JP2009529856A5 - - Google Patents
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- Publication number
- JP2009529856A5 JP2009529856A5 JP2008544686A JP2008544686A JP2009529856A5 JP 2009529856 A5 JP2009529856 A5 JP 2009529856A5 JP 2008544686 A JP2008544686 A JP 2008544686A JP 2008544686 A JP2008544686 A JP 2008544686A JP 2009529856 A5 JP2009529856 A5 JP 2009529856A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- protein
- acid sequence
- dna
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004169 proteins and genes Human genes 0.000 claims description 14
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 13
- 230000000694 effects Effects 0.000 claims description 11
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 claims description 10
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 claims description 10
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 7
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims description 4
- 125000000539 amino acid group Chemical group 0.000 claims description 3
- 238000012217 deletion Methods 0.000 claims description 3
- 230000037430 deletion Effects 0.000 claims description 3
- 238000003780 insertion Methods 0.000 claims description 3
- 230000037431 insertion Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000006467 substitution reaction Methods 0.000 claims description 3
- TYEYBOSBBBHJIV-UHFFFAOYSA-N 2-oxobutanoic acid Chemical compound CCC(=O)C(O)=O TYEYBOSBBBHJIV-UHFFFAOYSA-N 0.000 claims description 2
- LWHINZJANGNUBR-UHFFFAOYSA-N 4-hydroxy-3-methyl-2-oxopentanoic acid Chemical compound CC(O)C(C)C(=O)C(O)=O LWHINZJANGNUBR-UHFFFAOYSA-N 0.000 claims description 2
- 108020004414 DNA Proteins 0.000 claims 9
- 108020004511 Recombinant DNA Proteins 0.000 claims 2
- 238000007792 addition Methods 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000002523 gelfiltration Methods 0.000 claims 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 claims 1
- OSCCDBFHNMXNME-DSDZBIDZSA-N 4-Hydroxy-L-isoleucine Chemical compound CC(O)[C@H](C)[C@H](N)C(O)=O OSCCDBFHNMXNME-DSDZBIDZSA-N 0.000 description 3
- OSCCDBFHNMXNME-UHFFFAOYSA-N gamma-hydroxyisoleucine Natural products CC(O)C(C)C(N)C(O)=O OSCCDBFHNMXNME-UHFFFAOYSA-N 0.000 description 3
- 239000003125 aqueous solvent Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2006109216/13A RU2338784C2 (ru) | 2006-03-24 | 2006-03-24 | Новая альдолаза, днк, кодирующая альдолазу, клетки, трансформированные днк, способ получения альдолазы и способ получения 4-гидрокси-l-изолейцина (варианты) |
| PCT/JP2007/056756 WO2007119575A1 (en) | 2006-03-24 | 2007-03-22 | Novel aldolase and production process of 4-hydroxy-l-isoleucine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009529856A JP2009529856A (ja) | 2009-08-27 |
| JP2009529856A5 true JP2009529856A5 (enExample) | 2010-05-13 |
Family
ID=38222150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008544686A Pending JP2009529856A (ja) | 2006-03-24 | 2007-03-22 | 新規アルドラーゼ及び４−ヒドロキシ−ｌ−イソロイシンの製造方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7670822B2 (enExample) |
| EP (1) | EP1999258A1 (enExample) |
| JP (1) | JP2009529856A (enExample) |
| RU (1) | RU2338784C2 (enExample) |
| WO (1) | WO2007119575A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006113897A2 (en) * | 2005-04-20 | 2006-10-26 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| US8158389B2 (en) * | 2005-04-20 | 2012-04-17 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| US8076108B2 (en) * | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| CA2643416C (en) | 2006-03-07 | 2016-07-26 | Cargill, Incorporated | Aldolases, nucleic acids encoding them and methods for making and using them |
| EP2066799B1 (en) | 2006-09-28 | 2013-12-11 | Ajinomoto Co., Inc. | Method for producing 4-hydroxy-l-isoleucine |
