai Medical Center | Therapeutically active cells and exosomes |
| AU2020288888A1 (en) * | 2019-06-06 | 2022-01-27 | President And Fellows Of Harvard College | Cardiomyocytes and compositions and methods for producing the same |
| WO2021050877A1 (en) * | 2019-09-11 | 2021-03-18 | Icahn School Of Medicine At Mount Sinai | Compositions including molecules of modified mrna and methods of using the same |
| JP7514546B2 (ja) * | 2019-12-03 | 2024-07-11 | 学校法人自治医科大学 | 心筋細胞の成熟方法、心筋細胞の成熟度評価方法、成熟心筋細胞の純化方法、心筋細胞成熟度評価装置、心筋細胞成熟度評価プログラム、及び心筋細胞成熟キット |
| CN113046308A (zh) * | 2021-03-05 | 2021-06-29 | 苏州大学附属第二医院 | 促进心脏损伤后修复的一类新型成纤维细胞及其标识方法 |
| WO2023201207A1 (en) | 2022-04-11 | 2023-10-19 | Tenaya Therapeutics, Inc. | Adeno-associated virus with engineered capsid |
| CN120390645A (zh) | 2023-01-10 | 2025-07-29 | 庆应义塾 | 心脏舒张功能改善剂和心脏舒张功能改善剂的筛选方法 |
| WO2025129079A1 (en) * | 2023-12-13 | 2025-06-19 | Tenaya Therapeutics, Inc. | Cardiac-specific promoters for gene therapy |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4352883A (en) | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
| US4353888A (en) | 1980-12-23 | 1982-10-12 | Sefton Michael V | Encapsulation of live animal cells |
| US5158881A (en) | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
| US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| US5591624A (en) | 1988-03-21 | 1997-01-07 | Chiron Viagene, Inc. | Retroviral packaging cell lines |
| US7070994B2 (en) | 1988-03-21 | 2006-07-04 | Oxford Biomedica (Uk) Ltd. | Packaging cells |
| DE3829766A1 (de) | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Verfahren zur herstellung von membranen |
| DE3829752A1 (de) | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Integrale asymmetrische polyaethersulfonmembran, verfahren zur herstellung und verwendung zur ultrafiltration und mikrofiltration |
| EP0432216A1 (en) | 1988-09-01 | 1991-06-19 | Whitehead Institute For Biomedical Research | Recombinant retroviruses with amphotropic and ecotropic host ranges |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5084350A (en) | 1990-02-16 | 1992-01-28 | The Royal Institution For The Advance Of Learning (Mcgill University) | Method for encapsulating biologically active material including cells |
| US5817491A (en) | 1990-09-21 | 1998-10-06 | The Regents Of The University Of California | VSV G pseusdotyped retroviral vectors |
| DK0585368T3 (da) | 1991-04-25 | 1998-03-16 | Univ Brown Res Found | Implanterbart biokompatibelt immunisolatorisk vehikel til afgivelse af udvalgte terapeutiske produkter |
| DE69233013T2 (de) | 1991-08-20 | 2004-03-04 | The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer | Adenovirus vermittelter gentransfer in den gastrointestinaltrakt |
| US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
| FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| CA2592997A1 (en) | 1992-12-03 | 1994-06-09 | Genzyme Corporation | Pseudo-adenovirus vectors |
| US5834256A (en) | 1993-06-11 | 1998-11-10 | Cell Genesys, Inc. | Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells |
| JP3532566B2 (ja) | 1993-06-24 | 2004-05-31 | エル． グラハム，フランク | 遺伝子治療のためのアデノウイルスベクター |
| CA2169292C (en) | 1993-08-12 | 2010-11-23 | E. Edward Baetge | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
| JP3875990B2 (ja) | 1993-10-25 | 2007-01-31 | カンジ，インコーポレイテッド | 組換えアデノウイルスベクターおよび使用方法 |
| US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
| US6013517A (en) | 1994-05-09 | 2000-01-11 | Chiron Corporation | Crossless retroviral vectors |
