JP2013524837A5 - - Google Patents
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- JP2013524837A5 JP2013524837A5 JP2013508153A JP2013508153A JP2013524837A5 JP 2013524837 A5 JP2013524837 A5 JP 2013524837A5 JP 2013508153 A JP2013508153 A JP 2013508153A JP 2013508153 A JP2013508153 A JP 2013508153A JP 2013524837 A5 JP2013524837 A5 JP 2013524837A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- reprogramming
- poly
- postnatal
- genetically modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32898810P | 2010-04-28 | 2010-04-28 | |
| US61/328,988 | 2010-04-28 | ||
| US36429510P | 2010-07-14 | 2010-07-14 | |
| US61/364,295 | 2010-07-14 | ||
| PCT/US2011/033938 WO2011139688A2 (en) | 2010-04-28 | 2011-04-26 | Methods for generating cardiomyocytes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013524837A JP2013524837A (ja) | 2013-06-20 |
| JP2013524837A5 true JP2013524837A5 (enExample) | 2015-05-28 |
| JP5988961B2 JP5988961B2 (ja) | 2016-09-07 |
Family
ID=44904333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013508153A Expired - Fee Related JP5988961B2 (ja) | 2010-04-28 | 2011-04-26 | 心筋細胞を発生させるための方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US9517250B2 (enExample) |
| EP (1) | EP2563907B1 (enExample) |
| JP (1) | JP5988961B2 (enExample) |
| WO (1) | WO2011139688A2 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| US7907222B2 (en) | 2005-09-08 | 2011-03-15 | Universal Electronics Inc. | System and method for simplified setup of a universal remote control |
| US11769398B2 (en) | 2005-09-08 | 2023-09-26 | Universal Electronics Inc. | System and method for widget-assisted setup of a universal remote control |
| US9852615B2 (en) | 2011-03-25 | 2017-12-26 | Universal Electronics Inc. | System and method for facilitating appliance control via a smart device |
| JP5988961B2 (ja) | 2010-04-28 | 2016-09-07 | ザ ジェイ. デヴィッド グラッドストーン インスティテューツ | 心筋細胞を発生させるための方法 |
| WO2011163531A2 (en) * | 2010-06-23 | 2011-12-29 | Vivoscript, Inc. | Compositions and methods for re-programming cells without genetic modification for treatment of cardiovascular diseases |
| US9017661B2 (en) | 2011-02-22 | 2015-04-28 | The Board Of Regents Of The University Of Texas System | Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes |
| US20140289882A1 (en) * | 2011-07-19 | 2014-09-25 | Oregon Health And Science University | Compositions and methods for re-programming cells without genetic modification for repairing cartilage damage |
| US9828585B2 (en) | 2011-08-30 | 2017-11-28 | The J. David Gladstone Instututes | Methods for generating cardiomyocytes |
| US9019435B2 (en) | 2011-09-22 | 2015-04-28 | Universal Electronics Inc. | System and method for configuring controlling device functionality |
| US10593195B2 (en) | 2011-10-28 | 2020-03-17 | Universal Electronics Inc. | System and method for optimized appliance control |
| US10937308B2 (en) | 2011-10-28 | 2021-03-02 | Universal Electronics Inc. | System and method for optimized appliance control |
| US11756412B2 (en) | 2011-10-28 | 2023-09-12 | Universal Electronics Inc. | Systems and methods for associating services and/or devices with a voice assistant |
| US9449500B2 (en) | 2012-08-08 | 2016-09-20 | Universal Electronics Inc. | System and method for optimized appliance control |