| EP2094858B1 (en) * | 2006-12-11 | 2015-02-18 | Ajinomoto Co., Inc. | Method for producing an l-amino acid |
| JP2010110217A (ja) * | 2007-02-22 | 2010-05-20 | Ajinomoto Co Inc | Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法 |
| JP2010130899A (ja) | 2007-03-14 | 2010-06-17 | Ajinomoto Co Inc | Ｌ−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法 |
| JPWO2008133131A1 (ja) * | 2007-04-16 | 2010-07-22 | 味の素株式会社 | 有機酸の製造方法 |
| WO2008133161A1 (ja) * | 2007-04-17 | 2008-11-06 | Ajinomoto Co., Inc. | カルボキシル基を有する酸性物質の製造法 |
| JP2009131254A (ja) * | 2007-11-07 | 2009-06-18 | Ajinomoto Co Inc | ４−ヒドロキシイソロイシン又は２−アミノ−３−メチル−４−ケトペンタン酸の製造法 |
| RU2392323C2 (ru) * | 2007-11-07 | 2010-06-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Способ продукции 2-амино-3-метил-4-кетопентаноата |
| RU2395580C2 (ru) * | 2007-12-21 | 2010-07-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Способ конструирования бактерии-продуцента (2s,3r,4s)-4-гидрокси-l-изолейцина, бактерия-продуцент (2s,3r,4s)-4-гидрокси-l-изолейцина и способ продукции (2s,3r,4s)-гидрокси-l-изолейцина или его соли |
| RU2007147436A (ru) * | 2007-12-21 | 2009-06-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Бактерия-продуцент (2s,3r,4s)-4-гидрокси-l-изолейцина и способ продукции (2s,3r,4s)-4-гидрокси-l-изолейцина |
| JP5499714B2 (ja) * | 2008-02-15 | 2014-05-21 | 味の素株式会社 | 腸管免疫賦活剤 |
| EP2286836A4 (en) * | 2008-04-17 | 2011-10-12 | Ajinomoto Kk | IMMUNOSTIMULATING AGENT |
| RU2010101135A (ru) | 2010-01-15 | 2011-07-20 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Бактерия семейства enterobacteriaceae - продуцент l-аспартата или метаболитов, производных l-аспартата, и способ получения l-аспартата или метаболитов, производных l-аспартата |
| EP3630798B1 (en) * | 2017-05-27 | 2022-11-23 | Enzymaster (Ningbo) Bio-Engineering Co., Ltd. | Engineered aldolase polypeptides and their applications in synthesis of beta-hydroxy-alpha-amino acids |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2745718B1 (fr) * | 1996-03-08 | 1998-05-07 | Gestion Jouvenet Soc Civ De | Composition antidiabetique a base de 4-hydroxyisoleucine |
| EP1375664B1 (en) * | 2001-03-30 | 2009-11-04 | Ajinomoto Co., Inc. | Method for the secretion and production of protein |
| AU2003205041A1 (en) * | 2002-07-12 | 2004-01-29 | Ajinomoto Co., Inc. | Method for producing target substance by fermentation |
| EP1533376B1 (en) * | 2002-08-26 | 2010-04-07 | Ajinomoto Co., Inc. | Novel aldolases and process for producing substituted alpha-keto acid |
| BR0304860A (pt) * | 2002-11-11 | 2004-08-31 | Ajinomoto Kk | Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia |
| US7468262B2 (en) * | 2003-05-16 | 2008-12-23 | Ajinomoto Co., Inc. | Polynucleotides encoding useful polypeptides in corynebacterium glutamicum ssp. lactofermentum |
| PL1651758T3 (pl) * | 2003-07-29 | 2009-04-30 | Ajinomoto Kk | Sposób wytwarzania L-lizyny lub L-treoniny przy użyciu bakterii Escherichia o atenuowanej aktywności enzymu jabłczanowego |
| US20050181488A1 (en) * | 2004-02-12 | 2005-08-18 | Akhverdian Valery Z. | Method for producing L-threonine using bacteria belonging to the genus Escherichia |
| WO2006093322A2 (en) * | 2005-03-03 | 2006-09-08 | Ajinomoto Co., Inc. | Method for manufacturing 4-hydroxy-l-isoleucine or a salt thereof |
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2006
- 2006-03-24 RU RU2006109216/13A patent/RU2338784C2/ru not_active IP Right Cessation
-
2007
- 2007-03-22 WO PCT/JP2007/056756 patent/WO2007119575A1/en not_active Ceased
- 2007-03-22 EP EP07740194A patent/EP1999258A1/en not_active Withdrawn
- 2007-03-22 JP JP2008544686A patent/JP2009529856A/ja active Pending
-
2008
- 2008-09-18 US US12/212,767 patent/US7670822B2/en not_active Expired - Fee Related