| US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5549974A (en) | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
| EP0855024A4 (en) | 1995-09-20 | 2001-08-22 | Merck & Co Inc | HISTONE DEACETYLASE AS THE ATTACK POINT FOR ANTIPROTOZOIC ACTIVE SUBSTANCES |
| FR2751345B1 (fr) | 1996-07-16 | 1998-09-18 | Univ Paris Curie | Lignees d'encapsidation hautement productrices |
| US7078387B1 (en) | 1998-12-28 | 2006-07-18 | Arch Development Corp. | Efficient and stable in vivo gene transfer to cardiomyocytes using recombinant adeno-associated virus vectors |
| WO2000073423A1 (en) | 1999-06-01 | 2000-12-07 | Chugai Seiyaku Kabushiki Kaisha | Packaging cell |
| WO2002018202A1 (de) | 2000-08-31 | 2002-03-07 | Edwin Lundgren | Steuervorrichtung für einen lenkdrachen an einem boot |
| US6953560B1 (en) | 2000-09-28 | 2005-10-11 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
| IL159580A0 (en) | 2001-07-12 | 2004-06-01 | Geron Corp | Cells of the cardiomyocyte lineage produced from human pluripotent stem cells |
| WO2004094610A2 (en) * | 2003-04-21 | 2004-11-04 | Baylor College Of Medicine | Wnt as a factor for cardiac myogenesis |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| US7695731B2 (en) | 2004-03-22 | 2010-04-13 | Cordis Corporation | Local vascular delivery of etoposide in combination with rapamycin to prevent restenosis following vascular injury |
| US20090275032A1 (en) | 2005-08-01 | 2009-11-05 | Nupotential, Inc. | Reprogramming a cell by inducing a pluripotent gene through use of an HDAC modulator |
| US7620013B2 (en) * | 2005-12-21 | 2009-11-17 | Broadcom Corporation | Method and system for decoding control channels using repetition redundancy |
| US20100135970A1 (en) | 2006-10-27 | 2010-06-03 | Caritas St. Elizabeth Medical Center Of Boston, In | Methods for Reprogramming Adult Somatic Cells and Uses Thereof |
| US20100172883A1 (en) * | 2007-01-19 | 2010-07-08 | Bruneau Benoit Gaetan | Methods of generating cardiomyocytes |
| EP2205723A1 (en) | 2007-06-14 | 2010-07-14 | Cytomatrix PTY LTD | Method of initiating cardiomyocyte differentiation |
| US20090081170A1 (en) * | 2007-09-13 | 2009-03-26 | Paul Riley | Cardiac progenitor cells |
| KR101532442B1 (ko) | 2007-12-10 | 2015-06-29 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 효율적인 핵 초기화 방법 |
| WO2009086015A2 (en) | 2007-12-21 | 2009-07-09 | Boston Scientific Scimed, Inc. | Flexible stent-graft device having patterned polymeric coverings |
| US20090208465A1 (en) | 2008-02-15 | 2009-08-20 | Keio University | Method of treating neural defects |
| AU2009234423A1 (en) | 2008-04-07 | 2009-10-15 | Nupotential, Inc. | Reprogramming a cell by inducing a pluripotent gene through RNA interference |
| EP2283118A4 (en) | 2008-05-06 | 2012-11-21 | Agency Science Tech & Res | METHOD FOR LEARNING THE DEDIFFERENCING OF A CELL |
| CN102203275A (zh) | 2008-06-13 | 2011-09-28 | 国立大学法人京都大学 | 药物发现方法和平台 |
| US20100150879A1 (en) * | 2008-10-16 | 2010-06-17 | Wary Kishore K | Methods for the detection, isolation, and use of lipid phosphate phosphatase-3-positive stem cells |
| US20120115225A1 (en) | 2009-04-23 | 2012-05-10 | Xu C W | Reprogramming of somatic cells with purified proteins |
| US20100330044A1 (en) | 2009-06-30 | 2010-12-30 | Universite Libre De Bruxelles | Mesp1 as a master regulator of multipotent cardiovascular progenitor specification and uses thereof |
