JP2009529856A5 - - Google Patents

Info

Publication number

JP2009529856A5

JP2009529856A5 JP2008544686A JP2008544686A JP2009529856A5 JP 2009529856 A5 JP2009529856 A5 JP 2009529856A5 JP 2008544686 A JP2008544686 A JP 2008544686A JP 2008544686 A JP2008544686 A JP 2008544686A JP 2009529856 A5 JP2009529856 A5 JP 2009529856A5

Authority

JP

Japan

Prior art keywords

amino acid

protein

acid sequence

dna

seq

Prior art date

2007-03-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 102000004169 proteins and genes Human genes 0.000 claims description 14
• 108090000623 proteins and genes Proteins 0.000 claims description 14
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 13
• 230000000694 effects Effects 0.000 claims description 11
• 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 claims description 10
• 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 claims description 10
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 7
• IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims description 4
• 125000000539 amino acid group Chemical group 0.000 claims description 3
• 238000012217 deletion Methods 0.000 claims description 3
• 230000037430 deletion Effects 0.000 claims description 3
• 238000003780 insertion Methods 0.000 claims description 3
• 230000037431 insertion Effects 0.000 claims description 3
• 238000004519 manufacturing process Methods 0.000 claims description 3
• 238000006467 substitution reaction Methods 0.000 claims description 3
• TYEYBOSBBBHJIV-UHFFFAOYSA-N 2-oxobutanoic acid Chemical compound CCC(=O)C(O)=O TYEYBOSBBBHJIV-UHFFFAOYSA-N 0.000 claims description 2
• LWHINZJANGNUBR-UHFFFAOYSA-N 4-hydroxy-3-methyl-2-oxopentanoic acid Chemical compound CC(O)C(C)C(=O)C(O)=O LWHINZJANGNUBR-UHFFFAOYSA-N 0.000 claims description 2
• 108020004414 DNA Proteins 0.000 claims 9
• 108020004511 Recombinant DNA Proteins 0.000 claims 2
• 238000007792 addition Methods 0.000 claims 2
• 150000001768 cations Chemical class 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 238000002523 gelfiltration Methods 0.000 claims 1
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 claims 1
• OSCCDBFHNMXNME-DSDZBIDZSA-N 4-Hydroxy-L-isoleucine Chemical compound CC(O)[C@H](C)[C@H](N)C(O)=O OSCCDBFHNMXNME-DSDZBIDZSA-N 0.000 description 3
• OSCCDBFHNMXNME-UHFFFAOYSA-N gamma-hydroxyisoleucine Natural products CC(O)C(C)C(N)C(O)=O OSCCDBFHNMXNME-UHFFFAOYSA-N 0.000 description 3
• 239000003125 aqueous solvent Substances 0.000 description 1
• 150000003839 salts Chemical class 0.000 description 1