| US11295603B2 (en) | 2011-10-28 | 2022-04-05 | Universal Electronics Inc. | System and method for optimized appliance control |
| ES2685319T3 (es) | 2011-11-09 | 2018-10-08 | Cedars-Sinai Medical Center | Generación de células marcapasos basada en factor de transcripción y métodos de uso de las mismas |
| JP2013240308A (ja) * | 2012-05-23 | 2013-12-05 | Kagoshima Univ | ヒトES/iPS細胞における遺伝子発現方法 |
| EP3563859B1 (en) | 2012-08-13 | 2021-10-13 | Cedars-Sinai Medical Center | Cardiosphere-derived exosomes for tissue regeneration |
| WO2014071323A2 (en) | 2012-11-02 | 2014-05-08 | Duke University | Inhibition of histone methyltransferase for cardiac reprogramming |
| ES2651716T3 (es) * | 2012-11-02 | 2018-01-29 | Cornell University | Acondicionamiento angiogénico para potenciar la reprogramación celular cardiaca de fibroblastos del miocardio infartado |
| EP3060649A4 (en) | 2013-10-23 | 2017-07-12 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Reprogramming cardiomyocytes with one transcription factor |
| US11377639B2 (en) * | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
| DE102013114671B4 (de) | 2013-12-20 | 2015-10-29 | Universität Rostock | Verfahren zur Erzeugung von Sinusknotenzellen ("Herz-Schrittmacherzellen") aus Stammzellen |
| JP2015213441A (ja) * | 2014-05-08 | 2015-12-03 | 学校法人慶應義塾 | 心筋様細胞の作製方法及びそれに用いる培地 |
| US10760040B1 (en) | 2014-07-03 | 2020-09-01 | NanoCav, LLC | Mechanical transfection devices and methods |
| US10081816B1 (en) | 2014-07-03 | 2018-09-25 | Nant Holdings Ip, Llc | Mechanical transfection devices and methods |
| CA2962444C (en) | 2014-10-03 | 2023-09-05 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| JPWO2016056438A1 (ja) * | 2014-10-06 | 2017-10-05 | 学校法人慶應義塾 | 心筋様細胞の作製方法及びそれに用いる心筋様細胞の作製用組成物 |
| WO2016134293A1 (en) | 2015-02-20 | 2016-08-25 | Baylor College Of Medicine | p63 INACTIVATION FOR THE TREATMENT OF HEART FAILURE |
| CN118340951A (zh) * | 2015-03-12 | 2024-07-16 | 株式会社艾迪科 | 使用脱细胞化组织的抗粘连材料和代用生物膜 |
| EP3402543B1 (en) | 2016-01-11 | 2021-09-08 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| US10729789B2 (en) * | 2016-03-01 | 2020-08-04 | University Of Virginia Patent Foundation | Compositions and methods for adeno-associated virus mediated gene expression in myofibroblast-like cells |
| EP3431593A4 (en) * | 2016-03-15 | 2019-11-13 | Keio University | METHOD FOR THE DIRECT PREPARATION OF A CARDIGENT CELL OR MYOCARDIAL CELL FROM FIBROBLAST |
| BR112018070255A2 (pt) * | 2016-03-30 | 2019-01-29 | The J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Gladstone | reprogramação cardíaca direta melhorada. |
| US11433116B2 (en) | 2016-04-14 | 2022-09-06 | Cedars-Sinai Medical Center | GJA1 isoforms protect against metabolic stress |
| US11351200B2 (en) | 2016-06-03 | 2022-06-07 | Cedars-Sinai Medical Center | CDC-derived exosomes for treatment of ventricular tachyarrythmias |
| EP3474868A4 (en) * | 2016-06-27 | 2020-07-29 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | MODIFIED GLYCOPROTEINS. |
| WO2018057542A1 (en) | 2016-09-20 | 2018-03-29 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| WO2018055235A1 (en) | 2016-09-21 | 2018-03-29 | University Of Helsinki | Isoxazole-amides for treating cardiac diseases |