| EP2542669B1 (en) | 2010-03-05 | 2015-01-21 | Texas Heart Institute | Ets2 and mesp1 generate cardiac progenitors from fibroblasts |
| EP2563907B1 (en) | 2010-04-28 | 2019-06-19 | The J. David Gladstone Institutes | Methods for generating cardiomyocytes |
| CN102947444A (zh) | 2010-06-23 | 2013-02-27 | 帷幄生物技术公司 | 用于治疗心血管疾病的非遗传修饰性重编程细胞的组合物和方法 |
| EP2750509B1 (en) | 2011-08-30 | 2016-12-28 | The J. David Gladstone Institutes | Methods for generating cardiomyocytes |
-
2011
- 2011-04-26 EP EP11777910.8A patent/EP2563907B1/en active Active
- 2011-04-26 JP JP2013508153A patent/JP5988961B2/ja active Active
- 2011-04-26 US US13/642,391 patent/US9517250B2/en active Active
- 2011-04-26 WO PCT/US2011/033938 patent/WO2011139688A2/en not_active Ceased
-
2014
- 2014-03-19 US US14/219,541 patent/US9517251B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013524837A5 (enExample) | ||
| Khodabukus et al. | In vitro tissue‐engineered skeletal muscle models for studying muscle physiology and disease | |
| Lakshmanan et al. | Living cardiac patch: the elixir for cardiac regeneration | |
| Koutsopoulos | Self‐assembling peptide nanofiber hydrogels in tissue engineering and regenerative medicine: progress, design guidelines, and applications | |
| Tong et al. | Application of biomaterials to advance induced pluripotent stem cell research and therapy | |
| Rogers et al. | Electroconductive hydrogels for tissue engineering: current status and future perspectives | |
| Alcon et al. | Regenerating functional heart tissue for myocardial repair | |
| Streeter et al. | Therapeutic cardiac patches for repairing the myocardium | |
| Ye et al. | Strategies for tissue engineering cardiac constructs to affect functional repair following myocardial infarction | |
| Carotenuto et al. | Turning regenerative technologies into treatment to repair myocardial injuries | |
| Min et al. | State-of-the-art strategies for the vascularization of three-dimensional engineered organs | |
| Trossmann et al. | Design of recombinant spider silk proteins for cell type specific binding | |
| Murphy et al. | Mimicking biological phenomena in hydrogel-based biomaterials to promote dynamic cellular responses | |
| CN105814195A (zh) | 层粘连蛋白应用于角膜内皮细胞培养 | |
| Matsuura et al. | Toward the development of bioengineered human three-dimensional vascularized cardiac tissue using cell sheet technology | |
| Liang et al. | Concise review: reduction of adverse cardiac scarring facilitates pluripotent stem cell-based therapy for myocardial infarction | |
| WO2017082220A1 (ja) | ラミニンフラグメント含有培地を用いる細胞培養方法 | |
| Kafili et al. | Recent advances in soluble decellularized extracellular matrix for heart tissue engineering and organ modeling | |
| Zhao et al. | Cardiac tissue engineering | |
| Guo et al. | High-strength cell sheets and vigorous hydrogels from mesenchymal stem cells derived from human embryonic stem cells | |
| WO2018131033A1 (en) | Patterned electrospun fibers for tissue engineering | |
| US12173321B2 (en) | Material and method for storing, transferring and delivering mesenchymal stem cells which are immediately available and functional in the context of a myocardial infarction | |
| Bernava et al. | Advances in the design, generation, and application of tissue-engineered myocardial equivalents | |
| Chen et al. | In vitro adipogenesis and long-term adipocyte culture in adipose tissue-derived cell banks | |
| Kuraitis et al. | Functionalization of soft materials for cardiac repair and regeneration |