| EP3612191B1 (en) | 2017-04-19 | 2026-03-11 | Cedars-Sinai Medical Center | Methods and compositions for treating skeletal muscular dystrophy |
| CA3067863A1 (en) * | 2017-06-21 | 2018-12-27 | Mogrify Limited | Cell reprogramming to cardiomyocytes |
| US11660355B2 (en) | 2017-12-20 | 2023-05-30 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| CN111684059A (zh) * | 2018-01-30 | 2020-09-18 | 株式会社片冈制作所 | 心肌细胞的制备方法 |
| EP3749344A4 (en) | 2018-02-05 | 2022-01-26 | Cedars-Sinai Medical Center | METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS |
| KR20210102870A (ko) | 2018-08-30 | 2021-08-20 | 테나야 테라퓨틱스, 인코포레이티드 | 미오카르딘 및 ascl1을 사용한 심장 세포 재프로그래밍 |
| CN114450411A (zh) | 2019-04-01 | 2022-05-06 | 特纳亚治疗股份有限公司 | 具有工程化衣壳的腺相关病毒 |
| AU2020267561A1 (en) * | 2019-05-08 | 2021-12-23 | Capricor, Inc. | Therapeutically active cells and exosomes |
| JP7592251B2 (ja) * | 2019-06-06 | 2024-12-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 心筋細胞及び組成物ならびにそれらを生成する方法 |
| WO2021050877A1 (en) * | 2019-09-11 | 2021-03-18 | Icahn School Of Medicine At Mount Sinai | Compositions including molecules of modified mrna and methods of using the same |
| JP7514546B2 (ja) * | 2019-12-03 | 2024-07-11 | 学校法人自治医科大学 | 心筋細胞の成熟方法、心筋細胞の成熟度評価方法、成熟心筋細胞の純化方法、心筋細胞成熟度評価装置、心筋細胞成熟度評価プログラム、及び心筋細胞成熟キット |
| AU2021259422A1 (en) | 2020-04-20 | 2022-12-08 | Tenaya Therapeutics, Inc. | Adeno-associated virus with engineered capsid |
| JP7415042B2 (ja) | 2020-10-09 | 2024-01-16 | テナヤ セラピューティクス, インコーポレイテッド | プラコフィリン2遺伝子治療の方法および組成物 |
| CN113046308A (zh) * | 2021-03-05 | 2021-06-29 | 苏州大学附属第二医院 | 促进心脏损伤后修复的一类新型成纤维细胞及其标识方法 |
| WO2023201207A1 (en) | 2022-04-11 | 2023-10-19 | Tenaya Therapeutics, Inc. | Adeno-associated virus with engineered capsid |
| US20260224660A1 (en) | 2023-01-10 | 2026-08-06 | Keio University | Cardiac dilatation function improving agent, and method for screening for cardiac dilatation function improving agent |
| WO2025129079A1 (en) * | 2023-12-13 | 2025-06-19 | Tenaya Therapeutics, Inc. | Cardiac-specific promoters for gene therapy |
| WO2026009883A1 (ja) * | 2024-07-03 | 2026-01-08 | 慶應義塾 | 心筋ダイレクトリプログラミングのための組換えアデノ随伴ウイルスベクター |
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| EP2542669B1 (en) | 2010-03-05 | 2015-01-21 | Texas Heart Institute | Ets2 and mesp1 generate cardiac progenitors from fibroblasts |
| JP5988961B2 (ja) | 2010-04-28 | 2016-09-07 | ザ ジェイ. デヴィッド グラッドストーン インスティテューツ | 心筋細胞を発生させるための方法 |
| WO2011163531A2 (en) * | 2010-06-23 | 2011-12-29 | Vivoscript, Inc. | Compositions and methods for re-programming cells without genetic modification for treatment of cardiovascular diseases |
| US9828585B2 (en) | 2011-08-30 | 2017-11-28 | The J. David Gladstone Instututes | Methods for generating cardiomyocytes |
-
2011
- 2011-04-26 JP JP2013508153A patent/JP5988961B2/ja not_active Expired - Fee Related
- 2011-04-26 US US13/642,391 patent/US9517250B2/en active Active
- 2011-04-26 EP EP11777910.8A patent/EP2563907B1/en active Active
- 2011-04-26 WO PCT/US2011/033938 patent/WO2011139688A2/en not_active Ceased
-
2014
- 2014-03-19 US US14/219,541 patent/US9517251B2/en active Active
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